Science
Great White Sharks Washing Up Dead in Canada With Brain Swelling
The first great white shark was found dead in August 2023 on a beach in a national park on Prince Edward Island, Canada: a young male, 500 pounds, 8 feet 9 inches from snout to tail. Park workers soon arrived with a pickup truck, loaded the carcass and drove it to a cooler at the Atlantic Veterinary College at the University of Prince Edward Island. Aside from some scrapes acquired en route, the shark showed no signs of injury.
Dr. Megan Jones, a veterinary pathologist at the college and regional director of the Canadian Wildlife Health Cooperative, or C.W.H.C., began a necropsy early the next morning, while the body “was really, really fresh,” she said. “When we look through the microscope at the tissues, they’re very well preserved.”
The C.W.H.C., a network affiliated with Canada’s veterinary schools, studies wildlife health issues. In 30 years, however, the group had never come across a great white, and it was not at all obvious how this one had died. Starvation was ruled out from the very first incision, when the shark’s 76-pound liver, where the animal stores fat, spilled onto the examination table. Other organs showed no sign of trauma. Only later, after microscopic testing, did the cause of death become apparent: meningoencephalitis, an inflammation of brain tissues.
At first Dr. Jones found the diagnosis more interesting than alarming. Then came the other sharks. Over the next few months the C.W.H.C. received either whole animals or tissue samples from four more white sharks found beached in eastern Canada. “Three of these five seem to have the same potentially infectious disease affecting their brain,” Dr. Jones said. “We need to know more about what that is.”
Those five white sharks are among nine known deaths dating from a shark found on July 4, 2022, in Massachusetts; most of those had brain inflammation. Such inflammation has been seen in other shark species, but the cause in those cases — bacterial infection, for instance — was obvious, unlike in white sharks. Dr. Jones is now part of a small group of scientists in the United States and Canada who are trying to untangle the mystery — and determine whether white sharks are facing a broader threat.
“I feel very strongly that there’s something significant going on,” said Dr. Alisa Newton, the chief veterinarian for OCEARCH, a shark research organization based in Florida that developed Shark Tracker, a popular app that monitors the movements of sharks. But Dr. Newton’s alarm is tempered by the fact that so little is known about the base-line incidence of shark deaths along the Atlantic Coast.
As research subjects, the sharks of the western North Atlantic population, which ranges from southern Florida to Newfoundland, are less understood than white sharks in other areas, and far less understood than marine mammals such as whales and dolphins. Shark science is relatively underfunded, and there are few protocols to connect local officials with scientists when a white shark is found beached on the eastern coast of North America. As a result, information — including tissue samples — tends to move slowly.
Dr. Newton was the first scientist to observe meningoencephalitis in white sharks on the Atlantic Coast, in 2022. She spotted it in a sample of brain tissue that she received at her lab in Jacksonville, Fla.: reddish cubes taken from a shark found on Long Island, N.Y., on July 20 of that year.
She also found swelling in the brain of the shark found on July 4, 2022 — although the tissue samples didn’t reach her lab until early 2023 — and in another recovered in South Carolina in April 2023. Six other earlier cases of beached sharks are being evaluated for possible meningoencephalitis. She wonders whether there are still more samples out there, sitting on shelves in jars of formalin, perhaps collected by state wildlife officials who don’t know that she’d like a piece of their brain.
The brains of white sharks are big, by fish standards, although considerably smaller than those of dolphins. They are smooth on the surface and knobby, roughly the size and shape of three Ping-Pong balls in a row.
Meningoencephalitis, an inflammation of the brain and surrounding tissues, is a symptom of an underlying issue. With nowhere for swollen tissue to go in the hard skull, the brain is squeezed and its normal functioning disrupted. In a shark, that may mean it is unable to feed, Dr. Jones said, or it loses its balance while swimming and gets stuck in shallow water, becoming beached when the tide goes out. But given the paucity of knowledge, it could be normal for white sharks to live with some amount of brain swelling.
“We know lots of animals that live with parasites or bacteria and they’re good, they’re fine, they always have sort of a natural load,” said Tonya Wimmer, executive director of the Marine Animal Response Society, or MARS, the organization that is called when animals are discovered beached in eastern Canada. “You should see the lungs of harbor porpoises: They’re chock-full of really icky worms, but it’s natural for them.”
