Health
Study finds that proteins may predict who will get dementia in 10 years based on blood samples
A study of frozen blood samples has turned up a trove of proteins that may predict several forms of dementia more than 10 years before the disease is diagnosed, researchers from the U.K. and China reported on Monday.
The study, published in the journal Nature Aging, is part of ongoing research from multiple teams to identify patients at risk for dementia using a simple blood test, an advance many scientists believe will accelerate the development of new treatments.
Currently, brain scans can detect abnormal levels of a protein called beta amyloid many years before Alzheimer’s dementia develops, but the tests are costly and often not covered by insurance.
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“Based on this study, it does seem likely that blood tests will be developed that can predict risk for developing dementia over the next 10 years, although individuals at higher risk often have difficulty knowing how to respond,” said Dr. Suzanne Schindler, an Alzheimer’s researcher at Washington University in St. Louis, who was not involved in the research.
A new study proved that proteins may be able to predict who will get dementia 10 years prior to a diagnosis. (REUTERS/Denis Balibouse)
Study author Jian-Feng Feng of Fudan University in Shanghai said such tests are critical in aging populations such as China’s, and noted that he is in talks for potential commercial development of a blood test based on their research.
In the study, researchers at the University of Warwick and Fudan University studied 52,645 blood samples from the U.K.’s Biobank research repository, collected between 2006 and 2010 from people who had no signs of dementia at the time.
Of these, 1,417 people eventually developed Alzheimer’s disease, vascular dementia or dementia from any cause. The researchers studied protein signatures common in these individuals and turned up 1,463 proteins associated with dementia and ranked these according to how likely they were to predict dementia.
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They found that people whose blood carried higher levels of the proteins GFAP, NEFL, GDF15 and LTBP2 were consistently more likely to have developed Alzheimer’s disease, vascular dementia or dementia from any cause. People with elevated levels of GFAP were 2.32 times more likely to develop dementia, confirming findings from smaller studies that had pointed to the contribution of this protein.
The authors noted that their research has not been independently validated.
One protein that performed well in predicting dementia, neurofilament light, is already used in the clinic for diagnosing and monitoring some conditions such as multiple sclerosis, Schindler said in an email.
“This study did not include clinically available blood tests for Alzheimer disease, which likely would even better predict development of dementia due to Alzheimer’s disease,” she said.
Such tests are already being used in identifying candidates for clinical trials testing treatments in patients with early-stage or even presymptomatic disease, such as Eisai and Biogen’s Leqembi. The drug recently won regulatory approval in the United States, Japan and China.
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Red light therapy has been shown to reduce brain inflammation, protecting people who experience head trauma from long-term health consequences, a University of Utah study has shown.
Brain damage from repeated impact over the years is known to cause cognitive symptoms, ranging from memory issues to full-blown dementia, particularly affecting soldiers and athletes.
Chronic traumatic encephalopathy (CTE) is a progressive, degenerative brain disease linked to repeated head impacts rather than a single injury, according to Mayo Clinic.
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More than 100 former NFL football players have been posthumously diagnosed with CTE, according to the new study, which was published in the Journal of Neurotrauma.
Other research has shown that military personnel in active combat suffer from similar issues, as do first responders and veterans.
The treatment was administered three times a week for 20 minutes using specialized headsets and intranasal devices designed to penetrate the skull. (iStock)
In the new study, the researchers recruited 26 current football players to understand more about the impact of red-light therapy on brain injuries.
The participants received either red light therapy delivered by a light-emitting headset and a device that clips into the nose, or a placebo treatment with an identical device that doesn’t produce light. Players self-administered the therapy three times a week, 20 minutes each time, for 16 weeks.
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“My first reaction was, ‘There’s no way this can be real,’” said first author Hannah Lindsey, Ph.D., in the university press release. “That’s how striking it was.”
Specific wavelengths of light are believed to enter the brain and reduce molecules that trigger inflammation, potentially halting the path toward dementia and other cognitive conditions. (iStock)
Players using the placebo treatment experienced increased brain inflammation over the course of the season. Magnetic resonance imaging (MRI) scans taken at the end of the season showed significantly more signs of inflammation than at the beginning of the season, the study found.
For players who used red-light therapy during the season, their brain inflammation didn’t increase at all.
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Previous studies have shown that red light, if powerful enough, can penetrate the skull and reach the brain, where it may reduce inflammation-related molecules.
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“When we first started this project, I was extremely skeptical,” said Elisabeth Wilde, Ph.D., the senior author on the study. “But we’ve seen consistent results across multiple of our studies, so it’s starting to be quite compelling.”
Study limitations
The study was conducted using a small sample size, which led to different levels of inflammation in the treatment and control groups, the researchers acknowledged.
While the placebo group showed increased brain inflammation during the football season, those receiving red light therapy showed no increase in inflammatory markers. (iStock)
Future large randomized clinical trials will be “crucial to back up the results” in larger populations, they noted.
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“We’ve been trying to figure out how to make sports safer, so that our kids, friends and family can participate in sports safely for the long term while they’re involved in activities that give them happiness and joy,” Carrie Esopenko, Ph.D., second author of the study, said in the release.
“And this really feels like part of the hope for protecting the brain that we’ve been searching for.”
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The team plans to recruit 300 people with persistent symptoms from TBI or concussion for a randomized controlled trial in 2026, with a focus on first responders, veterans and active-duty service members.
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Drinking heavily and consistently over an adult’s lifetime could lead to a higher risk of colorectal cancer, according to a study published in the journal Cancer by the American Cancer Society (ACS).
