North Carolina
Fujifilm Invests Additional $1.2 Billion to Expand its North Carolina CDMO
Fujifilm invested $1.2 billion in its large-scale cell culture CDMO business to further expand the planned Fujifilm Diosynth Biotechnologies end-to-end bio-manufacturing facility in Holly Springs, NC. The total investment in the facility now totals over $3.2 billion.
The new investment will add 8 x 20,000 liters mammalian cell culture bioreactors by 2028, to the already planned 8 x 20,000 L for bulk drug substance as part of the initial investment. This new facility allows for flexibility to expand with additional bioreactors to accommodate new projects to meet the emerging needs of partners, and upon completion will make the site one of the largest cell culture biopharmaceutical CDMO facilities in North America, according to Fujifilm officials.
Ability to construct identical large-scale production facilities
Through Fujifilm Diosynth Biotechnologies’ modular production model, KojoXTM, the expansion enables the company to construct identical large-scale production facilities in U.S. and Europe to ensure that customers can seamlessly integrate drug manufacturing production regardless of location, noted Teiichi Goto, president and CEO, representative director, Fujifilm.
Based on the Evaluate Pharma World Preview, the antibody drug market is expected to grow at an annual rate of eight percent through 2030 due to increasing demands for conventional antibody drugs as well as the expansion of antibody drug conjugates (ADCs) and novel antibody drugs using bispecific antibodies.
“Securing adequate capacity to support market demands is a cornerstone of our Partners for Life strategy and essential to helping our partners bring life-impacting medicines to patients,” said Lars Petersen, president and CEO, Fujifilm Diosynth Biotechnologies.
In line with the overall design and construction of the Holly Springs facility, the new investment will incorporate sustainability initiatives that contribute to net-zero operations. All energy needs for operations is expected to be 100% offset through the use of renewable landfill gas, onsite solar and the 125,000 MWh of annual sustainable solar energy from a virtual power purchase agreement.
Additional sustainability goals for water and waste reduction align with Fujifilm’s Sustainable Value Plan 2030, and the campus is on track to achieve LEED Gold Certification with initiatives that include diverting 90% of construction waste from landfill, additional rooftop solar electricity, installation of heat recovery chiller systems to maximize efficiency between boilers and the chilled water system, use of low embodied carbon concrete utilizing waste fly ash which delivers a 10% reduction in carbon emissions compared to standard cement, and installing ultra-low Nitrogen Oxide boilers, leading to a 50% reduction in nitrogen emissions, pointed out Petersen.
For related articles see GEN: “$2B or Not $2B: Fujifilm Diosynth Breaks Ground on NC Cell Culture Facility” and “Fujifilm Diosnynth Plans $2B Cell Culture Facility in Holly Springs, NC.”
North Carolina
North Carolina’s Berger optimistic about budget, blames Democrats for primary loss
A top North Carolina lawmaker who suffered a stunning upset in his primary election last month spoke publicly about the result Tuesday, blaming the loss on political opponents across the aisle.
North Carolina Senate leader Phil Berger — who has led the chamber since 2011 — lost the Republican primary for his seat to Rockingham County Sheriff Sam Page by 23 votes, one of the closest elections in state history. Berger conceded defeat in a March 24 statement after a machine recount and partial hand recount yielded no change in Page’s lead.
Berger discussed the experience with reporters Tuesday after lawmakers convened for a short legislative session in Raleigh. Asked what message voters sent him in the primary, Berger said: “Democrats like to vote in some Republican primaries. That’s the message.”
Berger didn’t elaborate on his explanation. Registered Democrats are only allowed to take Democratic ballots in primary elections. But unaffiliated voters are allowed to participate in a party primary of their choice. Berger didn’t suggest changes to that law, but he mentioned possible examination of other election laws.
He said lawmakers should reconsider the number of days North Carolina allows for early voting in primaries. In-person early voting started on Feb. 12 and ended Feb. 28.
“Seventeen days of early voting just seemed pretty excessive and it really stresses the local boards of elections,” Berger said. Some county election boards struggle to find daily staffing for all of their voting sites in the early voting period, he said.
Minority Leader Sydney Batch, D-Wake, called Berger’s comments “an insult to his district and an affront to our democracy.”
“The voters sent him a clear message,” Batch said. “It’s time he accept it and get back to work to finish the job he still has, while he still has it. Pass a budget.”
State lawmakers haven’t adopted a comprehensive state budget since 2023. They were expected to do so last year, but Berger and Republican House Speaker Destin Hall have been at odds over a range of issues, including tax policy, Medicaid funding, and other line items affecting billions of dollars in state funding.
Berger said Tuesday that he and Hall were on the verge of a spending agreement for Medicaid, the government-funded health insurer for people who are young, impoverished or disabled. Republican legislators plan to approve Democratic Gov. Josh Stein’s $319 Medicaid request, while adding guardrails and oversight measures to prevent fraud and waste.
To strike the deal, Berger said Tuesday that he had agreed to postpone discussions about funding for a massive new children’s hospital. The 2023 budget authorized about $320 million over three fiscal years for North Carolina Children’s Health — a partnership between UNC Health and Duke Health — to open in Apex in 2032. About $216 million has already been spent. Hall has said his caucus wants to reconsider the final installment of funds, about $103 million, while Berger has called on House leaders to release the money.
