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Ozempic, the happy drug? Study suggests weight-loss medications could reduce depression, anxiety

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Ozempic, the happy drug? Study suggests weight-loss medications could reduce depression, anxiety

For the millions of people who take Ozempic and Wegovy, weight loss is the best-known outcome — but a new study suggests the medications could also help squash depression.

Investigators from Epic Research, a health analytics firm based in Verona, Wisconsin, found that patients with diabetes who were prescribed glucagon-like peptide-1 receptor agonist (GLP-1) medications were less likely to develop depression compared to people who are not taking the drugs.

GLP-1 medications include semaglutide (Ozempic or Wegovy), tirzepatide (Mounjaro), dulaglutide (Trulicity) and exenatide (Byetta and Bydureon).

OZEMPIC, OTHER WEIGHT-LOSS DRUGS MAY STRENGTHEN NEW YEAR’S RESOLUTIONS, EXPERTS SAY: HEALTH GOAL ‘BOOST’

“The likelihood of anxiety in diabetic patients is lower for those on all five GLP-1 medications studied,” the researchers wrote in a release on Epic’s website.

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For those without diabetes, semaglutide was linked to a lower likelihood of depression and anxiety, while liraglutide did not show any statistically significant benefit.

Weight loss is the best-known perk of Ozempic and Wegovy, but a new study suggests the medications could also help to reduce depression. (iStock)

The study analyzed the GLP-1 medications and mental health diagnoses of 3,081,254 diabetic patients and 929,174 non-diabetic patients.

Dr. Brett Osborn, a Florida neurologist and founder of the longevity company Senolytix, was not surprised to hear of the Epic Research study findings.

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“Ozempic’s potential antidepressive effects are garnering interest, both from the scientific community and those seeking holistic ways to manage their mental health alongside physical conditions,” he told Fox News Digital.

Weight loss often leads to a boost in mood and overall outlook in Osborn’s patients, he noted.

GLP-1 medications include semaglutide (Ozempic or Wegovy), tirzepatide (Mounjaro), dulaglutide (Trulicity) and exenatide (Byetta and Bydureon). (Getty Images)

“Losing weight can significantly impact an individual’s self-esteem and overall mood, leading to a more positive outlook on life,” the doctor said. 

“The confidence boost that comes with achieving weight loss goals can be transformative, reducing feelings of depression and enhancing mental well-being.”

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OZEMPIC AND WEGOVY COULD LEAD TO MUSCLE LOSS, EXPERTS SAY, BUT PREVENTION IS POSSIBLE

Dr. Jennifer Bourgeois, PharmD, a Dallas-based pharmacy and health expert with SingleCare, a prescription discount service, said none of the companies that produce GLP-1 medications studied the effect on depression in the original clinical trials.

“At this time, none of the GLP-1 medications used to improve glycemic control in adults with type 2 diabetes or in chronic weight management claim to curb depression and anxiety,” she told Fox News Digital.

That doesn’t mean it’s not possible, however, the expert said.

Physical and mental mood-lifters

In previous research, Ozempic and other GLP-1 drugs were shown to have antidepressant-like effects in diabetic mice with type 2 diabetes, suggesting that the drugs have direct effects on brain chemistry and connectivity, Osborn said.

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“It is thought that this results from GLP-1’s influence on the release of neurotransmitters, such as norepinephrine and serotonin, in a deep brain region known as the hypothalamus,” Osborn said.

Weight loss often leads people to adopt healthier lifestyle habits, such as regular exercise and improved dietary choices, an expert pointed out.  (iStock)

GLP-1 drugs also modify the release of dopamine in the amygdala, the “emotional center” of the brain, Osborn said, which is involved in mood regulation. 

While Bourgeois agrees that these medications may impact mood via brain changes, she said the likelier reason for the reduced depression and anxiety is the positive mental and physical health effects of weight loss.

OZEMPIC AND WEGOVY WEIGHT LOSS DRUGS COULD HELP REDUCE ALCOHOL USE DISORDER SYMPTOMS, STUDY SUGGESTS

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Weight loss induced by GLP-1 medications triggers biological changes that positively impact mood regulation, Bourgeois said. 

“As excess adipose tissue (body fat) decreases, the production of inflammatory cytokines reduces, leading to a decrease in systemic inflammation,” she said. 

“Research suggests that chronic inflammation may disrupt neurotransmitters like serotonin and dopamine as well as the balance of gut bacteria, potentially leading to mood imbalances.”

A pharmacist holds boxes of Eli Lilly & Co. Mounjaro brand tirzepatide medication at a pharmacy in Provo, Utah, on Monday, Nov. 27, 2023.  (Getty Images)

The boost to self-esteem and body image can also curb depression and anxiety, Bourgeois noted, leading to an overall more positive outlook. 

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“Individuals who achieve weight loss through GLP-1 receptor agonists may experience a sense of accomplishment and empowerment, which can positively influence their mental health,” she said.

