Health
Heart attack damage reversed with injectable RNA therapy, study finds
Heart attack deaths rising among young Americans
Fox News senior medical analyst Dr. Marc Siegel joins ‘America’s Newsroom’ to discuss a dramatic increase in fatal heart attacks among people under the age of 55 and how to keep the heart healthy.
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Scientists have developed a new therapy designed to repair cardiac damage after a heart attack.
The study, led by researchers at Columbia University and published in the journal Nature Biomedical Engineering, explored a two-step strategy that uses skeletal muscle to produce a healing molecule that activates when it reaches an injured heart.
Unlike many organs, the adult human heart has a limited ability to repair itself after a heart attack, the researchers noted.
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“The heart is one of the organs with the least ability to regenerate,” said Ke Cheng, a professor of biomedical engineering at Columbia and the study’s lead author, in a press release.
Dead muscle is typically replaced by stiff scar tissue, often leading to heart failure. However, newborns’ hearts can spontaneously regenerate during a brief window of time.
Scientists have developed a new therapy designed to repair cardiac damage after a heart attack. (iStock)
“The neonatal heart spontaneously produces more of this molecule after a heart attack,” Cheng said. “The adult can’t produce a sufficient amount, so we found a way to supplement this to the heart.”
“The whole idea is that we learn from nature.”
The secret to this treatment is a protein called ANP, which acts as a repair mechanism for the heart, according to the researchers. Normally, this protein is impossible to use as a drug because it dissolves in the blood within minutes, long before it can reach the heart.
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To solve this, researchers turned the body’s own skeletal muscles into a sort of factory to produce ANP, using a specialized RNA injection to give the arm or leg muscles a set of instructions.
These instructions tell the muscle to produce a “sleeping” version of the repair protein. This inactive version safely travels through the bloodstream until it hits the heart, according to the release.
Dead muscle is typically replaced by stiff scar tissue, often leading to heart failure, the researchers noted. (iStock)
Once there, it meets a specific enzyme that acts like a key, “waking up” the protein so it can begin repairing exactly where it’s needed.
In preclinical trials involving both small and large animals, a single injection into the limb reduced scarring and significantly improved heart function.
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Because the researchers used self-amplifying RNA, which replicates once it’s inside the body, the treatment continued to produce the healing protein for at least four weeks.
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The therapy remained effective even when administered a week after the initial injury, providing hope for patients who do not receive immediate treatment, the researchers also found.
The treatment continued to produce the healing protein for at least four weeks. (iStock)
“The patient doesn’t have to go to the hospital today and tomorrow,” Cheng said, noting that the method avoids the risks associated with injecting treatments directly into the heart muscle.
So far, the treatment has only been tested in animals, which poses a significant limitation to the study. Human hearts are much more complex, and clinical trials are needed to determine whether they react in the same way.
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Additionally, because the RNA remains active for several weeks, scientists need to ensure that producing this repair protein for an extended time doesn’t cause any unintended side effects in other parts of the body.
Health
Officials slam hospital food as health experts demand menu overhaul: ‘Farm to gurney’
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HHS Secretary Robert F. Kennedy Jr. is pushing to expand the Dietary Guidelines for Americans into hospitals, integrating federal nutrition standards into patient care.
On March 30, the Centers for Medicare & Medicaid Services (CMS), led by Dr. Mehmet Oz, sent a memo directing hospitals to align their meals with the guidelines by reducing ultraprocessed foods, sugar-sweetened beverages, refined carbohydrates and added sugars.
Kennedy reportedly shared that Oz’s memo effectively acts like a federal mandate, as hospitals may need to follow the dietary guidelines to maintain funding.
DR OZ BLASTS ‘WHITE FOODS’ AS OBESITY DRIVERS AS FEDERAL DIETARY GUIDELINES CONTINUE TO MAKE WAVES
Most hospital menus rely heavily on convenience foods, according to Dr. Hamid Khan, chief medical officer of Jorie AI, a healthcare revenue service.
“Patients are often served items such as pasta, processed deli meats, packaged snacks with artificial components, sugary desserts, cereals, juice and soda,” he told Fox News Digital.
The Centers for Medicare & Medicaid Services sent a memo directing hospitals to align their meals with the Dietary Guidelines for Americans. (iStock)
“Although many hospitals have begun the implementation of ‘healthier options,’ the average menu still tends to prioritize low cost, long shelf life and ease of preparation over nutrition.”
Larger concerns include high sugar and sodium levels, processed ingredients and refined carbohydrates in hospital foods, Khan said. “There seems to be a lack of high-quality protein, fresh fruits, vegetables and healthy fats,” he added.
“The average hospital menu still tends to prioritize low cost, long shelf life and ease of preparation over nutrition.”
Khan said he has seen patients order their meals from Grubhub, DoorDash or Uber Eats because they felt the hospital menu options were not healthy enough.
“Most of the hospital meals do not provide adequate nutrients … to properly support healing, muscle maintenance, immunity or overall recovery,” he told Fox News Digital.
“Poor nutrition only makes things worse for this patient pool,” Khan went on. “Ultimately, poor nutrition is very harmful for elderly patients and people with chronic illnesses. They are at a higher risk for muscle loss, weakness, delayed healing, infection and re-infection.”
“There seems to be a lack of high-quality protein, fresh fruits, vegetables and healthy fats,” a doctor said. (iStock)
Celebrity chef and restaurateur Geoffrey Zakarian is partnering with Tampa General Hospital in Florida to transform hospital dining, introducing Mediterranean diet–inspired meals for patients.
