Science
Immune amnesia: Why even mild measles infections can lead to serious disease later
Dr. Adam Ratner has heard a lot of myths and misunderstandings about measles in his decades as a New York City pediatric infectious disease specialist.
A troubling untruth he’s seen circulating on social media during the current outbreak is that being infected with the virus instead of getting vaccinated confers benefits on the immune system — a strength-training program of sorts for the cells.
The truth, Ratner said, “is exactly the opposite.”
Measles is a highly contagious virus that presents as a rash and cold-like symptoms for many patients, and can lead to serious or fatal complications for others. An outbreak that began in west Texas in January has since infected nearly 500 people across 19 states, including eight people in California.
An insidious but lesser-known consequence of even a mild measles infection is that it kills the very cells that remember which pathogens the patient has previously fought and how those battles were won. As a result, recurring bugs that might have caused only minor symptoms make patients as sick as if they’d never encountered them before.
Measles destroys lymphocytes that defend against other bugs to make way for ones that defend against measles, an immunity won at the cost of other protections.
This “immune amnesia,” physicians say, leaves patients vulnerable to reccurrences of diseases their immune cells were previously able to resist.
If a child gets sick with measles, “for the next two or three years, you kind of have to be looking over your kid’s shoulder, wondering if some otherwise routine virus or bacteria that they should be very well protected against is potentially going to land them in the hospital,” said Dr. Michael Mina, an epidemiologist who was previously an assistant professor of immunology and infectious diseases at Harvard Medical School.
“Even if your measles virus infection seemed mild and you kind of blew through it, it doesn’t mean that it was mild on your immune system,” Mina added.
Take rotavirus, Ratner said, which causes severe diarrhea that can be life-threatening for children if untreated. A child who has rotavirus once will have antibodies that offer protection against future infections.
But a measles infection, said Ratner, author of the recent book “Booster Shots: The Urgent Lessons of Measles and the Uncertain Future of Children’s Health,“ “could wipe out that immunity and they could be just as vulnerable to rotavirus as if they had never seen it before.”
Immune amnesia results from the measles virus’ plan of attack. Viral particles travel via airborne droplets of saliva, mucus and cells that make their way into a new body when their unsuspecting host breathes them in.
From there, they sneak past the protective barrier lining the respiratory system and head to the lymph nodes in search of cells that express a particular protein called signaling lymphocytic activation molecule, or SLAM.
The virus then rides around the bloodstream on these hijacked SLAM-expressing cells, further infecting and destroying other SLAM expressers it meets on the way.
Among the SLAM-expressing cells that measles wrecks are memory B and T cells, two crucial players in a functioning immune system. Memory B cells manufacture the right antibodies quickly when a familiar microbe appears. Memory T cells recognize and kill viruses that your cells have encountered in the past.
A measles infection feeds on these memory cells. Vaccines, in contrast, stimulate the production of memory B and T cells without consuming others in the process.
This was not yet understood in the decades before the measles, mumps and rubella vaccine’s approval in 1963, when measles was a common childhood disease that killed some 400 children in the U.S. each year.
“For 100 years or more, we’ve known that measles does cause an acute susceptibility to other infections,” Mina said.
A measles infection temporarily suppresses the immune system, Mina said, and it was long assumed that opportunistic infections around the time of the illness were the result of that short-term suppression.
In 2015, Mina and colleagues published a paper that looked at mortality data in the U.S., the United Kingdom and Denmark before and after measles vaccines were introduced. They found that whenever there were measles outbreaks, childhood deaths from all other infectious diseases remained significantly higher for two to three years in outbreak locations, an increase that accounted for up to half of all childhood deaths from infectious disease.
Once those countries rolled out the MMR vaccine, measles cases fell, as expected. But so did childhood deaths from other infectious diseases, by about half.
Three years later, Mina and his collaborators took blood samples from 77 unvaccinated children in a community in the Netherlands before and then two to six months after the children contracted measles. They found that the virus wiped out 11% to 73% of the children’s preexisting antibodies to a host of pathogens.
Just as children in preschool fall ill constantly with common diseases they’re encountering for the first time, unvaccinated children who contract measles are at higher risk in the ensuing years for common early childhood sicknesses such as respiratory infections, earaches and viruses that cause diarrhea, said Shelly Bolotin, a scientist at Public Health Ontario in Canada and director of the Center for Vaccine Preventable Diseases at the University of Toronto.
“In order to correct that depletion [of B and T cells], you need to be reexposed to everything you were immune to before, and this can take years,” she said.
As of late March, 97% of the people sickened in the current outbreak were unvaccinated or didn’t disclose their vaccine status. The measles virus is attenuated in the MMR vaccine, meaning that it has been altered to produce the appropriate immune response without triggering the disease itself. In the case of measles, that means no mass destruction of the cells that hold the immune system’s memory.
“It doesn’t have this very, very damaging effect, which is why we recommend vaccination, because we get all of the immunity with none of the adverse consequences,” Bolotin said.
