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Spinal cord stimulation restores movement for people with 'muscle wasting' disorder

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Spinal cord stimulation restores movement for people with 'muscle wasting' disorder

People with spinal muscle atrophy (SMA), an inherited neuromuscular disease, usually experience muscle weakness that impacts movement.

New research suggests that electrical spinal cord stimulation could improve muscle function for these patients, even restoring the capability to walk.

In studies at the University of Pittsburgh School of Medicine, sessions of spinal cord stimulation were shown to restore motor neuron activity and improve muscle strength in the legs for patients with SMA.

The findings were published in Nature Medicine on Feb. 5.

SPINAL CORD TREATMENT RESTORES FUNCTION FOR PARALYZED PATIENTS IN STUDY: ‘NEW HOPE’

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“The patients all had a rare disease that destroys neurons in the spinal cord (much like polio) due to a genetic disorder from birth,” Dr. Peter Konrad, chairman of the Department of Neurosurgery at WVU Rockefeller Neuroscience Institute in West Virginia, told Fox News Digital. (Konrad was not involved in the study.)

Research participant Doug McCullough uses an adaptive exercise bike during a testing session at the University of Pittsburgh. (Nate Langer, UPMC and University of Pittsburgh Health Sciences)

“The disease weakens the legs and ability to walk … causing a form of slow paralysis. Stimulation of the input to the remaining neurons was thought to improve strength and stamina in patients treated this way.”

Study co-author Marco Capogrosso, assistant professor of neurological surgery at Pitt School of Medicine, said that two things need to happen to counteract neurodegeneration: neuron death must be stopped and the function of surviving neurons must be restored.

“There has been no major breakthrough in curing this disease, and so treatment is still focused on helping improve their quality of life.”

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“In this study, we proposed an approach to treat the root cause of neural dysfunction, complementing existing neuroprotective treatments with a new approach that reverses nerve cell dysfunction,” Capogrosso said in a press release.

Three people with SMA participated in the study. For one month, they received spinal cord stimulation five times a week for four hours each. At the end of the trial period, they all experienced “improved motoneuron function, reduced fatigue and improved strength and walking in all participants,” the release stated.

Research participant Doug McCullough uses a bodyweight support system to walk during a testing session at the University of Pittsburgh. (Nate Langer, UPMC and University of Pittsburgh Health Sciences)

“The three patients saw an average of 40% improvement in step length, up to 180% improvement in strength, and 26-minute improvement in walking time,” said Konrad, based on his review of the study.

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“That’s a big deal for patients with this condition, who depend on assistive devices to move about with little stamina.”

One of the participants, Doug McCullough, was experiencing advanced symptoms and had difficulty walking.

NEW BRAIN THERAPY ALLOWS PARALYZED PATIENTS TO WALK AGAIN: ‘I FEEL MY LEGS’

“Because my hip flexors are so weak, I basically have this waddling gait where my hips sway back and forth and I swing my legs out to the side because I can’t pick them straight up,” he said in the release. “You could clearly see from the video that my walk was improved and that I was walking faster. I had a little more natural gait. It still wasn’t completely normal, but it was better than what it was before the study.” 

Researchers Genis Prat Ortega (left) and Serena Donadio (right) with the research participant Doug McCullough (center) during a testing session at the University of Pittsburgh. (Nate Langer, UPMC and University of Pittsburgh Health Sciences)

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Although SMA is a progressive disease that worsens over time, the patients in the study had noticeable improvements, according to study co-author Elvira Pirondini, assistant professor of physical medicine and rehabilitation at Pitt School of Medicine.

      

“Over the four weeks of treatment, our study participants improved in several clinical outcomes, with improvements in activities of daily living,” she said in the release. 

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“For instance, toward the end of the study, one patient reported being able to walk from their home to the lab without becoming tired.”

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The study is a “proof of concept” that gives hope to people with this type of genetic disability, according to Konrad.

“Toward the end of the study, one patient reported being able to walk from their home to the lab without becoming tired.”

“There has been no major breakthrough in curing this disease, and so treatment is still focused on helping improve their quality of life,” he told Fox News Digital. 

“It also shows that devices such as spinal cord stimulation and other types of neuromodulation are a safe and effective method to treat paralysis when there is little to offer in the form of medications or gene therapy.”

Graduate student Scott Ensel (left) assists research participant Doug McCullough during a testing session at the University of Pittsburgh. (Nate Langer, UPMC and University of Pittsburgh Health Sciences)

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Looking ahead, the team plans to continue research with other SMA patients in a new clinical trial to test the treatment’s safety and efficacy.

In the future, they hope to apply this therapy to other neurodegenerative diseases, such as ALS or Huntington’s disease.

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Natural Ozempic? 6 GLP-1 Foods That Work Just Like the Shot

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Natural Ozempic? 6 GLP-1 Foods That Work Just Like the Shot


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Simple daily habit could help people with type 2 diabetes manage blood sugar

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Simple daily habit could help people with type 2 diabetes manage blood sugar

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Sitting next to a window may help people with type 2 diabetes control their insulin levels, according to new research.