The organization performed necropsies on three of the five beached sharks, including two that could not be moved to a lab and had to be dissected on sand that quickly soaked with blood. The group also enlisted a dive team to recover the head of the most recent casualty, a white shark found dead in November of 2023 in 30 feet of water near Halifax. (Its time in the water degraded the brain tissues too much for the C.W.H.C. to make any diagnosis about swelling.)
One juvenile male had eaten just before it died, and there were “big chunks of porpoise” in its stomach, including a flipper and part of the head, Ms. Wimmer said. And it showed no sign of meningoencephalitis under the microscope. Another white shark, which made Canadian headlines in October 2023 for its death throes, swimming erratically around a harbor and bumping into the wharf before beaching, seemed like a clear case of brain inflammation. But testing again showed none.
To further the investigation, Dr. Newton has submitted brain tissue from the South Carolina shark to the Washington Animal Disease Diagnostic Laboratory for genetic sequencing. The procedure catalogs all the DNA in the tissue to establish whether there is evidence of another organism, such as a virus or bacteria, inside the shark that could be causing the meningoencephalitis. That sequencing has not been completed yet, leaving the mystery open.
Ms. Wimmer is optimistic that the “baffling” wave of deaths could actually be a positive sign, the natural result of a population upswing for an animal that is listed as an endangered species in Canada. More white sharks might be turning up on beaches simply because there are more white sharks in the water.
Science
What My Father’s Experience Taught Me About Memory and the Brain
A couple of years ago, in the middle of the night, I crept downstairs to find my father sitting at the kitchen table, sobbing like a child.
My mother was beside him, trying to comfort him, an activity that took up more and more of her time. He was 87 and had dementia. It wasn’t unusual to find him upset or confused. But on this night, something seemed to be happening to him in real time — in 1941.
He was 6 years old, and was leaving Pittsburgh, the only home he had ever known, for an Air Force base in San Antonio, where his father had been ordered for duty. He and his parents were traveling there by train, transferring in Chicago.
It was the beginning of a lonely, difficult time for my father’s family, moving between Air Force bases in the South, where landlords sometimes turned them away because they were Catholic. An only child, he had been allowed to take one pet with him, a canary he was carrying in a birdcage.
As they were changing trains in Chicago, the bottom fell out of the cage. The canary flew out, up into the vaulted atrium of the station’s Great Hall. There was no way to get the bird — there was no time, they had to board a train to Texas. So my 6-year-old father shuffled after his parents, holding an empty cage.
In the years that had elapsed, he had negotiated arms treaties with the Soviets, had advised presidents, had served as a U.S. ambassador, all with the same watchful, wisecracking reserve. I thought I knew who he was. I could count on one hand the times I had seen him cry. Now here he was, sobbing over the canary as if it were yesterday.
This was all, it seemed, because of his brain. He had fallen hard in their house in Washington, D.C., smacking his head on the hardwood floor. Blood rushed into spaces in his brain, and cells starved of oxygen began to die. Eventually, he was diagnosed with vascular dementia, which is most often caused by strokes.
For five years after that, my parents lived with my family outside Boston, and we learned firsthand how brain injury affects behavior. My father recovered in some ways, but he became chaotic, his thoughts broken into mirror shards.
The biggest problem was that he had no idea where he was. Specifically, he did not know why he was living with us in Massachusetts, and no matter how many times we tried to remind him, over and over, he tried to leave. We would catch him packing the car, and gently — or not so gently — guide him back into the house.
This child-father was full of surprises. He bought surprising things: Five laptops! A cruise on the Norwegian fjords! Recurring $2 donations to every Democrat running for any office, anywhere! Once, in a weeklong cascade of Amazon deliveries, we received seven identical birdbaths from China.
Science
Dirty mind? Study suggests gut movement may flush excess material from our brains
With each step you take, coordinated contractions in your abdominal muscles help keep you stable and upright.
Now, new research finds that those gentle changes in tension and pressure also affect your brain, and may play a role in the organ’s overall health.
Imaging in humans and other animal species has long shown that the brain gently moves inside the fluid-filled skull cavity, but it’s never been clear what, exactly, is propelling this motion, said neuroscientist Patrick Drew, a Penn State University professor and associate director of the Huck Institutes of the Life Sciences.