There may also be a “trickle-down” effect, with weight loss often leading people to adopt healthier lifestyle habits — such as regular exercise and improved dietary choices, the expert pointed out. 

“These lifestyle changes can have profound effects on mental health,” she said.  

The boost to self-esteem and body image that comes with weight loss can also curb depression and anxiety, experts say. (iStock)

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“Physical activity is known to stimulate the release of endorphins, which promote feelings of happiness and euphoria, and a nutrient-rich diet can provide essential vitamins and minerals that support brain function and mood regulation.”

More research needed

While the Epic data is “promising,” said Bourgeois, “more research is needed to determine if the medication itself is responsible for the reduction in depression and anxiety diagnoses.”

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“Other factors like physical activity, diet and sleep were not controlled and could be contributing to the mood-altering effects.”

Osborn added, “I’m not saying that Ozempic will become a first-line treatment for depression, but it certainly highlights the interconnectedness of physical and mental health.”

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Detransitioner Chloe Cole shares complications after gender procedures: ‘I am grieving’

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Detransitioner Chloe Cole shares complications after gender procedures: ‘I am grieving’

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Medical victim Chloe Cole was at the center of the U.S. Department of Health and Human Services’ Thursday announcement of proposed regulatory actions to end “sex-rejecting procedures” on minors.

The proposed regulatory actions by the HHS are part of President Donald Trump‘s January executive order calling on the department to protect children from “chemical and surgical mutilation.”

The department is rolling out a series of policy updates and regulatory actions that would effectively defund hospitals that provide gender transition procedures, according to an HHS official. 

NUMBER OF YOUNG ADULTS IDENTIFYING AS TRANSGENDER PLUNGES BY NEARLY HALF IN TWO YEARS

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Cole, now 21 years old, went through the process of medical transition from female to male between the ages of 12 and 16.

The California native took to the stage alongside HHS Secretary Robert F. Kennedy Jr. and other officials Thursday to advocate for the protection of children. Afterward, she told Fox News Digital the puberty blockers, testosterone injections and double mastectomy she endured have irreversibly and permanently affected her health.

Detransitioner Chloe Cole joined HHS Secretary Robert F. Kennedy Jr. on Thursday as he announced proposed regulations ending gender treatments for children. (Fox News Digital)

“As soon as gender was in the picture, none of my doctors or psychologists asked the real questions that they should have,” said Cole. “The entire focus was on my feelings and what I wanted rather than what I really needed in that moment.”

What she needed, Cole said, was to be loved and affirmed for the way God created her — “as a young and yet tomboyish little girl.”

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She maintained that her doctors neglected to share risks, only touting the “benefits” of stopping female puberty and using testosterone to promote body hair growth, musculature and different fat distribution.

“There was nothing they could say to me that would make me understand the gravity of what I was about to go through, because I was still growing up,” said Cole. “I had very little experience in the world, and I simply would not be mature enough to be equipped to undergo such a life-changing procedure in every way.”

“I had very little experience in the world, and I simply would not be mature enough to be equipped to undergo such a life-changing procedure in every way,” Cole, pictured above in both pictures, told Fox News Digital. (Chloe Cole; Fox News Digital)

Cole noted that her parents never thought she was transgender, but felt like the odds were stacked against them.

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“At the time when we started going through this as a family, there really were no resources that would speak to the reality of transgenderism, especially for children,” she said. “Most people were not aware then that this was something that was even happening in our hospital systems.”

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Cole said her parents were warned that if they did not allow her to transition, she would likely commit suicide. 

“My legal guardians were forced to make this decision under duress,” she shared in a previous statement. “But even if my parents had supported transitioning medically from the start, no parent or any adult, ultimately, has a right to determine whether a child gets to be chemically sterilized or mutilated.”

“While there are only two sexes, there’s a million different ways that you can be yourself,” said Cole, pictured above during her surgeries.  (Chloe Cole)

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Cole said she’s suffered numerous complications from her medications and surgery. “My quality of life is still being impacted to this day,” she wrote in her statement.

Her fertility status now remains unknown, she said. She will not be able to breastfeed because her breasts were surgically removed.

“As an adult, I am now grieving, and on top of that, the areolar skin grafts they used in my surgery began to fail two years afterward. I must wear bandages on my chest every day,” Cole wrote. 

“As an adult, I am now grieving.”

In 2023, Cole filed a lawsuit with the Center for American Liberty (CAL) against hospitals for pushing her into what she believes is medical mutilation.

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Mark Trammell of CAL told Fox News Digital that Thursday’s HHS announcement “represents a critical acknowledgment that experimental medical interventions on children with gender distress have failed to meet basic standards of safety and effectiveness.”

Cole, who detransitioned after medical procedures, is warning others to wait and seek family support before transitioning. (Fox News Digital)

“It signals that medicine must return to its core ethical obligation: First, do no harm,” Trammell added. 

“We will continue fighting to ensure accountability for the institutions that promoted these practices and to secure justice for the children and detransitioners whose lives were forever altered.”

