New England Patriots at San Francisco 49ers: Predictions, picks and odds for NFL Week 4 game

After a stunning defeat at the hands of the Los Angeles Rams in Week 3, the San Francisco 49ers have found themselves in unfamiliar territory. They are at the bottom of the NFC West standings. While injuries to players like Deebo Samuel, George Kittle, and Christian McCaffrey will certainly hinder a team’s chances of winning, the team is still talented enough to beat an 0-2 Rams team, right? That is, of course, unless the team’s new $30 million receiver gets outshined by Jauan Jennings.

The New England Patriots, meanwhile, were looking like a surprisingly competent team through two weeks. They beat the Cincinnati Bengals in Week 1 and took the now 3-0 Seattle Seahawks to overtime in Week 2. Week 3 was a different story though as the entire world watched Aaron Rodgers and the Jets dominate New England on national television. So, which of these two teams will put their horrendous Week 3 performances behind them?

PROP TALK: These are the best prop bets for NFL games this week 

49ers vs. Patriots odds, moneyline, over/under

The 49ers are favorites to defeat the Patriots, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

• Spread: 49ers (-10)
• Moneyline: 49ers (-550); Patriots (+400)
• Over/under: 39.5

Not interested in this game? Our guide to NFL betting odds, picks and spreads has you covered with Thursday Night Football odds and Monday Night Football odds.

New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites.

FEELING LUCKY? Here are the best parlay bets and odds for NFL games this week 

NFL Week 4 odds, predictions and picks

Giants vs. Cowboys | Falcons vs. Saints | Panthers vs. Bengals | Bears vs. Rams | Packers vs. Vikings | Texans vs. Jaguars | Colts vs. Steelers | Jets vs. Broncos | Buccaneers vs. Eagles | Cardinals vs. Commanders | 49ers vs. Patriots | Chargers vs. Chiefs | Raiders vs. Browns | Ravens vs. Bills | Dolphins vs. Titans | Lions vs. Seahawks

Lorenzo Reyes: 49ers 23, Patriots 17

In theory, this is a game San Francisco should easily win. But the team’s play the last two weeks, with all its injuries, doesn’t inspire me to back them by double digits. The concern is the defense, now on its third different defensive coordinator in as many seasons, which is allowing far too many explosive plays.

Tyler Dragon: 49ers 26, Patriots 17

Brock Purdy had a 137.1 passer rating and Jauan Jennings had career-highs in catches (11), receiving yards (175), and touchdowns (3), and the shorthanded 49ers still managed to lose last week. The 49ers won’t spoil good performances from reserve players this week, but their injuries are beginning to mount.

Richard Morin: 49ers 31, Patriots 21

A visit from the mediocre Patriots will be a welcome sight for the 49ers, who desperately need some momentum in their favor after a 1-2 start. The spread is pretty large and the over/under is pretty low, however, so I’d be wary of putting action on this one.

Jordan Mendoza: 49ers 23, Patriots 9

San Francisco is spiraling with two straight losses and plenty of injuries, but playing the lowly Patriots comes at the right time. The defense makes a statement in an easy win.

MOST VALUABLE BET: Who is the favorite to win NFL MVP in 2024?