World

A twice-yearly shot could help end AIDS. But will it get to everyone who needs it?

Published

1 year ago

December 1, 2024

A twice-yearly shot could help end AIDS. But will it get to everyone who needs it?

MEXICO CITY (AP) — It’s been called the closest the world has ever come to a vaccine against the AIDS virus.

The twice-yearly shot was 100% effective in preventing HIV infections in a study of women, and results published Wednesday show it worked nearly as well in men.

Drugmaker Gilead said it will allow cheap, generic versions to be sold in 120 poor countries with high HIV rates — mostly in Africa, Southeast Asia and the Caribbean. But it has excluded nearly all of Latin America, where rates are far lower but increasing, sparking concern the world is missing a critical opportunity to stop the disease.

“This is so far superior to any other prevention method we have, that it’s unprecedented,” said Winnie Byanyima, executive director of UNAIDS. She credited Gilead for developing the drug, but said the world’s ability to stop AIDS hinges on its use in at-risk countries.

In a report issued to mark World AIDS Day on Sunday, UNAIDS said that the number of AIDS death last year — an estimated 630,000 — was at its lowest since peaking in 2004, suggesting the world is now at “a historic crossroads” and has a chance to end the epidemic.

The drug called lenacapavir is already sold under the brand name Sunlenca to treat HIV infections in the U.S., Canada, Europe and elsewhere. The company plans to seek authorization soon for Sunlenca to be used for HIV prevention.

While there are other ways to guard against infection, like condoms, daily pills, vaginal rings and bi-monthly shots, experts say the Gilead twice-yearly shots would be particularly useful for marginalized people often fearful of seeking care, including gay men, sex workers and young women.

“It would be a miracle for these groups because it means they just have to show up twice a year at a clinic and then they’re protected,” said UNAIDS’ Byanyima.

Such was the case for Luis Ruvalcaba, a 32-year-old man in Guadalajara, Mexico, who participated in the latest published study. He said he was afraid to ask for the daily prevention pills provided by the government, fearing he would be discriminated against as a gay man. Because he took part in the study, he’ll continue to receive the shots for at least another year.

“In Latin American countries, there is still a lot of stigma, patients are ashamed to ask for the pills,” said Dr. Alma Minerva Pérez, who recruited and enrolled a dozen study volunteers at a private research center in Guadalajara.

How widely available the shots will be in Mexico through the country’s health care system isn’t yet known. Health officials declined to comment on any plans to buy Sunlenca for its citizens; daily pills to prevent HIV were made freely available via the country’s public health system in 2021.

“If the possibility of using generics has opened, I have faith that Mexico can join,” said Pérez.

Byanyima said other countries besides Mexico that took part in the research were also excluded from the generics deal, including Brazil, Peru and Argentina. “To now deny them that drug is unconscionable.” she said.

In a statement, Gilead said it has “an ongoing commitment to helping enable access to HIV prevention and treatment options where the need is the greatest.” Among the 120 countries eligible for generic version are 18 mostly African countries that comprise 70% of the world’s HIV burden.

The drugmaker said it is also working on establishing “fast, efficient pathways to reach all people who need or want lenacapavir for HIV prevention.”

On Thursday, 15 advocacy groups in Peru, Argentina, Ecuador, Chile, Guatemala and Colombia wrote to Gilead, asking for generic Sunlenca to be made available in Latin America, citing the “alarming” inequity in access to new HIV prevention tools while infection rates were rising.

While countries including Norway, France, Spain and the U.S. have paid more than $40,000 per year for Sunlenca, experts have calculated it could be produced for as little as $40 per treatment once generic production expands to cover 10 million people.

Dr. Chris Beyrer, director of the Global Health Institute at Duke University, said it will be enormously useful to have Sunlenca available in the hardest-hit countries in Africa and Asia. But he said the rising HIV rates among groups including gay men and transgender populations constituted “a public health emergency” in Latin America.

Hannya Danielle Torres, a 30-year-old trans woman and artist who was in the Sunlenca study in Mexico, said she hoped the government would find a way to provide the shots. “Mexico may have some of the richest people in the world but it also has some of the most vulnerable people living in extreme poverty and violence,” Torres said.

Another drugmaker, Viiv Healthcare, also left out most of Latin America when it allowed generics of its HIV prevention shot in about 90 countries. Sold as Apretude, the bi-monthly shots are about 80% to 90% effective in preventing HIV. They cost about $1,500 a year in middle-income countries, beyond what most can afford to pay.

Asia Russell, executive director of the advocacy group Health Gap, said that with more than 1 million new HIV infections globally every year, established prevention methods are not enough. She urged countries like Brazil and Mexico to issue “compulsory licenses,” a mechanism where countries suspend patents in a health crisis.

