Science
Column: Meet the most dangerous quack in America
It used to be fairly easy to dismiss Florida’s surgeon general, Dr. Joseph A. Ladapo, as a clownish anti-vaccine quack posing a danger mostly to residents of his home state.
That has become harder to do as time goes on, as Ladapo has moved from promoting useless treatments for COVID-19, such as the drugs hydroxychloroquine and ivermectin, to waging an ever-expanding fact-free campaign against the leading COVID vaccines.
This month, Ladapo established a new low for himself. In a public advisory issued Wednesday by the Florida Department of Health, he declared the vaccines “not appropriate for use in human beings” and counseled doctors to steer patients to other treatments. He explicitly called for a “halt in the use of COVID-19 mRNA vaccines.”
Scaring people unnecessarily like this has been hard to watch. … It is hard to believe that Dr. Ladapo actually issued that statement.
— Vaccine authority Paul Offit
For several reasons, this advisory ranks as the single most dangerous statement by a government health agency since the start of the pandemic, if not for all time.
First and foremost, it’s based on a claim in a paper co-authored by known anti-vaccine activists that was almost instantaneously debunked upon its publication in October.
Then there’s the public health context: As COVID infections have been surging coast to coast, advisories from public health authorities to resume masking and take other protective measures, such as making sure you’re up to date on vaccinations, are almost invisible.
Even more worrisome, the incidence of other vaccine-preventable diseases may be rising. As many as nine cases of measles have been reported in Philadelphia, some associated with an infection started at a daycare center with a family that violated quarantine rules.
Among the victims, according to the Philadelphia Inquirer, are “an infant who was too young to get vaccinated, an unvaccinated older child and the older child’s unvaccinated parent.”
Nine cases may not sound like a lot — 41 were reported nationwide in 2023 — but they could be a harbinger of worse to come, in clusters in which anti-vaccine propaganda has taken hold.
Finally, one must consider the source. Despite his state post and a tenured position as a professor of medicine at the University of Florida — courtesy of his patron Ron DeSantis, the extremist anti-vaccine Republican governor — Ladapo has zero credibility within the medical establishment. Taking medical advice from Ladapo makes about as much sense as taking investment advice from Sam Bankman-Fried or your view of academic integrity from Christopher Rufo.
Ladapo has become a card-carrying member of the anti-vaccine mafia. Just before Christmas, he appeared on a podcast hosted by anti-vax agitator Del Bigtree, who stirs up his audiences with hysterical rants against vaccines and who was recently appointed communications director for the presidential campaign of notorious anti-vax figure Robert F. Kennedy Jr.
Last January, a faculty committee at the University of Florida medical school found that Ladapo engaged in “careless, irregular and contentious” research practices that may have violated university rules. The committee referred its findings to the university’s research integrity officer, but that officer ruled that since the behavior at issue was performed in Ladapo’s role as surgeon general, not as a UF professor, he had no grounds to take action.
The accusations pertained to Ladapo’s recommendation that males aged 18 to 39 avoid the mRNA vaccines. He claimed that research indicated that for men in that age group, the vaccines presented a heightened risk of cardiac-related death.
In fact, the research indicated no such thing; rather, it showed that the risk of cardiac death from the vaccines was statistically nonexistent and, in any case, was lower than the risk of cardiac death resulting from catching COVID-19. In fact, Ladapo had personally edited the state-sponsored analysis he cited in his recommendation to remove language in earlier drafts stating that there was “little suggestion of any [cardiac] effect immediately following vaccination.”
The Food and Drug Administration has been pushing back against Ladapo’s fire hose of misinformation and disinformation for the better part of a year. Last March, the agency informed him by letter that “overstating the risks, or emphasizing the risks without acknowledging the overwhelming benefits” of the vaccines — as Ladapo had done in his cardiac death warning — “puts people at risk of death or serious illness that could have been prevented by timely vaccination.”
That brings us to Ladapo’s latest adventure in medical quackery, his claim that no one should take the mRNA vaccines. Let’s take a look.
Ladapo’s advice is based on what he says is research that the Pfizer and Moderna mRNA COVID vaccines contain fragments of DNA that are injected into human cells, which they can contaminate and turn into cancer cells.
