Connect with us

Science

James Watson, Nobel Prize winner and DNA pioneer, dies

Published

on

James Watson, Nobel Prize winner and DNA pioneer, dies

On a chilly February afternoon in 1953, a gangly American and a fast-talking Brit walked into the Eagle pub in Cambridge, England, and announced to the assembled imbibers that they had discovered the “secret of life.”

Even by the grandiose standards of bar talk, it was a provocative statement. Except, it was also pretty close to the truth. That morning, James Watson, the American whiz kid who had not yet turned 25, and his British colleague, Francis Crick, had finally worked out the structure of DNA.

Everything that followed, unlocking the human genome, learning to edit and move genetic information to cure disease and create new forms of life, the revolution in criminal justice with DNA fingerprinting, and many other things besides, grew out of the discovery of the double-helix shape of DNA.

It took Watson decades to feel worthy of a breakthrough some consider the equal of Einstein’s famous E=MC2 formula. But he got there. “Did Francis and I deserve the double helix?” Watson asked rhetorically, 40 years later. “Yeah, we did.”

James Dewey Watson, Nobel Prize winner and “semi-professional loose cannon” whose racist views made him a scientific pariah late in life, died Thursday in hospice care in New York after a brief illness, according to officials at his former laboratory, Cold Spring Harbor Laboratory. He was 97.

Advertisement

Born April 6, 1928, in Chicago, he was the son of a bill collector for a mail-order school who had written a small book about birds in northern Illinois. The younger Watson originally hoped to follow his father’s passion and become an ornithologist. “My greatest ambition had been to find out why birds migrate,” he once said. “It would have been a lost career. They still don’t know.”

At 12, the brainy boy who read the World Almanac for pleasure appeared on the popular radio show “Quiz Kids.” As is often the case for the gifted, his teen years were trying. “I never even tried to be an adolescent,” Watson said. “I never went to teenage parties. I didn’t fit in. I didn’t want to fit in. I basically passed from being a child to an adult.”

He was admitted to the University of Chicago at 15, under a program designed to give bright youngsters a head start in life. It was there he learned the Socratic method of inquiry by oral combat that would underlie both his remarkable achievements and the harsh judgments that would precipitate his fall from grace.

Reading Erwin Schrodinger’s book, “What Is Life?” in his sophomore year set the aspiring ornithologist on a new course. Schrodinger suggested that a substance he called an “aperiodic crystal,” which might be a molecule, was the substance that passed on hereditary information. Watson was inspired by the idea that if such a molecule existed, he might be able to find it.

“Goodbye bird migration,” he said, “and on to the gene.”

Advertisement

Coincidentally, Oswald Avery had only the year before shown that a relatively simple compound — deoxyribonucleic acid, DNA — must play a role in transferring genetic information. He injected DNA from one type of bacterium into another, then watched as the two became the same.

Most scientists didn’t believe the results. DNA, which is coiled up in every cell in the body, was nothing special, just sugars, phosphates and bases. They couldn’t believe this simple compound could be responsible for the myriad characteristics that make up an animal, much less a human being.

Watson, meanwhile, had graduated and moved on to Indiana University, where he joined a cluster of scientists known as the “phage group,” whose research with viruses infecting bacteria helped launch the field of molecular biology. He often said he came “along at the right time” to solve the DNA problem, but there was more to it. “The major credit I think Jim and I deserve is for selecting the right problem and sticking to it,” Crick said many years later. “It’s true that by blundering about we stumbled on gold, but the fact remains that we were looking for gold.”

The search began inauspiciously enough, when Watson arrived at the Cavendish Laboratory at Cambridge University in late 1951, supposedly to study proteins. Crick was 12 years older, working on his PhD. When they met, the two found an instant camaraderie. “I’m sure Francis and I talked about guessing the structure of DNA within the first half-hour of our meeting,” Watson recalled.

Their working method was mostly just conversation, but conversation conducted at a breakneck pace, and at high volume. So high, they were exiled to an office in a shabby shack called the Hut, where their debates would not disturb others.

