Health
How Measles Attacks an Unvaccinated Child
For a child who is not vaccinated against measles — one of the world’s most infectious viruses — no classroom, school bus or grocery store is safe. Nine out of 10 unvaccinated people exposed to an infected person will catch it, and once measles takes root, the virus can damage the lungs, kidneys and the brain.
With falling U.S. vaccination rates and outbreaks that have caused more than 580 cases and at least one death, health experts expect measles to infect hundreds or even thousands more across the nation. Here is how measles takes over the body.
Unlike viruses that require person-to-person contact, measles lingers in the air for up to two hours after the person carrying it has left the space.
A child can inhale virus-containing droplets in a room where another child — unknowingly infected with measles — has been studying or playing an hour earlier. The virus can enter her body through the lining of her nose or mouth, or when she’s rubbing her eyes.
During the subsequent 24 hours, the virus takes root by lodging in her nasopharynx cells in the upper part of the throat and starts spreading to her lungs.
Then, the virus takes over, multiplying inside the cells and building up an army for an attack.
Within a few days, the virus begins to spread to infect the nearby lymphoid tissues. About a week after the initial exposure, infected cells begin traveling to other organs throughout the body. (At this time, the immune system of a vaccinated child would recognize the virus and fight it off.)
Typically, during the replication and spread of the virus, the child does not feel sick. The average incubation period is about two weeks — though it can range from one to three. When the viral load has increased significantly, it moves to infect other cells of the lungs and eyes, making the child feel ill.
A couple of weeks after the unvaccinated child inhales the droplets, she starts feeling sick.
Children often first show signs of malaise and a fever, followed later by reddish, irritated eyes, a cough and a stuffy nose as the mucus membranes and nasal passages become inflamed.
Some children at this stage develop millimeter-wide, whitish-gray bumps on the inner lining of the cheeks, as far back as the molars. For some, the spots go undetected, or do not show up at all.
Then comes the characteristic feature: the breakout of a red rash, starting on the face and spreading down the neck, trunk, and extremities.
Many of these symptoms should resolve themselves. The rash can last up to a week, often fading along the same route it appeared. The cough can last for up to two weeks after the illness has resolved. But a fever lasting beyond the third or fourth day of the rash suggests that a complication could be developing — and that is where cases can become dangerous.
Even as the rash fades, the infection can spread to the lungs and other organs.
Children are typically brought to the hospital after having the body rash for several days. Most have low oxygen levels and are laboring to breathe and need support, said Dr. Summer Davies, who sees children at Covenant Children’s Hospital in Lubbock, Texas, and has been treating measles cases there since the outbreak started in late January.
“A lot of families have kind of been surprised, like, ‘Oh, my child was fine, and then all of a sudden, they’re not,’ ” she said.
That mild disease evolves into a fever as high as 104 or 105 degrees for two, three or four days. Poor fluid intake, a sore throat and diarrhea can lead to dehydration, which over time can begin to threaten kidney function.
Young children are more at risk because of their smaller anatomy and their inability to articulate symptoms clearly, explained Dr. Lara Johnson, the chief medical officer of a group of Covenant hospitals in the area.
About one in 20 children with measles will develop pneumonia, an infection in the lungs; and severe cases can be fatal.
Dr. Davies said many children admitted to her hospital recently had cases of pneumonia caused by either the measles virus or by a second pathogen that attacked while their immune systems were weakened.
The 6-year-old girl who recently died of measles in Texas had a case of pneumonia that caused fluid to build up in her left lung, making it difficult for her to breathe, according to a video interview with her parents that was posted online. She was eventually sedated and intubated, but she became too sick to survive.
One of the hallmarks of measles is what researchers call “immune amnesia,” the temporary weakening of the immune system. Measles wipes the protection children have acquired from other infections, which leaves them susceptible to other infections for several months or even years.
Inflammation in the brain
About one in 1,000 children who contract measles will also develop encephalitis, or inflammation of the brain tissue, which can result in permanent damage.
For infants or children who are already immunocompromised, a condition called measles inclusion body encephalitis (or MIBE) occurs when the child cannot clear the infection. It can trigger mental changes and seizures, leading to a coma and death in most patients.
Another type, called subacute sclerosing panencephalitis (SSPE), is a degenerative condition that can occur up to a decade after a measles infection. Children often first show signs of behavior change and academic decline, followed by seizures, motor issues like poor coordination and balance, and eventually death. The mortality rate approaches 95 percent.
Erica Finkelstein-Parker, a mother in Pennsylvania who lost her 8-year-old child Emmalee to the condition, had not known that the girl had had measles before she had been adopted from India as a toddler. But she noticed one day that Emmalee was tripping and falling, slumping over to one side of her chair and struggling to lift her chin off her chest during dinner.
Doctors explained that there was no cure. Emmalee passed away about five months later.
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The American Cancer Society (ACS) has updated its guidelines for colorectal cancer screening.
The organization released the update in its flagship journal on Wednesday, noting that the new recommendations “re-affirm” that adults at average risk should be screened for colorectal cancer at age 45 and continue through 75, for those with a life expectancy greater than 10 years.
In addition to the standard colonoscopy, the ACS also recommends that patients receive a blood-based screening test in a doctor’s office, which is designed to detect tumor DNA in the blood.
COMMON CANCER TYPE COULD BE DETECTED WITH NEW BLOOD TEST
The ACS also suggested an at-home screening option that looks for hidden blood and molecular markers in stool samples.
These new guidelines reflect recent advancements in disease detection, as well as a “critical shift in public health strategy to expand screening options and lower barriers to access,” the ACS stated in a press release.