In a Dec. 6 letter to the FDA and in the Florida Department of Health advisory, Ladapo raised “concerns regarding nucleic acid contaminants in the approved … vaccines, particularly in the presence of lipid nanoparticle complexes, and Simian Virus 40 (SV40) promoter/enhancer DNA. … The presence of SV40 promoter/enhancer DNA may also pose a unique and heightened risk of DNA integration into human cells.”
Followers of anti-vaccine propaganda will find familiar features in this statement. For one thing, it sounds science-y as hell, filled to bursting with abstruse terms and jargon. One would have to be an expert in the field to identify it as total balderdash. The statement also bristles with scary references to DNA contamination and cancer and to “billions of fragments [of DNA] per dose.”
The same goes for Ladapo’s hand-wringing in his statements about the FDA’s 2007 standards for DNA in vaccines and his implication that the COVID vaccines violate those standards.
Fortunately, scientific and medical professionals have weighed in. One is Paul Offit, a vaccine expert at Children’s Hospital of Philadelphia. Offit explains that it’s true that “small amounts of fragmented DNA” are injected into the body with the vaccines.
It’s also irrelevant. For those fragments to affect your DNA, he explains, “things would have to occur, all of which are for the most part impossible.”
The human cell has a panoply of mechanisms to destroy foreign DNA. Even if the fragments managed to penetrate the cell nucleus, which can’t happen, they would have to cut up the existing DNA, which would require a mechanism the fragments don’t have.
“So the chance that DNA could affect your DNA is zero,” Offit said in a video interview with Medpage Today.
As for the Florida statement’s scary references to DNA contamination and cancer and to “billions of fragments [of DNA] per dose,” the vaccines don’t contaminate patients’ DNA, the fragments have no cancer-causing abilities, and that “billions” is, in the context of the vaccines, an incredibly tiny number.
The research paper on which Ladapo based his intimation that the vaccines breach the FDA’s DNA contamination standard is self-refuting. The paper, which was based on an analysis of 24 vials of the mRNA vaccines, actually found that in all cases the fragments were well below the concentration limits set by the FDA.
The FDA, in responding to Ladapo’s Dec. 6 letter, told him that studies of the vaccines showed “no evidence” that the shots damaged recipients’ DNA and that the experience of “hundreds of millions of individuals” who received the vaccines “indicate no evidence indicative of genotoxicity.”
On the other hand, “the challenge we continue to face is the ongoing proliferation of misinformation and disinformation about these vaccines which results in vaccine hesitancy that lowers vaccine uptake,” the FDA lectured Ladapo. “Given the dramatic reduction in the risk of death, hospitalization and serious illness afforded by the vaccines, lower vaccine uptake is contributing to the continued death and serious illness toll of COVID-19.”
In the words of the veteran pseudoscience debunker David Gorski, disinformation like Ladapo’s output is “not about science. It’s about fear-mongering about vaccines.”
Ladapo’s words and actions have surely contributed to his state’s pathetic performance in getting its citizens vaccinated against COVID. With 11.6% of its population fully vaccinated with a booster as of last May, Florida had a rate among the lowest in the nation. (California’s rate was 20.6%.) Among those 65 and older — purportedly the population that Florida strives to protect — only 31.2% were fully vaccinated. (California: 48.3%.)
Florida’s death rate from COVID of 375 per 100,000 people is among the worst in the country. (California: 283.) You can ignore the defense that the difference is due to Florida’s relatively older population; states with even older median ages have done much better: Vermont (170), New Hampshire (245) and Maine (252). The difference is the indifference of Ladapo and DeSantis to their own residents’ health.
Ladapo’s colleagues in science and medicine face the challenge of understanding what drives someone with Ladapo’s credentials — a Harvard education and a stint on the medical faculty at UCLA — to descend so deeply into professional irresponsibility.
“It is hard to believe that Dr. Ladapo actually issued that statement,” Offit said of Ladapo’s advice to avoid the vaccines. “Scaring people unnecessarily like this has been hard to watch.”
