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‘Gender-affirming’ treatments don’t benefit youth, says pediatricians group: ‘Irreversible consequences’

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‘Gender-affirming’ treatments don’t benefit youth, says pediatricians group: ‘Irreversible consequences’

A national organization of pediatricians and other health care professionals claims that “gender-affirming” therapies have not been shown to benefit adolescents with gender dysphoria.

The American College of Pediatricians (ACPeds), based in Florida, released a position statement on Feb. 7 stating that “social transition, puberty blockers and cross-sex hormones have no demonstrable, long-term benefit on the psychosocial well-being of adolescents with gender dysphoria.”

“A review of at least 60 research papers demonstrates no benefit to social affirmation, puberty blockers, cross-sex hormones or surgical interventions for these youth,” lead author and vice president of ACPeds, Dr. Jane Anderson, wrote in an email to Fox News Digital.

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All 60 of the reviewed studies focused on the mental health of adolescents struggling with gender dysphoria.

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The position statement was voted on and passed by the ACPeds board and members, a spokesperson told Fox News Digital.

A national organization of pediatricians and other health care professionals claims that “gender-affirming” therapies have not been shown to benefit adolescents with gender dysphoria. (iStock)

In a fact sheet summarizing the findings, ACPeds noted that “youth whose perceived gender identity does not align with their biological sex have high rates of mental health problems regardless of any affirmation of their gender identities.”

Adolescents who identify as “gender-incongruent” often have existing mental health illnesses, including depression and anxiety, according to Anderson.

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ACPeds also stated that over half of LGBTQ+ sexual minority individuals experience “adverse childhood experiences,” including child abuse.

Transgender youth reported the highest levels of abuse and neglect, the data showed.

The researchers said their review “casts doubt on claims that social affirmation (like using desired pronouns) of transgender-identified youth helps their long-term psychosocial well-being.”

The researchers found that the use of puberty-blocking drugs — medications that delay puberty in children — did not have significant benefits for young people experiencing gender dysphoria. (iStock)

“Adolescents have immature brains and should not be allowed to make decisions with lifelong implications, such as decreased fertility, when they are so young,” Anderson told Fox News Digital.

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In terms of specific therapies, the researchers found that the use of puberty-blocking drugs — medications that delay puberty in children — did not have significant benefits for youths experiencing gender dysphoria.

“Adolescents have immature brains and should not be allowed to make decisions with lifelong implications, such as decreased fertility, when they are so young.”

“A study [that] purported to show a ‘lifetime suicidal ideation’ reduction in those who received puberty blockers actually found twice as many serious suicidal attempts in participants who received the blockers than in those who just wished they had received them,” the study’s fact sheet noted.

Cross-sex hormonal interventions — treatments that trigger a transition to a desired gender — were also shown to have “little mental health benefit” and were even linked to a higher need for psychiatric care, ACPeds stated.

The data shows that a large percentage of gender-dysphoric adolescents will ultimately identify with their birth sex — which means in those cases the treatments are proven unnecessary, a doctor said. (iStock)

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The review also discovered that many teens who pursue gender-affirming therapy — whether surgical or hormonal — ultimately revert to their biological gender.

“There are individuals who now express regret regarding their transition,” Anderson told Fox News Digital.

Doctors react to the report

Dr. Brett Osborn, a Florida neurologist and longevity expert, was not involved in the analysis but shared his input on the topic, which he said is “often fueled by political bias and religious undertones.”

“I agree with the position statement of the ACPeds,” he told Fox News Digital. “Namely, a holistic approach with intense psychiatric interventions should be adopted prior to any gender-altering therapeutic.”

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The data shows that a large percentage of gender-dysphoric adolescents will ultimately identify with their birth sex, which means in those cases the treatments are proven unnecessary, the doctor noted.

“Medical professionals should strive to address gender dysphoria primarily through a holistic psychological approach — involving both the patient and family — before more invasive pharmaceutical or surgical measures,” Osborn told Fox News Digital.

Dr. Brett Osborn, a Florida neurologist and longevity expert, said he agrees with the position statement issued by the ACPeds. (Dr. Brett Osborn)

While taking hormone-altering therapies or transitioning to the opposite sex has become “all the rage,” he said, the data suggests there is no long-term mental health benefit. 

