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A California panel is holding up studies on psychedelics. Some researchers want it gone

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A California panel is holding up studies on psychedelics. Some researchers want it gone

At the Pacific Neuroscience Institute in Santa Monica, scientists are eager to explore whether a psychedelic chemical found in a toad could help people whose depression has not eased with typical treatments. Patients regularly call or send emails about joining clinical trials to test that and other compounds, but the research center is turning them away.

“We have to tell them we don’t have any studies enrolling right now,” said Dr. Keith Heinzerling, director of the institute’s TRIP Center, which focuses on treatment and research on psychedelics. “We’ve been put on hold by the state.”

Across the state, dozens of such studies are in limbo thanks to a little-known government panel that monitors research on federally restricted drugs and addiction treatment.

The holdup, tied to a state law requiring government meetings to be held in public, has dragged on since the fall and galvanized some scientists to push for the panel to be dissolved.

Lawmakers in Sacramento established the Research Advisory Panel of California more than half a century ago to vet studies involving cannabis, hallucinogens and treatments for “abuse of controlled substances,” according to the state’s health and safety code.

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The panel, which includes representatives of state agencies and universities, has the power to reject studies if they are poorly conceived, would produce little of scientific value, or would expose Californians who sign on as research subjects to excessive risk. It also monitors ongoing research and can revoke its approval if studies veer from what it approved.

Getting the panel’s blessing is a crucial hurdle for researchers working in the state to find better ways to treat drug addiction, a crisis leading to more than 100,000 overdose deaths across the country each year. The panel also has oversight over research in the burgeoning field of psychedelics, which is developing potential treatments for depression, substance use disorder and other conditions.

The panel typically meets every other month, but gatherings scheduled for October and December were canceled with little explanation. Scientists waiting for the go-ahead to launch their studies say they’ve received no information about when meetings will resume.

Among those frustrated by the standstill is David, a 50-year-old grappling with post-traumatic stress disorder. The Los Angeles resident, who asked not to be identified by his full name to protect his medical privacy, reached out to the Pacific Neuroscience Institute to ask about upcoming clinical trials.

“I’ve been in search of a treatment that will alleviate symptoms of PTSD for a long time,” David said. Some existing treatments “have worked pretty well, but there are still times where there’s challenges and episodes that can be pretty destabilizing,” including prolonged bouts of insomnia.

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Researchers use a quiet room to test psilocybin therapy at the Pacific Neuroscience Institute in Santa Monica.

(Genaro Molina / Los Angeles Times)

The potential of a psychedelic compound like psilocybin is appealing, but since he’s in recovery for alcohol use, David wants to try it only if it’s administered by medical professionals in a therapeutic environment. The Santa Monica center told him their next possible trial was being held up indefinitely.

“It just seems like the gears of bureaucracy conspire against meaningful solutions,” he said.

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At UC San Francisco, Dr. Josh Woolley said two of his planned studies on psilocybin are on indefinite hold. One of them is for young adults with anorexia, a disorder that can significantly ramp up the risk of death if left untreated. Now “we don’t know when it will be approved,” said Woolley, director of the Translational Psychedelic Research Program at UCSF.

The holdup has also interrupted plans for Dr. Charles Grob, a psychiatrist doing research with the Lundquist Institute at Harbor-UCLA Medical Center to examine whether psilocybin could help patients suffering from existential anxiety and demoralization near the end of life.

“Just when things are ready to take off with more research, the field is frozen,” Grob said.

Just when things are ready to take off with more research, the field is frozen.

— Dr. Charles Grob, a psychiatrist with the Lundquist Institute at Harbor-UCLA Medical Center

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Several current or former members of the panel declined to comment or did not respond to messages. Dr. Tanveer Khan, the panel’s executive officer, referred questions to the California attorney general’s office.

In a statement, the office said the panel was created to ensure that research involving addiction or certain controlled substances is tracked by the state and proceeds safely in line with “best medical practices and California law.” It attributed the interruption in its meetings to concerns about how a state law requiring public meetings might apply to the panel, but declined to clarify whether those concerns were prompted by recent changes to the Bagley-Keene Open Meetings Act or a new interpretation of existing rules.

