Published March 25, 2026 12:36PM
Fitness
What Happens to Your Body When You Take Ozempic Without Exercising
Losing weight doesn’t necessarily make you fitter, a new study finds.
(Photo: Oleg Breslavtsev / Getty)
Is exercise obsolete in the age of Ozempic? Now that the initial hype has settled down, nobody makes that claim with a straight face. In fact, one of the big fears among people taking GLP-1 agonists (the class of drug to which Ozempic belongs) is that they’ll lose too much muscle along with all the fat, leaving them weaker and less healthy. But at this point, there’s very little data on what happens when you combine these drugs with an exercise routine (or lack thereof).
A newly published study in the journal Sports Medicine steps into this gap. It’s a secondary analysis of data from a previously published study by researchers at the University of Copenhagen in Denmark, funded in part by the Novo Nordisk Foundation (Novo Nordisk is the company that makes Ozempic). The study follows volunteers taking another Novo Nordisk GLP-1 agonist called liraglutide (sold under the brand names Victoza and Saxenda) for an entire year, with or without the addition of a regular exercise program. The results show that without exercise, both health and physical function suffer—and it’s not just about muscle.
What the GLP-1 Study Found
The study involved 193 adults between the ages of 18 and 65. It’s a little unusual in that they started by following an eight-week very-low-calorie diet before starting either exercise or the GLP-1 drug. That’s because the original study was designed to look at ways of maintaining weight loss. Everyone included in the study lost at least 5 percent of their starting weight, which resulted in an average weight loss of 29 pounds. Then, for the following year, they either exercised, took the GLP-1 drug, did both, or did neither. (Those who didn’t get the drug got a placebo.)
The exercise program involved two group exercise classes per week, including 30 minutes of intervals on an exercise bike, then 15 minutes of circuit training (step-ups, boxing, squats, kettlebells, and so on). The subjects were also asked to do two additional workouts on their own; the details were up to them, but most chose running, cycling, brisk walking, or circuits. Adherence was decent: they averaged 2.65 workouts a week and met standard public health guidelines for physical activity.
The first outcome of interest (as reported in the original analysis) is weight. Here’s the trajectory of the four groups:
Doing nothing was the worst option. Exercising and taking a GLP-1 drug was the best option. If you had to choose one or the other, the drug looks marginally better, though the difference wasn’t statistically significant.
Does Fitness or Fatness Matter More?
There’s a longstanding debate about the relative health effects of being overweight versus being aerobically unfit. The two often go together, so they get conflated—but they’re not the same thing. The general trend of evidence, according to the Danish research team, is that it’s better for health and longevity to be fit and overweight than unfit and normal weight. This distinction is important in the context of GLP-1 drugs, because if they help you lose weight without gaining fitness, then the health benefits may be less than you’d expect.
Figuring out how to measure fitness in this context isn’t straightforward. When you lose weight, you’ll generally lose some muscle mass in addition to fat loss. Both strength and aerobic fitness (as measured by VO2 max) are roughly proportional to muscle mass, so your absolute fitness might appear to decline when you lose a lot of weight. But if you lose less strength or fitness in proportion to your overall weight loss, you’ll still end up with greater functional fitness: you’ll have an easier time getting up from a chair, be able to walk for longer, and so on.
One of the simple functional tests the Danish study included was a stair-climb test: climb up and down an 11-step stairway twice, as fast as possible. Here’s what those results looked like:
It’s clear here that the exercise program helped people speed up and down the stairs more quickly, whether or not they were taking the GLP-1 drug. Just taking the drug without exercising didn’t have any benefit.
There are a whole bunch of other fitness measures in the paper: VO2 max tests, leg strength tests, body composition tests to measure muscle mass in the arms and legs. The fitness outcomes can be expressed in absolute terms, or relative to total body weight, or relative to muscle mass. No matter how you express it, the overall pattern, with a few minor exceptions, is the same as the graph above: exercise makes you fitter, simply taking the drug doesn’t.
(An example of a minor exception: the drug alone was enough to improve relative leg strength, i.e. leg strength divided by total body weight, because weight decreased more than strength. But adding exercise worked even better.)
This conclusion—that the best way to get fitter is to exercise—is not exactly surprising. But I think it has been overlooked in discussions about GLP-1 drugs. I’ve certainly seen lots of chatter about the dangers of muscle loss with Ozempic, and the need to pound protein and lift weights. That’s a legitimate concern, but aerobic fitness is an even better predictor of longevity and marker of general health. GLP-1 drugs have remarkable properties, but they haven’t made exercise obsolete.
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Fitness
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Fitness
Are Stamina and Endurance the Same Thing?
Athletes need to think about stamina and endurance all the time. Whether you’re a runner, a basketball player or a swimmer, your ability to push hard and keep going often determines who wins and who comes out on top.
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But endurance and stamina aren’t just important for athletes. They can also affect how easily you tackle everyday activities, like yardwork or helping a friend move.
Exercise physiologist Christopher Travers, MS, explains what sets stamina and endurance apart and how to build up both with a variety of workouts.
How stamina and endurance work together
Stamina and endurance often go hand in hand — but they’re different.
Think of stamina as how hard you can push yourself, and endurance as how long you can maintain that effort.
In car terms, stamina reflects how hard you push on the gas pedal for a quick jump in speed. Endurance reflects how far you can go before running out of fuel.
Together, they help you reach your destination and achieve milestones in your physical performance.