Science
Why new dads shouldn’t panic about low testosterone
Three months after his son was born, Kevin Maguire felt alone.
It was 2019. He had recently moved to Barcelona with his wife and daughter and was working on marketing projects for Fortune 500 companies. The birth of his son, Bodhi, should have been a joyous event. But Maguire, now 43, became sad and irritable, and didn’t want to be around his newborn. He withdrew from family and friends, often playing video games late into the night or finding excuses to get out of the house.
“I would take the dog out for a walk,” Maguire said. “I wanted to get far away enough that I wouldn’t bump into anyone I knew and I would just sit and cry.”
Desperate for answers, he entered his symptoms online. Maguire, author of the recently published book “The New Fatherhood: Why Everything They Told You About Being a Dad Is Wrong, and How Embracing It Will Transform Your Life,” knew to look for signs of the “baby blues” in his wife. But he was surprised by articles that said men could experience postpartum depression too. The diagnosis resonated and he began writing about his condition and the trials of fatherhood on Substack.
New dads face psychological pressures, from sleepless nights to sky-high bills, which can contribute to postpartum depression. So can shifting hormone levels.
“One thing I found in my lab’s research is that when new dads have really low levels of testosterone, they might report more symptoms of postpartum depression,” said Darby Saxbe, a professor of psychology at USC and author of the recently published “Dad Brain: The New Science of Fatherhood and How It Shapes Men’s Lives.”
While hormonal shifts can create challenges, they also help men adapt to fatherhood, Saxbe explained. Several hormones can spike in men when they become dads, including oxytocin, linked to better relationship quality; vasopressin, associated with emotional bonding; and prolactin, which promotes lactation in women and caregiving behavior in guys.
New dads can also experience a decline in testosterone. According to a 2011 paper from University of Notre Dame professor Lee Gettler, part of the largest study on fatherhood and testosterone ever conducted, men averaged around a 25% drop in testosterone after becoming fathers.
While dads have reasons to be concerned by plummeting levels of testosterone, a modest dip isn’t necessarily a disaster — in fact, it can make men better parents and partners.
“We often get invested in the idea that men should always have the highest possible levels of testosterone,” Saxbe said. “What the research tells us is a little more nuanced. You really want flexibility. You want a hormonal system that can adapt to the different demands of your life.”
The prospect of a decline might scare soon-to-be fathers, especially those on TikTok and Instagram, where accounts push the idea that having “high T” is the key to being a “real man,” according to a recent study in the journal Social Science & Medicine.
Influencers stand to profit persuading men there’s a widespread “masculinity crisis,” the researchers found, noting that 72% of the accounts they analyzed had a stake in testosterone supplements and treatments.
But studies show more testosterone isn’t always better. “We found that when dads have higher testosterone, even before birth, they’re less invested [than men with lower testosterone] in co-parenting a few months after birth,” Saxbe said. High T fathers were more stressed from parenting than their lower T counterparts, and had partners who were less satisfied in their romantic relationships.
This jibes with the challenge hypothesis, which says, in multiple species, testosterone levels rise when males battle for attention from potential mates and go down when it’s time to take care of the young.
While a small decline can be adaptive, dads face mental health risks when their testosterone drops too low.
There is no “normal” level of testosterone, said Dr. Jesse Mills, director of the Men’s Clinic at UCLA Health. Experts recommend that men should consider treatment if their levels dip below 300 nanograms per deciliter (ng/dL). But men metabolize testosterone in different ways, meaning a healthy level for one might be low for another.
“If a new dad comes to me and his testosterone is 298 [ng/dL], he’s below the threshold,” Mills said. “But if he has zero symptoms and everything else is going great — he’s over the moon with his new child, he’s so happy — that’s not somebody I’m going to treat with testosterone.”
He notes that the drop in testosterone fathers experience can partly be attributed to the stresses that come with a new kid: less sleep, a poor diet and fewer trips to the gym. That means there are precautions that expectant fathers can take that don’t involve testosterone replacement therapy (TRT).
Still, while some guys with low testosterone levels might not need TRT, others in the “normal” range could benefit from treatment. (Dads who want another kid soon, beware. Mills notes that testosterone replacement therapy can take a man’s sperm count to zero.)
Both Mills and Saxbe stress that men should be paying attention to symptoms of low testosterone — such as depression and low libido — rather than trying to reach or maintain an ideal number. They also agree that tending to mental health concerns is hugely important for new fathers.
Eventually, after Maguire researched his condition, he recovered after time spent meditating, exercising and bonding with his son.
“A lot of new dads don’t realize how much they’re struggling because they feel ashamed or because they don’t realize it’s common shortly after the birth of a baby,” Saxbe said.
When they struggle, fathers can fixate on testosterone because that’s what modern culture tells them will make them feel better. And sometimes testosterone replacement therapy works. But Saxbe stresses a lot of men could use psychotherapy or support groups that bring dads together, as well as more time bonding with loved ones in general.
“The thing that predicts a man’s well-being and longevity is the quality of his relationships with other people,” said Saxbe. “You can be the world’s best weightlifter. You can have a low body-fat percentage. You can be killing it at work. Those things don’t predict how happy you’re going to be at 80.”
