Picks And Predictions For Week 14 at The San Francisco 49ers 

Victoria Hernandez, USA Today: 49ers 32, Seahawks 20

“The 49ers pulled off an impressive road win last week and made a case for best team in the NFC when everyone’s healthy. The Seahawks have shown grit and gave Dallas a scare last week, but they are dealing with their own injuries right now and are on the road. San Francisco has an encore of Thanksgiving and takes this one easily.” 

Safid Deen, USA Today: 49ers 31, Seahawks 17

“The Seahawks rebounded from their Thanksgiving loss against the 49ers against the Cowboys last week and lost a close game. I’m not sure if Seattle has what it takes to keep their season alive against the best team in the NFL for the second time in three weeks.” 

Jordan Mendoza, USA Today: 49ers 34, Seahawks 17

“After last week’s demolition of Philadelphia, nobody wants to play San Francisco right now. The 49ers made easy work of Seattle on Thanksgiving, and with the groove the team is in, it’ll be more of the same this time around.” 

*Bill Bender, Sporting News: 49ers 34, Seahawks 24 *

“San Francisco has outscored opponents 134-49 since the bye week – an impressive four-game winning streak where Brock Purdy owns a 74.1% completion percentage with 11 TDs and one interception. San Francisco won the first meeting 31-13, and they are at home. There is value in the underdog, but it’s hard to bet against the 49ers – who are 2-1 ATS when favored by double digits. We’re going to try with a desperate Seattle team.” 

Pete Prisco, CBS Sports: 49ers 35, Seahawks 23

“The Seahawks have lost three straight games and have major issues on defense right now. The 49ers are rolling on offense. That means this will be a mismatch. The 49ers blew them out in Seattle, and they will do it again in this one. I do think both teams will score as Brock Purdy continues his MVP push.” 

*Bob Condotta, Seattle Times: 49ers 34, Seahawks 23 *

“Expect the Seahawks to put up more of a fight than in the first game, particularly early. But the 49ers are healthy, rolling and on paper, anyway, just too good for the Seahawks right now. But that’s usually proven true on game day, as well, as evidenced by the 49ers’ current four-game winning streak against the Seahawks. It’ll be a major upset for that not to become five.” 

Matt Calkins, Seattle Times: 49ers 24, Seahawks 13

“San Francisco, frankly, is playing better than any team in the NFL and has been for a while now. Would be surprised if the struggling Seahawks gave them any kind of challenge on the road.” 

Adam Jude, Seattle Times: 49ers 28, Seahawks 24

“Geno Smith and the offense found their footing in Dallas. This matchup in Santa Clara will be telling for Seattle’s defense, which has allowed 30.4 points per game over the past five weeks. It has to be better — much better — if the Seahawks are going to have a chance to upset the NFL’s best team Sunday.”