Science
Department of Education finds San Jose State violated Title IX regarding transgender volleyball player
The U.S. Department of Education has given San José State 10 days to comply with a list of demands after finding that the university violated Title IX concerning a transgender volleyball player in 2024.
A federal investigation was launched into San José State a year ago after controversy over a transgender player marred the 2024 volleyball season. Four Mountain West Conference teams — Boise State, Wyoming, Utah State and Nevada-Reno — each chose to forfeit or cancel two conference matches to San José State. Boise State also forfeited its conference tournament semifinal match to the Spartans.
The transgender player, Blaire Fleming, was on the San José State roster for three seasons after transferring from Coastal Carolina, although opponents protested the player’s participation only in 2024.
In a news release Wednesday, the Education Department warned that San José State risks “imminent enforcement action” if it doesn’t voluntarily resolve the violations by taking the following actions, not all of which pertain solely to sports:
1) Issue a public statement that SJSU will adopt biology-based definitions of the words “male” and “female” and acknowledge that the sex of a human — male or female — is unchangeable.
2) Specify that SJSU will follow Title IX by separating sports and intimate facilities based on biological sex.
3) State that SJSU will not delegate its obligation to comply with Title IX to any external association or entity and will not contract with any entity that discriminates on the basis of sex.
4) Restore to female athletes all individual athletic records and titles misappropriated by male athletes competing in women’s categories, and issue a personalized letter of apology on behalf of SJSU to each female athlete for allowing her participation in athletics to be marred by sex discrimination.
5) Send a personalized apology to every woman who played in SJSU’s women’s indoor volleyball from 2022 to 2024, beach volleyball in 2023, and to any woman on a team that forfeited rather than compete against SJSU while a male student was on the roster — expressing sincere regret for placing female athletes in that position.
“SJSU caused significant harm to female athletes by allowing a male to compete on the women’s volleyball team — creating unfairness in competition, compromising safety, and denying women equal opportunities in athletics, including scholarships and playing time,” Kimberly Richey, Education Department assistant secretary for civil rights, said.
“Even worse, when female athletes spoke out, SJSU retaliated — ignoring sex-discrimination claims while subjecting one female SJSU athlete to a Title IX complaint for allegedly ‘misgendering’ the male athlete competing on a women’s team. This is unacceptable.”
San José State responded with a statement acknowledging that the Education Department had informed the university of its investigation and findings.
“The University is in the process of reviewing the Department’s findings and proposed resolution agreement,” the statement said. “We remain committed to providing a safe, respectful, and inclusive educational environment for all students while complying with applicable laws and regulations.”
In a New York Times profile, Fleming said she learned about transgender identity when she was in eighth grade. “It was a lightbulb moment,” she said. “I felt this huge relief and a weight off my shoulders. It made so much sense.”
With the support of her mother and stepfather, Fleming worked with a therapist and a doctor and started to socially and medically transition, according to the Times. When she joined the high school girls’ volleyball team, her coaches and teammates knew she was transgender and accepted her.
Fleming’s first two years at San José State were uneventful, but in 2024 co-captain Brooke Slusser joined lawsuits against the NCAA, the Mountain West Conference and representatives of San José State after alleging she shared hotel rooms and locker rooms with Fleming without being told she is transgender.
The Education Department also determined that Fleming and a Colorado State player conspired to spike Slusser in the face, although a Mountain West investigation found “insufficient evidence to corroborate the allegations of misconduct.” Slusser was not spiked in the face during the match.
President Trump signed an executive order a year ago designed to ban transgender athletes from competing on girls’ and women’s sports teams. The order stated that educational institutions and athletic associations may not ignore “fundamental biological truths between the two sexes.” The NCAA responded by banning transgender athletes.
The order, titled “Keeping Men Out of Women’s Sports,” gives federal agencies, including the Justice and Education departments, wide latitude to ensure entities that receive federal funding abide by Title IX in alignment with the Trump administration’s view, which interprets a person’s sex as the gender they were assigned at birth.
San José State has been in the federal government’s crosshairs ever since. If the university does not comply voluntarily to the actions listed by the government, it could face a Justice Department lawsuit and risk losing federal funding.