It’s a strategy some countries embraced for previous HIV treatments, including in the late 1990s and 2000s when AIDS drugs were first discovered. More recently, Colombia issued its first-ever compulsory license for the key HIV treatment Tivicay in April, without permission from its drugmaker, Viiv.

Dr. Salim Abdool Karim, an AIDS expert at South Africa’s University of KwaZulu-Natal, said he had never seen a drug that appeared to be as effective as Sunlenca in preventing HIV.

“The missing piece in the puzzle now is how we get it to everyone who needs it,” he said.

___

Cheng reported from London.

___

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

Click to comment

World

Minnesota braces for what’s next amid immigration arrests and in the wake of Renee Good shooting

Published

6 hours ago

January 11, 2026

Press Room

Minnesota braces for what’s next amid immigration arrests and in the wake of Renee Good shooting

MINNEAPOLIS (AP) — Already shaken by the fatal shooting of a woman by an immigration officer, Minnesota’s Twin Cities on Sunday braced for what many expect will be a new normal over the next few weeks as the Department of Homeland Security carries out what it called its largest enforcement operation ever.

Protesters screamed at heavily-armed federal agents and honked car horns, banged on drums and blew whistles in attempts to disrupt their operations in one Minneapolis neighborhood filled with single-family homes.

There was some pushing and several people were hit with chemical spray just before agents banged down the door of one home on Sunday. They later took one man away in handcuffs.

“We’re seeing a lot of immigration enforcement across Minneapolis and across the state, federal agents just swarming around our neighborhoods,” said Jason Chavez, a Minneapolis city councilmember. “They’ve definitely been out here.”

Chavez, the son of Mexican immigrants who represents an area with a growing immigrant population, said he is closely monitoring information from chat groups about where residents are seeing agents operating.

People holding whistles positioned themselves in freezing temperatures on street corners in the neighborhood where 37-year-old Renee Good was shot and killed Wednesday, watching for any signs of federal agents.

Stay up to date with the news and the best of AP by following our WhatsApp channel.

Follow on

More than 20,000 people have taken part in a variety of trainings to become “observers” of enforcement activities in Minnesota since the 2024 election, said Luis Argueta, a spokesperson for Unidos MN, a local human rights organization .

“It’s a role that people choose to take on voluntarily, because they choose to look out for their neighbors,” Argueta said.

The protests have been largely peaceful, but the Twin Cities remained anxious. Minneapolis public schools on Monday will start offering remote learning for the next month in response to concerns that children might feel unsafe venturing out while tensions remain high.

Many schools closed last week after Good’s shooting and the upheaval that followed.

While the enforcement activity continues, two of the state’s leading Democrats said on Sunday that the investigation into Good’s shooting death shouldn’t be overseen solely by the federal government.

Minneapolis Mayor Jacob Frey and U.S. Sen. Tina Smith said in separate interviews Sunday that state authorities should be included in the investigation because the federal government has already made clear what it believes happened.

“How can we trust the federal government to do an objective, unbiased investigation, without prejudice, when at the beginning of that investigation they have already announced exactly what they saw — what they think happened,” Smith said on ABC’s “This Week.”

The Trump administration has defended the officer who shot Good in her car, saying he was protecting himself and fellow agents and that Good had “weaponized” her vehicle.

Todd Lyons, acting director of ICE, defended the officer on Fox News Channel’s “The Sunday Briefing.”

“That law enforcement officer had milliseconds, if not short time to make a decision to save his life and his other fellow agents,” he said.

Lyons also said the administration’s enforcement operations in Minnesota wouldn’t be needed “if local jurisdictions worked with us to turn over these criminally illegal aliens once they are already considered a public safety threat by the locals.”

The killing of Good by an ICE officer and the shooting of two people by federal agents in Portland, Oregon, led to dozens of protests across the country over the weekend.

Thousands of people marched Saturday in Minneapolis, where Homeland Security called its deployment of immigration officers in the Twin Cities its biggest ever immigration enforcement operation.

___

Associated Press journalists Giovanna Dell’Orto in Minneapolis, Thomas Strong in Washington, Bill Barrow in Atlanta, and John Seewer in Toledo, Ohio, contributed.

World

Netanyahu and Rubio discuss US military intervention in Iran amid ongoing nationwide protests: report

Published

7 hours ago

January 11, 2026

Press Room

Netanyahu and Rubio discuss US military intervention in Iran amid ongoing nationwide protests: report

NEWYou can now listen to Fox News articles!

Israeli Prime Minister Benjamin Netanyahu and Secretary of State Marco Rubio discussed the possibility of U.S. intervention in Iran, according to a report.

The two leaders spoke by phone Saturday as Israel is on “high alert,” preparing for the possibility of U.S. military intervention in Iran, according to Reuters, citing multiple Israeli sources. A U.S. official confirmed the call to Fox News Digital but did not provide additional details.

The report comes as nationwide anti-regime demonstrations across Iran hit the two-week mark.