Using advanced imaging, Drew’s team observed mice brains before and after the animals began walking. They realized that the brain actually moved just milliseconds before a mouse took a step — the brief moment when the animal’s abdominal muscles contracted in preparation for movement.
To test the observation, they strapped pressure sensors around the bellies of lightly anesthetized mice and observed the brain when slight pressure was applied only to the abdominal muscles. The same motion followed. Breathing or cardiac activity didn’t trigger the same response.
The connection, Drew and his colleagues determined, is the vertebral venous plexus, a network of veins that connects the abdomen to the spine in mice and humans alike.
“It’s like a hydraulic system. It really is very much like the jacks that push your car up, or something that an excavator might have,” Drew said. “Whenever you tense those muscles, which you do whenever you make a movement … that pushes blood into the spinal cord, it increases the pressure on your brain, and it moves your brain forward.”
The paper, which was published April 27 in Nature Neuroscience, answers a puzzling question about the mechanism controlling this long-observed cerebral movement.
It also puts forward hypotheses about why this belly-brain choreography exists.
Drew and his team ran computer simulations of fluid’s motion in and around mouse brains. The kind of contraction generated by walking moves cerebrospinal fluid out of the brain, leading Drew to hypothesize that the mechanism plays an important role in flushing out protein waste and other unnecessary material.
“It’s more speculative, but using simulations, we can see that this sort of motion should drive fluid movement and could help clear waste in the brain,” Drew said.
In future research, Drew said, the team would like to explore whether the brain is detecting these mechanical signals, and how physical conditions like obesity affect the hydraulic relationship between the abdominal muscles and the brain.
These current findings clarify the relationship between the brain and physical movement, illuminating fundamental mechanics that can apply to other research, said Michael Goard, an associate professor at UC Santa Barbara who studies sensory and spatial processing.
“He did, what I think is a very thorough job figuring out what’s causing this movement in the case of locomotion and tying down the mechanical elements,” Goard said.
Science
The Longevity Secrets Helping Athletes Blow Past the Limits of Age
The assessment covers seven simple movements — various lunges, jumps and timed balances — and produces a player score relative to the rest of the league and the player’s own history. The report also includes “jump” and “landing strategy” metrics that chart the distribution of force across a player’s hips, knees and ankles, and it translates arcana like “max ankle dorsification angle” into the lingua franca of basketball: “how small your ankle angle can get like when you get low on a quick first step.” The file, which a player can access throughout his career, regardless of team, is meant to give him information about how hard he can push his body — and, just as critically, when it’s time to ease off.
“When you’re younger, there’s days you can take as many — for us — baseball swings as you want,” New York Yankees first baseman Paul Goldschmidt, who is 38, told me. We were talking in mid-February at the team’s spring training facility in Tampa, Fla., as he was getting ready for eight straight months of baseball. “As you get older, there’s times when rest is more important than work.”
For some athletes, the right biometric data presented in the right context represents “permission to rest,” says Ana Montero, a co-founder of Atlas, a San Francisco-based company that makes brain-wave-scanning, behind-the-ear wearables about the size of Mentos candies. “It’s quantifiable evidence that is showing you: Dude, today — or right now — is not the day. Go to the gym, go for a walk, go for whatever it is. And then coming back and actually seeing that you’ve bounced back.”
The Atlas device gathers several types of data, including electroencephalography, or EEG, which measures electrical activity in the brain, and galvanic skin response, or G.S.R., which is what a polygraph test measures. That data is sorted into five categories (among them agility, vitality and stress) and then delivered with advice through a smartphone app.
“There’s always some noise in brain activity because neurons are not perfect chips or transistors,” André Marques-Smith, Atlas’s other co-founder, says. “So mistakes get made.” He adds that what causes neurons to lose their precision are things that we’re all familiar with: fatigue, stress, anxiety, hunger, aging. Tom Ryan, the N.B.A.’s senior vice president of basketball strategy, says Launchpad chose Atlas because it was eager to find a device that collected this sort of data in real time. If it works the way it’s supposed to, then a vet like Goldschmidt will know exactly when he’s good for some extra batting practice and when he should take a nap instead.
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