The study, published in Cell Metabolism, found that exposure to natural light — even indoors next to a window — changes how the body processes glucose and uses energy.

People in Western societies spend 80% to 90% of their time under artificial lights, which are much dimmer and less dynamic than sunlight, the researchers noted. Natural daylight is a powerful cue for the body’s internal clock, also known as the circadian rhythm.

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The body’s internal clock influences many processes, including digestion, hormone release and metabolism, according to research. When it gets out of sync, it can worsen insulin resistance and blood sugar control, which are two of the main issues caused by type 2 diabetes.

Typical lighting in homes and offices is much dimmer and lacks the biological signals provided by natural daylight. (iStock)

To test the effects of daylight on blood sugar, scientists recruited 13 adults with type 2 diabetes. Each person spent two separate 4.5-day periods in a controlled office setting, according to a press release.

DIABETES PREVENTION LINKED TO SPECIFIC TYPE OF EXERCISE, STUDY SHOWS

In one period, they worked in front of large windows with natural daylight streaming in. In the other period, participants worked in the same room with the windows covered and were exposed only to typical indoor lighting.

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Daylight isn’t a replacement for medication or traditional management strategies like diet and exercise, the researchers noted.

Everyone ate similar meals, followed the same schedule and continued their usual diabetes medications in both conditions.

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While average blood sugar levels didn’t differ drastically between the two conditions, people spent more time in the healthy glucose range when they were exposed to natural daylight — their blood sugar fluctuated less and stayed within a desirable range for a greater portion of the day.

Participants who were exposed to daylight burned more fat and fewer carbohydrates, a metabolic pattern linked to better blood sugar regulation. (iStock)

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Exposure to natural light also affected metabolism. In daylight, participants burned more fat and fewer carbohydrates for energy.

Muscle biopsies and laboratory tests further showed that the genes responsible for the body’s cellular clocks were more synchronized under natural light conditions, the study revealed.

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Better alignment of these genes can improve nutrient processing and how cells respond to insulin, the researchers concluded.

Sitting near windows or spending more time outdoors could support diabetes management alongside standard treatments, researchers say. (iStock)

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However, daylight isn’t a replacement for medication or traditional management strategies like diet and exercise, according to the team.

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The study did have some limitations, including that the group of patients was small. The researchers cautioned that larger studies are needed to confirm these results and determine how much natural light exposure is optimal.

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“This study also highlights the often unnoticed impact of the built environment on our health, and raises further concerns about the prevalence of office environments with poor (natural) daylight access,” the researchers noted.

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Frequent heartburn may be a warning sign of a more dangerous condition, doctor says

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Frequent heartburn may be a warning sign of a more dangerous condition, doctor says

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For most people, heartburn is an occasional annoyance and source of temporary discomfort. But for some, chronic heartburn can lead to more dangerous conditions — potentially even pre-cancerous ones.

About 10% of people with chronic gastroesophageal reflux disease (GERD) will develop Barrett’s esophagus, a condition where the lining of the lower esophagus is replaced with abnormal cells that are more prone to cancer, according to medical experts.

Some studies have shown that among those with Barrett’s esophagus, between 3% and 13% will go on to develop cancer, but most will not.

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When acid reflux becomes dangerous

“Your stomach is designed to handle acid. Your esophagus is not,” Dr. Daryl Gioffre, a Florida-based gut health specialist and certified nutritionist, told Fox News Digital.

About 10% of people with chronic acid reflux will develop Barrett’s esophagus, a condition where the lining of the lower esophagus is replaced with abnormal cells that are more prone to cancer. (iStock)

“With reflux, the danger is not the burn in the chest or throat — the real danger is the constant backflow of acid traveling the wrong way.”

In most people, the lower esophageal sphincter — which Gioffre refers to as the “acid gate” — keeps acid in the stomach, which is lined with thick mucus and specialized cells designed to protect it.

“With reflux, the danger is not the burn in the chest or throat — the real danger is the constant backflow of acid traveling the wrong way.”

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“But when the gate gets weak, it relaxes or stays slightly open, and acid slips back up the wrong way,” he said. This “gate” can weaken with magnesium deficiency, high stress, alcohol, poor sleep, dehydration and late-night snacking, all of which can disrupt healthy digestion.

When acid hits the esophagus, it irritates tissue that was never designed to withstand it, according to the doctor.

“Every time acid comes back up the wrong way, it injures the lining like a slow chemical burn,” said Gioffre, who is also the author of “Get Off Your Acid” and “Get Off Your Sugar.” Over time, that irritation erodes the lining, drives inflammation and can change the cells.

NOT ALL FIBER IS CREATED EQUAL — DOCTORS SHARE WHICH KINDS TRULY SUPPORT LONGEVITY

“These new cells are no longer normal esophageal cells — they begin to shift into cells that look more like stomach lining, because those cells can tolerate the acid,” the doctor said. “That change is called metaplasia, or Barrett’s esophagus.”

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Once the cells start changing, the risk of further mutation goes up. If that process continues, Gioffre warned, it can progress to dysplasia, which is the stage right before esophageal cancer.