Advertisement

In January 1953, the brilliant American chemist Linus Pauling stole a march on them when he announced he had the answer: DNA was a triple helix, with the bases sticking out, like charms on a bracelet.

Watson and Crick were devastated, until they realized Pauling’s scheme would not work. After seeing an X-ray image of DNA taken by crystallographer Rosalind Franklin, they built a 6-foot-tall metal model of a double helix, shaped like a spiral staircase, with the rungs made of the bases adenine and thymine, guanine and cytosine. When they finished, it was immediately apparent how DNA copies itself, by unzipping down the middle, allowing each chain to find a new partner. In Watson’s words, the final product was “too pretty” not to be true.

American biology professor James Dewey Watson from Cambridge, Nobel laureate in medicine in 1962, explains the possibilities of future cancer treatments at a Nobel Laureate Meeting in Lindau on July 4, 1967. Watson had received the Nobel Prize together with the two British scientists Crick and Wilkins for their research on the molecular structure of nucleic acids (DNA).

(Gerhard Rauchwetter / picture alliance via Getty Images)

Advertisement

It was true, and in 1962, Watson, Crick and another researcher, Maurice Wilkins, were awarded the Nobel Prize in physiology or medicine. Franklin, whose expert X-ray images solidified Watson’s conviction that DNA was a double helix, had died four years earlier of ovarian cancer. Had she lived, it’s unclear what would have happened, since Nobel rules allow only three people to share a single prize.

In the coming years, Watson’s attitude toward Franklin became a matter of controversy, which he did little to soothe by his unchivalrous treatment of her in his 1968 book, “The Double Helix.” “By choice, she did not emphasize her feminine qualities,” he wrote, adding that she was secretive and quarrelsome.

To his admirers, this was just “Honest Jim,” as some referred to him, being himself, a refreshing antidote to the increasingly politically correct world of science and society. But as the years passed, more controversies erupted around his “truth-telling” — he said he would not hire an overweight person because they were not ambitious, and that exposure to the sun in equatorial regions increases sexual urges — culminating with remarks in 2007 that he could not escape. He said he was “inherently gloomy” about Africa’s prospects because policies in the West were based on assumptions that the intelligence of Black people is the same as Europeans, when “all the testing says, not really.”

He apologized “unreservedly,” but was still forced to retire as chancellor of Cold Spring Harbor Laboratory, the Long Island, N.Y., institution he had rescued from the brink of insolvency decades earlier. Afterward, he complained about being reduced to a “non-person,” but rekindled public outrage seven years later by insisting in a documentary that his views had not changed. This time, citing his “unsubstantiated and reckless personal opinions,” the laboratory rescinded the honorary titles it had bestowed, chancellor emeritus and honorary trustee.

Mark Mannucci, director of the documentary “American Masters: Decoding Watson,” compared him to King Lear, a man “at the height of his powers and, through his own character flaws, was brought down.” Those sympathetic to Watson said the problem was he didn’t know any of his Black colleagues. If he had, they argued, he would have immediately renounced his prejudices.

Advertisement

Following his DNA triumph, Watson spent two years at Caltech before joining the faculty at Harvard University. During this period, he worked to understand the role ribonucleic acid (RNA) plays in the synthesis of proteins that make bodily structures. If the double-stranded DNA contains the body’s master plan, the single-stranded RNA is the messenger, telling the cell’s protein factories how to build the three-dimensional shapes that make the whole. Watson’s 1965 textbook, “Molecular Biology of the Gene,” became a foundation stone of modern biology.

As great as was his obsession with DNA, Watson’s pursuit of, and failure to obtain, female companionship was a matter of only marginally less critical mass. At Harvard, he recruited Radcliffe coeds to work in his lab, reasoning that “if you have pretty girls in the lab, you don’t have to go out.” He started attending Radcliffe parties known as jolly-ups. “Here comes this 35-year-old and he wants to come to jolly-ups,” said a biographer, Victor McElheny. “He was constantly swinging and missing.”