The ACS recommends blood-based testing and at-home stool sampling as options for colorectal cancer screening. (iStock)
Dr. Robert Smith, senior vice president of early cancer detection science at the American Cancer Society and senior author of the report, wrote in a statement that colorectal cancer should be emphasized as a “highly preventable disease as much as a treatable one.”
“By offering more screening tools in our guideline update, more eligible adults will be able to participate in lifesaving colorectal cancer testing, helping to close the screening gap and catch more cancers at an earlier, treatable stage,” he added.
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According to the ACS, colorectal screening “dramatically improves survival,” as studies show early-stage detection yields a five-year survival rate of more than 90% in the U.S.
About one in three American adults are eligible for colorectal cancer screening but have not been tested, although ACS research marks colorectal cancer as the top cancer killer of adults under 50.
Colorectal cancer is the top cancer killer of adults under the age of 50, according to the ACS. (iStock)
People at a high risk of colorectal cancer may need to begin screening before age 45 or be screened more often, the ACS added. Those over 85 years old should no longer be screened for colorectal cancer, per the guidelines.
Dr. William Dahut, chief scientific officer at the ACS, commented that “no matter which test you choose, what’s most important is to get screened, and that includes underserved, rural and minority populations.”
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These guideline changes follow a surge in colorectal cancer diagnoses in younger individuals. Recent ACS research revealed a 50% relative increase in diagnoses in adults aged 45 to 49 from 2021 to 2022.
Dr. Aparna Parikh, medical director of the Center for Young Adult Colorectal Cancer at the Mass General Cancer Center, who is not affiliated with the ACS, shared that experts don’t “entirely understand why” cases are on the rise.
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“But it seems to be an interplay of a person’s risk factors, overall makeup and early exposures,” she previously told Fox News Digital. “[Those] include dietary exposures, environmental exposures and possible antibiotic exposures, as well as lifestyle factors in the right host.”
Changes in bowel habits are the primary red flag that should raise the suspicion of colorectal cancer. (iStock)
Another recent ACS study found that drinking heavily and consistently over an adult’s lifetime could lead to a higher risk of colorectal cancer.
Other known risk factors include family history, obesity, smoking, a diet high in red and processed meats, inflammatory bowel disease, and a personal history or family history of polyps.
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While there may be no symptoms of colorectal cancer before diagnosis, especially in the early stages, certain symptoms should not be overlooked, experts say.
Dr. Eitan Friedman, PhD, an oncologist and founder of The Suzanne Levy-Gertner Oncogenetics Unit at the Sheba Medical Center in Israel, confirmed to Fox News Digital that changes in bowel habits are the primary red flag that should raise the suspicion of colorectal cancer.
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Other symptoms include fatigue as a result of anemia, stomach pain or abdominal discomfort, rectal bleeding or blood in the stool, weakness and unexplained weight loss.
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The sudden death of Kyle Busch has drawn attention to a rare but devastating medical progression: when pneumonia escalates into fatal sepsis.
An ER doctor spoke with Fox News Digital about how sepsis can trigger a rapid health decline.
“Sepsis is actually not a specific disease or diagnosis, but rather the syndrome that occurs when the body has certain abnormal findings and a presumed infection,” said Dr. Kenneth J. Perry, a South Carolina-based emergency medicine physician.
HOW PNEUMONIA PROGRESSES TO SEPSIS: DOCTORS EXPLAIN AFTER KYLE BUSCH’S DEATH
The markers of sepsis include elevated white blood cell counts, a high or low temperature, and elevated heart and respiratory rates, according to Perry. Because of this, a patient with pneumonia is often already technically septic by definition.
In the wake of Kyle Busch’s sudden passing, there is a focus on the rapid decline from pneumonia to fatal sepsis. (Getty; iStock)
While many people assume a worsening infection means bacteria are multiplying uncontrollably, it often has more to do with the body’s internal environment.
“It is often not the bacteria itself that is causing the specific decline,” Perry said. “In most cases, it is a cascade of inflammatory processes that are set in motion by the infection.”
When this inflammation spirals out of control, the body moves from having a manageable infection into severe sepsis. This is when otherwise healthy people can rapidly deteriorate.
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“The concerning thing that can happen with any individual … is that sepsis can then lead to low blood pressure, worsening vital signs and organ damage,” Perry said.
“As multiple organs fail, it becomes very difficult for the medical team to treat and can sometimes lead ultimately to death.”
“The medical evaluation provided to the Busch Family concluded that severe pneumonia progressed into sepsis, resulting in rapid and overwhelming associated complications,” the family shared in a statement. (James Gilbert/Getty Images)
It is very unlikely to have pneumonia and not have any symptoms, according to Perry. Early signs can mimic a severe flu, including fevers, chills, a productive cough, and chest or back pain in cases where the lung is infected.
When sepsis begins to take hold, time becomes the most critical factor. “We have known for a number of years that early antibiotic therapy is beneficial in the treatment of sepsis,” Perry said.
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If you or a loved one are managing an infection at home, the doctor says the following red flags mean you should bypass the clinic and head straight to the emergency room.
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- Shortness of breath or difficulty breathing
- A racing heart rate or fever that continues to worsen even after starting treatment
- Severe chest pain associated with a productive cough
The slide into sepsis is, in most cases, a cascade of inflammatory processes that are set in motion by the infection, the doctor said. (iStock)
While cases like Busch’s are tragic, Perry stressed that this shouldn’t cause widespread panic. Most patients with pneumonia do very well with standard oral antibiotics.
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The NASCAR star’s rapid decline underscores the importance of medical vigilance and “having a primary care physician with whom you have a good relationship,” according to the ER doctor.
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“Monitoring symptoms while having easy access to primary care is a very beneficial and appropriate plan for most patients,” he added.
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