“We will not relent until SJSU is held to account for these abuses and commits to upholding Title IX to protect future athletes from the same indignities,” Richey said.
San José State was found in violation of Title IX in an unrelated case in 2021 and paid $1.6 million to more than a dozen female athletes after the Department of Justice found that the university failed to properly handle the students’ allegations of sexual abuse by a former athletic trainer.
The federal investigation found that San José State did not take adequate action in response to the athletes’ reports and retaliated against two employees who raised repeated concerns about Scott Shaw, the former director of sports medicine. Shaw was sentenced to 24 months in prison for unlawfully touching female student-athletes under the guise of providing medical treatment.
The current findings against San José State came two weeks after federal investigators announced that the California Community College Athletic Assn. and four other state colleges and school districts are the targets of a probe over whether their transgender participation policies violate Title IX.
The investigation targets a California Community College Athletic Assn. rule that allows transgender and nonbinary students to participate on women’s sports teams if the students have completed “at least one calendar year of testosterone suppression.”
Also, the Education Department’s Office of Civil Rights has launched 18 Title IX investigations into school districts across the United States on the heels of the Supreme Court hearing oral arguments on efforts to protect women’s and girls’ sports.
Science
The share of Americans medically obese is projected to rise to almost 50% by 2035
On Wednesday, a new study published in JAMA by researchers at the University of Washington in Seattle projected that by 2035, nearly half of all American adults, about 126 million individuals, will be living with obesity. The study draws on data from more than 11 million participants via the U.S. Centers for Disease Control and Prevention’s National Health and Nutrition Examination and Behavioral Risk Factor Surveillance System, and from the independent Gallup Daily Survey.
The projections show a striking increase in the prevalence of obesity over the past few decades in the U.S. In 1990, only 19.3% of U.S. adults were obese, according to the study. That figure more than doubled to 42.5% by 2022, and is forecast to reach 46.9% by 2035.
The study highlights significant disparities across states, ages, and racial and ethnic groups. While every state is expected to see increases, the sharpest rises are projected for Midwestern and Southern states.
For example, nationwide, by 2035, the study projects that 60% (11.5 million adults) of Black women and 54% (14.5 million) of Latino women will suffer from obesity when compared with 47% (36.5 million) of white women. Similarly, 48% (13.2 million) of Latino men will suffer from the disease compared with 45% (34.4 million) of white men and 43% (7.61 million) of Black men.
The findings say California will see similar trends in gender and racial disparities. The study projects that by 2035, obesity rates among Latino and Black women in California will reach nearly 60%, compared with nearly 40% for their white counterparts. Additionally, Latino men in California could see rates over 50%, compared with nearly 40% for their white counterparts.
“These numbers are not surprising, given the systemic inequalities that exist,” in many California cities, said Dr. Amanda Velazquez, director of obesity medicine at Cedars-Sinai Hospital, pointing to economic instability, chronic stress and the car-dependency of Los Angeles and other California metro areas. “There are challenges for access to nutritious foods, depending on where you’re at in the city,” Velazquez said. ”There’s also disparities in the access to healthcare, especially to treatment for obesity.”
That’s recently become more of a challenge, since changes in Medi-Cal plans that went into effect at the beginning of this year mean obesity medication and treatment are no longer covered for hundreds of thousands of low-income Californians. “To take that away is devastating,” said Velazquez.
Despite these disparities, California is projected to fare better than most other states, with its rates of obesity growing more slowly than the national average.
“There are statewide and local policies that influence food, nutrition and social determinants of health for individuals,” said Velazquez.
Church pointed to measures such as SB 12 and SB 677, passed in the mid 2000s, which set strict nutritional standards for schools, existing menu labeling laws at both the state and federal levels requiring restaurants to provide nutritional facts on menu items, and cities like Berkeley and Oakland imposing local soda taxes as key local and statewide initiatives to keep obesity at bay.
To keep up this momentum, both doctors stressed that California must continue to strengthen school nutrition standards, expand transportation infrastructure that encourages walking instead of driving, maintain and expand economic disincentives to unhealthy foods, such as beverage taxes, and address food deserts by incentivizing new grocery stores and farmers’ markets in underserved neighborhoods.