On Saturday, the Iranian regime triggered an internet “kill switch” in an apparent effort to conceal alleged abuses by security forces and as protests against it surged nationwide, according to a cybersecurity expert. The blackout reduced internet access to a fraction of normal levels.

KEANE WARNS IRANIAN REGIME TO TAKE TRUMP ‘DEAD SERIOUS’ ON PROTEST KILLING THREAT AMID ONGOING DEMONSTRATIONS

Secretary of State Marco Rubio holds his end-of-year press conference at the State Department in Washington, D.C., Dec. 19, 2025. (Kevin Mohatt/Reuters)

On Sunday, Iran’s parliament speaker warned that the U.S. military and Israel would be “legitimate targets” if America strikes the Islamic Republic.

Parliament Speaker Mohammad Bagher Qalibaf issued the threat as lawmakers rushed the dais in the Iranian parliament, shouting, “Death to America!” according to The Associated Press.

President Donald Trump offered support for the protesters on Saturday, writing on Truth Social that “Iran is looking at FREEDOM, perhaps like never before. The USA stands ready to help!!!”

IRANIAN MILITARY LEADER THREATENS PREEMPTIVE ATTACK AFTER TRUMP COMMENTS

In this frame grab from video obtained by the AP outside Iran, a masked demonstrator holds a picture of Iran’s Crown Prince Reza Pahlavi during a protest in Tehran, Iran, Friday, Jan. 9, 2026. (UGC via AP)

At a news conference Friday, Trump said Iran was facing mounting pressure as unrest spreads across the country.

“Iran’s in big trouble,” he said. “It looks to me that the people are taking over certain cities that nobody thought were really possible just a few weeks ago. We’re watching the situation very carefully.”

The president said the U.S. would respond forcefully if the regime resorts to mass violence.

“We’ll be hitting them very hard where it hurts. And that doesn’t mean boots on the ground, but it means hitting them very, very hard where it hurts,” he said.

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

Protests in Iran intensify for the 12th day. (The National Council of Resistance of Iran)

Fox News Digital reached out to the State Department and White House for comment.

Fox News Digital’s Emma Bussey, Brie Stimson and The Associated Press contributed to this report.

World

Four killed, 20 injured in overnight Russian strikes across Ukraine

Published

9 hours ago

January 11, 2026

Press Room

Four killed, 20 injured in overnight Russian strikes across Ukraine

Published on
11/01/2026 – 14:33 GMT+1

Russia fired more than 150 drones overnight into Sunday targeting close to two dozen locations across Ukraine, killing at least four people and injuring 20 more.

Ukraine’s Air Forces say they intercepted 125 drones aerially but confirmed that at least 25 strike drones struck their targets.

They added that Moscow’s latest barrage mainly targeted Kharkiv, Kherson, Zaporizhzhia and Dnipropetrovsk, all of which were targeted in Saturday’s overnight strikes as well.

Local officials in the southern region of Zaporizhzhia say the strikes targeted residential areas and energy infrastructure. More than 385,000 homes were affected by electric, gas or water outages, at a critical time as temperatures plunged to 10 degrees below Celsius.

Regional lawmakers say service was restored to most of the affected households and areas by Sunday morning, but added that emergency work was still being carried out to restore power to the remaining homes.

Ukraine’s President Volodymyr Zelenskyy accused Russia of timing their attacks with the cold peaks of winter as to maximise civilian suffering.

“They struck targets that have no military purpose whatsoever – energy infrastructure, residential buildings. They deliberately waited for freezing weather to make things worse for our people. This is deliberate, cynical Russian terror specifically against civilians,” wrote Zelenskyy in a post on X.

He also noted that this week had seen heightened Russian assault on Ukrainian cities, announcing that his country’s defence forces recorded thousands of attacks using a variety of different weapons.

“Over the course of this week, Russia launched almost 1,100 attack drones against Ukraine, more than 890 guided aerial bombs, and over 50 missiles of various types – ballistic, cruise, and even the Oreshnik medium-range ballistic missile.”

The Ukrainian leader thanked all units responsible for protecting the country and responding to attacks, and praised their tireless efforts and resilience.

He also called on allies to ensure his embattled country maintains “stable support”, in defence and diplomatic fields as coordinated dialogue efforts continue in search of peace.

Meanwhile, Russia says that one person was killed in Ukrainian strikes on the western city of Voronezh. Officials say a young woman succumbed to her wounds at an intensive care unit of a local hospital after debris from a drone fell on her house during Saturday’s attacks.

They added that at least three others were injured in the attacks which targeted more than 10 residential apartment buildings, private homes and a high school.

The city of Voronezh lies just 250 kilometres from the Ukrainian border and is home to approximately one million people. The attacks, which Kyiv have yet to confirm, came after the Kremlin’s major offensive on Ukraine in the early hours of Saturday.

Additional sources • AP