Health
Seniors taking multiple medications may face unexpected health effects
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Older adults discharged from hospitals on multiple medications are less likely to regain independence during rehabilitation, a new study suggests.
The Japanese study, published in the journal BMC Geriatrics Dec. 17, explored the effects of polypharmacy — defined as taking six or more regular medications on a regular basis — at a convalescent rehabilitation hospital in Japan.
The retrospective observational study looked at 1,903 patients 65 and older who underwent rehabilitation at the hospital from April 2017 to March 2024, according to a press release.
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The patients had one of three conditions: cerebrovascular disease (a disorder of the brain’s blood vessels that reduce or block blood flow), motor disorder (a condition that affects movement and muscle control) or disuse syndrome (inactivity leading to muscle weakness and physical decline).
Of the total group, 62.1% of the patients were taking six or more medications when they were discharged from the hospital, and more than 76% of them were 80 or older.
Older adults discharged from the hospital on multiple medications are less likely to regain independence during rehabilitation, a new study suggests. (iStock)
Those taking multiple medications were also more likely to be taking benzodiazepine receptor agonists (taken for anxiety or insomnia), laxatives and psychotropic medications (mainly used for depression, anxiety, psychosis and other mood disorders).
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The researchers determined that those with polypharmacy who had cerebrovascular disease and disuse syndrome scored significantly lower in the functional independence measure (FIM), which assesses how independently a person can perform everyday activities, especially after illness, injury or hospitalization. Those in the motor disorder group didn’t show any link between polypharmacy and FIM.
The negative effects were stronger among adults over 80 and those recovering from stroke-related conditions or general weakness due to inactivity.
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Based on these findings, the researchers suggest that reviewing and reducing unnecessary medications could help improve recovery for those undergoing rehabilitation.
Dr. Marc Siegel, Fox News senior medical analyst, refers to polypharmacy with seniors as a “risky proposition.”
The retrospective observational study looked at 1,903 patients 65 and older who underwent rehabilitation at a hospital from April 2017 to March 2024. (iStock)
“Even though each medication may have a purpose, often important, we must keep in mind that the ability to tolerate various medications and metabolize them efficiently diminishes as you get older,” he told Fox News Digital.
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“For example, a med that sedates you or even has the potential to disorient you may be more likely to do so as you become elderly.”
Drug interactions also tend to increase as patients grow older, Siegel added.
“This must all be monitored carefully by your physician, and, sometimes, less is more,” he said.
Based on these findings, the researchers suggest that reviewing and reducing unnecessary medications could help improve recovery for those undergoing rehabilitation. (iStock)
The study did have some limitations, the researchers acknowledged. Due to its retrospective and observational design, it does not prove that the medications caused the outcome.
The researchers also lacked data on specific doses of the medications and the intensity of the rehabilitation, they noted. Also, the study was conducted at just a single hospital, so the results may not apply to more general populations.
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Future research is needed to determine which specific medications most affect recovery and to explore the best approaches for reducing prescriptions.
Health
At least 46 children dead amid measles outbreak as virus spreads globally
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Public health officials are warning of measles exposure as the disease spreads on a global scale.
At least 46 children have died in Bangladesh, with about 684 measles cases confirmed in the country since late January, according to Reuters.
Government officials recently announced deaths linked to measles after laboratory testing of 33 samples.
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“Of the tested samples, 15 deaths have been directly linked to measles infection,” said Health Services Division Secretary Kamruzzaman Chowdhury in a statement.
Bangladesh has modified its vaccine schedule after health officials found a significant share of measles cases were occurring in infants younger than 9 months, who are not yet eligible for routine vaccination, according to local reports.
At least 46 children have died in Bangladesh, with about 684 measles cases confirmed in the country since late January. (MH Akash/Drik/Getty Images)
World Health Organization guidance recommends that children receive two doses of the measles, usually given at 9 months of age in countries where measles is common and at 12-15 months in other countries. The second dose should usually be administered at 15-18 months.
In the U.S., as of March 26, 1,575 confirmed measles cases had been reported by the Centers for Disease Control and Prevention.
There have been 16 new outbreaks reported this year, with 94% of confirmed cases deemed outbreak-associated, per the CDC.
As of March 26, 1,575 confirmed measles cases had been reported by the Center for Disease Control and Prevention in the U.S. (iStock)
The agency attributes the spike in measles activity to a trend of lower “herd immunity” in communities — meaning vaccination rates have fallen below the roughly 95% threshold needed to prevent outbreaks.
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“U.S. national MMR coverage among kindergartners has decreased and is now below the 95% coverage target,” the CDC states on its website.
