Health
New Alzheimer’s treatment accelerates removal of plaque from the brain in clinical trials
A new Alzheimer’s therapy has shown potential in the first human trials.
Researchers at the West Virginia University Rockefeller Neuroscience Institute (RNI) found that by pairing focused ultrasound in combination with antibody therapies, they were able to accelerate the removal of amyloid-beta plaques from the brains of patients with Alzheimer’s disease.
The study findings were published in The New England Journal of Medicine on Jan. 11.
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An abnormal buildup of amyloid-beta proteins is one of the hallmarks of Alzheimer’s, as these proteins clump together to form plaques that interfere with neurons in the brain.
Anti-amyloid-beta monoclonal antibody treatments, such as aducanumab and lecanemab, have proven to be effective in clearing these plaques and slowing disease progression.
An Alzheimer’s patient undergoes focused ultrasound treatment with the WVU RNI team. (Rockefeller Neuroscience Institute (RNI) at West Virginia University (WVU))
But until now the drugs have been limited by the blood-brain barrier (BBB), which is designed to keep harmful substances from reaching the brain, according to a press release from RNI.
“A study like this is important because it demonstrates that there may be safe ways to increase drug delivery to the brain without any serious adverse effects.”
More than 98% of drugs are blocked by the barrier, which means patients require higher doses and more frequent therapies, the researchers noted.
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In this study, scientists used a focused ultrasound (FUS) system to temporarily open the blood-brain barrier, which allowed the antibodies to have greater access to areas of the brain with high amyloid-beta plaques.
After six months of antibody treatment, the study participants had an average of 32% more reduction in amyloid-beta plaques in areas where the BBB was opened compared to areas where the drug was used without the ultrasound, the release stated.
The WVU RNI team, shown in the MRI suite’s control area, plans ultrasound blood-brain barrier treatment. (Rockefeller Neuroscience Institute (RNI) at West Virginia University (WVU))
“This was a first in human safety and feasibility study in three participants demonstrating that the BBB opening can accelerate clearance of beta amyloid plaques,” study lead Dr. Ali Rezai, director of the Rockefeller Neuroscience Institute (RNI) at WVU, told Fox News Digital.
“Non-invasive focused ultrasound is an outpatient procedure that allows for targeted delivery of therapeutics to the brain that can potentially accelerate the benefit of the antibody treatment in Alzheimer’s disease,” he added.
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The three patients, between the ages of 59 and 77, all had mild Alzheimer’s disease.
During the study, they received six monthly infusions of the aducanumab antibody.
After each treatment, the focused ultrasound was used to open the BBB at the sites of the highest plaque buildup.
While there are some potential risks associated with ultrasound use, such as brain swelling and hemorrhage, Rezai said those effects were not observed in this study.
The focused ultrasound helmet unit with 1,024 ultrasound transducers attaches to the MRI table for MRI-guided treatment. (Rockefeller Neuroscience Institute (RNI) at West Virginia University (WVU))
“We verified with MRI scans that the BBB opening was temporary and it closed 24 to 48 hours after the FUS procedure,” he told Fox News Digital.
The reductions in amyloid plaques were verified in PET scans.
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This was the first step toward larger studies; in those, researchers will be able to evaluate more patients and larger areas of the brain, Rezai noted.
In the next phase of the clinical trial, the ultrasound therapy will be paired with lecanemab, another anti-beta amyloid antibody.
This 3-D illustration shows how ultrasound waves from inside the helmet converge on a focal point on the brain used for blood-brain barrier opening. (Rockefeller Neuroscience Institute (RNI) at West Virginia University (WVU))
Dr. James Galvin, director of the Comprehensive Center for Brain Health at UHealth, the University of Miami Health System, was not involved in the WVU research but shared his reaction.
“A study like this is important because it demonstrates that there may be safe ways to increase drug delivery to the brain without any serious adverse effects,” he told Fox News Digital.
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“Focused ultrasound has been used in other treatment paradigms for brain diseases such as Parkinson’s disease and brain tumors,” Galvin went on.
Galvin also cautioned that this research was conducted with only three patients and was not a placebo-controlled study.