Before it stopped meeting altogether, the Research Advisory Panel routinely convened behind closed doors. Scientists argued that meeting in public would be a nonstarter with funders who wanted to protect their intellectual property.

“Realistically, the pharmaceutical companies are not going to allow their stuff to be reviewed in public, unless there’s a very well-thought-out process that protects their interests,” Heinzerling said.

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The backlog of studies awaiting review and approval has ballooned since the panel last met in August. By December, 33 new proposals were on ice, as were 13 amendments to existing research projects, according to the attorney general’s office.

The attorney general’s office said it was working with lawmakers and the governor’s office on a legislative solution to resolve the problem but declined to give specifics.

The impasse, first reported in the newsletter Psychedelic Alpha, has deepened longtime frustrations among scientists who argue that even when the panel is meeting normally, it is an outdated and unnecessary entity that slows down vital research.

Dozens of researchers in a newly formed consortium are now calling for the panel to be eliminated. They argue that studies involving controlled substances and addiction treatment are vetted by other oversight boards and that the California panel often rehashes issues that were already decided by other regulators.

Dr. Keith Heinzerling holds a ceramic bowl containing one psilocybin pill that will be used by a study volunteer to try to treat her alcoholism.

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(Genaro Molina / Los Angeles Times)

Psychologist Steven Shoptaw, director of the Center for Behavioral and Addiction Medicine at UCLA, said there was a time when such experiments were conducted on people in jails and other settings who could not freely consent. But the rigorous scrutiny from institutional review boards, the Food and Drug Administration, the National Institutes of Health and others now makes the California panel obsolete, he said.

“I’ve never understood why this was not dismantled decades ago,” said Shoptaw, who has studied possible treatments for people who use methamphetamine.

Stanford University clinical psychologist Keith Humphreys said he was asked to join the panel years ago by then-Gov. Jerry Brown, but he declined “because I could see no purpose to it.”

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“I just thought, ‘We have an FDA. We have an NIH. Why is the state doing this?’” Humphreys said.

We have an FDA. We have an NIH. Why is the state doing this?

— Stanford clinical psychologist Keith Humphreys

Even without hiccups, undergoing the state review can delay a study for upward of five months, researchers complained. That means wasting $100,000 or more on “unnecessary staff expenditures” during that time, they argued in a letter sent Thursday to Gov. Gavin Newsom and other decision makers.

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Such delays can also shut Californians out of multi-state trials of emerging treatments, scientists argue. The lag time now looms larger as medication studies are expected to be run more quickly — within as little as a year instead of five, they said.

“If you’re competing against other states where they don’t have this delay, the industry is going other places,” said Woolley of UC San Francisco.

Dr. Phillip Coffin, director of the Center on Substance Use and Health at the San Francisco Department of Public Health, wanted to join a federally funded study on whether ketamine could help people struggling with methamphetamine addiction. But he said his site and others in California were excluded because of the panel’s delays.

Losing out on the ketamine study and other research opportunities means that “I won’t be able to hire or I will have to let go of staff,” Coffin said.

Compass Pathways, a London biotech firm developing psilocybin treatments, decided not to establish a new “centre of excellence” in San Diego. In an email sent in 2019 to a San Diego researcher, company co-founder George Goldsmith cited the “incredibly slow” state panel as a reason. (A Compass representative reached this week said the company’s clinical trials for depression treatments underway in California had not encountered any delays.)

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Many researchers are frustrated that the panel has been reviewing trials for addiction treatment even if they involve ordinary medications. For instance, the panel vetted a study Coffin undertook on mirtazapine — an FDA-approved antidepressant — as a treatment for people who use meth.

In 2022, the panel reviewed 52 new applications plus two submitted the previous year, according to its most recent available annual report. Among those 54 applications, three were either not approved or withdrawn. The reasons weren’t given in the report.

By the end of that year, the panel was monitoring 132 ongoing research projects, including studies on whether cannabis use affects antiretroviral therapy and how psilocybin helps people suffering from phantom limb pain.

Michiel van Elk, who studies altered states of consciousness at Leiden University in the Netherlands, said he wasn’t familiar with the California panel, but could understand the need for a specialized review board because assessing research procedures for psychedelics poses some unique challenges.