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In a previous statement provided to Fox News Digital, Dr. Marc Siegel, Fox News senior medical analyst, said he is in favor of a “more conservative approach” for minors.

“Long-term effects of puberty blockers may include bone loss, trouble concentrating, interference with learning and interference with fertility,” he said. “I think it makes sense in most cases to treat underlying mental health concerns before jumping into treatments, including surgery, that may be difficult to reverse.”

“It makes sense in most cases to treat underlying mental health concerns before jumping into treatments.”

The doctor also emphasized that gender issues should not be overly politicized. “This means not superimposing an ideology or pushing physicians to act in a certain way or under pressure,” Siegel said. 

Cole began the gender transition process at age 12 and received a double mastectomy surgery at 15 years old. (Fox News Digital)

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“The welfare of the child must come first. In this case, it means going very slowly and providing support to a child or teen with gender dysphoria.”

Cole shared that she hopes any children who are questioning whether they should transition wait. 

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While there are only two sexes, there are a million different ways that you can be yourself,” she added.

“God is there for you. He is the one who has created you this way, and you can seek his counsel,” Cole went on. 

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“You can continue praying, and I think ultimately it’s connecting with your family, building your purpose in this world, and looking to the gospel and up to God.”

Fox News Digital’s Emma Colton contributed reporting.

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Simple lifestyle changes could slash heart attack risk for millions, scientists report

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Simple lifestyle changes could slash heart attack risk for millions, scientists report

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Those at risk of type 2 diabetes may be able to prevent heart problems later.

A new study published in The Lancet Diabetes & Endocrinology discovered that lowering the blood sugar of those with prediabetes could reduce the risk of heart attack by half.

Diabetes researchers and endocrine experts across Europe, China and the U.S. investigated how bringing blood sugar back to normal levels affected the chances of heart problems later in life, based on a 20-year American study and a 30-year Chinese study, according to a press release.

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In both studies, the prediabetic participants were coached to make appropriate lifestyle changes to lower blood sugar (the amount of glucose in the bloodstream) through diet and exercise, also targeting weight loss.

Participants worked to lower blood sugar through diet and exercise targeted at weight loss. (iStock)

The researchers split the participants into a remission group (where blood sugar returned to normal) and a non-remission group, which included those still in the prediabetes range. They then determined who in these groups had died from heart disease or were hospitalized for heart failure.

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Participants who went into remission had a 58% lower risk of dying from heart disease and being hospitalized for heart failure. This group also had a lower risk of other major heart events and lower overall death rates.

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These heart-protective benefits lasted for decades after the program ended, the researchers found.

Those in prediabetes remission had their risk of a heart event reduced by more than half. (iStock)

“Reaching prediabetes remission is linked to a decades-long benefit, halving the risk of cardiovascular death or hospitalization for heart failure in diverse populations,” the researchers commented in the publication of the study. “Targeting remission might represent a new approach to cardiovascular prevention.”

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In an interview with Fox News Digital, Dr. Andreas Birkenfeld, study co-author and professor of medicine at the University Hospital Tübingen in Germany, reiterated that reaching prediabetes remission is not only relevant for reducing the progression of type 2 diabetes, but may also be associated with a “meaningful reduction in… heart attack risk, cardiac death and heart failure.” 

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“Importantly, this underscores that prediabetes is a modifiable stage where timely, evidence-based interventions (especially lifestyle measures, and in selected cases, medication) can make a real difference,” he added.

“Reaching prediabetes remission is linked to a decades-long benefit, halving the risk of cardiovascular death or hospitalization for heart failure in diverse populations,” the researchers commented. (iStock)

The study did have some limitations, including that it is based on analysis of trials not originally designed to measure cardiovascular outcomes, which means the results show association but cannot prove causation.

In addition, unmeasured lifestyle and health factors, population differences and lack of randomization for heart outcomes may have influenced the reduced cardiovascular risk, the researchers acknowledged.

“This underscores that prediabetes is a modifiable stage where timely, evidence-based interventions … can make a real difference.”

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Birkenfeld suggested that those with prediabetes should ask their doctors the following questions: “What is my current status? What is my personal cardiovascular risk? What is my target blood glucose level?”

Patients should also inquire about the frequency of testing for blood sugar and key risk factors like blood pressure, cholesterol and other related conditions, such as kidney function or sleep apnea, he advised.

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“If lifestyle changes aren’t enough or my risk is high, would medication be appropriate for me — and what are the benefits and downsides?” the researcher asked as an example.

About 98 million American adults, more than one in three, have prediabetes, according to CDC data. Eight in 10 of these adults are unaware that they have the disease.

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New Weight Loss Drug Beats Ozempic and Eases Joint Pain With ‘Insane’ Results, Doctors Say

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New Weight Loss Drug Beats Ozempic and Eases Joint Pain With ‘Insane’ Results, Doctors Say


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‘Triple G’ Retatrutide Shows ‘Insane’ Results on Weight Loss, Knee Pain | Woman’s World




















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