The NFL will release the 2025 schedules for all 32 teams at 8 p.m. (ET) Wednesday. Here is what we know about the San Francisco 49ers’ schedule so far.

The 49ers will play each team from the NFC South and AFC South, as well as the 2024 fourth-place teams from the NFC North, NFC East and AFC North. San Francisco also will see its NFC West division rivals twice, once on the road and once at Levi’s Stadium, as part of its 17-game schedule.

Here is the lineup of home and road opponents, listed alphabetically.

The 49ers went 6-11 in 2024 as injuries and a Super Bowl hangover again got the best of them. San Francisco has reached the Super Bowl twice in Kyle Shanahan’s eight seasons, and both times followed up that appearance with a last-place finish (the 49ers went 6-10 in 2020 after losing quarterback Jimmy Garoppolo and defensive end Nick Bosa to early-season injuries).

After a roster reset this offseason ahead of Brock Purdy’s anticipated massive contract extension, the 49ers, with the benefit of playing a last-place schedule, will need to show they can bounce back and re-establish themselves as one of the NFC’s contenders.

Come back Wednesday night for the 49ers’ week-to-week schedule, plus season analysis and predictions.

(Photo of Brock Purdy: Ezra Shaw / Getty Images)