NFL Week 2 continues with the highly anticipated clash between the San Francisco 49ers and the Minnesota Vikings at U.S. Bank Stadium on Sunday.

The defending NFC champions dominated their Week 1 game against the New York Jets, securing a 32-19 victory over a team led by Aaron Rodgers, who made his return from an Achilles tendon injury. Quarterback Brock Purdy completed 19 of 29 pass attempts for 231 yards and added 11 rushing yards in Monday’s win. The 49ers achieved the victory without star running back Christian McCaffrey, who didn’t play in a last-minute decision due to a calf injury. The star running back has also been ruled out against the Vikings.

The Minnesota Vikings are coming off a Week 1 victory against the New York Giants. Veteran quarterback Sam Darnold, who left the San Francisco 49ers to sign a one-year deal worth $ 10 million with the Vikings, put up an impressive performance. He completed 19 of 24 passes for 208 yards with two touchdowns and one interception in the 28-6 victory over the Giants.

Here are the latest odds and predictions for the Week 2 matchup between the San Francisco 49ers and the Minnesota Vikings.

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NFL Week 2: San Francisco 49ers vs. Minnesota Vikings odds, moneyline, over/under

The San Francisco 49ers are favorites to defeat the Minnesota Vikings, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

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• Spread: 49ers (-5.5)
• Moneyline: 49ers (-230); Vikings (+195)
• Over/under: 46.5

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NFL Week 2: San Francisco 49ers vs. Minnesota Vikings predictions and picks

ESPN’s Seth Walder: 49ers 31, Vikings 24

Walder writes: “49ers wide receiver Brandon Aiyuk will record 100-plus receiving yards. One bad week, we can chalk up to rust — he had just two catches for 28 yards in the 49ers’ opener. But I don’t see the weak numbers lasting long because Aiyuk is just too good: He was the No. 1 WR in ESPN’s receiver tracking metric’s overall score last season for a reason.”

CBS Sports: 49ers but proceed with caution

Garrett Podell writes: “San Francisco certainly has the matchups to prevail on Sunday and improve to 2-0, but a Sam Darnold and Aaron Jones revenge game with a healthy Justin Jefferson could potentially prove to be tougher than anticipated. Jones ran for 108 rushing yards on 18 carries for a six yards per carry average in the Green Bay Packers’ 24-21 NFC Divisional Round loss at the 49ers in January. Minnesota has enough credible matchups, plus some voodoo (if you believe in superstitious things), when this matchup takes place at U.S. Bank Stadium. Sunday afternoon between these two squads should be top tier programming in the NFL’s 1 p.m. ET Week 2 slate.”

Pickswise: San Francisco 49ers

Kevin Davies writes: “The Vikings had the perfect Week 1. First of all, they were fortunate enough to play the Giants. Daniel Jones looked just as sharp as normal, which is about as sharp as a marble, and Minnesota came away with the 28-6 win. The Vikings defense was putting pressure on Jones all game and that resulted in 5 sacks and 2 interceptions. On offense, Sam Darnold looked fantastic and he was unsurprisingly targeting Justin Jefferson throughout the game. However, we have to put this win into perspective. New York is expected to have one of the worst offenses to go with a severely below-average defense in 2024. It would have been concerning if Minnesota didn’t stomp on the Giants. Now the Vikings have to go from facing Daniel Jones and Malik Nabers to Brock Purdy and Deebo Samuel. The difference is night and day, and San Francisco should demonstrate that by covering the touchdown spread on Sunday.”

Doc Sports: Take the Vikings

Guy Bruhn writes: “The Vikings are relinquishing 6.0 points per game, which has them sitting 1st of all teams in the NFL. They have allowed 0 touchdowns through the air in addition to 166.0 yards/outing, which has them in 16th in the NFL. Minnesota has surrendered a total of 74 yards on the ground. The Vikings defense has taken part in 68 plays, which ranks 25th in the league. They have compiled 2 turnovers on the year.”