“It is really difficult to evaluate the risks of the drug itself, because it always interacts with the mind-set of the person and also with the setting in which it’s administered,” Van Elk said. In general, “our current system is not set up for dealing with those type of challenges.”

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Not all researchers who interact with the panel are joining the calls to eliminate it. Grob said going through the panel is “extra work, but it’s been positive,” praising its members as astute and helpful.

“California has this extra layer of regulatory oversight, but the problem is not the committee itself,” he said. “It’s that the committee is unable to do its job.”

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July Fourth fireworks may bring ‘hazardous’ air quality to Southern California. What you need to know

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July Fourth fireworks may bring ‘hazardous’ air quality to Southern California. What you need to know

L.A.’s love of fireworks makes for a colorful Fourth of July, with dozens of official celebrations and countless illicit explosions expected for the holiday.

But as each sparkler, Roman candle, palm and peony dissipates, it leaves behind a cloud of noxious gases, soot and finely ground toxic metals — some of which ends up in the lungs of revelers and passersby below.

Hazardous levels of air pollution are expected across central and southern Los Angeles County, northern Orange County, and Riverside and San Bernardino counties from 5 p.m. Saturday evening through 3 p.m. Sunday, according to the South Coast Air Quality Management District. Unhealthy air quality is also expected in northern Los Angeles County and southern Orange County.

Pollution levels are expected to build from dusk onward Saturday, as light winds and increased firework activity lead to an increase in smoke, a South Coast AQMD advisory said. Soot and particulates will likely linger through Sunday afternoon before being dispersed by the wind.

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Firework-related pollution can trigger coughs, breathing problems, asthma flares and heart attacks, according to Los Angeles County Public Health, and anyone experiencing severe or worsening cardiovascular symptoms like chest pain or difficulty breathing should seek medical attention immediately.

Pyrotechnics set off at home are even more likely to trigger cardiovascular problems, the American Lung Assn. says, as the burst of pollutants takes place closer to the ground.

July 4 and 5 are traditionally two of the worst days of the year for the region’s air quality, according to South Coast AQMD. This year’s celebration comes on the heels of a late June warehouse fire in Boyle Heights that released extraordinary amounts of soot and smoke across the county, on par with pollution generated by the previous year’s wildfires.

To limit negative health effects, the L.A. County public health department recommends avoiding strenuous physical activity and keeping doors and windows closed. As whole house fans and swamp coolers can suck additional pollutants inside, the department recommends using air purifiers or air conditioners as alternatives when possible.

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Contributor: Alcohol should be stigmatized like smoking

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Contributor: Alcohol should be stigmatized like smoking

Few substances are as deeply woven into everyday life as alcohol. It is a fixture at holiday celebrations, work-related social gatherings, sporting events, airports, and brunch or dinner tables. All demonstrate how deeply alcohol has become embedded in social customs and cultural traditions.

Yet alcohol contributes to millions of deaths globally each year and is linked to cancer, liver disease, unintentional accidents, violence and, importantly, dependence and addiction. Despite this, the disconnect between alcohol’s cultural role and its serious health burden is striking. An estimated 2.3 billion people worldwide consume alcohol.

As a physician working in addiction medicine, I regularly care for patients whose alcohol use affects nearly every organ system. It is often not until these patients end up admitted to the hospital that they learn the effects of alcohol on various parts of their body besides their liver.

Newer evidence challenges assumptions about what was long considered “safe drinking.” Even moderate drinking carries risk and is not as harmless as people, including experts, once thought.

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Many people associate alcohol risk primarily with addiction or dangerous behaviors such as driving while intoxicated. However, its effects extend far beyond this, into nearly every aspect of a person’s well-being.

While alcohol may transiently improve mood and ease social anxiety, long-term alcohol use can lead to a worsening of mood, cognition and sleep, which can further compound use.

A 2021 literature review found that consuming approximately two standard drinks roughly doubles the odds of sustaining injuries — with or without a vehicle involved. The review also found that heavy episodic (binge) drinking can increase the risk of injury by 50-fold, depending on the amount of alcohol consumed and the type of injury. While alcohol’s effects on the liver are well known, it can also lead to gastrointestinal complications and heart disease

The World Health Organization estimates that 2.6 million deaths each year are attributable to alcohol, accounting for nearly 1 in every 20 deaths worldwide.

