Science
Q&A: What oncologists can glean from Kate Middleton's cancer announcement
After months of speculation about her recent health challenges, Catherine, Princess of Wales, revealed Friday that she has cancer.
The video announcement was short on specifics, prompting a new set of questions about her condition. She said she was initially told her “condition was non-cancerous.” Learning otherwise after medical tests had been conducted “came as a huge shock,” the former Kate Middleton said.
She said she told the public the same thing she told her young children, Princes George and Louis and Princess Charlotte: “I am well and getting stronger every day.”
Here’s a look at what is known about the princess’ condition:
What kind of cancer does Catherine have?
She didn’t say.
In Friday’s video statement, she explained that she had “major abdominal surgery” in January and didn’t suspect she had cancer at the time. Only later was it discovered that “cancer had been present,” she said.
With so little information to go on, it’s impossible to know exactly what the princess is up against, experts said. The fact that she had abdominal surgery would seem to rule out breast cancer, which is the most commonly diagnosed cancer for women in the United Kingdom, according to the World Cancer Research Fund.
Other than that, “it can be anything in the abdominal cavity — ovary, colon, appendix, stomach,” said Dr. Beth Karlan, a gynecologic oncologist at UCLA’s Jonsson Comprehensive Cancer Center. “Any of the organs you think of in your tummy could have a malignancy.”
Among women in Britain, the most common types of cancers that affect the abdominal area are those of the bowel, uterus, ovaries, pancreas and kidney, the World Cancer Research Fund says.
If she was initially told she didn’t have cancer, why did her diagnosis change?
Sometimes a cancer patient’s initial symptoms look like something else. For instance, doctors may think a blockage in the ducts of a patient’s gallbladder is caused by a gallstone, but when they perform surgery to remove it, they find cancer, said Dr. Syma Iqbal, gastrointestinal oncologist at USC Norris Comprehensive Cancer Center.
During surgery, pieces of tissue are removed and sent to a pathology lab, where they are sliced up and examined under a microscope. That close inspection reveals features that are too small to be seen in an operating room.
Discovering that a patient has cancer only after surgical treatment is “not common, but it’s not rare,” Karlan said.
What is Catherine’s prognosis?
Experts said it’s probably good, based on the fact that she said she was now undergoing “preventative chemotherapy.”
What is ‘preventative chemotherapy’?
It’s chemotherapy treatment given after the primary treatment — in Catherine’s case, surgery — that’s intended to reduce the risk that the cancer will come back.
Surgery can remove the bulk of a tumor, and if surgeons know they are operating on a malignancy, they will remove some surrounding tissue and lymph nodes to increase their odds of capturing breakaway cancer cells, Iqbal said. But if there’s a risk that some cells may remain, chemotherapy is a way to kill them off, thus reducing the risk of a recurrence.
“It can improve the chance of long-term cure and survival,” said Dr. Edward Kim, physician-in-chief for City of Hope Orange County in Irvine.
In the United States, this kind of secondary treatment is called adjuvant chemotherapy. Radiation treatment and hormone therapy are other examples of adjuvant therapies for cancer patients.
“The fact that they think all of the cancer was removed and preventative or adjuvant chemotherapy was given gives us some cause for optimism,” said Dr. Bill Dahut, chief scientific officer with the American Cancer Society.
”If you had found a lot more cancer than you expected, you’d have to go in for another operation. Or if the cancer had already spread, it would be treatment for metastatic or advanced cancer,” Dahut said. “This is chemotherapy given for what’s presumed to be microscopic spread.”
Catherine is 42. Isn’t that kind of young to get cancer?
Generally speaking, the risk of cancer increases with age. But several kinds of cancer have been increasingly seen in younger adults, experts said.
At 42, the princess is on the younger side of cancer patients. But the incidence of cancer has been rising among people under 50, Kim said.
“We are absolutely seeing younger people being diagnosed with cancer,” he said.
In the United States, colorectal cancer is largely to blame. It is now the leading cause of cancer death in men under 50 and is second only to breast cancer among women in that age group, according to the most recent annual report from the American Cancer Society. Both Dahut and Iqbal said the trend is probably similar in the U.K.
Science
What’s in a Name? For These Snails, Legal Protection
The sun had barely risen over the Pacific Ocean when a small motorboat carrying a team of Indigenous artisans and Mexican biologists dropped anchor in a rocky cove near Bahías de Huatulco.
Mauro Habacuc Avendaño Luis, one of the craftsmen, was the first to wade to shore. With an agility belying his age, he struck out over the boulders exposed by low tide. Crouching on a slippery ledge pounded by surf, he reached inside a crevice between two rocks. There, lodged among the urchins, was a snail with a knobby gray shell the size of a walnut. The sight might not dazzle tourists who travel here to see humpback whales, but for Mr. Avendaño, 85, these drab little mollusks represent a way of life.
Marine snails in the genus Plicopurpura are sacred to the Mixtec people of Pinotepa de Don Luis, a small town in southwestern Oaxaca. Men like Mr. Avendaño have been sustainably “milking” them for radiant purple dye for at least 1,500 years. The color suffuses Mixtec textiles and spiritual beliefs. Called tixinda, it symbolizes fertility and death, as well as mythic ties between lunar cycles, women and the sea.
The future of these traditions — and the fate of the snails — are uncertain. The mollusks are subject to intense poaching pressure despite federal protections intended to protect them. Fishermen break them (and the other mollusks they eat) open and sell the meat to local restaurants. Tourists who comb the beaches pluck snails off the rocks and toss them aside.
A severe earthquake in 2020 thrust formerly submerged parts of their habitat above sea level, fatally tossing other mollusks in the snail’s food web to the air, and making once inaccessible places more available to poachers.
