Physical activity is not only important for fitness but also for overall health. This is confirmed by a new study, which identified PanK4 as a key regulator of energy metabolism in skeletal muscle, regulating glucose uptake and fatty acid oxidation and being activated by physical exercise.
The study suggests that PanK4 could be a promising approach for treating metabolic disorders such as type 2 diabetes. The findings were published in the journal Nature Communications.
Skeletal muscle accounts for 30% to 40% of body weight and is critical for maintaining healthy glucose and lipid metabolism. Impairment in the skeletal muscle’s capacity to efficiently use or store glucose can disturb overall glucose homeostasis, potentially resulting in insulin resistance—a major risk factor for type 2 diabetes. Nevertheless, there are only a few therapeutic options that target musculature to treat metabolic disorders.
Studies in humans and mice
Physical activity enhances glucose uptake in muscles and promotes metabolic flexibility. Therefore, it is an effective method for improving glucose metabolism, particularly in insulin resistance and type 2 diabetes. However, the underlying molecular mechanisms are largely unknown.
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These mechanisms were the focus of investigations by a broad international research team, including scientists from the German Center for Diabetes Research (DZD), coordinated by Prof. Dr. Maximilian Kleinert, head of the Department of Molecular Physiology of Exercise and Nutrition at the DIfE.
Using modern mass spectrometric methods, the team successfully identified proteins that are phosphorylated in human and animal muscles following physical exercise. One of these proteins is pantothenate kinase 4 (PanK4).
To elucidate the role of PanK4 in regulating energy metabolism in skeletal muscle, Kleinert and his team utilized various genetic mouse models (knockout and overexpression) to conduct comprehensive physiological investigations. These studies included treadmill running experiments and glucose tolerance tests to assess metabolic function.
Furthermore, the researchers analyzed human muscle tissue samples obtained post-exercise, conducted metabolic analyses, and utilized advanced molecular biological techniques such as RNA sequencing and protein analyses.
Mice lacking PanK4 are struggling
The researchers observed that the general absence of PanK4 in mice resulted in reduced growth and decreased skeletal muscle mass, among other effects. Furthermore, animals with a muscle-specific deficiency of PanK4 exhibited an increased fat content and impaired fatty acid oxidation within the muscle tissue.
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Metabolomic analyses indicated that PanK4 plays a critical role in regulating acetyl-CoA levels in skeletal muscle. The absence of PanK4 led to a significant increase in acetyl-CoA, which disrupted the regulation of fatty acid oxidation and glucose metabolism. During training studies with mice specifically lacking PanK4 in their muscles, this was manifested by reduced glucose uptake during insulin stimulation and muscle contraction.
In contrast, mice with overexpression of PanK4 showed a significant improvement in glucose uptake in the muscles and a reduction in acetyl-CoA levels, underscoring the importance of PanK4 as a regulator of glucose metabolism. These results suggest that PanK4 plays a key role in maintaining metabolic flexibility, particularly in terms of the simultaneous utilization of fatty acids and glucose as energy sources.
Novel therapeutical approaches
Identifying PanK4 as a key regulator of muscle metabolism offers a promising new avenue for therapeutic interventions. According to Kleinert, “PanK4’s significance in metabolism places it alongside established key players like mTOR, AMPK, and Akt. Targeted modulation of PanK4 could potentially improve metabolic health and support blood sugar control, making it a promising target for therapies aimed at treating metabolic disorders such as type 2 diabetes.”
Furthermore, the finding that PanK4 is activated by physical activity and enhances energy metabolism in muscles underscores the importance of regular exercise for overall health. Kleinert emphasizes, “Regular physical activity not only enhances fitness but also has profound effects on metabolism, which can serve as a motivating factor for adopting an active lifestyle.”
Kleinert and his team plan to conduct further investigations to understand the precise mechanisms by which the phosphorylation of PanK4 by exercise or insulin modulates its activity. Specifically, they aim to elucidate how this phosphorylation event influences the regulation of acetyl-CoA levels and metabolic flexibility in skeletal muscle. Moreover, the role of PanK4 in other tissues, including the hypothalamus, and its impact on systemic energy homeostasis will be explored in greater detail.
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More information:
Adriana Miranda-Cervantes et al, Pantothenate kinase 4 controls skeletal muscle substrate metabolism, Nature Communications (2025). DOI: 10.1038/s41467-024-55036-w
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One of the harder parts of committing to a training routine is knowing where to start, and that’s true of those who have never trained regularly before as well as more experienced people coming back after a break.
This 20-minute workout from fitness trainer Lindsey Bomgren, founder of Nourish Move Love on YouTube, is perfect for easing your way into a training routine, especially if you’re coming back from a break because of illness or any other reason.
The workout trains the whole body through two rounds of exercises that you can complete in 20 minutes, even with a quick warm-up and cool-down included.
You do need a set of dumbbells for the workout, with Bomgren suggesting 15-25lb weights as a rough guideline. If you have a set of the best adjustable dumbbells available, you can change the weight to suit each exercise as and when required.
