Will the Denver Broncos Bo-lieve in Nix?

After a disastrous tenure, Russell Wilson is out of Denver and Sean Payton has appointed first-round draft pick Bo Nix to take over the starting duties. The Broncos have always been a defensive team, but the unit struggled last season and will need to tighten up to give its rookie some help.

It’s a new era in Seattle with Mike Macdonald the new head coach for the Seahawks after Pete Carroll stepped down. The second half of last season was disappointing and resulted in missing the playoffs. The hope is its key players remain healthy to get the team back into contending in the NFC West.

PROP TALK: These are the best prop bets for NFL games this week 

Seahawks vs. Broncos odds, moneyline, over/under

The Seahawks are favorites to defeat the Broncos, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

• Spread: Seahawks (-6)
• Moneyline: Seahawks (-250); Broncos (+200)
• Over/under: 42

Not interested in this game? Our guide to NFL betting odds, picks and spreads has you covered with Thursday Night Football odds and Monday Night Football odds.

New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites.

FEELING LUCKY? Here are the best parlay bets and odds for NFL games this week 

NFL Week 1 odds, predictions and picks

Ravens vs. Chiefs | Packers vs. Eagles | Jaguars vs. Dolphins | Steelers vs. Falcons | Vikings vs. Giants | Panthers vs. Saints | Patriots vs. Bengals | Titans vs. Bears | Cardinals vs. Bills | Texans vs. Colts | Raiders vs. Chargers | Broncos vs. Seahawks | Commanders vs. Buccaneers | Cowboys vs. Browns | Rams vs. Lions | Jets vs. 49ers

Lorenzo Reyes: Seahawks 24, Broncos 17

I would tend to avoid this game, given the variables on both sides. Seattle has a rookie head coach in Mike Macdonald, the Broncos have a rookie quarterback in Bo Nix. But if I had to pick, I trust Seattle more with its experience on the roster and playing at home.

Tyler Dragon: Seahawks 21, Broncos 16

Bo Nix’s first NFL start is in a rowdy environment at Lumen Field, one of the loudest stadiums in the NFL. The Seahawks are entering the season under the radar. But they have a playoff-caliber roster and new defensive-minded head coach Mike Macdonald should improve Seattle’s defense.

Safid Deen: Seahawks 23, Broncos 16

It’s life well after Russell Wilson for both of these teams. The Seahawks even have a new coach, too. And Mike Macdonald’s defense will give Broncos coach Sean Payton and rookie quarterback Bo Nix fits in Seattle during their opener.

Richard Morin: Broncos 23, Seahawks 21

Don’t go against Bo!

Jordan Mendoza: Seahawks 24, Broncos 16

Bo Nix has been nothing but impressive since he’s arrived in Denver, but going into a raucous Seattle home crowd will be a tough task for a first regular season game. The Broncos couldn’t stop the run last season, and that’s something Kenneth Walker has to be looking forward to exposing. Seattle limits Denver in a convincing win.

MOST VALUABLE BET: Who is the favorite to win NFL MVP in 2024?