His batting average improved when he met Elizabeth Vickery Lewis, a 19-year-old Radcliffe sophomore working in the Harvard lab. He married her in 1968, realizing by only days his goal of marrying before 40. On his honeymoon, he sent a postcard back to Harvard: “She’s 19; she’s beautiful; and she’s all mine.” The couple had two sons, Rufus, who developed schizophrenia in his teens, and Duncan.

The same year, Watson finished writing “The Double Helix.” When he showed it to Crick and Wilkins, both objected to the way he characterized them and persuaded Harvard not to publish it. Watson soon found another publisher.

It was certainly true his book could be unkind and gossipy, but that was why the public, which likely had trouble sorting out the details of crystallography and hydrogen bonds, loved it. “The Double Helix” became an international bestseller that remained in stock for many years. Eventually, Watson and Crick made up and by the time the Englishman died in 2004, they were again the boon pals they’d been 50 years earlier.

Advertisement

After their discovery of DNA’s structure, the two men took divergent paths. Crick hoped to find the biological roots of consciousness, while Watson devoted himself to discovering a cure for cancer.

After serving on a voluntary basis, Watson became director of Cold Spring Harbor Laboratory on Long Island in 1976. It had once been a whaling village, and the humble buildings retained a rustic charm, though when Watson arrived the rustic quality was on a steep descent toward ruination. Its endowment was virtually nonexistent and money was so tight a former director mowed the lawn himself.

As skilled at raising money as he was at solving difficult scientific problems, Watson turned the institution into a major research center that helped reveal the role of genetics in cancer. By 2019, the endowment had grown to $670 million, and the research staff had tripled. From an annual budget of $1 million, it had grown to $190 million.

“You have to like people who have money,” Watson said in explanation of his success at resurrecting Cold Spring Harbor. “I really like rich people.” His growing eccentricity, which included untied shoelaces and hair that spiked out in all directions, completed the stock image of a distracted scientist. Acquaintances swore they saw him untie his shoelaces before meeting with a potential donor.

In 1988, he became the first director of the $3-billion Human Genome Project, whose goal was to identify and map every human gene. He resigned four years later, after a public falling-out with the director of the National Institutes of Health. “I completely failed the test,” he said of his experience as a bureaucrat.

Advertisement

Among his passions were tennis and charity work. In 2014, the year of the documentary that sealed his fate as an exile, Watson put his Nobel gold medal up for auction. He gave away virtually all the $4.1 million it fetched. The buyer, Russian billionaire Alisher Usmanov, returned it a year later, saying he felt bad the scientist had to sell possessions to support worthy causes.

A complex, beguiling, maddening man who defied easy, or any, categorization, Watson followed his own star to the end of his life, insisting in 2016, when he was nearly 90, that he didn’t want to die until a cure for cancer was found. At the time, he was still playing tennis three times a week, with partners decades younger.

Besides the Nobel Prize, Watson was awarded the Presidential Medal of Freedom, the Eli Lilly Award in Biochemistry and the Albert Lasker Award for Basic Medical Research. He was a member of the American Academy of Arts and Sciences, the National Academy of Sciences, and was made an honorary Knight of the British Empire. Among his literary works were both scientific and popular books, from “Recombinant DNA” to “Genes, Girls, and Gamow,” a typically cheeky book recounting his twin obsessions, scientific glory and the opposite sex.

Johnson is a former Times staff writer.

Advertisement

Science

Very little plastic being recycled in California as state efforts falter

Published

on

Very little plastic being recycled in California as state efforts falter

California touts itself as a leader on the problem of plastic garbage, but recent developments suggest otherwise.

A new report issued by the state’s waste agency shows plastic yogurt containers, shampoo bottles and restaurant takeout trays are being recycled at rates only in the single digits.

  • Share via

    Advertisement

Advertisement

Polypropylene, labeled as #5 on packaging, is used for yogurt containers, margarine tubs and microwavable trays. Only 2% of it is getting recycled. Colored shampoo and detergent bottles, made from polyethylene, or #1 plastic, are getting recycled at a rate of just 5%.