As of 2023, an estimated 6.7 million Americans age 65 and older were living with Alzheimer’s. (iStock)
“It was also designed as a safety study and not appropriately powered to detect significant clinical changes,” he added. “It is still too early to make any specific recommendations, but I am excited to see if there are planned follow-up studies with a larger number of patients.”
Rebecca M. Edelmayer, PhD, senior director of scientific engagement at the Alzheimer’s Association, was also not involved in the study but called the results “very intriguing,” albeit preliminary.
“The blood brain barrier, in its healthy form, protects the brain from harmful agents that could reach it via the bloodstream,” she told Fox News Digital via email.
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“Getting therapeutics across this barrier — from the bloodstream into the brain tissue — is a challenge for any drug used to treat brain diseases, including drugs to treat Alzheimer’s disease.”
Edelmayer added that while this was a “very small study of relatively short length,” it was a worthwhile way to test a “cutting-edge idea” for improving the effectiveness of Alzheimer’s medications.
This illustration of the MRI-guided focused ultrasound system includes a representation of treatment delivery, the target region, and the corresponding opening of the blood-brain barrier demonstrated by contrast enhancement. (Rockefeller Neuroscience Institute (RNI) at West Virginia University (WVU))
Focused ultrasound-induced blood-brain barrier opening has also been shown to improve drug delivery to treat brain tumors, Edelmayer pointed out.
“This is a great example of how learnings from research in other diseases might be repurposed for Alzheimer’s disease and other dementia.”
Looking ahead, Edelmayer said the results of this early research point to the need for larger-scale, longer trials.
“We need more research in individuals with Alzheimer’s disease from all communities to know the full impact this approach could have.”
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Health
July 4 heat delays America 250 celebration as State Fair guests share love of USA
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The Great American State Fair was postponed Saturday after multiple people reportedly fainted the day before, forcing thousands of visitors to pivot during celebrations for America’s 250th anniversary.
Friday’s medical emergencies required onsite attention as crowds flocked to the nation’s capital for Independence Day.
The fair reopened later Friday evening but was postponed again Saturday.
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Fox News Digital asked attendees what it took to get to the capital and what they made of the closure.
“We are so blessed to live in the best country in the world,” Whitney Thomas, a mother from North Carolina who traveled with her family for the Great American State Fair, told Fox News Digital Friday.
An arch across the street from a 110-foot “Freedom 250” Ferris wheel during final preparations for the Great American State Fair on the National Mall June 22, 2026 in Washington, D.C. (Al Drago for The Washington Post via Getty Images)
Despite the weather closure, she said her family was able to enjoy the State Fair Thursday evening and planned to wait out the heat in nearby museums until the fair reopened.
“I wanted my kids, who are 9 and 10, to be able to experience this with us,” she said.
“You cannot tell me that America was won by shutting things down when it gets hot.”
Brad Shultis, a retired Marine who traveled from Stafford, Virginia, expressed frustration over the decision to halt festivities.
“You cannot tell me that America was won by shutting things down when it gets hot,” he told Fox News Digital.
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“It gets hot, and we shut it down because it’s hot? Who cares? If it’s too hot, stay home.”
Shultis noted that he drove to Springfield and took the Metro just to be turned away right after buying lunch. He questioned the decision to shut down the celebration of America’s 250th anniversary, arguing that if people find the weather too hot, they should simply stay home or seek medical help rather than forcing a mass evacuation for those who spent time and money to get there.
Whitney Thomas brought her children with her from North Carolina to Washington to experience the historic event as a family. (Fox News Digital)
Wendy Lamb, who traveled eight hours from Connecticut with her family to support the state’s booth, noted that organizers were likely worried about the intense conditions and simply did not want visitors to suffer.
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While disappointed that her home state did not send official representation due to budget issues, Lamb and her fellow travelers refused to let the heat ruin their first trip to Washington, D.C.
“We’ve had a really, really fun time so far,” added John, another member of the group.
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He said they plan to navigate the heat by moving from museum to museum and using the Metro system to stay cool until the gates reopen.
For these visitors, the setback was minor compared to the emotional weight of seeing the U.S. Capitol and the Rotunda.