Future efforts, Church says, should prioritize the Black and Latino populations identified by the study as most affected.
Science
Pediatricians urge Americans to stick with previous vaccine schedule despite CDC’s changes
For decades, the American Academy of Pediatrics and the U.S. Centers for Disease Control and Prevention spoke with a single voice when advising the nation’s families on when to vaccinate their children.
Since 1995, the two organizations worked together to publish a single vaccine schedule for parents and healthcare providers that clearly laid out which vaccines children should get and exactly when they should get them.
Today, that united front has fractured. This month, the Department of Health and Human Services announced drastic changes to the CDC’s vaccine schedule, slashing the number of diseases that it recommends U.S. children be routinely vaccinated against to 11 from 17. That follows the CDC’s decision last year to reverse its recommendation that all kids get the COVID-19 vaccine.
On Monday, the AAP released its own immunization guidelines, which now look very different from the federal government’s. The organization, which represents most of the nation’s primary care and specialty doctors for children, recommends that children continue to be routinely vaccinated against 18 diseases, just as the CDC did before Robert F. Kennedy Jr. took over the nation’s health agencies.
Endorsed by a dozen medical groups, the AAP schedule is far and away the preferred version for most healthcare practitioners. California’s public health department recommends that families and physicians follow the AAP schedule.
“As there is a lot of confusion going on with the constant new recommendations coming out of the federal government, it is important that we have a stable, trusted, evidence-based immunization schedule to follow and that’s the AAP schedule,” said Dr. Pia Pannaraj, a member of AAP’s infectious disease committee and professor of pediatrics at UC San Diego.
Both schedules recommend that all children be vaccinated against measles, mumps, rubella, polio, pertussis, tetanus, diphtheria, Haemophilus influenzae type B (Hib), pneumococcal disease, human papillomavirus (HPV) and varicella (better known as chickenpox).
AAP urges families to also routinely vaccinate their kids against hepatitis A and B, COVID-19, rotavirus, flu, meningococcal disease and respiratory syncytial virus (RSV).
The CDC, on the other hand, now says these shots are optional for most kids, though it still recommends them for those in certain high-risk groups.
The schedules also vary in the recommended timing of certain shots. AAP advises that children get two doses of HPV vaccine starting at ages 9 to12, while the CDC recommends one dose at age 11 or 12. The AAP advocates starting the vaccine sooner, as younger immune systems produce more antibodies. While several recent studies found that a single dose of the vaccine confers as much protection as two, there is no single-dose HPV vaccine licensed in the U.S. yet.
The pediatricians’ group also continues to recommend the long-standing practice of a single shot combining the measles, mumps and rubella (MMR) and varicella vaccines in order to limit the number of jabs children get. In September, a key CDC advisory panel stocked with hand-picked Kennedy appointees recommended that the MMR and varicella vaccines be given as separate shots, a move that confounded public health experts for its seeming lack of scientific basis.
The AAP is one of several medical groups suing HHS. The AAP’s suit describes as “arbitrary and capricious” Kennedy’s alterations to the nation’s vaccine policy, most of which have been made without the thorough scientific review that previously preceded changes.
Days before AAP released its new guidelines, it was hit with a lawsuit from Children’s Health Defense, the anti-vaccine group Kennedy founded and previously led, alleging that its vaccine guidance over the years amounted to a form of racketeering.
The CDC’s efforts to collect the data that typically inform public health policy have noticeably slowed under Kennedy’s leadership at HHS. A review published Monday found that of 82 CDC databases previously updated at least once a month, 38 had unexplained interruptions, with most of those pauses lasting six months or longer. Nearly 90% of the paused databases included vaccination information.
“The evidence is damning: The administration’s anti-vaccine stance has interrupted the reliable flow of the data we need to keep Americans safe from preventable infections,” Dr. Jeanne Marrazzo wrote in an editorial for Annals of Internal Medicine, a scientific journal. Marrazzo, an infectious disease specialist, was fired last year as head of the National Institute of Allergy and Infectious Diseases after speaking out against the administration’s public health policies.
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