“In addition, those opting for hormone-altering therapies are potentially interfering with not only sexual development, but also brain development,” Osborn warned. “Testosterone and estrogen, the hormones primarily manipulated with such therapies, are integral to memory formation and mood.”

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The doctor also noted the dangers associated with “gender-affirming” surgeries. 

“Adolescents, prior to undergoing intense psychiatric therapy, are opting for sex-change operations in an almost whimsical manner,” he said. “But this is short-sighted, and the decision is often tainted by ongoing psychological issues.”

He added, “Such surgeries permanently alter one’s physical appearance, carrying with them irreversible consequences, such as infertility and sexual dysfunction.”

“Adolescents, prior to undergoing intense psychiatric therapy, are opting for sex-change operations in an almost whimsical manner,” a doctor said. (Cyberguy.com)

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Adolescents haven’t lived long enough to make such high-level decisions, according to Osborn.

“They’re confused,” he said. “An alternative must be sought.”

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was also not involved in the ACPeds study, but commented on the findings of what he described as a “conservative advocacy group.”

“Hormone-altering therapies are potentially interfering with not only sexual development, but also brain development.”

“I am in favor of a more conservative approach as well in minors,” he told Fox News Digital.  

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“Long-term effects of puberty blockers may include bone loss, trouble concentrating, interference with learning and interference with fertility.”

Siegel added, “I think it makes sense in most cases to treat underlying mental health concerns before jumping into treatments, including surgery, that may be difficult to reverse.”

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, warned of the long-term effects of puberty blockers. (Fox News)

The doctor also emphasized that gender issues should not be overly politicized. 

“This means not superimposing an ideology or pushing physicians to act in a certain way or under pressure,” Siegel said. 

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“The welfare of the child must come first. In this case, it means going very slowly and providing support to a child or teen with gender dysphoria.”

Siegel also pointed out that many U.K. and European countries, from Sweden to France, have restricted gender-affirming care for adolescents in favor of mental health support.

Organizations in favor of gender-affirming procedures

The American Medical Association (AMA) states on its website that “improving access to gender-affirming care is an important means of improving health outcomes for the transgender population.” 

“Receipt of gender-affirming care has been linked to dramatically reduced rates of suicide attempts, decreased rates of depression and anxiety, decreased substance use, improved HIV medication adherence and reduced rates of harmful self-prescribed hormone use,” the organization claimed.

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Many U.K. and European countries, from Sweden to France, have restricted gender-affirming care for adolescents in favor of mental health support. (iStock)

The AMA also said it supports public and private health insurance coverage for the treatment of gender dysphoria.

The Office of Population Affairs (OASH), part of the Department of Health and Human Services, released a similar statement in support of gender-affirming care, calling it a “supportive form of health care that may include medical, surgical, mental health and non-medical services for transgender and nonbinary people.” 

“The welfare of the child must come first.”

“Research demonstrates that gender-affirming care improves the mental health and overall well-being of gender-diverse children and adolescents,” the statement continued.

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OASH claimed that gender-affirming care allows “transgender and nonbinary children and adolescents” to focus on social transitions and can increase their confidence in navigating the health care system.

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The American Academy of Pediatrics (AAP) also has expressed support of gender-affirming care, stating on its website that it recommends “providing youth with access to comprehensive gender-affirming and developmentally appropriate health care.”

The AAP also calls for electronic health records, notifications and research files to be updated to reflect the patient’s desired gender identity.

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Fox News Digital reached out to the AMA, OASH and the American Academy of Pediatrics requesting comment on the ACPeds study.

For more Health articles, visit www.foxnews.com/health.

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Aging process could accelerate due to ‘forever chemicals’ exposure, study finds

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Aging process could accelerate due to ‘forever chemicals’ exposure, study finds

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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”

The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.

PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted. 

Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.

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Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.

A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)

The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.

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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.

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Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.

“People should not panic.”

The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.

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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital. 

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“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”

The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)

Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.

Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.

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While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure. 

That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.

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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.

The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)

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Study limitations

The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.

“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.

The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.

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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.

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Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.

