Health
Study discovers 'trigger gene' in IBD as researchers look for drugs to prevent the bowel disease
Inflammatory bowel disease (IBD) — which includes Crohn’s disease and ulcerative colitis — affects around 3.1 million U.S. adults.
The disease can cause debilitating symptoms such as diarrhea, abdominal pain and cramping, blood in the stool and more.
Now, researchers at the U.K.’s Francis Crick Institute, working with UCL and Imperial College London, have discovered a genetic component — referred to as a “weak spot” in the DNA — that is present in 95% of those living with the disorder.
FIRST-EVER AUGMENTED REALITY ABDOMINAL SURGERY PERFORMED IN CHILE: ‘A REVOLUTION’
The study, published in the journal Nature earlier this month, identified a section of DNA that boosts the activity of a gene called ETS2.
ETS2 has been linked to inflammatory functions that increase the chances of IBD.
Inflammatory bowel disease (IBD) can cause debilitating symptoms such as diarrhea, abdominal pain and cramping, blood in the stool and more. (iStock)
Rosario Ligresti, M.D., chief of the Division of Gastroenterology at Hackensack University Medical Center in New Jersey, was not involved in the research but called the findings “quite important.”
CANCER PREVENTION IN THE ESOPHAGUS COULD BE JUST A PILL AWAY, DOCTOR SAYS: ‘TREMENDOUS BENEFIT’
“The researchers finally showed that all autoimmune and inflammatory disease — including IBD — appear to be caused by a single gene, ETS2,” he told Fox News Digital.
“The research identified this gene as a central regulator of a type of inflammatory cell called the macrophage, which is the main inflammatory cell in all these processes.”
“IBD usually develops in young people and can cause severe symptoms that disrupt education, relationships, family life and employment.”
“The more the gene was ‘turned on’ or amplified, the greater the risk of inflammation. Without this gene, these cells do not ‘turn on’ and there is no IBD.”
While diet and stress have long been suspected to worsen IBD, the exact “‘molecular switch’ that activates inflammatory bowel disease has been unknown until now,” Ligresti noted.
Inflammatory bowel disease (IBD) — which includes Crohn’s disease and ulcerative colitis — affects around 3.1 million U.S. adults. (iStock)
“This discovery is so exciting and significant because it only gives us a better understanding of the inner workings of the disease, and it will allow researchers to adapt existing drugs to finally treat it,” added Ligresti.
The research team is now investigating drugs that could reduce the activity of the ETS2 gene, thus reducing the occurrence of IBD.
HERE’S WHY YOU’RE BLOATED — AND WHAT TO DO ABOUT THE COMMON DIGESTIVE CONDITION
They found that a group of existing anti-inflammatory medications called MEK inhibitors could do the trick.
“Although there have been many factors suggested as risks for IBD, there is currently no way to prevent the onset of IBD,” Ligresti said.
“The researchers finally showed that all autoimmune and inflammatory disease — including IBD — appear to be caused by a single gene, ETS2,” a researcher (not pictured) told Fox News Digital. (iStock)
“We do know, however, that inflammatory pathways in the body are likely activated at least five years before the onset of symptoms of IBD.”
Ideally, he said, patients at increased risk could be given a drug during this window of time that could “nip IBD in the bud.”
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
While more research is needed to find ways to deliver these MEK inhibitors to the target cells, Ligresti noted that this finding opens a “tantalizing door” to the future of very effective therapies to “shut off” inflammatory bowel disease.
The research team is now investigating drugs that could reduce the activity of the ETS2 gene, thus reducing the occurrence of IBD. (iStock)
James Lee, group leader of the Genetic Mechanisms of Disease Laboratory at the Crick, who led the research, agreed that better treatments are “urgently needed.”
“IBD usually develops in young people and can cause severe symptoms that disrupt education, relationships, family life and employment,” Lee said in a Crick press release.
“Using genetics as a starting point, we’ve uncovered a pathway that appears to play a major role in IBD and other inflammatory diseases,” he said.