Science
Video: NASA Announces Artemis III Crew
new video loaded: NASA Announces Artemis III Crew
transcript
transcript
NASA Announces Artemis III Crew
NASA announced the crew of Artemis III mission, which will fly to low-Earth orbit to test rendezvous and docking maneuvers with one or two lunar landers.
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“I am excited to welcome you as the next crew in the Artemis journey to successfully return to the moon — this time to stay.” “I’m honored by the role that I’ve been given. I’m also very humbled by the task in front of us. But first and foremost, I’m grateful.” “So with that, the Artemis II crew, comrade, hands you the baton. You got the controls.” “As you know, we had a significant anomaly at our Launch Complex 36A on May 28. We’ve redoubled our efforts and are moving forward.”
By Alisa Shodiyev Kaff
June 9, 2026
Science
Santa Monica Mountains’ last steelhead trout survived the Palisades fire — and even had babies
Scientists feared the Santa Monica Mountains’ last remaining steelhead trout were dead, smothered by debris flows unleashed by the Palisades fire.
But the endangered fish surprised them: A team of biologists recently spotted 30 of the rare trout — and 21 babies — in Topanga Creek.
“There was a lot of happy dancing in the creek,” said Rosi Dagit, principal conservation biologist for the Resource Conservation District of the Santa Monica Mountains, which works with public and private landowners to conserve natural resources.
That’s because the steelhead here are endangered, at both the state and federal levels. Once, they swam in most streams of the Santa Monicas, but their numbers plummeted amid overfishing and coastal development. Increasingly frequent wildfire has further stressed their habitat. Topanga Creek, a biodiversity hot spot, is home to their last known population in the mountains that stretch from the Hollywood Hills to Point Mugu in Ventura County.
The trout that were spotted, including this one, are part of a distinct Southern California population that’s listed as endangered at the state and federal levels.
(RCDSMM Stream Team)
The California Department of Fish and Wildlife spearheaded a complex mission to rescue trout threatened by the Palisades fire that sparked in January 2025.
Time was of the essence. The fire hadn’t yet been fully contained. But rain was on the way, which would sweep massive amounts of sediment from the denuded hillsides into the water. Fish are often killed this way.
Crews stunned the fish with electricity, scooped them up in buckets, trucked them to a hatchery and ultimately moved them to Arroyo Hondo Creek in Santa Barbara County.
Within days, Topanga Creek was choked with mud. Some assumed the fish left behind were goners.
But in March, the conservation district’s team found four. The following month, when water conditions were clearer, they saw more.
“These fish continue to amaze me,” said Kyle Evans, environmental program manager for the state Department of Fish and Wildlife, who had seen the damage to the creek. “I had seen populations get wiped out in similar situations. So when I heard, I was thrilled.”
Evans surmises the fish that survived were in an area of the creek where less charred material and sediment were swept in.
“These fish likely hunkered down, were hiding under some rocks or places to try to get away from the main concentration of flow,” he said. “And luckily they weren’t buried.”
The ones that were spotted were fairly small, around 6 to 14 inches. Rainbow trout and steelhead trout are the same species, but with different lifestyles. If the fish remain in freshwater, they’ll be considered rainbows. However, they can migrate to the ocean and become steelhead, where they typically grow larger before returning to their natal waters to spawn.
Topanga Creek hasn’t fully recovered from the damage it sustained, but scientists say it’s looking better. Surveys last year were “so depressing,” Dagit said, with very few animals, and stretches that were essentially transformed into flat roads from all the sediment buildup. Some of the riparian canopy burned right down to the creek.
Then came 32 inches of rain over the last nine months, scouring out and moving sediment, creating deeper pools. Dagit said they recently found newt egg masses for the first time in years, as well as a few adult newts and many frogs. Plants that provide cover are starting to recover.
She provided photos comparing certain pools last year and this year, some dramatically transformed. In September 2025, the Shrine Pool could have been an overgrown hiking trail. This April, it was filled with shallow water.
The Shrine Pool in September 2025, left, and the same location in April 2026, right, with RCDSMM’s Isaac Yelchin donning a wetsuit.
(RCDSMM Stream Team)
Topanga Creek is home to another endangered fish, the small but hardy northern tidewater goby, often described as cute. Not long before the trout operation, Dagit led a rescue of hundreds of these fish too. Many were repatriated to the lagoon at the mouth of the creek in a moving ceremony last June.
There’s still the matter of what to do with the trout that were moved to Santa Barbara County last year. Evans would like to bring them home to the Santa Monicas at some point, but isn’t sure if it will happen. On one hand, they could bolster the small, genetically isolated surviving population. On the other, they might inadvertently bring in a disease or bacteria. There is some time to decide. Evans estimates the creek still needs to recover for two to three more years.
For now, the fish are functioning fine in their adopted creek. Experts worried the trauma wrought by the move would disrupt their spawning process, but they had babies that spring. This year, they spawned again.
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