Judy drove with her family from Connecticut to support the state after officials withdrew support prior to the fair opening. (Fox News Digital)
“I mean, we are so fortunate we are free, and yet we have people out there that hate our country. … it’s very emotional,” said Pat Lamb, who fanned her face to stop tears welling in her eyes as she described the pride she felt for the nation.
The decision to close the fairgrounds aligns with severe weather protocols designed to prevent mass casualty medical events.
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According to the Centers for Disease Control and Prevention, extreme heat can quickly impair the body’s ability to cool itself, causing internal temperatures to rise faster than they can dissipate.
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When exposure to extreme conditions triggers a heat-related illness, symptoms can escalate rapidly from heat exhaustion — marked by heavy sweating, dizziness, nausea and fainting — to a life-threatening medical emergency, according to the CDC.
Brad Shultis, a veteran, was turned away just after lunch due to extreme heat at The Great American State Fair. (Fox News Digital)
The most severe risk is heat stroke, which occurs when the body’s cooling mechanism fails entirely, potentially driving core body temperatures to 103 degrees Fahrenheit or higher within minutes.
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To prevent severe complications like permanent organ damage or death, the CDC advises that anyone exhibiting warning signs such as confusion, slurred speech or a loss of consciousness should receive immediate medical treatment.
Public health officials urge individuals in high-heat environments to seek shade, stay heavily hydrated and identify air-conditioned cooling centers.
Health
The ‘1776 Diet’: What Americans really ate during the nation’s founding
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Many of the American colonists’ eating habits have made a comeback in recent years. They ate minimally processed, locally sourced whole foods and regularly incorporated organ meats into their meals.
Livestock and many Old World crops had already been introduced to North America by European explorers and settlers during the centuries before the nation’s founding.
Early settlers adapted European cooking traditions using ingredients available in North America, the Center for the Study of the Presidency and Congress (CSPC) reported.
Indigenous peoples introduced corn to the colonists, and it became a core ingredient in many of their recipes. Beans, squash, and potatoes were among the other crops that became incorporated into colonial cooking, according to the CSPC.
“Cornmeal appeared in dishes such as hasty pudding — a thick porridge similar to polenta — and johnnycakes, simple griddle cakes that were popular from New England to the South,” History Facts reported.
Cornmeal Johnnycakes, roast pork and cream cheese are distinctly early-American foods the CSPC has recipes for on its website.
Corn became a staple of early colonists’ diets after Indigenous peoples introduced the crop to the settlers and taught them how to cultivate it. (iStock)
Regional customs and crops greatly influenced what the colonists ate. Rice and okra grew well and were plentiful in the South, where French and African influences also shaped eating habits.
Dutch, English and German immigrants largely settled in the north and established the region’s culinary traditions.
Seafood such as rockfish and crab dominated the diets of early Maryland settlers, NPR reported.
Meat was a status symbol, local food historian Joyce White told the publication. Beef was prized, and chicken was often saved for egg production.
“If it’s your pig or cow coming from your plantation, you don’t want to waste it,” White said.
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Thomas Jefferson was known for his decadent tastes and a fondness for French wine and macaroni and cheese. Records show that black-eyed peas, turnip greens and ham were also part of the Founding Father’s diet.
Salted and preserved fish and meats, including bacon, sausage, liver pudding and offal, were staples of working-class people’s diets, while the upper classes indulged in such luxuries as white flour and sugar.
Interest in these traditional foods has resurfaced in recent years as some Americans seek diets centered on whole, minimally processed ingredients.
Founding Father Thomas Jefferson was known for his continental tastes and enjoyed French wine and macaroni and cheese. (iStock)
Advocates of the Make America Healthy Again movement, for instance, have promoted organ meats, or offal, as some of the cheapest and most nutrient-dense foods people can eat.
Stews that evolved as ingredients became available were also common an America’s early days.
The amount of alcohol the colonists consumed was “staggering,” Adrian Miller, author of “The President’s Kitchen Cabinet,” told NPR.
“They were very open about how much they were drinking,” he said.
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George Washington wrote a recipe for “small beer” in a journal he kept as a young colonel in charge of the Virginia militia during the Seven Years’ War, Fox News Digital previously reported. The New York Public Library houses the journal.