Other plastics, including ones promoted as highly recyclable, such as clear polyethylene bottles, which hold some medications, or hard water bottles, are being recycled at just 16%.

No plastic in the report exceeds a recycling rate of 23%, with the majority reported in just the single digits.

Adding to this disquieting assessment, CalRecycle also just pulled back regulations that were supposed to finalize a landmark single-use plastic law known as Senate Bill 54 — a law designed to make the majority of packaging waste in the state recyclable or compostable by working with the plastic and packaging industries.

The report and delay have sparked a wide variety of reactions by those who have closely watched the law as it was written and implemented.

Advertisement

The proposed regulations were regarded as friendly to industry. As a result, some are hopeful that CalRecycle’s decision to pull them back for tweaking means the agency will make the law stronger. Others say the two developments just show the state has never really been serious about plastic recycling.

“California’s SB 54 … will NEVER increase the recycling rates of these items … because cartons and plastic packaging are fundamentally not technically or economically recyclable,” said Jan Dell, the founder of Orange County-based Last Beach Cleanup, an anti-plastic organization.

Industry representatives are also expressing disappointment, saying the more delays and changes the state makes, the harder it is “for California businesses to comply with the law and implement the resulting changes,” said John Myers, a spokesman for the California Chamber of Commerce, which represents companies that will be affected.

Reports on abysmally low rates of recycling for milk cartons and polystyrene have been widely shared and known. But the newest numbers were still a grim confirmation that there are few options for dealing with these materials.

According to one state analysis, 2.9 million tons of single-use plastic and 171.4 billion single-use plastic components were sold, offered for sale or distributed in California in 2023.

Advertisement

Single-use plastics and plastic waste more broadly are considered a growing environmental and health problem. In recent decades, plastic waste has overwhelmed waterways and oceans, sickening marine life and threatening human health.

Last spring, the Newsom administration was accused of neutering the regulations that CalRecycle had initially proposed to implement the law. The changes excluded all packaging material related to produce, meat, dairy products, dog food, toothpaste, condoms, shampoo and cereal boxes, among other products. These are all products that might fall under the purview of the U.S. Food and Drug Administration and the U.S. Department of Agriculture.

It also opened the door to “alternative” recycling, such as chemical recycling, which environmentalists say is polluting, and was banned in the language of the law.

The waste agency then submitted those draft regulations to the Office of Administrative Law, whose lawyers and staff review proposed regulations to ensure they are “clear, necessary, legally valid, and available to the public” before finalizing them. They were set to release their determination on Friday; CalRecycle pulled the regulations back before the office issued its determination.

Neither the law office nor governor’s office responded to requests for comment.

Advertisement

Melanie Turner, CalRecycle’s spokeswoman, said the agency withdrew its proposed regulations “to make changes … to improve clarity and support successful implementation of the law,” and its revisions were focused on areas that dealt with “food and agricultural commodities.”

California State Sen. Ben Allen (D-Santa Monica), author of the original legislation, called the delay “entirely avoidable” in a statement, but said it would allow CalRecycle an “opportunity to ensure the regulations truly follow the law as it was signed.”

He urged the waste agency and Newsom’s administration not to “allow broad, sweeping exemptions that would undermine the program and increase costs for ratepayers.”

Critics of the watered-down regulations, such as Anja Brandon, the director of plastics policy for the Ocean Conservancy, said she wasn’t surprised by the withdrawal.

The proposed regulations “would have gone beyond CalRecycle’s authority by creating a sweeping categorical exclusion for food and agricultural packaging — effectively a loophole that would have allowed producers to continue putting vast amounts of plastic packaging into the marketplace, completely undermining SB 54’s goals and success,” she said in a text message.

Advertisement

Turner said CalRecycle will conduct a 15-day comment period — although when that begins has not yet been divulged.

Continue Reading

Science

Cancer survival rates soar nationwide, but L.A. doctors warn cultural and educational barriers leave some behind

Published

on

Cancer survival rates soar nationwide, but L.A. doctors warn cultural and educational barriers leave some behind

The American Cancer Society’s 2026 Cancer Statistics report, released Tuesday, marks a major milestone for U.S. cancer survival rates. For the first time, the annual report shows that 70% of Americans diagnosed with cancer can expect to live at least five years, compared with just 49% in the mid-1970s.