“Excitingly, we’ve shown that this can be targeted therapeutically, and we’re now working on how to ensure this approach is safe and effective for treating people in the future.”
Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, often occur early in life, experts say. (iStock)
Lauren Golightly, 27, was diagnosed with Crohn’s disease in 2018 after experiencing stomach cramps, bleeding and irregular bowel habits, according to the release.
“I’ve had a rocky road since diagnosis, with many hospital admissions, several different medications and even surgery to have a temporary stoma bag,” she said in the release.
For more Health articles, visit www.foxnews/health
“I still experience flare-ups and can still spend quite a bit of time in hospital.”
She also said, “Learning about this research is so exciting and encouraging. I am hopeful this could potentially make a difference for myself and so many other hundreds of thousands of people living with IBD.”
Fox News Digital reached out to the researchers for additional comment.
Health
Dad jokes may be good for your brain in one surprising way, experts say
JD Vance reveals his favorite dad joke
Dana Perino, Greg Gutfeld, Jesse Watters, and Jessica Tarlov engage in a lighthearted exchange of classic dad jokes on Fox News’ ‘The Five’. The discussion is sparked by recent research highlighted in The Washington Post, which indicates that humor, even ‘cringeworthy’ dad jokes, plays a surprisingly important role in parenting and can help strengthen the bond between fathers and children. The panel illustrates this point with their own memorable one-liners.
NEWYou can now listen to Fox News articles!
“My neighbor tiled my roof for free. He said it was on the house.”
While that dad joke might elicit a heavy sigh from family members, experts say a silly pun can alter internal body chemistry and lower stress, potentially providing real health benefits.
Dad jokes are uniquely distinguished by their structure, content and comedic devices, according to a study published on PsyArXiv, an open-access preprint repository for psychology research.
TRENDY ‘CORTISOL COCKTAIL’ COULD MELT STRESS AND POUNDS AWAY, INFLUENCERS CLAIM
In analyzing thousands of examples, psychologists Paul J. Silvia (University of North Carolina at Greensboro) and Meriel I. Burnett (University of Massachusetts Amherst) found that dad humor is firmly rooted in puns and wordplay.
While more advanced comedy requires context, a joke about a neighbor’s roof may only require someone to understand the dual meaning of a single phrase.
Experts claim a pun can change body chemistry and lower stress. (iStock)
This predictable structure makes dad jokes broadly accessible, creating opportunities for shared humor across generations, the researchers said.
Laughter alters internal chemistry by decreasing stress hormones like cortisol and epinephrine, while simultaneously increasing happiness chemicals like dopamine, serotonin and endorphins.
GRANDPARENTS WHO BABYSIT THEIR GRANDCHILDREN STAY MENTALLY SHARPER, NEW STUDY REVEALS
A 2023 review in PLOS One found that a single laughter session could slash cortisol levels by more than 36%. This drop in stress lights up regions like the prefrontal cortex, helping the brain to process complex ideas.
CLICK HERE FOR MORE HEALTH STORIES
Studies have linked pun comprehension to verbal ability, creative thinking and the ability to make connections between different meanings.
Sharing a good laugh can boost oxytocin, a hormone known to deepen emotional bonds between parents and children. (iStock)
“When we see children laugh, we witness the brilliance of the brain in action: learning, connecting and growing,” Jacqueline Harding, PhD, an early childhood expert at Middlesex University in London, told Fox News Digital.
In her book, “The Brain That Loves to Laugh,” Harding states that joy is a complex biological phenomenon that helps children navigate stress and build more resilient, receptive minds.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
“Hope and humor, it seems, are not just the seasoning of life, but foundational to a recipe for healthy development.”
The physical benefit extends directly to the family unit. Sharing a good laugh can boost oxytocin, a hormone known to deepen emotional bonds between parents and children. It also promotes what psychologists call co-regulation, experts say.
Sharing a good laugh can boost oxytocin, a hormone known to deepen emotional bonds between parents and children. (iStock)
This process allows individuals to manage their own stress by drawing on a shared biological store of positive, safe experiences.