20 Minute FULL BODY Comeback Workout (Easy Re-Entry After Sickness/Break) – YouTube
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The workout contains nine exercises, with some of those being done on both sides for 12 moves in total in each round. You do two rounds of the exercises, completing 10 reps of each move, or 10 on each side if appropriate.
Bomgren demonstrates each move and sets the pace for the session, so you can follow her when possible, or slow down if you need to. Bomgren’s fellow trainer, Rachel, is also on hand to offer easier modifications of some exercises you can do instead.
In order to work as many muscles as possible in 20 minutes, the workout is mostly made up of compound exercises that recruit several joints and muscle groups at once, like squats and lunges.
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There are also some more focused moves like triceps extensions, and your core is also worked with some bicycle crunches and glute bridges.
It’s a fast-paced session that will not only get you fitter and stronger, but also help you prepare for longer, harder workouts if you are kicking off a regular workout routine.
Bomgren also includes a quick warm-up and cool-down in the video, which is invaluable and well worth doing. The warm-up will get you ready for the workout, so you can get the most out of the first few exercises, while the cool-down will help start your recovery and reduce any muscle soreness you might feel after the workout, especially if it’s your first session in a while.
If you are a beginner or finding it hard to match Bomgren’s pace throughout the session, you can also reduce the number of reps you do for each move to six or eight. This will give you a bit more time to complete your set, rather than rushing to do 10 reps and potentially sacrificing good form.
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The beauty of a standing abs workout is that you do not need a mat, much space, or to get down on the ground for any of the exercises. That makes it easy to fit into a busy day, whether you are working out at home, short on space, or prefer to stay off the floor altogether.
None of that means it is easier or delivers fewer results. Pilates instructor and Balance Body Educator Portia Page built this five-move, all-standing core workout to show that you can still challenge your abs effectively without a mat or traditional floor exercises.
Her routine focuses on strength, rotation, balance and power, training the core in an upright position that mirrors how it works in everyday movement and exercise. To get the most out of the workout, having a handle on how to switch your core on can make a real difference.
What is the workout?
1. Standing “Hollow” Scoop + Reach + Deep Squat
Stand tall, feet hip-width, knees soft.
Exhale and scoop your abs up and in (think: ribs to hips, belly hollow).
Keeping the scoop, reach your arms overhead, maintaining the scoop.
Keeping the arms up, bend your knees and sit back & down into a deep, low squat
Straighten legs, lower arms and lift heels into a balance
Repeat, moving slowly down and up
2. High Knee Twist with Extension
Lift your right knee to hip height slowly.
Rotate your ribs toward (not down to) the lifted knee.
Lower leg and extend behind while rotating & extending in the opposite direction.
Repeat 5-10x on one side, repeat the same amount on the other.
Make it harder: Lift the knee higher than hip height and/or hold arms overhead.
3. Lateral Side Crunch
Stand tall, hands behind your head.
Shift weight to one leg.
Lift the opposite leg out to the side.
Pull your ribs toward your lifted hip like a side crunch.
Lower leg and crunch to the other side.
Repeat 5-10 times on each side.
Make it harder: Keep the leg lifted the whole interval. Your obliques will file a complaint!
4. Woodchop Squat & Twist
Bring your hands together over your right shoulder.
Bend the knees slightly, then powerfully chop down toward the left hip.
Pause at the bottom, stop the momentum, then return slowly to start.
Repeat 5-10 times on each side.
5. Single-Leg Hover Hold with Rotation
Stand tall with arms stretched to the side, shift weight to the left foot.
Lift right knee to hip height.
Extend the right leg straight forward, creating an upside-down L-shape while rotating the upper body to the right, and bend the right knee.
Straighten the standing leg and twist back to center.
Repeat 5-10 times. Switch legs.
What’s so good about standing abs workouts?
Standing ab exercises challenge the core in a more upright, everyday way than floor-based exercises do. Instead of working from a fixed position on a mat, you are asking your body to remain stable while standing, moving and balancing, which naturally brings more of the core into play.
Pilates instructor Page explains that this routine works the core through rotation, anti-rotation and lateral stability, the types of strength you use when walking, lifting, or changing direction. Because you are on your feet, balance becomes part of the challenge too, and even small wobbles force the deeper muscles to switch on.
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She also includes elements of controlled power and standing hollow work, which asks the core to absorb and redirect force rather than just hold tension. The result is a stronger, more responsive midsection, without the need for any planks or crunches.
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Fitness and health apps have been promising “smart coaches” and “personalised training plans” for years. But, to date, most programmes have been like online shopping recommendations, with exercises broadly matching your demographic profile and performance level.
However, the rapid advances in real-time image recognition, generative AI and natural language processing are bringing an AI coach worthy of the name within our grasp. And not just for high-tech gyms like Lumin, but also for people working out at home or in the park. Peloton, for example, films how you exercise and provides feedback in real time. Google has also announced AI-powered personalised fitness and health advice for its Fitbit range.
HYROX pro athlete Jake Dearden putting in the work on an indoor bike
Market analysts think the AI fitness market could be worth close to $35b USD by 2030. But how close are we to that future? Which company is training up the supertrainer? And how will that change the way we exercise, sweat and track our progress? And what do we need to know about this new world?