World Health Organization guidance recommends that children should receive two doses of the measles vaccine, usually given at 9 months of age in countries where measles is common and 12-15 months in other countries. (iStock)
Measles symptoms include a high fever, cough, runny nose, watery and red eyes, and a rash that usually appears between three and five days after symptoms start, according to medical sources.
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The rash usually begins as flat red spots that appear on the face at the hairline and spread downward to the neck, torso, arms, legs and feet.
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The airborne virus can spread when someone coughs or sneezes. Measles is known to stay in the air for up to two hours after an infected person leaves the area.
Reuters contributed to this report.
Health
Ozempic Hair Loss? The Real Reason You’re Shedding and How To Fix It
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Health
Fatal drug combination sparks alert as ‘rhino tranq’ spreads across US
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Health and government officials are warning of a potential deadly substance in the illegal drug supply.
The Centers for Disease Control and Prevention (CDC) and the White House Office of National Drug Control Policy (ONDCP) issued a health advisory on Thursday about reports of medetomidine being detected in fentanyl.
Also known as “rhino tranq,” “mede” or “dex,” medetomidine is a veterinary sedative that causes severe, prolonged sedation. Classified as an alpha-2 agonist, it acts on the nervous system similar to other veterinary sedatives, like xylazine, and can cause life-threatening withdrawal symptoms.
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The advisory is based on surveillance data, including forensic drug testing, wastewater analysis, clinical case reports and overdose investigations.
In 2023, there were 247 incidences of medetomidine detected in drug samples, which rose to 2,616 in 2024 and 8,233 in 2025 – a more than 3,000% increase. Forensic drug reports showed that about 98% of medetomidine-positive samples also contained fentanyl.
Health and government officials are warning of a potential deadly substance in the illegal drug suppl (iStock)
The drug has been detected in at least 18 states and Washington, D.C., with a concentration in the Northeast and Midwest regions of the U.S., per the CDC alert.
Dr. Adam Scioli, chief medical officer of Caron Treatment Centers in Pennsylvania, said the alert highlights a “concerning and rapidly evolving development” in the illicit opioid supply.
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“Its co‑occurrence with fentanyl significantly complicates overdose presentation and withdrawal management, further increasing both clinical acuity and unpredictability,” he told Fox News Digital.
“Medetomidine is not routinely detected on standard toxicology screens, increasing the risk of under‑recognition without a high index of clinical suspicion.”
The drug has been detected in at least 18 states and Washington, DC, with a concentration in the Northeast and Midwest regions of the U.S. (iStock)
Naloxone (Narcan), known for its overdose reversal effects, does not counteract medetomidine, the advisory warned.
“While naloxone remains essential for reversing opioid‑induced respiratory depression, it does not address the sedative effects of medetomidine,” Scioli confirmed.
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The initial effects of the drug include deep sedation or decreased consciousness, bradycardia (slow heart rate), hypotension (low blood pressure) and respiratory depression, especially when combined with fentanyl and other opioids.
Withdrawal symptoms typically begin about a few hours after taking medetomidine. They can be severe and rapid, peaking at about 18-36 hours, according to experts.
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Initial withdrawal symptoms include rising blood pressure, tachycardia, agitation and nausea/vomiting, gradually leading to severe hypertension, altered mental status, and possible cardiac or neurologic complications, per the alert.
Severe cases require intensive care in a hospital. “Management may require ICU‑level monitoring and care,” said Scioli.
Naloxone (Narcan), known for its overdose reversal effects, does not counteract medetomidine, the advisory warned. (Reuters/Andrew Kelly)
In a May 2024 example cited by the CDC, medetomidine in the illegal opioid supply was linked to a cluster of overdoses in Chicago, potentially exceeding 175. At least 16 people were hospitalized and one died.
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There were some limitations to the surveillance, the agency acknowledged. Surveillance systems rely on small samples that may not be representative of all areas.
There is also the chance that the numbers could be overestimated due to contamination or repeated use of drug paraphernalia. Conversely, numbers could actually be higher than recorded, as medetomidine is rapidly metabolized in the body and is not typically tested in clinical settings.
An expert noted that the alert highlights the need for “careful assessment beyond standard opioid toxicity models,” as well as close coordination with toxicology, emergency medicine and public health partners. (iStock)
The surveillance was conducted by the CDC with support from federal public health programs and collaboration with other agencies.
Scioli noted that the alert highlights the need for “careful assessment beyond standard opioid toxicity models,” as well as close coordination with toxicology, emergency medicine and public health partners.
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“The drug supply is evolving in ways that strain traditional opioid‑focused frameworks and demand greater clinical vigilance,” he said.
“From a treatment perspective, this is another clear example of why addiction care must be adaptive, medically sophisticated, and grounded in whole‑person, long‑term recovery — not solely acute stabilization,” he added.
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