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Common menopause medication might prevent breast cancer while treating hot flashes

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Common menopause medication might prevent breast cancer while treating hot flashes

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A drug intended to treat menopause symptoms could double as breast cancer prevention.

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New research from Northwestern University in Illinois found that Duavee, a Pfizer-made drug, “significantly reduced” breast tissue cell growth, which is a major indicator of cancer progression.

A phase 2 clinical trial included 141 post-menopausal women who had been diagnosed with ductal carcinoma in situ (DCIS), also known as stage 0 breast cancer, according to a press release from Northwestern.

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This non-invasive breast cancer affects more than 60,000 American women each year, often leading to an outcome of invasive breast cancer.

The women were separated into two groups — one received Duavee and the other took a placebo for a month before undergoing breast surgery.

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A drug intended to treat menopause symptoms could double as breast cancer prevention, new research suggests. (iStock)

Duavee is a conjugated estrogen/bazedoxifene (CE/BZA) drug, which combines estrogen with another medication that minimizes the potential harmful side effects of the hormone.

“The key takeaway from the study is that CE/BZA slows the growth (proliferation) of cells in milk ducts of DCIS that expressed the estrogen receptor significantly more than placebo,” Dr. Swati Kulkarni, lead investigator and professor of breast surgery at Northwestern University Feinberg School of Medicine, told Fox News Digital.

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Another major finding is that the quality of life did not differ significantly between the two groups, but patients who took the CE/BZA reported fewer hot flashes during the study, she noted.

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“This would be expected, as the drug is FDA-approved to treat hot flashes.”

“What excites me most is that a medication designed to help women feel better during menopause may also reduce their risk of invasive breast cancer.”

Kulkarni presented the study last week at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago. 

The findings are preliminary and have not yet been published in a medical journal.

“What excites me most is that a medication designed to help women feel better during menopause may also reduce their risk of invasive breast cancer,” said the doctor, who is also a Northwestern Medicine breast surgeon.

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Ductal carcinoma in situ (DCIS), also known as stage 0 breast cancer, affects more than 60,000 U.S. women each year. (iStock)

Women who face a higher risk of breast cancer — including those who have experienced “high-risk lesions” — and who also have menopausal symptoms are most likely to benefit from the drug, according to Kulkarni. 

“These women are typically advised against standard hormone therapies, leaving them with few menopausal treatment options,” the release stated. 

Study limitations

The researchers said they are “encouraged” by these early results, but more research is required before the medication can be considered for approval as a breast cancer prevention mechanism.

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“Our findings suggest that CE/BZA may prevent breast cancer, but larger studies with several years of follow-up are needed before we would know this for sure,” Kulkarni told Fox News Digital.

Post-menopausal patients who took the CE/BZA reported fewer hot flashes during the study. (iStock)

Dr. Sheheryar Kabraji, chief of breast medicine at the Roswell Park Comprehensive Cancer Center in Buffalo, New York, was not involved in the study but commented on the findings.

“While intriguing, this study is highly preliminary, and more research will be needed before we can conclude that conjugated estrogen/bazedoxifene (CD/BZA), a form of the hormone estrogen commonly prescribed to address symptoms of menopause, prevents invasive breast cancer or is effective at reducing cancer risk,” she told Fox News Digital.

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Kabraji also noted that the study focused on reducing levels of one specific protein, “which does not always predict reduced recurrence of breast cancer.” 

“This study did not directly show that CE/BZA treatment reduces the risk of DCIS recurrence or development of invasive cancer,” she noted. 

“While intriguing, this study is highly preliminary.”

“Importantly, however, patients who received this therapy experienced no worsening of quality of life, and saw improvement in vasomotor symptoms, such as hot flashes. If found to be effective in preventing breast cancer, CE/BZA is likely to have fewer side effects than current medications used for breast cancer prevention.”

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Lead researcher Kulkarni emphasized that this medication is not for the treatment of invasive breast cancer or DCIS.

“Right now, we can say that women who are concerned about their risk of developing breast cancer can consider this medication to treat their menopausal symptoms,” she added.

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Brain Health Challenge: Doctor Appointments for Your Mind and Body

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Brain Health Challenge: Doctor Appointments for Your Mind and Body

Congratulations, you’ve reached the final day of the Brain Health Challenge! Today, we’re asking you to do a few things that might feel a bit out of left field — like getting your blood pressure checked.

No, it isn’t as fun as playing Pips, but experts say it’s one of the most important things you can do for your brain. That’s because heart health and brain health are intrinsically linked.

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High blood pressure, in particular, can damage brain cells, and it’s a significant risk factor for stroke and dementia. When blood pressure is too high, it places stress on the walls of arteries in the brain. Over time, that added stress can cause the blood vessel walls to thicken, obstructing blood flow. In other cases, the increased pressure causes the artery walls to thin and leak blood into the brain.

These changes to the blood vessels can sometimes cause a large stroke to occur. More commonly, the damage leads to micro-strokes and micro-hemorrhages, which cause fewer immediate problems and often go unnoticed. But if someone has hypertension for years or decades, these injuries can build up, and the person may start to experience cognitive impairment.

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High blood pressure “is known as a silent killer for lots of reasons,” said Dr. Shyam Prabhakaran, the chair of neurology at the University of Chicago. “It doesn’t cause you any symptoms until it does.”

Because the damage accumulates over many years, experts say that managing blood pressure in midlife matters most for brain health. Hypertension can be addressed with medication or lifestyle changes, as directed by your doctor. But the first thing you need to do is know your numbers. If your blood pressure comes back higher than 120/80, it’s important to take it seriously, Dr. Prabhakaran said.