The new findings, based on data from national cancer records and death statistics from 2015 to 2021, also show promising progress in survival rates for people with the deadliest, most advanced and hardest-to-treat cancers when compared with rates from the mid-1990s. The five-year survival rate for myeloma, for example, nearly doubled (from 32% to 62%). The survival rate for liver cancer tripled (from 7% to 22%), for late-stage lung cancer nearly doubled (from 20% to 37%), and for both melanoma and rectal cancer more than doubled (from 16% to 35% and from 8% to 18%, respectively).

For all cancers, the five-year survival rate more than doubled since the mid-1990s, rising from 17% to 35%.

This also signals a 34% drop in cancer mortality since 1991, translating to an estimated 4.8 million fewer cancer deaths between 1991 and 2023. These significant public health advances result from years of public investment in research, early detection and prevention, and improved cancer treatment, according to the report.

“This stunning victory is largely the result of decades of cancer research that provided clinicians with the tools to treat the disease more effectively, turning many cancers from a death sentence into a chronic disease,” said Rebecca Siegel, senior scientific director at the American Cancer Society and lead author of the report.

Advertisement

As more people survive cancer, there is also a growing focus on the quality of life after treatment. Patients, families and caregivers face physical, financial and emotional challenges. Dr. William Dahut, the American Cancer Society’s chief scientific officer, said that ongoing innovation must go hand in hand with better support services and policies, so all survivors — not just the privileged — can have “not only more days, but better days.”

Indeed, the report also shows that not everyone has benefited equally from the advances of the last few decades. American Indian and Alaska Native people now have the highest cancer death rates in the country, with deaths from kidney, liver, stomach and cervical cancers about double that of white Americans.

Additionally, Black women are more likely to die from breast and uterine cancers than non-Black women — and Black men have the highest cancer rates of any American demographic. The report connects these disparities in survival to long-standing issues such as income inequity and the effects of past discrimination, such as redlining, affecting where people live — forcing historically marginalized populations to be disproportionately exposed to environmental carcinogens.

Dr. René Javier Sotelo, a urologic oncologist at Keck Medicine of USC, notes that the fight against cancer in Southern California, amid long-standing disparities facing vulnerable communities, is very much about overcoming educational, cultural and socioeconomic barriers.

While access to care and insurance options in Los Angeles are relatively robust, many disparities persist because community members often lack crucial information about risk factors, screening and early warning signs. “We need to insist on the importance of education and screening,” Sotelo said. He emphasized that making resources, helplines and culturally tailored materials readily available to everyone is crucial.

Advertisement

He cites penile cancer as a stark example: rates are higher among Latino men in L.A., not necessarily due to lack of access, but because of gaps in awareness and education around HPV vaccination and hygiene.

Despite these persisting inequities, the dramatic nationwide improvement in cancer survival is unquestionably good news, bringing renewed hope to many individuals and families. However, the report also gives a clear warning: Proposed federal cuts to cancer research and health insurance could stop or even undo these important gains.

“We can’t stop now,” warned Shane Jacobson, the American Cancer Society’s chief executive.

“We need to understand that we are not yet there,” Sotelo concurred. ”Cancer is still an issue.”

Advertisement
Continue Reading

Science

Clashing with the state, L.A. City moves to adopt lenient wildfire ‘Zone Zero’ regulations

Published

on

Clashing with the state, L.A. City moves to adopt lenient wildfire ‘Zone Zero’ regulations

As the state continues multiyear marathon discussions on rules for what residents in wildfire hazard zones must do to make the first five feet from their houses — an area dubbed “Zone Zero” — ember-resistant, the Los Angeles City Council voted Tuesday to start creating its own version of the regulations that is more lenient than most proposals currently favored in Sacramento.