While many people recognize the risks of alcohol addiction, people are generally much less aware of the links between alcohol use and cancer risk.

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The World Health Organization classifies alcohol as a Group 1 carcinogen — the same category as tobacco and asbestos. In 2025, the U.S. surgeon general emphasized that alcohol increases the risk of at least seven cancers, including cancers of the breast, colorectal, liver, oral, esophagus and larynx. An advisory called for updated warning labels.

Yet fewer than half of Americans recognize alcohol as a risk factor for cancer, particularly for cancers such as breast cancer that are not commonly associated with alcohol use.

Throughout the 1990s and early 2000s, observational studies suggested that moderate alcohol consumption might offer cardiovascular benefits. Over the past decade, however, higher-quality studies have challenged these findings, suggesting that much of the apparent benefit may have reflected differences in the health and lifestyles of moderate drinkers rather than a protective effect of alcohol itself.

Current evidence increasingly suggests that even low levels of alcohol may increase cancer risk.

Federal guidelines acknowledge that adults should “consume less alcohol for better overall health.” However, the most recent version of the “Dietary Guidelines for Americans,” updated in January, removed the previous recommendation to limit intake to no more than one drink per day for women and two for men. It also omitted explicit discussion of alcohol’s links to cancer.

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These changes have drawn criticism from public health experts, who argue that the revised language plays down the growing evidence of alcohol-related harms and provides less specific guidance to consumers. The current administrator of the Centers for Medicare & Medicaid Services characterized alcohol as a “social lubricant” that brings people together, rather than emphasizing its well-established health risks.

This may be true physiologically, at least temporarily, but obscures the fact that relying on it as a social lubricant can lead to chemical and psychological dependency. In my view, statements to that effect are shortsighted, prioritizing short-term social effects over more insidious and long-term issues, including addiction.

While many dangerous mind-altering substances are hidden from public perception, alcohol is often placed at the center of it – a trend that shows no sign of changing imminently.

Further, large companies often profit from ads that appeal to young people.

Looking back at the history of tobacco smoking provides some helpful insights. In 1965, 42.4% of the U.S. population smoked. By 2022, that figure had dropped to 11.6%.

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This steep decline did not happen because of a single intervention, but through decades of accumulating scientific evidence, public education campaigns, warning labels, restrictions on advertising, smoke-free policies, higher tobacco taxes and shifts in social norms. Together, these efforts transformed smoking from a widely accepted social behavior into one broadly recognized as a major health risk and correspondingly, less socially accepted.

Although alcohol consumption has modestly declined in recent years, it remains deeply embedded in social life in ways cigarette smoking no longer is.

People often assume that if a substance is legal, common and widely socially accepted — even encouraged — it must also be safe. But public health history suggests those assumptions can and should change.

Emma Fenske is an addiction medicine fellow and internal medicine physician at Oregon Health & Science University. This article was produced in partnership with the Conversation.

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Boyle Heights blaze choked L.A. with astronomical soot pollution

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Boyle Heights blaze choked L.A. with astronomical soot pollution

The air near the Lineage refrigerated warehouse fire in Boyle Heights carried astronomically high levels of smoke and soot, surpassing some of the worst air pollution during the Los Angeles County fires in January 2025, according to preliminary data from air officials.

The fire spewed thick black smoke for days. From downtown Los Angeles to the San Gabriel Valley, tens of thousands were enveloped in unhealthful levels of smoke, even as some local officials told residents that the air posed no danger.

As the days wore on, worst off were communities nearest the blaze. On June 19, three days after the facility ignited, a temporary air quality monitoring station at Eastman Elementary in unincorporated East Los Angeles measured an extremely hazardous 755 micrograms per cubic meter of fine particles for more than an hour, according to the South Coast Air Quality Management District.

For comparison, a Caltech air monitor in Pasadena recorded about 650 micrograms per cubic meter during the Eaton fire.

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These high levels of fine particles, known as PM 2.5, probably resulted in the surge of residents into local emergency rooms during the fire, according to local health officials. But even now with the smoke gone, people still have not been told what chemicals they were breathing in during the weeklong ordeal.