Some studies have shown that among those with Barrett’s esophagus, between 3% and 13% will go on to develop cancer. (iStock)

“So the real danger is not the heartburn you feel,” he summarized. “It is the repeated acid exposure forcing the esophagus to adapt in ways it was never designed to. Fixing reflux at the root stops this entire cascade before those cellular changes begin.”

Men at higher risk

Men generally have a higher risk because they burn through magnesium faster, tend to carry more visceral fat pushing upward on the stomach, eat heavier meals and snack late at night, Gioffre cautioned. These activities all weaken the acid gate and shut down healthy digestion. 

THE BREAD THAT KEEPS THINGS MOVING IN THE BATHROOM — AND DOCTORS SAY IT REALLY WORKS 

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“Eating within three hours of lying down almost guarantees the stomach does not empty, and that is one of the biggest drivers of nighttime reflux,” he said. “On top of that, men often ignore symptoms, or mask them with PPIs and antacids instead of fixing the root cause.”

All of these factors contribute to a “perfect storm” for chronic inflammation and long-term damage, according to Gioffre.

Warning signs

There are certain red flags that indicate when acid reflux has gone beyond an occasional annoyance and has progressed to constant and chronic. 

“If that burn becomes more frequent or more intense, or starts showing up even when you have not eaten, your body is waving a giant warning flag,” Gioffre said.

Difficulty swallowing, a feeling that food is “stuck,” chronic hoarseness, a constant cough, throat clearing or the feeling of a lump in the throat are all indicators that the acid is moving upward into areas it should never reach. (iStock)

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Difficulty swallowing, a feeling that food is “stuck,” chronic hoarseness, a constant cough, throat clearing or the feeling of a lump in the throat are all indicators that the acid is moving upward into areas it should never reach, according to the doctor. 

EXPERT WARNS OF ‘SILENT EPIDEMIC’ THAT PUTS MEN’S HEALTH AT SERIOUS RISK

“Ulcers in your throat, or even in your mouth, are another sign that the acid is doing real damage,” he warned. 

“Another major warning sign is when reflux goes from something you notice occasionally to something you feel every day or every night, or when PPIs and antacids stop helping,” Gioffre said. “That usually means the lining is irritated and eroded, and may already be changing on a cellular level.”

Nighttime reflux is the most dangerous because the acid sits on the esophagus for hours, causing deep inflammation and long-term cellular changes, the doctor said. (iStock)

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Unexplained weight loss, vomiting blood and black stools are all serious symptoms that demand immediate attention, the doctor added.

“The bottom line: When reflux becomes consistent, chronic and starts impacting swallowing, your voice, or the tissues in your mouth or throat, it is no longer just a nuisance,” Gioffre told Fox News Digital. “That is the point where the esophagus may be moving toward a precancerous state, and men especially cannot afford to wait on it.”

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3 key ways to prevent reflux

Gioffre shared the following essential steps to preventing acid reflux and improving digestive health.

No. 1: Follow the 3-hour rule

“Stop eating three hours before bed,” the doctor recommends. “When you eat late, the stomach does not empty, pressure builds and the acid gate relaxes, guaranteeing that acid travels upward into your esophagus while you sleep.”

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Nighttime reflux is the most dangerous because the acid sits on the esophagus for hours, causing deep inflammation and long-term cellular changes, he warned. “This one rule alone can dramatically lower acid reflux and cancer risk.”

No. 2: Strengthen the acid gate

When stomach acid is low, the lower esophageal sphincter loses its tone, allowing acid to travel upward instead of staying in the stomach, Gioffre said.

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“The fastest way to tighten that gate is to build your mineral reserves, especially magnesium,” he said.

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The best way to do this is to load up on magnesium-rich foods like avocado, spinach, pumpkin seeds, chia seeds, quinoa and almonds, and consider adding a clean magnesium supplement.

No. 3: Remove or neutralize daily triggers

The fastest way to protect your esophagus, according to Gioffre, is to eliminate or neutralize the foods and habits that weaken the acid gate and push acid the wrong way.

For people who can’t fully eliminate these triggers, certain habits can help neutralize their impact by reducing acid strength and pressure before it reaches the esophagus.

The doctor recommends cutting back on alcohol and caffeine, both of which relax the acid gate and increase the risk of acid reflux. (iStock)

“Drinking most of your water earlier in the day helps, because pounding water at night stretches the stomach and relaxes the acid gate, making it much easier for acid to flow the wrong way once you lie down,” he said.

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He also recommends cutting back on alcohol and caffeine, both of which relax the acid gate instantly.

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Some other major triggers that fuel the reflux cycle include chocolate, spicy foods, garlic, onions, sugar, ultraprocessed foods and heavy nighttime meals, according to the doctor. 

“These foods and habits weaken the lower esophageal sphincter, drive up inflammation and push pressure upward,” he said. “That’s exactly how a little heartburn turns into chronic reflux, and slowly causes the kind of damage that puts the esophagus at risk for cancer.”

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