Science
11% of high school seniors report using delta-8 THC, advertised as 'legal' form of cannabis
A molecular lookalike of the intoxicating compound found in marijuana has become popular among teens in the United States, especially in areas where marijuana use is illegal, a new study shows.
More than 11% of high school seniors who took part in a national survey last spring said they had used delta-8 THC, a psychoactive compound typically derived from hemp, in the last year.
That figure surprised researchers at USC and the University of Michigan, who published their findings this week in the Journal of the American Medical Assn.
Products containing delta-8 “have really only been on the market since 2018,” said study leader Alyssa Harlow, a USC epidemiologist and faculty member of the school’s Institute for Addiction Science.
Gummies, vapes and other products containing delta-8 are available online and in gas stations and convenience stores. They are often marketed as a federally legal substitute for marijuana — and often without solid measures for age verification.
“We don’t know enough about these drugs, but we see that they are already extremely accessible to teens,” said Dr. Nora Volkow, director of the National Institute on Drug Abuse, which helped fund the research. “Cannabis use in general has been associated with negative impacts on the adolescent brain.”
Delta-8 looks much like delta-9 THC — the more common molecule in cannabis that makes people feel high — but has a slightly different structure, with a double bond located between a different set of carbon atoms. Although both are naturally found in cannabis, delta-8 is less abundant.
In a 2021 survey, delta-8 users reported it to have less intense effects than delta-9, on average. But the Food and Drug Administration has warned consumers that it has not evaluated the safety of delta-8 products. Chemicals used to convert cannabinoids found in hemp into delta-8 may include harmful contaminants, the agency cautioned.
Products containing delta-8 exploded in popularity after the 2018 passage of an agricultural bill that eased federal restrictions on hemp and created a legal loophole for the compound.
The Agriculture Improvement Act allowed for the broader production of hemp, “which is cannabis that has only a very small amount of delta-9 THC,” said Ziva Cooper, director of the UCLA Center for Cannabis and Cannabinoids. That opened the door for people to extract chemical compounds from hemp, such as CBD, and convert them into other substances that can produce intoxicating effects, she said.
The result was that “delta-8 THC now seems to be legal, because it’s not specifically banned,” Cooper said. However, another federal law restricts a broader category of compounds that includes delta-8, she said, making things “very, very confusing.”
Some states have restricted or banned delta-8. But as of November, the National Cannabis Industry Assn. described it as “de facto legal” in nearly half of states.
The new findings on teen use of delta-8 come from the annual Monitoring the Future survey, a NIDA-funded project that asks U.S. adolescents about drug and alcohol use.
Some were using delta-8 fairly frequently: Among high school seniors who said they had used it in the previous year, more than a third said they had done so 10 or more times during that period.
It’s unclear if delta-8 affects teens differently than other forms of THC, but “even if it’s the same as other forms, we’re not in favor of 13-, 14- and 15-year-olds using cannabis,” said Dr. Wilson M. Compton, NIDA’s deputy director.
For teens, “we’d be concerned about its impact on learning and memory and day-to-day brain function,” Compton said. “There are also concerns about its use being associated with development of psychiatric illness, particularly psychotic disorders in those that are using cannabis particularly earlier in life,” he added.
Harlow and her colleagues found that in states where marijuana use is illegal for adults, 14% of high school seniors said they had used delta-8 in the last year. However, in states where marijuana was legal for adults, 8% of high school seniors said they used delta-8 in the previous year.
There was no clear difference based on state policies when it came to marijuana use, with more than 30% of the seniors overall saying they had used the drug in the last year. Among teens who reported using delta-8, nearly 91% said they had used marijuana as well.
The survey also revealed that teen use of delta-8 was more common in states where the psychoactive compound was not regulated.
“The alarm bells go off for me that these products are being marketed with claims of being a completely legal substitute for marijuana and they seem to be proliferating in areas where there’s really no regulation,” Harlow said. That lack of oversight can mean no required testing for potential contaminants, she said.
“We don’t necessarily know what is in the product that you are using — and you don’t know either,” Cooper said. “People are not making sure that there’s quality control or that there’s accurate labeling. … That in itself should make people who are thinking about experimenting pause.”
