Health
Chemotherapy drug could have a serious and surprising side effect, study finds
A chemotherapy drug could cause “significant” hearing loss among cancer survivors, according to a study from the University of South Florida and Indiana University.
Researchers tracked 100 testicular cancer survivors who received a chemo drug called cisplatin for an average of 14 years, as a press release from USF noted.
Among the participants, who averaged 48 years of age, 78% of them reported experiencing “significant difficulties in everyday listening situations.”
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This was reportedly the first study to assess potential hearing loss among cancer survivors.
“Patients receiving cisplatin-based chemotherapy are at high risk for permanent hearing loss, and for some, that hearing loss will progress years after chemo treatment,” lead author Victoria Sanchez, associate professor in the USF Health Department of Otolaryngology Head & Neck Surgery, told Fox News Digital in an email.
A chemotherapy drug could cause “significant” hearing loss among cancer survivors, according to a study. (iStock)
“This hearing loss affects how people hear in everyday life, like a noisy restaurant or other social gatherings.”
Cisplatin is a type of chemotherapy drug that contains the metal platinum, according to the National Cancer Institute’s website.
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The IV-administered drug is approved to treat bladder cancer, ovarian cancer and testicular cancer, the NCI states, either alone or in combination with other medications.
Higher doses of cisplatin were linked to more severe cases of hearing loss, the researchers found.
Cisplatin is a type of chemotherapy drug that contains the metal platinum, according to the National Cancer Institute’s website. (iStock)
Those at highest risk included patients with poor heart health or high blood pressure.
“It was surprising to see that cardiovascular conditions are related to increased hearing loss and progression of hearing loss, which speaks to the need for patients to consider healthy lifestyle choices to help protect their ears,” Sanchez said.
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The ears are especially vulnerable to the drug because they cannot filter it out, according to the USF researchers.
“This leads to inflammation and the destruction of sensory cells that are critical for coding sound, causing permanent hearing loss that can progressively get worse well after cisplatin treatments are completed,” the release stated.
Researchers tracked 100 testicular cancer survivors who received a chemo drug called cisplatin for an average of 14 years. (iStock)
The U.S. Food and Drug Administration (FDA) approved cisplatin for testicular cancer treatment in 1978, according to the NIH.
Packaging labels for the drug warn of the potential for ototoxicity, which involves damage to the inner ear as a side effect of medication.
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“Hearing loss can be unilateral or bilateral and tends to become more frequent and severe with repeated doses,” the packaging stated.
“Decreased ability to hear normal conversational tones may occur.”
It is unclear whether the drug-induced ototoxicity is reversible, according to the packaging.
“If a hearing loss is identified, treatment and help for hearing loss is available,” the lead study author said. “Health care providers can talk to patients about their risk of hearing loss and a plan for survivorship.” (iStock)
Based on the findings, the researcher recommends that cancer patients talk to their health care providers about possible hearing loss as a side effect of treatment and to receive hearing evaluations while receiving chemotherapy.
“Check your hearing if you have any concerns,” Sanchez advised.
“If hearing loss is identified, treatment and help for hearing loss is available. Health care providers can talk to patients about their risk of hearing loss and a plan for survivorship.”
The ears are especially vulnerable to the drug because they cannot filter it out, according to the USF researchers. (iStock)
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, noted that cisplatin is a “highly effective treatment” for testicular cancer, improving the cure rate from 10% to 90% when used in combination with other drugs.
“[The drug has a] very high degree of side effects, [including] hearing loss, which is very well-known, in up to 80% of patients,” Siegel, who was not involved in the study, told Fox News Digital via email.
A cost-benefit analysis should be performed for all treatments, the doctor advised.
“High doses of chemotherapy (especially ones that are platinum-based) and radiation to the head, ear or brain can cause damage and hearing problems in one or both ears,” the ACS stated. (iStock)
“Since this is a potentially deadly cancer, the benefits are generally worth the side effects, until newer, less toxic and equally effective treatments are developed,” Siegel said.
The main limitation of the study, according to Sanchez, is that all of the patients were very similar — males treated for testicular cancer.
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“We need to conduct additional studies to understand women treated with cisplatin and for other types of cancers,” she said.
The goal is that the research will lead to alternatives in chemotherapy treatment plans and preventative medications to reduce the risk of hearing loss, according to USF.
“Hearing loss related to cancer treatment is often permanent (doesn’t go away), but a hearing aid might help.”
The American Cancer Society warns on its website of the potential for chemotherapy drugs to impact hearing.
“High doses of chemotherapy (especially ones that are platinum-based) and radiation to the head, ear or brain can cause damage and hearing problems in one or both ears,” the ACS stated.
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“Hearing loss related to cancer treatment is often permanent (doesn’t go away), but a hearing aid might help.”
Fox News Digital reached out to the FDA, the ACS and several manufacturers of branded cisplatin medications requesting comment.
Health
Heart disease threat projected to climb sharply for key demographic
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A new report by the American Heart Association (AHA) included some troubling predictions for the future of women’s health.
The forecast, published in the journal Circulation on Wednesday, projected increases in various comorbidities in American females by 2050.
More than 59% of women were predicted to have high blood pressure, up from less than 49% currently.
The review also projected that more than 25% of women will have diabetes, compared to about 15% today, and more than 61% will have obesity, compared to 44% currently.
As a result of these risk factors, the prevalence of cardiovascular disease and stroke is expected to rise to 14.4% from 10.7%.