Decades ago, dense clusters of snails the size of doorknobs were easy to find, according to Mr. Avendaño. “Full of snails,” he said, sweeping a calloused, violet-stained hand across the coves. Now, most of the snails he finds are small, just over an inch, and yield only a few milliliters of dye.
Science
Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order
new video loaded: This Parrot Has No Beak, But Is at the Top of the Pecking Order
By Meg Felling and Carl Zimmer
April 20, 2026
Science
Contributor: Focus on the real causes of the shortage in hormone treatments
For months now, menopausal women across the U.S. have been unable to fill prescriptions for the estradiol patch, a long-established and safe hormone treatment. The news media has whipped up a frenzy over this scarcity, warning of a long-lasting nationwide shortage. The problem is real — but the explanations in the media coverage miss the mark. Real solutions depend on an accurate understanding of the causes.
Reporters, pharmaceutical companies and even some doctors have blamed women for causing the shortage, saying they were inspired by a “menopause moment” that has driven unprecedented demand. Such framing does a dangerous disservice to essential health advocacy.
In this narrative, there has been unprecedented demand, and it is explained in part by the Food and Drug Administration’s recent removal of the “black-box warning” from estradiol patches’ packaging. That inaccurate (and, quite frankly, terrifying) label had been required since a 2002 announcement overstated the link between certain menopause hormone treatments and breast cancer. Right-sizing and rewording the warning was long overdue. But the trouble with this narrative is that even after the black-box warning was removed, there has not been unprecedented demand.
Around 40% of menopausal women were prescribed hormone treatments in some form before the 2002 announcement. Use plummeted in its aftermath, dipping to less than 5% in 2020 and just 1.8% in 2024. According to the most recent data, the number has now settled back at the 5% mark. Unprecedented? Hardly. Modest at best.
Nor is estradiol a new or complex drug; the patch formulation has existed for decades, and generic versions are widely manufactured. There is no exotic ingredient, no rare supply chain dependency, no fluke that explains why women are suddenly being told their pharmacy is out of stock month after month.
The story is far more an indictment of the broken insurance industry: market concentration, perverse incentives and the consequences of allowing insurance companies to own the pharmacy benefit managers that effectively control drug access for the majority of users. Three companies — CVS Caremark, Express Scripts and OptumRx — manage 79% of all prescription drug claims in the United States. Those companies are wholly owned subsidiaries of three insurance behemoths: CVS Health, Cigna and UnitedHealth Group, respectively. This means that the same corporation that sells you your insurance plan also decides which drugs get covered, at what price, and whether your pharmacy can stock them. This is called vertical integration. In another era, we might have called it a cartel. The resulting problems are not unique to hormone treatments; they have affected widely used medications including blood thinners, inhalers and antibiotics. When a low-cost generic such as estradiol — a medication with no blockbuster profit margins and no patent protection — runs into friction in this system, the friction is not random. It is structural. Every decision in that chain is filtered through the same corporate profit motive. And when the drug in question is an off-patent estradiol patch that has negligible profit margins because of generic competition but requires logistical investment to keep consistently in stock? The math on “how much does this company care about ensuring access” is not complicated.
Unfortunately, there is little financial incentive to ensure smooth, consistent access. There is, however, significant financial incentive to steer patients toward branded alternatives, or simply to let supply tighten — because the companies aren’t losing much profit if sales of that product dwindle. This is not a conspiracy theory: The Federal Trade Commission noted this dynamic in a report that documented how pharmacy benefit managers’ practices inflate costs, reduce competition and harm patient access, particularly for independent pharmacies and for generic drugs.
Any claim that the estradiol patch shortage is meaningfully caused by more women now demanding hormone treatments is a distraction. It is also misogyny, pure and simple, to imply that the solution to the shortage is for women’s health advocates to dial it down and for women to temper their expectations. The scarcity of estradiol patches is the outcome of a broken system refusing to provide adequate supply.
Meanwhile, there are a few strategies to cope.
- Ask your prescriber about alternatives. Estradiol is available in multiple formulations, including gel, spray, cream, oral tablet, vaginal ring and weekly transdermal patch, which is a different product from the twice-weekly patch and may be more consistently available depending on manufacturer and region.
- Consider an online pharmacy. Many are doing a good job locating and filling these prescriptions from outside the pharmacy benefit manager system.
- Call ahead. Patch shortages are inconsistent across regions and distributors. A call to pharmacies in your area, or a broader geographic radius if you’re able, can locate stock that your regular pharmacy doesn’t have.
- Consider a compounding pharmacy. These sources can sometimes meet needs when commercially manufactured products are inaccessible. The hormones used are the same FDA-regulated bulk ingredients.
Beyond those Band-Aid solutions, more Americans need to fight for systemic change. The FTC report exists because Congress asked for it and committed to legislation that will address at least some of the problems. The FDA took action to change the labeling on estrogen in the face of citizen and medical experts’ pressure; it should do more now to demand transparency from patch manufacturers.
Most importantly, it is on all of us to call out the cracks in the current system. Instead of repeating “there’s a patch shortage” or a “surge in demand,” say that a shockingly small minority of menopausal women still even get hormonal treatments prescribed at all, and three drug companies control the vast majority of claims in this country. Those are the real problems that need real solutions.
Jennifer Weiss-Wolf, the executive director of the Birnbaum Women’s Leadership Center at New York University School of Law, is the author of the forthcoming book “When in Menopause: A User’s Manual & Citizen’s Guide.” Suzanne Gilberg, an obstetrician and gynecologist in Los Angeles, is the author of “Menopause Bootcamp.”
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