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
“Spontaneous, joyful play is an antidote to stress, as it increases levels of endorphins released by the brain,” Harding said.
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
“Creative, happy play does its most brilliant work at a molecular level, especially at a time when the human brain is at its most receptive.”
Health
7 Celebrity Weight Loss Success Stories—From Adele to the Pioneer Woman
Use left and right arrow keys to navigate between menu items.
Use escape to exit the menu.
Sign Up
Create a free account to access exclusive content, play games, solve puzzles, test your pop-culture knowledge and receive special offers.
Already have an account? Login
Health
This one question may reveal whether your body is getting the rest it needs, study finds
NEWYou can now listen to Fox News articles!
Feeling older than your actual age could be a sign that you’re not getting enough quality sleep, according to new research.
A study led by researchers at the National Sleep Foundation and published in the journal Sleep found that adults who felt older than their chronological age were more likely to report insomnia symptoms, irregular sleep patterns and daytime fatigue.
The study involved more than 3,100 adults, who were asked a simple question: “How old do you feel?”
HERE’S WHY 90% OF AMERICANS DON’T SLEEP THROUGH THE NIGHT, ACCORDING TO EXPERT
Researchers then compared participants’ answers with measures of sleep quality, sleep consistency and daytime functioning.
People who felt older than their actual age consistently reported poorer sleep and greater sleep-related impairment than those who felt younger or closer to their chronological age.
Feeling older than your actual age may indicate that you’re not getting enough high-quality sleep, new research suggests. (iStock)
Researchers also found that people who felt older than their age were more likely to report poorer physical health.
Jonathan Alpert, a New York-based psychotherapist and author who was not involved in the research, told Fox News Digital that the findings align with what he frequently sees in his practice.
CLICK HERE FOR MORE HEALTH STORIES
“I’ve worked with many people who come in saying they feel older than they are. They’re exhausted, mentally foggy, less patient, less motivated and generally not functioning at their best,” Alpert said. “Poor sleep is often a major part of the picture.”
Experts say insufficient sleep can make everyday demands feel more overwhelming and reduce a person’s ability to concentrate. (iStock)
Inadequate sleep can make everyday responsibilities feel more difficult and leave people struggling to concentrate, manage stress and maintain their usual energy levels, Alpert said.
Over time, he said, those challenges can contribute to a feeling of premature aging.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
“Many people assume feeling older is just an inevitable part of aging, but sometimes the issue is simply that they’re chronically sleep-deprived,” Alpert said.
For that reason, he suggested looking at sleep habits before assuming fatigue and low energy are simply consequences of getting older.
The findings showed that people who felt older than their chronological age consistently experienced worse sleep and more sleep-related impairment than those who felt younger or closer to their actual age. (iStock)
For now, Alpert said the findings offer a reminder that fatigue should not automatically be blamed on getting older.
While the findings were notable, there are several limitations to consider.
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
The study relied on self-reported survey responses, meaning participants provided information about both their perceived age and sleep habits. The observational design also means the research cannot determine whether poor sleep influences how old a person feels or vice versa.
-
Augusta, GA38 seconds agoBoys & Girls Clubs of Greater Augusta showcases importance of summer programs
-
Washington, D.C8 minutes agoAlan Greenspan, the legendary former Federal Reserve chair, dies
-
Cleveland, OH11 minutes ago3 dead in Lakewood double murder-suicide
-
Austin, TX15 minutes agoPOLL: Do you support proposed changes to Texas’ social studies curriculum?
-
Alabama23 minutes agoCrash Closes Crescent Ridge Road Early Monday Morning
-
Alaska25 minutes agoJuneau couple who helped change LGBTQ+ rights in Alaska reflect on living openly and joyfully
-
Arizona31 minutes agoWhere Brayden Burries, Arizona players are projected to land in final NBA mock drafts
-
Arkansas38 minutes agoArkansas Looking To Do Something it Hasn’t Done To LSU Since Nick Saban Was HC