Michael Jerrett, an environmental health professor at the UCLA Fielding School of Public Health, said his concern is the composition of materials emitted when the building burned.

“These contain many particularly toxic components,” Jerrett said, “and we know little about how these mixtures affect health.”

There is no completely safe level of fine particulate pollution, he noted, meaning higher concentrations are always worse.

During the 2025 L.A. County fires, local air officials announced that several monitors downwind had detected elevated levels of brain-damaging lead and cancer-causing arsenic from toxic paint and construction materials used in older homes.

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The Lineage warehouse, built in 2018, is likely to contain different materials of concern. Thick insulation foam required for a massive refrigeration operation, solar panels and refrigerants were burned, leaving many residents on edge.

Even though three public agencies conducted air monitoring, the picture is still murky.

“[Public officials] are speaking with a lot of confidence but not a lot of information,” said mark! Lopez, a community organizer with East Yard Communities for Environmental Justice. “We’ve gotten in the room with folks to discuss where the gaps lie and where assumptions are being made. And I think they are realizing these agencies supposed to protect our air and our health aren’t as reliable as they thought they were.”

In response to the Boyle Heights fire, the South Coast air district deployed a mobile monitoring vehicle to screen for toxic substances in the community near the fire, according to Nahal Mogharabi, a spokesperson for the air district. It found increased levels of bromine, a chemical commonly found in fire retardant, and chlorine, often released from burning plastic. Both were below short-term health-based exposure thresholds.

Toxic metals, including lead and arsenic, were not elevated, according to air district data.

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“That was the reassuring piece, that they were not picking up any of the metals,” said Dr. Nichole Quick, chief medical advisor for the Los Angeles County Department of Public Health. “But … that smoke is unhealthy. “You don’t want to be breathing it, regardless.”

The U.S. Environmental Protection Agency set up air monitors around the perimeter of the facility to test for toxic air contaminants, has the results and has not made them public. Julia Giarmoleo, an EPA spokesperson, said the monitors did not detect elevated metals, but would not provide a copy of the data without a federal records request.

The Los Angeles Fire Department’s hazardous material team also tested for ammonia, which is used in refrigeration, and hydrogen fluoride, a toxic chemical that could be released by burning lithium-ion batteries and solar panels.

Fire officials previously said they measured low levels of hydrogen fluoride on the second day of the fire. But the department would not answer questions about its air monitoring. It also told a reporter to submit a public records request.

It remains unclear whether any agency has tested for hydrogen cyanide or isocyanates, highly toxic gases that could be released from burning chemical-laden insulating foam inside the building.

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“The real issue is what monitoring has not been done to protect the fence-line community from the air toxics,” said Jane Williams, executive director of California Communities Against Toxics.

Without the EPA or LAFD data, what is known of the smoke’s toxicity rests on the air district’s mobile monitoring.

Jerrett, the UCLA researcher, said that is not ideal for understanding the kind of plume released by the Boyle Heights fire, which rapidly changed direction with the wind.

“This can in some instances lead to levels that look low, but they are resulting from a mismatch between the location of the vehicle and the plume,” he said.

The Boyle Heights blaze, similar to the Eaton and Palisades fires, has revealed the region’s air monitoring can’t always tell people what they’ve been exposed to in a disaster.

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“We do need a better monitoring system in place,” he said.

Local officials are now shifting their focus to the rancid odors from millions of pounds of rotting food in the ruined wing of the warehouse. Decomposing food can release hydrogen sulfide, a toxic gas synonymous with landfills and garbage. Lineage hired contractors who are measuring this noxious gas and other pollution. Their data indicate they have not detected hydrogen sulfide.

As Lineage workers haul the rotting food to local landfills, they are using deodorizing mist and have discussed using shrink wrapping to suppress the stench and minimize issues for nearby homes.

At this point, the odors are believed to be an inconvenience rather than a public health threat, according to Quick, the county medical advisor. She said running air purifiers may help to reduce odors indoors.

“It’s very important for folks to understand that the odors themselves do not indicate any dangerous levels of toxins, mold, bacteria, and so forth,” Quick said. “But the odors are a public nuisance.”

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The air district is still encouraging residents to report odors to its online complaint system or by calling (800) 288-7664.

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