San Francisco 49ers at Tampa Bay Buccaneers: Predictions, picks and odds for NFL Week 10 game

The San Francisco 49ers and Tampa Bay Buccaneers find themselves in very similar situations heading into Week 10. Both teams have four wins, are currently in second-place in their divisions, and have suffered tough losses to their divisional foes in first. They’ve also both suffered a myriad of injuries to their star skill position players and both teams have taken losses at the hands of the Kansas City Chiefs.

There is one key difference between these teams though. The 49ers are coming off a bye, while the Buccaneers just played on Monday Night Football. The 49ers should be well-rested, while the Bucs might be more banged up than usual, getting one fewer day to recover.

With both teams missing key players, like Christian McCaffrey and Brandon Aiyuk on the 49ers’ side as well as Mike Evans and Chris Godwin on the Bucs’ side, you’d think both teams would be struggling on offense. However, both teams rank top-ten in points per play.

Here are our experts’ predictions for this Week 10 showdown.

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Buccaneers vs. 49ers odds, moneyline, over/under

The 49ers are favorites to defeat the Buccaneers, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

• Spread: 49ers (-5.5)
• Moneyline: 49ers (-250); Buccaneers (+200)
• Over/under: 50.5

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NFL Week 10 odds, predictions and picks

Ravens vs. Bengals | Panthers vs. Giants | Bears vs. Patriots | Colts vs. Bills | Jaguars vs. Vikings | Chiefs vs. Broncos | Saints vs. Falcons | Buccaneers vs. 49ers | Commanders vs. Steelers | Chargers vs. Titans | Cardinals vs. Jets | Cowboys vs. Eagles | Texans vs. Lions | Rams vs. Dolphins

Lorenzo Reyes: 49ers 28, Buccaneers 20

The Buccaneers play up to elite competition, with the top strength of victory (.647) — or the combined winning percentage of teams Tampa has defeated. The Bucs, in fact, are the only team above .600 in that stat. But the 49ers are coming off a bye week, and one they needed to heal up. Frankly, I can see this going both ways and would likely look elsewhere for a safer play, but given the extra rest — and the fact that Tampa has a slightly shorter week after playing Monday night — I’ll cautiously back the Niners.

Tyler Dragon: 49ers 25, Bucs 21

Will Christian McCaffrey make his season debut this week? San Francisco is coming off a Week 9 bye. While the Bucs are playing on a short week. The 49ers know they need to start performing better if they want to reclaim top status in the NFC West. San Francisco should win this game whether McCaffrey plays or not.

Richard Morin: 49ers 28, Buccaneers 27

San Francisco desperately needs to get going, but it won’t be an easy task on the road in Tampa Bay. I think the 49ers pull out the win, but the 5.5-point spread is a bit much for me.

Jordan Mendoza: 49ers 23, Buccaneers 16

Could Christian McCaffrey actually play? He’ll make an immediate difference and get San Francisco back to being solidified contenders.