Other researchers have warned in the American Journal of Emergency Medicine that because of the lack of federal regulation, “products may be packaged in brightly-colored containers featuring cartoon characters, sweet or fruity flavors and candy-themed images that may be attractive to young children.”
In California, industrial hemp products may not legally contain more than a 0.3% concentration of THC — including delta-8 THC — nor can they include versions of the cannabinoid created through chemical synthesis, according to the state’s Department of Public Health. Harlow said that for delta-8, “most of the products that we’re seeing on the market are illegal in California.”
But “there is widespread flouting” of the state rules and “enforcement is practically nonexistent,” said Dale Gieringer, director of California NORML, an advocacy group focused on the rights of cannabis consumers. The result is “an enormous amount of delta-8 available by internet and convenience stores.”
Last year marked the first time the Monitoring the Future survey included a delta-8 question, which was posed to more than 2,000 high school seniors. In the coming years, researchers plan to query younger teens as well.
Compton said the numbers show that in a typical high school classroom, a handful of teens are likely using delta-8. In light of that, he said, “it’s incumbent on us to expand our research to understand the health impacts.”
Science
What’s in a Name? For These Snails, Legal Protection
The sun had barely risen over the Pacific Ocean when a small motorboat carrying a team of Indigenous artisans and Mexican biologists dropped anchor in a rocky cove near Bahías de Huatulco.
Mauro Habacuc Avendaño Luis, one of the craftsmen, was the first to wade to shore. With an agility belying his age, he struck out over the boulders exposed by low tide. Crouching on a slippery ledge pounded by surf, he reached inside a crevice between two rocks. There, lodged among the urchins, was a snail with a knobby gray shell the size of a walnut. The sight might not dazzle tourists who travel here to see humpback whales, but for Mr. Avendaño, 85, these drab little mollusks represent a way of life.
Marine snails in the genus Plicopurpura are sacred to the Mixtec people of Pinotepa de Don Luis, a small town in southwestern Oaxaca. Men like Mr. Avendaño have been sustainably “milking” them for radiant purple dye for at least 1,500 years. The color suffuses Mixtec textiles and spiritual beliefs. Called tixinda, it symbolizes fertility and death, as well as mythic ties between lunar cycles, women and the sea.
The future of these traditions — and the fate of the snails — are uncertain. The mollusks are subject to intense poaching pressure despite federal protections intended to protect them. Fishermen break them (and the other mollusks they eat) open and sell the meat to local restaurants. Tourists who comb the beaches pluck snails off the rocks and toss them aside.
A severe earthquake in 2020 thrust formerly submerged parts of their habitat above sea level, fatally tossing other mollusks in the snail’s food web to the air, and making once inaccessible places more available to poachers.
Decades ago, dense clusters of snails the size of doorknobs were easy to find, according to Mr. Avendaño. “Full of snails,” he said, sweeping a calloused, violet-stained hand across the coves. Now, most of the snails he finds are small, just over an inch, and yield only a few milliliters of dye.
Science
Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order
new video loaded: This Parrot Has No Beak, But Is at the Top of the Pecking Order
By Meg Felling and Carl Zimmer
April 20, 2026
Science
Contributor: Focus on the real causes of the shortage in hormone treatments
For months now, menopausal women across the U.S. have been unable to fill prescriptions for the estradiol patch, a long-established and safe hormone treatment. The news media has whipped up a frenzy over this scarcity, warning of a long-lasting nationwide shortage. The problem is real — but the explanations in the media coverage miss the mark. Real solutions depend on an accurate understanding of the causes.
Reporters, pharmaceutical companies and even some doctors have blamed women for causing the shortage, saying they were inspired by a “menopause moment” that has driven unprecedented demand. Such framing does a dangerous disservice to essential health advocacy.
In this narrative, there has been unprecedented demand, and it is explained in part by the Food and Drug Administration’s recent removal of the “black-box warning” from estradiol patches’ packaging. That inaccurate (and, quite frankly, terrifying) label had been required since a 2002 announcement overstated the link between certain menopause hormone treatments and breast cancer. Right-sizing and rewording the warning was long overdue. But the trouble with this narrative is that even after the black-box warning was removed, there has not been unprecedented demand.