Zakarian told Fox News Digital that hospital food is often a mix of “high desire, low-value and low-nutrition food,” typically priced to meet a strict per-plate cost that hospitals cannot exceed.
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“[There is] very little emphasis on original, pasture-raised proteins and fats like eggs, whole dairy grass-fed beef and poultry, and unprocessed vegetables,” he said.
In Tampa, Zakarian has been working since 2023 to eliminate all processed foods — removing items containing hormones, added sugars, seed oils and anything prepackaged.
“All the food originates from farms and gardens in and around Tampa,” he said, calling the mission “Farm to Gurney.”
“Patients are often served items such as pasta, processed deli meats, packaged snacks with artificial components, sugary desserts, cereals, juice and soda.” (iStock)
Sec. Kennedy and CMS administrator Dr. Mehmet Oz announced a similar initiative at Nicklaus Children’s Hospital in Miami.
Vani Hari, known as the “Food Babe,” told Fox News Digital that this is the first time leaders in Washington are openly acknowledging that food is medicine.
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“The fact that they had to send a memo reminding hospitals of that tells you everything about how broken the system is,” said Hari, who is based in North Carolina. “People are at their most vulnerable in a hospital bed – and for decades, nobody in charge seemed to care what they were eating.”
Medicare and Medicaid fund the majority of inpatient services, including at least half of inpatient days at 96% of hospitals and two-thirds or more at 80% of hospitals, according to the American Hospital Association (AHA).
An AHA spokesperson told Fox News Digital that hospitals recognize that nutritious food is an essential part of healing and recovery. (iStock)
An AHA spokesperson told Fox News Digital that hospitals recognize nutritious food is an essential part of healing and recovery.
“They are deeply committed to providing patients with high‑quality, nutritious meals that meet clinical standards, individual dietary needs and federal guidance,” said the spokesperson.
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Hospital teams collaborate with registered dietitians and clinical staff to make sure each patient receives meals tailored to their medical needs and recovery plan, according to the AHA.
The spokesperson also said the organization regularly evaluates current evidence-based nutrition recommendations and integrates them into meal programs.
“Beyond the hospital walls, we partner with community organizations to expand access to nutritious food, provide education on healthy eating, and support initiatives that promote long‑term wellness,” they added.
Health
5 key factors may predict stroke risk years after first event, study finds
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After a minor stroke, there are several risk factors that can predict another event, according to new research.
A study published in the journal Circulation by the American Heart Association investigated what happens after someone has a transient ischemic attack (TIA), also known as a “mini-stroke.”
This was a follow-up to the previous PERSIST study, which found that stroke risk persisted after the typical 90-day monitoring window.
NEARLY 90% OF AMERICANS AT RISK OF SILENT DISEASE — HERE’S WHAT TO KNOW
The Canada-based researchers measured long-term risk, finding that individuals who experience a minor stroke face an elevated chance of a recurrence for at least 10 years.
The systemic review included 28 observational studies with more than 86,000 participants who were followed for at least one year after experiencing a minor stroke. The median age was 69 and 57% of them were men.
Researchers discovered that people who had smaller strokes were at a high risk of experiencing another event in the 10 years following. (iStock)
The review identified the following five key factors that may predict another stroke.
- Hypertension (high blood pressure) is the most important modifiable risk factor for stroke, according to the American Stroke Association.
- Smoking is another leading modifiable cause, roughly doubling the risk of a repeat stroke, per the above source.
- Cardioembolism is a type of stroke that occurs when a blood clot forms in the heart and travels to the brain, according to medical experts. This event has a high risk of recurrence compared to other types of strokes.
- Large-artery atherosclerotic stroke occurs when plaque builds up in major arteries, reducing blood flow or sending clots to the brain. It also has a high risk of recurrent stroke, especially in the first days or weeks after the initial event, according to experts.
- Small-vessel disease is a type of stroke that causes damage to the brain’s small penetrating arteries, often due to chronic hypertension and aging. It has a significant risk of recurrence over time, although lower than the previous two types.
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Older age was also associated with a higher risk.
The researchers said these results can help doctors spot patients who have a long-term risk of stroke, so they can keep a closer eye on them, provide the right treatment, and create more focused ways to prevent strokes.
The five factors that may predict another stroke include hypertension, smoking and three subtypes of stroke. (Justin Tallis, AFP/Getty Images)
Cardiologist Bibhu D. Mohanty, MD, cardiovascular sciences associate professor at University of South Florida, Morsani College of Medicine, was not involved in the research but discussed the findings with Fox News Digital.
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“This is an interesting meta-analysis that is well-performed technically, in seeking to address a challenging question in a population that is demonstrating early signs of significant stroke risk,” he said.
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Identifying risk factors is an important first step in identifying “actionable intervention,” according to Mohanty.
“Now that we know what they are, what can we do about them?” he questioned. “As a medical community, we are all aware that there is considerable overlap in modification of brain health and heart health.”
“This highlights the importance of seeking collaborative insight and decision-making amongst cardiologist and neurologists when comprehensively managing patients with stroke or stroke risk,” a cardiologist said. (iStock)
The cardiologist said he treats many stroke patients, but was surprised by how many had cardioembolic strokes — caused by clots that form in the heart — on top of common vascular risk factors like high blood pressure and artery plaque.
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“From both a clinician and patient perspective, this highlights the importance of seeking collaborative insight and decision-making among cardiologists and neurologists when comprehensively managing patients with stroke or stroke risk,” he added.
Fox News Digital reached out to the study authors for comment.
Health
She Lost 117 Pounds With the Help of Daily Prayer—Here’s How
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