“We’ve agreed to move the discussion of whether or not the House is going to honor the agreement they made in 2023 to the full budget discussion,” Berger said Tuesday.
Earlier Tuesday, Hall told reporters that progress had been made on negotiating children’s hospital funding.
“It’s not resolved yet,” Hall said. “I think there’s some questions about how much more money it’s going to need exactly in order to be a viable project. And so, you know, those discussions continue.”
Those budget negotiations are ongoing, but Berger said recent conversations have given him reason to be optimistic. “We’re having conversations,” he said. “They are substantive. They haven’t gotten us to an agreement yet, but we are continuing to talk, continuing to exchange ideas,” Berger said.
Hall described budget talks similarly: “The trajectory is good [enough] to where we’re very likely to get a budget done, hopefully sooner rather than later.”
Berger said that, in the final months of his term, he wants to focus on policies that make North Carolina a top destination for businesses.
“I’d like to continue the progress that we’ve made over the years in making North Carolina number one state for business and making North Carolina a competitive state in terms of our tax climate and our regulatory climate,” Berger said, adding that he wants to boost education funding as well.
Addressing property taxes
House and Senate Republicans are also offering separate proposals for limiting property taxes in North Carolina.
House Republicans are pursuing a constitutional amendment that would give the state more control over how much cities and counties can raise property taxes. On Tuesday, Berger said he doesn’t think there’s a consensus on the proposed amendment and noted that it would take several months to enact into law. Voters must approve constitutional amendments at the polls in order for them to become law.
“It’s a start that we can look at,” Berger said of the proposed constitutional amendment. “But that, by itself, would not actually go into effect until after the voters approve it, if they approve it, and then the legislature actually passes some sort of legislation.”
Berger said he plans to introduce a bill that freezes municipal property tax revaluations for 12 months while legislators study the issue further.
“We’ve got to do something,” Berger said. “I just don’t know that there’s consensus as to what that something is.
“The best thing that we can do at this point is just call a timeout and give the legislature an opportunity to try to review whatever proposals might be out there.”
North Carolina
North Carolina High School Football Program Promotes From Within
Less than two weeks after losing its head coach to Duke University, a North Carolina high school football program has been promoted from within.
Kevin Reddick will become the new head coach at Rolesville High School, replacing Ranier Rackley, who became the Director of Player Development at Duke University.
News of the decision was first reported by High School OT.
Reddick was the defensive coordinator for the Rams for the past three seasons, helping the team win 25 games during that run. Last year, Rolesville allowed just under 15 points per game with Reddick in charge of the defense.
North Carolina High School Promotes Defensive Coordinator To Head Coach
Rolesville finished 9-4 last season under Rackley and Reddick.
Reddick is a graduate of New Bern High School, helping the Bears capture the 2007 Class 4AA North Carolina High School Athletic Association State Football championship. He was tabbed the most valuable player of that title game as a sophomore fullback after scoring two touchdowns in a 28-17 victory over Independence.
At New Bern, Reddick earned conference defensive player of the year honors and was all-state at lineback as a senior after recording 189 tackles, eight quarterback sacks, six forced fumbles and four blocked punts. He also ran for over 160 yards and scored six touchdowns.
Kevin Reddick Was College Standout, Had NFL Career Before Becoming Coach
Following his high school career, Reddick signed with North Carolina as a four-star prospect, earning first team all-ACC honors as a senior. He also had offers from North Carolina State, Virginia and Clemson.
With the Tar Heels, Reddick played in 50 games, recording 275 tackles, including 36 for loss, with 8.5 quarterback sacks, two interceptions and two forced fumbles.
Reddick signed with the New Orleans Saints as an undrafted rookie free agent, and also had stints with the San Diego Chargers, Carolina Panthers and Buffalo Bills.
Rolesville reached the North Carolina High School Athletic Association State Football championship game with Reddick on the coaching staff and the third round this past season.
Rolesville Returns Top Rusher, Several Other Key Players
The Rams will be replacing starting quarterback Kaleb Williams, who had almost 2,500 yards passing and 22 touchdowns, as freshman Chase Williams was 8-for-8 for 98 yards with a touchdown in three games.
They will have top running back Amir Brown back, as he ran for 1,374 yards with 22 touchdowns and six games of 100 yards rushing as a junior. He also had 13 receptions for 106 yards and another TD.
Anthony Roberts is another key player back, as he caught 35 passes for 656 yards and nine TDs. Top tacklers Jayden Broadie, Javon Campbell, Genesis Allen and Keonte Sutton are all set to return, as well.
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North Carolina
Shooting in park near North Carolina school leaves two dead and several hurt
At least two people are dead and “several” others are injured after a “planned fight” at a North Carolina park escalated into a mass shooting, authorities said.
Police have identified several victims and suspects after Monday’s shooting at Leinbach Park near Jefferson Middle School, according to the Winston-Salem Police Department.
Authorities confirmed there were multiple victims in the shooting, but did not provide an exact number. The suspects were still at large over two hours later.
Officers were called to the park just before 10 a.m. after reports of a fight, which then escalated into multiple people shooting each other.
Area schools are not in lockdown, and classes are operating as normal, police said.
“Due to the number of people involved, efforts are ongoing to account for everyone. At this time, some of those involved in the incident are juveniles,” police said.
According to local news station WFMY, at least three people were taken to the hospital. Officials have not shared their conditions.
Police said the shooting was an isolated incident and remains under investigation.
This is a developing story
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