The prevalence of cardiovascular disease and stroke in women is expected to rise to 14.4% from 10.7% by 2050. (iStock)
Not all trends were negative, as unhealthy cholesterol prevalence is expected to drop to about 22% from more than 42% today, the report stated.
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Dr. Elizabeth Klodas, a cardiologist and founder of Step One Foods in Minnesota, commented on these “jarring findings.”
“The fact that on our current trajectory, cardiometabolic disease is projected to explode in women within one generation should be a huge wake-up call,” she told Fox News Digital.
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“Hypertension, diabetes, obesity — these are all major risk factors for heart disease, and we are already seeing what those risks are driving. Heart disease is the No. 1 killer of women, eclipsing all other causes of death, including breast cancer.”
Cardiovascular disease is the leading cause of death for women in the U.S. and around the world. (iStock)
Klodas warned that heart disease starts early, progresses “stealthily,” and can present “out of the blue in devastating ways.”
The AHA published another study on Thursday revealing one million hospitalizations, showing that heart attack deaths are climbing among adults below the age of 55.
The more alarming finding, according to Klodas, is that young women were found more likely to die after their first heart attack than men of the same age.
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“This is all especially tragic since heart disease is almost entirely preventable,” she said. “The earlier you start, the better.”
Children can show early evidence of plaque deposition in their arteries, which can be reversed through lifestyle changes if “undertaken early enough and aggressively enough,” according to the expert.
Moving more is one part of protecting a healthy heart, according to experts. (iStock)
Klodas suggested that rising heart conditions are associated with traditional risk factors, like smoking, high blood pressure, high cholesterol, diabetes, obesity and a sedentary lifestyle.
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Doctors are also seeing higher rates of preeclampsia, or high blood pressure during pregnancy, as well as gestational diabetes. Klodas noted that these are sex-specific risk factors that don’t typically contribute to complications until after menopause.
The best way to protect a healthy heart is to “do the basics,” Klodas recommended, including the following lifestyle habits.
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Klodas especially emphasized making improvements to diet, as the food people eat affects “every single risk factor that the AHA’s report highlights.”
“High blood pressure, high blood sugar, high cholesterol, excess weight – these are all conditions that are driven in part or in whole by food,” she said. “We eat multiple times every single day, which means what we eat has profound cumulative effects over time.”
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health,” a doctor said. (iStock)
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health.”
The doctor also recommends changing out a few snacks per day for healthier choices, which has been proven to “yield medication-level cholesterol reductions” in a month.
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“Keep up that small change and, over the course of a year, you could also lose 20 pounds and reduce your sodium intake enough to avoid blood pressure-lowering medications,” Klodas added.
“Women should not view the AHA report as inevitable. We have power over our health destinies. We just need to use it.”
Health
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Health
Common vision issue linked to type of lighting used in Americans’ homes
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Nearsightedness (myopia) is skyrocketing globally, with nearly half of the world’s population expected to be myopic by 2050, according to the World Health Organization.
Heavy use of smartphones and other devices is associated with an 80% higher risk of myopia when combined with excessive computer use, but a new study suggests that dim indoor lighting could also be a factor.
For years, scientists have been puzzled by the different ways myopia is triggered. In lab settings, it can be induced by blurring vision or using different lenses. Conversely, it can be slowed by something as simple as spending time outdoors, research suggests.
Nearsightedness occurs when the eyeball grows too long from front to back, according to the American Optometric Association (AOA). This physical elongation causes light to focus in front of the retina rather than directly on it, making distant objects appear blurry.
The study suggests that myopia isn’t caused by the digital devices themselves, but by the low-light environments where they are typically used. (iStock)
Researchers at the State University of New York (SUNY) College of Optometry identified a potential specific trigger for this growth. When someone looks at a phone or a book up close, the pupil naturally constricts.
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“In bright outdoor light, the pupil constricts to protect the eye while still allowing ample light to reach the retina,” Urusha Maharjan, a SUNY Optometry doctoral student who conducted the study, said in a press release.
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“When people focus on close objects indoors, such as phones, tablets or books, the pupil can also constrict — not because of brightness, but to sharpen the image,” she went on. “In dim lighting, this combination may significantly reduce retinal illumination.”
High-intensity natural light prevents myopia because it provides enough retinal stimulation to override the “stop growing” signal, even when pupils are constricted. (iStock)
The hypothesis suggests that when the retina is deprived of light during extended close-up work, it sends a signal for the eye to grow.
In a dim environment, the narrowed pupil allows so little light through that the retinal activity isn’t strong enough to signal the eye to stop growing, the researchers found.
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In contrast, being outdoors provides light levels much brighter than indoors. This ensures that even when the pupil narrows to focus on a nearby object, the retina still receives a strong signal, maintaining healthy eye development.
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The team noted some limitations of the study, including the small subject group and the inability to directly measure internal lens changes, as the bright backgrounds used to mimic the outdoors made pupils too small for standard equipment.
Researchers believe that increasing indoor brightness during close-up work could be a simple, testable way to slow the global nearsightedness epidemic. (iStock)
“This is not a final answer,” Jose-Manuel Alonso, MD, PhD, SUNY distinguished professor and senior author of the study, said in the release.
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“But the study offers a testable hypothesis that reframes how visual habits, lighting and eye focusing interact.”
The study was published in the journal Cell Reports.
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