Around 40% of menopausal women were prescribed hormone treatments in some form before the 2002 announcement. Use plummeted in its aftermath, dipping to less than 5% in 2020 and just 1.8% in 2024. According to the most recent data, the number has now settled back at the 5% mark. Unprecedented? Hardly. Modest at best.
Nor is estradiol a new or complex drug; the patch formulation has existed for decades, and generic versions are widely manufactured. There is no exotic ingredient, no rare supply chain dependency, no fluke that explains why women are suddenly being told their pharmacy is out of stock month after month.
The story is far more an indictment of the broken insurance industry: market concentration, perverse incentives and the consequences of allowing insurance companies to own the pharmacy benefit managers that effectively control drug access for the majority of users. Three companies — CVS Caremark, Express Scripts and OptumRx — manage 79% of all prescription drug claims in the United States. Those companies are wholly owned subsidiaries of three insurance behemoths: CVS Health, Cigna and UnitedHealth Group, respectively. This means that the same corporation that sells you your insurance plan also decides which drugs get covered, at what price, and whether your pharmacy can stock them. This is called vertical integration. In another era, we might have called it a cartel. The resulting problems are not unique to hormone treatments; they have affected widely used medications including blood thinners, inhalers and antibiotics. When a low-cost generic such as estradiol — a medication with no blockbuster profit margins and no patent protection — runs into friction in this system, the friction is not random. It is structural. Every decision in that chain is filtered through the same corporate profit motive. And when the drug in question is an off-patent estradiol patch that has negligible profit margins because of generic competition but requires logistical investment to keep consistently in stock? The math on “how much does this company care about ensuring access” is not complicated.
Unfortunately, there is little financial incentive to ensure smooth, consistent access. There is, however, significant financial incentive to steer patients toward branded alternatives, or simply to let supply tighten — because the companies aren’t losing much profit if sales of that product dwindle. This is not a conspiracy theory: The Federal Trade Commission noted this dynamic in a report that documented how pharmacy benefit managers’ practices inflate costs, reduce competition and harm patient access, particularly for independent pharmacies and for generic drugs.
Any claim that the estradiol patch shortage is meaningfully caused by more women now demanding hormone treatments is a distraction. It is also misogyny, pure and simple, to imply that the solution to the shortage is for women’s health advocates to dial it down and for women to temper their expectations. The scarcity of estradiol patches is the outcome of a broken system refusing to provide adequate supply.
Meanwhile, there are a few strategies to cope.
- Ask your prescriber about alternatives. Estradiol is available in multiple formulations, including gel, spray, cream, oral tablet, vaginal ring and weekly transdermal patch, which is a different product from the twice-weekly patch and may be more consistently available depending on manufacturer and region.
- Consider an online pharmacy. Many are doing a good job locating and filling these prescriptions from outside the pharmacy benefit manager system.
- Call ahead. Patch shortages are inconsistent across regions and distributors. A call to pharmacies in your area, or a broader geographic radius if you’re able, can locate stock that your regular pharmacy doesn’t have.
- Consider a compounding pharmacy. These sources can sometimes meet needs when commercially manufactured products are inaccessible. The hormones used are the same FDA-regulated bulk ingredients.
Beyond those Band-Aid solutions, more Americans need to fight for systemic change. The FTC report exists because Congress asked for it and committed to legislation that will address at least some of the problems. The FDA took action to change the labeling on estrogen in the face of citizen and medical experts’ pressure; it should do more now to demand transparency from patch manufacturers.
Most importantly, it is on all of us to call out the cracks in the current system. Instead of repeating “there’s a patch shortage” or a “surge in demand,” say that a shockingly small minority of menopausal women still even get hormonal treatments prescribed at all, and three drug companies control the vast majority of claims in this country. Those are the real problems that need real solutions.
Jennifer Weiss-Wolf, the executive director of the Birnbaum Women’s Leadership Center at New York University School of Law, is the author of the forthcoming book “When in Menopause: A User’s Manual & Citizen’s Guide.” Suzanne Gilberg, an obstetrician and gynecologist in Los Angeles, is the author of “Menopause Bootcamp.”
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