While you’re at it, there are a few other aspects of your physical health that you should check on.

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Your eyes and ears are two of them. Hearing and vision loss have both been shown to increase the risk of dementia. Experts think that with less sensory information coming in to stimulate the brain, the regions that process hearing and vision can start to atrophy. What’s more, people with sensory loss often withdraw or are left out of social interactions, further depriving them of cognitive stimulation.

Oral health can also affect your brain health. Research has found a connection between regular flossing and reduced odds of having a stroke. That may be because good oral health can help to reduce inflammation in the body. The bacteria that cause gum disease have also been tied to an increased risk of Alzheimer’s.

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And have you gotten your shingles vaccine? There is mounting evidence that it’s a powerful weapon for protecting against dementia. One study found that it lowered people’s odds of developing the condition by as much as 20 percent.

To wrap up this challenge, we want you to schedule a few medical appointments that benefit your brain, as well as your body.

After five days of feeding, exercising and challenging your brain, you are well on your way to better cognitive health. Thanks for joining me this week, and keep up the good habits!

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Health experts react as Andrew Huberman backs Trump admin’s new food pyramid

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Health experts react as Andrew Huberman backs Trump admin’s new food pyramid

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The Trump administration has taken a new approach to the food pyramid.

The Department of Health and Human Services (HHS) announced new guidelines on Wednesday with an updated, inverted pyramid. The top of the pyramid, which is now the wider part of the structure, is built on meat, fats, fruits and vegetables, while whole grains are at the narrow bottom.

This follows HHS Secretary Robert F. Kennedy Jr.’s mission to “Make America Healthy Again” (MAHA), aimed at addressing chronic disease, childhood illnesses and ultraprocessed foods.

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“The new guidelines recognize that whole, nutrient-dense food is the most effective path to better health and lower health care costs,” Kennedy said during a press briefing in Washington, D.C. 

“Protein and healthy fats are essential, and were wrongly discouraged in prior dietary guidelines. We are ending the war on saturated fats.”

The Trump administration announces the 2025-2030 Dietary Guidelines for Americans, putting “real food” back at the center of health. (realfood.gov)

The HHS secretary rallied against refined carbohydrates, food additives and added sugar, highlighting the health risks associated with sugar-sweetened beverages. 

Kennedy’s main message to Americans was to “eat real food.”

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TRUMP ADMIN’S NEW NUTRITION GUIDELINES TARGET ULTRA-PROCESSED FOODS, EASE UP ON RED MEAT AND SATURATED FATS

The announcement triggered reactions from top health and wellness voices, including Stanford neuroscientist Dr. Andrew Huberman, host of the “Huberman Lab” podcast.

In a post on X, Huberman shared the White House’s graphic of the new pyramid, praising the decisions that were made.

“Oatmeal (and I think that’s rice and sourdough) made the cut!” he commented. “In all seriousness, assuming overall calories are kept in check and people exercise & get sun(day)light, this looks spot on.”

He added, “Maybe up the veggies a bit, add low-sugar fermented foods like sauerkraut & this is great.”

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Huberman said in a thread on the same post that Americans “don’t have to eat all the foods” shown in the diagram.

“You won’t see me drinking milk or eating shrimp,” he said. “Nothing against shrimp, I just don’t like the taste. Aversion to crustaceans.”

“Maybe up the veggies a bit, add low-sugar fermented foods like sauerkraut & this is great,” Huberman commented on X. (Chance Yeh/Getty Images for HubSpot; iStock)

The new guidelines received praise from other major health figures, including former FDA commissioner Dr. David Kessler.

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“There should be broad agreement that eating more whole foods and reducing highly processed carbohydrates is a major advance in how we approach diet and health,” Kessler told The Associated Press.

“Protein and healthy fats are essential, and were wrongly discouraged in prior dietary guidelines.”

Dr. Bobby Mukkamala, president of the American Medical Association, shared in a statement that these guidelines “affirm that food is medicine and offer clear direction patients and physicians can use to improve health.”

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“The American Medical Association applauds the Administration’s new Dietary Guidelines for spotlighting the highly processed foods, sugar-sweetened beverages and excess sodium that fuel heart disease, diabetes, obesity and other chronic illnesses,” Mukkamala wrote.

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The American Medical Association applauded the HHS for its updated nutrition guidelines. (iStock)

But not all feedback was positive.

Some people expressed concern about prioritizing red meat and dairy, while calling for the limitation of saturated fat.

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Neal Barnard, president of the Physicians Committee for Responsible Medicine, shared in a reaction to STAT that while the guidelines “do have one or two good points, emphasizing fruits and vegetables and limiting alcohol,” the guidelines are “for the most part a strong reflection of industry influence.”

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Christopher Gardner, a nutrition expert at Stanford University, also spoke out against the new guidelines, as reported by NPR.

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“I’m very disappointed in the new pyramid that features red meat and saturated fat sources at the very top, as if that’s something to prioritize. It does go against decades and decades of evidence and research,” said Gardner, who was a member of the Dietary Guidelines Advisory Committee.

Fox News Digital’s Rachel Wolf, as well as Alexandria Hoff of Fox News, contributed reporting.

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Matt Damon’s Gluten-Free Diet Helped Him Lose 18 Pounds

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Matt Damon’s Gluten-Free Diet Helped Him Lose 18 Pounds


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Matt Damon’s Weight Loss: Actor Drops 18 Lbs with This Diet | Woman’s World




















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