The study analyzed 20 years of data from more than 88,000 U.S. adults to determine how long-term drinking impacted the risk of developing colorectal cancer (CRC) or precancerous colorectal adenomas (polyps).
The participants reported their average weekly intake of beer, wine and liquor intake during four age periods — 18 to 24, 25 to 39, 40 to 54, and 55 and older.
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“Heavy drinkers” were identified as having more than 14 drinks per week and “moderate drinkers” had between seven and 14 drinks per week.
The observational research revealed that consistent heavy drinking over adulthood was linked to a higher risk of colorectal cancer, especially rectal cancer.
Researchers found a major association between colorectal cancer diagnosis and heavy lifetime drinking. (iStock)
Heavy lifetime drinking was associated with a 25% higher overall CRC risk and nearly double the risk of rectal cancer. Moderate lifetime drinking had a lower overall CRC risk.
Compared to light drinkers, the consistently heavy drinkers had about a 91% higher risk of CRC.
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For colorectal adenomas (precancerous polyps), higher current lifetime drinking did not show a strong pattern, although former drinkers showed a significantly lower risk of non-advanced adenoma compared to current light drinkers.
Out of the 88,092 participants, 1,679 were diagnosed with colorectal cancer.
Out of the 88,092 participants in the study, 1,679 were diagnosed with colorectal cancer. (iStock)
The authors noted that the research was limited, as it was observational and not based on a clinical trial. It also hinged on self-reported alcohol use.
The findings suggest that consistently heavy alcohol intake and higher average lifetime consumption “may increase CRC risk, whereas cessation may lower adenoma risk,” the researchers stated. Associations “may differ by tumor site,” they added.
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The link between drinking alcohol and cancer is not a new discovery, according to health experts.
In a recent episode of the podcast “The Dr. Mark Hyman Show,” Dr. Mark Hyman, chief medical officer of Function Health in California, detailed how even moderate drinking can impact “nearly every organ system in the body,” due to metabolic stress, inflammation, impaired detoxification and its effect on hormones.
The link between drinking alcohol and cancer is not a new discovery, according to health experts. (iStock)
Drinking has been found to increase the risk of many cancers, metabolic dysfunction, gut microbiome disturbances and mitochondrial toxins, Hyman said.
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“Bottom line, alcohol taxes every major system in your body, especially your liver, your brain, your gut, your hormones,” he warned.
Reducing or eliminating alcohol can lower the risk of several cancers, according to medical experts. (Getty Images)
In a previous interview with Fox News Digital, Dr. Pinchieh Chiang, a clinician at Circle Medical in San Francisco, shared that taking a break from drinking alcohol for longer periods of time can “reshape health more profoundly.”
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“Over months to a year, we see sustained improvements in blood pressure, liver function and inflammation,” she said. “Those changes directly affect long-term heart disease and stroke risk.”
Chiang added, “Reducing or eliminating alcohol lowers the risk of several cancers, including breast and colorectal, over time.”
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Fox News Digital reached out to the study researchers for comment.
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A mysterious hum is reportedly plaguing the residents of Cincinnati, keeping people up at night and even disturbing them psychologically.
Residents of the Northside, Clifton and Camp Washington neighborhoods have been reporting the disturbances since December. The noises are said to be louder and more noticeable at night.
“We were hearing this siren-like quality noise — whirring, oscillating, going up and down,” said Clifton resident Shaun Herold, who contacted local news outlet WKRC about the noises.
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“My son came up to me and said, ‘Dad, the tornado sirens are going off,’” Herold said. “Usually, it starts at about 10 p.m. It can go till 3 a.m., 4 a.m. But it’s quite unpredictable.”
“It kind of stresses me out ’cause I don’t know what it is. It’s kind of scary,” added his son, Elijah Herold.
A mysterious, intermittent hum has been disturbing Cincinnati residents since December, disrupting sleep and causing psychological stress. (iStock)
Herold said he spent one entire night tracking how many times he heard the noise going on and off. The duration of the noises can vary from a few seconds to several minutes.
“I feel like it’s definitely like a foreign sound,” Northside’s Brendan Marcum told the news outlet. “Some nights it would be a little louder, some nights it would be a little quieter.”
“It kind of stresses me out because I don’t know what it is, and it’s kind of scary,” added another resident.
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Hundreds of Cincinnati residents have shared their theories about potential sources of the sound on social media, ranging from biblical to supernatural.
On Reddit, other users blamed the recycling plant. “My favorite theory is River Metals Recycling,” one person wrote, claiming that the plant moved neighborhoods when the original location “wouldn’t put up with the noise from its metal shredder any longer.”
Residents have described the sound as a siren-like, oscillating whirring that can last from seconds to several minutes. (iStock)
Others suspect the noise is coming from a failing turbocharger on a diesel train engine at the nearby CSX Queensgate, a major freight rail yard in Cincinnati.
While the yard routinely generates loud, mechanical sounds, residents say they’ve never heard anything like this before.
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WKRC reported that an anonymous source sent recordings of the locomotive, claiming it to be the source of the sound. However, a spokesperson for CSX told the news station that he “has not heard a noise like that on our property” and suggested it could be coming from another location.
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He added that any equipment requiring maintenance is “handled through established operating and mechanical protocols.”
According to a source, rail crews have reported the engine for excessive noise and believe it will be repaired. (iStock)
“We just hope to get to the bottom of it, figure out what it is, and if it’s, you know, a temporary thing or not,” Herold told the news outlet. “And hopefully the community can rally if it’s not temporary, because it’s really impacting us.”
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City officials recommend that residents report the noise to 311, the city’s non-emergency line.
Fox News Digital reached out to Cincinnati officials for updates.
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