Harnessing AI’s potential to make personalised training available to all
Most fitness apps give generic exercise suggestions
Confidence Udegbue has the perfect CV for designing an AI coach. The Vice President of Product at fitness app Freeletics studied electrical and computer engineering and teaches fitness classes in his free time. His broad shoulders, muscular biceps and infectious spirit are a dead giveaway: this guy knows what he’s talking about.
“In the gym, I can see immediately when someone I’m teaching is making a mistake,” says Udegbue. “But that expertise is hard to scale.” Freeletics is trying to solve that problem with AI. The app has been using a predictive algorithm since 2019 to suggest workouts based on demographic data and self-assessed fitness levels. This means that a 39-year-old man who has been training for two years and is at level 63 in the app won’t receive the same instructions as a 25-year-old beginner.
Freeletics uses AI-based motion analysis powered by models like those from Google’s MediaPipe framework, which includes BlazePose – the successor to the earlier PoseNet model. The models provide a skeletal muscle database that can replicate all types of exercises, for which Freeletics sports scientists then define the movements. That way, the system can assess whether that squat you just did went low enough.
Can an AI coach give useful real-time workout feedback?
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World-class sabre fencer Olga Kharlan checks her phone
In 2024, Freeletics introduced the Coach+ feature – an AI-powered chatbot with Freeletics expertise and access to anonymised data from over 59m user journeys. Users can ask the virtual coach questions like, “How can I build muscle mass?” or “I feel weak – how can I motivate myself?”
Freeletics is currently testing a version that will allow the app to see you work out. As of April, users have been able to record themselves exercising on their smartphones. “AI counts the reps and gives direct feedback,” Udegbue says. That is particularly helpful because even experienced athletes do not always perform pistol squats or burpees correctly.
A personal coach was long the preserve of Hollywood actors, top models and CEOs – a highly competent service provider, always available whenever a slot opened up in their client’s busy schedule. They know their clients’ allergies, preferences and weak spots. They always know how to set the pace. Sometimes they’re pushy, sometimes they go easy. They are a mix of therapist, personal assistant and best friend – open 24/7, all major credit cards accepted.
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In the soccer world, the manager is often called “boss” – a figure of respect who takes care of the players both on and off the field. A good coach can tell when something is off in a movement – when the person’s mind is elsewhere, or they’re lacking energy. Anyone who has had that person in their life knows that a good coach is worth their weight in gold, which is why there are coaches for everything – careers, relationships, nutrition – and why the idea of a personalised fitness coach is so appealing.
AI has no body or talent. It doesn’t know what it feels like for sweat to run down the skin or for muscles to cramp or for adrenaline to rush through the veins. But it does recognise patterns and make predictions that we humans can use increasingly often and, in the best-case scenario, find out more about ourselves in the process.
Mirrors show you how you see yourself. But the Magic AI Mirror promises that you will like what you see if you follow the exercises and tips on the reflective screen. Behind the glass surface is an AI coach who steers your workouts in real time.
Growl goes even deeper into movement detection. The start-up has developed an exercise boxing bag that captures every movement with 3D cameras and Lidar (light detection and ranging) technology. AI corrects your posture or encourages you when your energy decreases.
Whoop’s fitness trackers combine biometric data with generative AI. If you’re wondering when you got your best sleep, you’ll get a precise answer: “On July 14, because the allergy season was over and you didn’t drink alcohol.” You can chat with your body.
Freeletics is also banking on predictive AI. “Soon the system will recognise that user X has had an increased resting heart rate for days, so I won’t suggest high-intensity exercises,” says Udegbue.
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The vision all companies are working on is a multimodal coach: AI that unlocks information – biometrics, genetics, video, training history – and conveys it intuitively to the user. But a perfect coach is more than just an algorithm. Researchers are working on reinforcement learning systems that set individual step goals that are challenging but achievable, and adapt whenever progress has been made.
“We will not be able to deliver on the promise of absolute personalisation for the mass market,” Eskofier says. But before you lose hope, you should know what he means by personalisation.
His laboratory supports, among other people, Sebastian Steudtner, the big wave surfer and world record holder. To do this, they measured his body in an MRI scanner, carried out psychological assessments, calculated strength curves and even fitted his surfboard and wetsuit with sensors.
Eskofier’s team created Steudtner’s digital twin. By the time the project concluded in May 2025, their AI system could already discuss with a real coach what angle Steudtner should surf a 100-foot wave at, and whether he’d be strong enough to do it.
The one thing AI will never change in fitness training
No equipment, no excuses – embrace the simplicity of pure movement
“We can’t offer that service to millions of people,” Eskofier says. “But these systems can still create real added value.” He believes AI coaches are a good base: “AI can take over data processing and routine personalisation, while real coaches can focus on mentoring.”
AI coaches are getting smarter all the time, too, which is why it’s important to know what they can and can’t do. Limited data sets can lead to bias if too few women or people of below-average height are represented in the data.
“No matter how good the technology gets, one thing will never change,” says Udegbue. “A coach can only make you better if you want to be better yourself, too.” It’s all in your hands.