Let’s dig a little bit more into what makes each unique.
What is stamina?
Stamina describes your mental and physical ability to sustain high-intensity effort over a shorter period of time. It’s that quick burst at the starting line, the second-wind sprint you get during the last push of a marathon and the fast acceleration that carries you uphill.
“With stamina, you’re trying to push through at a higher heart rate,” says Travers. “It’s your power, your speed and your repeated burst of effort.”
What is endurance?
Endurance describes your body’s ability to sustain low-to-moderate-intensity activity over very long periods of time. It’s the ability to endure a marathon, miles of cycling and long workout sessions without stopping or decreasing intensity.
“With endurance, you’re learning how to maintain a certain level of intensity for the longest period of time,” says Travers. “You’re focused on your breathing, keeping a steady pace and sticking to correct form so you can go longer without running out of energy.”
How to increase endurance and stamina
Building stamina and endurance involves different approaches to physical fitness. Stamina relies on quick bouts of high-intensity exercises, while endurance is less intense but for longer periods of time.
Working on both simultaneously can improve your performance and make a significant impact on your overall health. Let’s now focus on each one individually.
How to increase stamina
Circuit training is a great way to build stamina because it combines strength and cardio exercises with limited rest. A circuit involves moving through a series of exercises that target different muscle groups with little-to-no break between each one. After completing a circuit, you take a longer recovery before repeating the entire circuit.
“The big thing with stamina workouts is your recovery,” notes Travers. “When you finish an entire circuit made up of several quick exercises, you want a longer recovery so you can come back and do the entire circuit over again at the same high intensity.”
High-intensity interval training (HIIT) can also improve stamina. HIIT alternates short bursts of intense exercise with brief recovery periods, training your body to:
- Work hard even when you’re fatigued
- Recover quickly between exercises
- Tolerate higher levels of exertion
- Use oxygen more efficiently
A stamina workout might combine these approaches by using a circuit of high-intensity exercises followed by a longer recovery period before repeating the circuit.
Exercises commonly used in stamina workouts include:
- Hill sprints
- Box jumps
- Stair climbs
- Mountain climbers
- Jump squats
- Burpees
How to build endurance
To build endurance, you’ll need to learn how to maintain a certain level of intensity for longer stretches of time.
“With endurance, we’re going for that longer, steady state and gradually increasing our time and our distances,” explains Travers. “Endurance requires consistency over weeks and even months.”
It helps to focus on workouts that keep your body moving for extended periods. Cardiovascular exercises are especially effective at building endurance. But strength training can be adapted to improve muscular endurance, training your muscles to work longer before they become fatigued.
When working on endurance, you want to increase the amount of time, distance or reps as you progress through your training.
Common exercises for endurance include:
- Cycling
- Running
- Hiking
- Swimming
- Rowing
- Planks
Final note for the miles ahead
Whether your goal is to move faster, exercise longer or simply keep up with the demands of daily life, stamina and endurance can help you get there. Building both takes consistency and practice. But over time, those efforts can pay off in improved performance, better fitness and greater confidence in what your body can do.
“If you train consistently and you’re seeing progress, both your stamina and endurance are improving,” encourages Travers. “It doesn’t happen overnight. It takes time, practice and attention to your overall health.”
Fitness
What Fitness Experts Want GLP-1 Users to Know About Exercise | NewBeauty
GLP-1 medications have reshaped the conversation around weight loss, but fitness experts are quick to point out that the blueprint for a strong, healthy body hasn’t budged. In fact, it’s never mattered more. The fundamentals of healthy living, from strength training and prioritizing protein to staying active, remain essential for preserving muscle, supporting metabolism and creating results that last. Here’s what top trainers want everyone taking a GLP-1 to know.
“Weight changes quickly, but structure doesn’t,” says Tracy Anderson (@tracyandersonmethod), founder of her namesake movement catalog. For anyone relying on GLP-1s without prioritizing movement, she has a clear warning: The body you’re uncovering still needs tending. “The health of your metabolism relies a lot on how you interact with your muscles.” And for Anderson, that means keeping movement varied and consistent. “You want to recruit as much activity as you possibly can in your body. It’s not enough to just say, ‘I’m going to lift; I’m going to build muscle.’ Things atrophy, and you want to keep as much awake and as much alert as you possibly can.”
“When you’re on a GLP-1, as much as 40 percent of the weight you lose may be lean muscle mass,” explains Kira Jones (@kirajones), founder of Cacti Wellness, who adds that the fix for this is non-negotiable. “It’s essential that GLP-1 users actively work to gain and maintain strength and build muscle. Muscle protects your metabolism long-term and provides that toned appearance.” Her advice: Strength train two to three times a week with weight that genuinely challenges you, prioritize protein at every meal and protect your recovery. “Eating well and exercising means nothing if you don’t give your body time to properly digest food, rebuild muscle and release stress.”
Nicole Winhoffer (@nicolewinhoffer), founder of the NW Method, has watched GLP-1s change not only her clients’ bodies, but also their relationship with movement. The risks she highlights are both physical and behavioral, particularly when medication replaces lifestyle habits. “For some individuals, GLP-1s can work best when paired with natural long-term habits around nutrition, movement and overall wellness.” But, she’s also seen something more encouraging: clients who feel better in their bodies showing up differently in the studio. “I would encourage anyone on a GLP-1 to incorporate dance into their routine. Dancing is a great way to improve self-esteem and build confidence in both social settings and personal style.”
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