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Melissa Joan Hart, 49, Opens up About Weight Loss in Perimenopause

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Melissa Joan Hart, 49, Opens up About Weight Loss in Perimenopause


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Alzheimer’s prevention breakthrough found in decades-old seizure drug

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Alzheimer’s prevention breakthrough found in decades-old seizure drug

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A drug that has long been used to treat seizures has shown promise as a potential means of Alzheimer’s prevention, a new study suggests.

The anti-seizure medication, levetiracetam, was first approved by the FDA in November 1999 under the brand name Keppra as a therapy for partial-onset seizures in adults. The approval has since expanded to include children and other types of seizures.

Northwestern University researchers recently found that levetiracetam prevented the formation of toxic amyloid beta peptides, which are small protein fragments in the brain that are commonly seen in Alzheimer’s patients.

The medication was found to prevent the formation of amyloid-beta 42 in both animal models and cultured human neurons, according to the study findings, which were published in Science Translational Medicine.

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The effect was also seen in post-mortem human brain tissue obtained from individuals with Down syndrome, who are at high risk for Alzheimer’s disease.

The medication was found to prevent the formation of amyloid-beta 42 in both animal models and cultured human neurons. (iStock)

“While many of the Alzheimer’s drugs currently on the market, such as lecanemab and donanemab, are approved to clear existing amyloid plaques, we’ve identified this mechanism that prevents the production of the amyloid‑beta 42 peptides and amyloid plaques,” said corresponding author Jeffrey Savas, associate professor of behavioral neurology at Northwestern University Feinberg School of Medicine, in a press release. 

“Our new results uncovered new biology while also opening doors for new drug targets.”

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The brain is better able to avoid the pathway that produces toxic amyloid‑beta 42 proteins in younger years, but the aging process gradually weakens that ability, Savas noted. 

“This is not a statement of disease; this is just a part of aging. But in brains developing Alzheimer’s, too many neurons go astray, and that’s when you get amyloid-beta 42 production,” he said. 

The effect was also seen in post-mortem human brain tissue obtained from individuals with Down syndrome, who are at high risk for Alzheimer’s disease. (iStock)

That then leads to tau (“tangles”) — abnormal clumps of protein inside brain neurons — which can kill brain cells, trigger neuroinflammation and lead to dementia.

In order for levetiracetam to function as an Alzheimer’s blocker, high-risk patients would have to start taking it “very, very early,” Savas said — up to 20 years before elevated amyloid-beta 42 levels would be detected.

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“You couldn’t take this when you already have dementia, because the brain has already undergone a number of irreversible changes and a lot of cell death,” the researcher noted.

The researchers also did a deep dive into previous human clinical data to determine whether Alzheimer’s patients who were taking the anti-seizure drug had slower cognitive decline. They reported that the patients in that category had a “significant delay” in the span from cognitive decline to death compared to those not taking the drug.

“This analysis supports the positive effect of levetiracetam to slow the progression of Alzheimer’s pathology,” the researcher said. (iStock)

“Although the magnitude of change was small (on the scale of a few years), this analysis supports the positive effect of levetiracetam to slow the progression of Alzheimer’s pathology,” Savas said.

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Looking ahead, the research team aims to find people who have genetic forms of Alzheimer’s to participate in testing, Savas said.

Limitations and caveats

The study had several limitations, including that it relied on animal models and cultured cells, with no human trials conducted.

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Because the study was observational in nature, it can’t prove that the medication caused the prevention of the toxic brain proteins, the researchers acknowledged.

Savas noted that levetiracetam “is not perfect,” cautioning that it breaks down in the body very quickly.

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The team is currently working to create a “better version” that would last longer in the body and “better target the mechanism that prevents the production of the plaques.”

“You couldn’t take this when you already have dementia, because the brain has already undergone a number of irreversible changes and a lot of cell death.”

The medication’s common documented side effects include drowsiness, weakness, dizziness, irritability, headache, loss of appetite and nasal congestion.

It has also been linked to potential mood and behavior changes, including anxiety, depression, agitation and aggression, according to the prescribing information. In rare cases, it could lead to severe allergic reactions, skin reactions, blood disorders and suicidal ideation.

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Funding for the study was provided by the National Institutes of Health and the Cure Alzheimer’s Fund.

Fox News Digital reached out to the drug manufacturer and the researchers for comment.

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