“Small beer,” according to the library, derives its name from the small amount of alcohol it contains. It was quick to make, safer to drink because the brewing process helped eliminate bacteria in the water — and it was an “everyday, mainstay beverage,” the library reported.
“While the 1776 Diet has some positives — such as emphasizing whole foods, home cooking and fewer ultra-processed foods — it’s not one I’d recommend following too literally,” registered dietician Lisa R. Young, adjunct professor of nutrition at New York University, told Fox News Digital.
Working-class colonists would often save chickens for their eggs, rather than consuming their meat. (iStock)
“Colonial Americans often ate foods like salted ham, organ meats and other preserved meats out of necessity,” she said. “Today, we know it’s best to limit processed and cured meats because they’re high in sodium and saturated fat, and organ meats, while nutrient-dense, are best eaten in moderation due to their high cholesterol content.”
Focus on the healthiest aspects of the 1776 diet, Young recommended. That includes plenty of fruits and vegetables, beans, whole grains, fish and lean proteins.
“Of course, you can emulate the Founding Fathers’ diet for the week of the 250th anniversary,” she said. “What you eat for a day or a week won’t matter much in the scheme of things.”
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Some of the Founding Fathers drank a lot of ale, often in the morning, Young noted.
“We shouldn’t emulate that,” she said.
Health
Fourth of July fireworks pose hidden health risk for certain Americans, experts warn
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Fireworks have been a quintessential part of Fourth of July celebrations across the nation for generations.
But as Independence Day festivities light up the night sky, the colorful displays can also pose serious health risks — especially to the lungs.
Nearly 300 million pounds of fireworks are released into the atmosphere each year in the U.S., according to the American Lung Association. This creates smoke filled with tiny particles, as well as gases like sulfur dioxide, carbon dioxide and carbon monoxide, which are “very harmful to our lungs.”
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The smoke from fireworks can also release harmful metals, like aluminum, manganese and cadmium, into the air.
Some illegal fireworks may contain lead, which the association describes as “extremely dangerous” due to its potential to cause lasting health damage.
Attendees watch the Independence Day fireworks display along the National Mall in Washington, D.C. (Probal Rashid/LightRocket via Getty Images)
“Inhaling any of these chemicals can irritate the lungs, making it hard to breathe and causing serious health problems, which is why it is important to avoid firework smoke whenever possible,” the group said in a public advisory.
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Air pollution levels increase by an average of 42% on the Fourth of July, according to a 2015 study.
Smoke from fireworks can worsen symptoms and cause flare-ups in those who have asthma or chronic obstructive pulmonary disease (COPD).
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Fine particle pollution has also been linked to more serious health consequences, including heart attacks, stroke, lung cancer and premature death, according to the American Lung Association.
The organization warned that children, older adults and pregnant women, as well as people with lung and heart disease, are especially vulnerable.
Smoke from fireworks can worsen symptoms and cause flare-ups in those who have asthma or chronic obstructive pulmonary disease. (iStock)
Dr. Afif El-Hasan, member of the Lung Association’s board of directors, shared some advice for high-risk fireworks spectators in an interview with Fox News Digital.
Instead of using fireworks at home, El-Hasan recommends watching them from a distance.
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People with asthma who use a rescue inhaler should keep it close at hand in case fireworks trigger wheezing or other symptoms, the expert advised. Wearing a well-fitting N95 mask can also help reduce exposure to fine particles from fireworks smoke and debris.
“If you are familiar with the area and the wind patterns, try to be upwind from the fireworks display and avoid areas where smoke may accumulate,” he said.
An expert recommends watching fireworks from a distance to avoid exposure to air pollution. (iStock)
The expert also recommends attending fireworks events with friends or family, so someone is available to help if a medical emergency arises.
“Make sure you have taken all of your preventative medication before a fireworks show,” El-Hasan advised. “If possible, take a car to the fireworks display. Try to park as close as possible to the event in case you have to get to the car quickly.”
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The expert also recommends drinking water immediately after the show to clear the upper airway. Changing and washing clothes upon returning home can also help to prevent smoke particles from accumulating in the home.
If case of shortness of breath or chest pain, it’s important to seek medical care immediately.
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