Critics of Zone Zero, who are worried about the financial burden and labor required to comply as well as the detrimental impacts to urban ecosystems, have been particularly vocal in Los Angeles. However, wildfire safety advocates worry the measures endorsed by L.A.’s City Council will do little to prevent homes from burning.

“My motion is to get advice from local experts, from the Fire Department, to actually put something in place that makes sense, that’s rooted in science,” said City Councilmember John Lee, who put forth the motion. “Sacramento, unfortunately, doesn’t consult with the largest city in the state — the largest area that deals with wildfires — and so, this is our way of sending a message.”

Tony Andersen — executive officer of the state’s Board of Forestry and Fire Protection, which is in charge of creating the regulations — has repeatedly stressed the board’s commitment to incorporating L.A.’s feedback. Over the last year, the board hosted a contentious public meeting in Pasadena, walking tours with L.A. residents and numerous virtual workshops and hearings.

Advertisement
  • Share via

Advertisement

Some L.A. residents are championing a proposed fire-safety rule, referred to as “Zone Zero,” requiring the clearance of flammable material within the first five feet of homes. Others are skeptical of its value.

With the state long past its original Jan. 1, 2023, deadline to complete the regulations, several cities around the state have taken the matter into their own hands and adopted regulations ahead of the state, including Berkeley and San Diego.

“With the lack of guidance from the State Board of Forestry and Fire Protection, the City is left in a precarious position as it strives to protect residents, property, and the landscape that creates the City of Los Angeles,” the L.A. City Council motion states.

Advertisement

However, unlike San Diego and Berkeley, whose regulations more or less match the strictest options the state Board of Forestry is considering, Los Angeles is pushing for a more lenient approach.

The statewide regulations, once adopted, are expected to override any local versions that are significantly more lenient.

The Zone Zero regulations apply only to rural areas where the California Department of Forestry and Fire Protection responds to fires and urban areas that Cal Fire has determined have “very high” fire hazard. In L.A., that includes significant portions of Silver Lake, Echo Park, Brentwood and Pacific Palisades.

Fire experts and L.A. residents are generally fine with many of the measures within the state’s Zone Zero draft regulations, such as the requirement that there be no wooden or combustible fences or outbuildings within the first five feet of a home. Then there are some measures already required under previous wildfire regulations — such as removing dead vegetation like twigs and leaves, from the ground, roof and gutters — that are not under debate.

However, other new measures introduced by the state have generated controversy, especially in Los Angeles. The disputes have mainly centered around what to do about trees and other living vegetation, like shrubs and grass.

Advertisement

The state is considering two options for trees: One would require residents to trim branches within five feet of a house’s walls and roof; the other does not. Both require keeping trees well-maintained and at least 10 feet from chimneys.

On vegetation, the state is considering options for Zone Zero ranging from banning virtually all vegetation beyond small potted plants to just maintaining the regulations already on the books, which allow nearly all healthy vegetation.

Lee’s motion instructs the Los Angeles Fire Department to create regulations in line with the most lenient options that allow healthy vegetation and do not require the removal of tree limbs within five feet of a house. It is unclear whether LAFD will complete the process before the Board of Forestry considers finalized statewide regulations, which it expects to do midyear.

The motion follows a pointed report from LAFD and the city’s Community Forest Advisory Committee that argued the Board of Forestry’s draft regulations stepped beyond the intentions of the 2020 law creating Zone Zero, would undermine the city’s biodiversity goals and could result in the loss of up to 18% of the urban tree canopy in some neighborhoods.

The board has not decided which approach it will adopt statewide, but fire safety advocates worry that the lenient options championed by L.A. do little to protect vulnerable homes from wildfire.

Advertisement

Recent studies into fire mechanics have generally found that the intense heat from wildfire can quickly dry out these plants, making them susceptible to ignition from embers, flames and radiant heat. And anything next to a house that can burn risks taking the house with it.

Another recent study that looked at five major wildfires in California from the last decade, not including the 2025 Eaton and Palisades fires, found that 20% of homes with significant vegetation in Zone Zero survived, compared to 37% of homes that had cleared the vegetation.

Continue Reading
Advertisement

Trending