Health
Science backers say proposed federal research cuts pose dire risks.
Robert F. Kennedy Jr., the nation’s health secretary, has said that tackling a chronic disease “epidemic” would be a cornerstone of his Make America Healthy Again agenda, often invoking alarming statistics as an urgent reason for reforming public health in this country.
On Friday, President Trump released a proposed budget that called for cutting the funding of the Centers for Disease Control and Prevention by almost half. Its chronic disease center was slated for elimination entirely, a proposal that came as a shock to many state and city health officials.
“Most Americans have some sort of ailment that could be considered chronic,” said Dr. Matifadza Hlatshwayo Davis, health director for the city of St. Louis.
Of the proposed cuts, she said, “How do you reconcile that with trying to make America healthy again?”
The federal health department last month cut 2,400 jobs from the C.D.C., whose National Center for Chronic Disease Prevention and Health Promotion runs on the largest budget within the agency.
Programs on lead poisoning, smoking cessation and reproductive health were jettisoned in a reorganization last month.
Overall, the proposed budget would cut the C.D.C.’s funding to about $4 billion, compared with $9.2 billion in 2024.
The budget blueprint makes no mention of the Prevention and Public Health Fund, a $1.2 billion program. If that figure is taken into account, the cut may be even larger than Mr. Trump’s proposal indicates.
The agency would also lose a center focused on preventing injuries, including those caused by firearms, as well as programs for H.I.V. surveillance and prevention, and grants to help states prepare for public health emergencies.
According to the proposed budget, the cuts are needed to eliminate “duplicative, D.E.I., or simply unnecessary programs.” Congress draws up the federal budget, but given the Republican majority and its fealty to Mr. Trump, it is unclear how much his proposal will change.
C.D.C. officials had been told that the functions of the chronic disease center would be moved to a new organization within the health department called the Administration for a Healthy America.
And the proposal released on Friday appears to allocate $500 million to the health secretary in part “to tackle nutrition, physical activity, healthy lifestyles, overreliance on medication and treatments.”
But at the C.D.C., the chronic disease center’s budget was nearly three times as large. And even if part of the chronic disease center is resuscitated in the A.H.A., it’s unlikely that the new iteration would involve C.D.C. scientists relocated from Atlanta.
“The actual subject-matter experts, who administer the programs, might not be there at C.D.C. anymore,” said Dr. Scott Harris, state health officer at the Alabama Department of Public Health. “We certainly don’t have the same level of expertise in my state.”
The department of Health and Human Services did not respond to a request for comment.
The C.D.C.’s chronic disease center ran programs aimed at preventing cancer, heart disease, diabetes, epilepsy and Alzheimer’s disease. But the center has also seeded initiatives farther afield, ranging from creating rural and urban hiking trails to ensuring that healthy options like salads are offered in airports. It also promoted wellness programs in marginalized communities.
Dr. Davis, the health director in St. Louis, said her department was already reeling from cuts to programs to curb smoking and reduce lead poisoning and health disparities, as well as the rescinding of more than $11 billion that the C.D.C. had been providing to state health departments.
“I would take back Covid-19 in a heartbeat over what’s happening right now,” Dr. Davis said.
In the proposed budget, the administration suggested that the eliminated programs would be better managed by states. But state health departments already manage most chronic disease programs, and three-quarters of the C.D.C. center’s funding goes to support them.
Loss of those funds “would be devastating for us,” said Dr. Harris, the health officer in Alabama.
The state has one of the highest rates of chronic diseases in the country, and about 84 percent of the public health department’s budget comes from the C.D.C., Dr. Harris said. About $6 million goes to chronic disease programs, including blood pressure screening, nutrition education for diabetes and promotion of physical activity.
If those funds were cut, “I am at a loss right now to tell you where that would come from,” he added. “It just seems that no one really knows what to expect, and we’re not really being asked for any input on that.”
Minnesota’s vaunted health department has already laid off 140 employees, and hundreds more may be affected if more C.D.C. funding is lost. Cuts to chronic disease prevention will affect nursing homes, vaccine clinics and public health initiatives for Native Americans in the state.
“The actions of the federal government have left us out on a flimsy limb with no safety net below us,” said Dr. Brooke Cunningham, the state’s health commissioner.
Until recently, “there seemed to be a shared understanding at the local, state and federal level that health was important to invest in,” Dr. Cunningham said.
The C.D.C.’s chronic disease center’s work touches American lives in many unexpected ways.
In Prairie Village, Kan., Stephanie Barr learned about the center 15 years ago when, working as a waitress with no health insurance, she discovered a lump in her breast the size of a lemon.
Through the C.D.C.’s National Breast and Cervical Cancer Early Detection Program, she was able to get a mammogram and an ultrasound, and staff members helped her enroll in Medicaid for treatment after a biopsy determined the lump was malignant, Ms. Barr said.
“It was caught in the nick of time,” said Ms. Barr, now 45 and free of cancer.
Since that program began in 1991, it has provided more than 16.3 million screening exams to more than 6.3 million people with no other affordable access, said Lisa Lacasse, president of the American Cancer Society Cancer Action Network.
The organization is one of 530 health associations that have signed a petition asking lawmakers to reject the proposed H.H.S. budget, which cuts discretionary spending by about one-third. The signatories said the cuts would “effectively devastate” the nation’s research and public health infrastructure.
The budget also proposes dismantling disease registries and surveillance systems.
“If you don’t collect the information or keep these surveillance systems going, you don’t know what’s happening, you don’t know what the trends are,” said Dr. Philip Huang, director of Dallas County Health and Human Services in Texas.
“You’re losing all of that history,” he said.
In a previous position as director of chronic diseases for Texas, Dr. Huang said he worked closely with C.D.C. experts who successfully reduced tobacco use among Americans.
“Eliminating the Office on Smoking and Health is just craziness if you’re still wanting to address chronic diseases,” he said.
Smoking is still the leading cause of preventable death in the United States, causing more than 480,000 deaths each year, according to the C.D.C.
More than one in 10 American adults still smoke cigarettes regularly, but rates vary drastically by region, and C.D.C. surveillance helps target cessation programs to areas where they are needed most.
“Smoking rates have come down, but if the federal government takes its foot off the gas, the tobacco companies are ready to pop back up again,” said Erika Sward, assistant vice president for advocacy at the American Lung Association.
She warned that tobacco companies are constantly developing new products like nicotine pouches, whose use by teenagers doubled last year. “It will take a lot more money to put the genie back in the bottle,” she said.
The C.D.C.’s chronic disease center works with communities and academic centers to promote effective programs, from creating quitting hotlines to reach young Iowans in rural areas to training members of Black churches in Columbia, S.C., to lead exercise and nutrition classes for their congregations.
In rural Missouri, dozens of walking trails have been developed in the “boot heel” in the southeastern part of the state, an area with high rates of obesity and diabetes, said Ross Brownson, a public health researcher at Washington University in St. Louis who directs the Prevention Research Center in collaboration with the C.D.C.
“There’s strong evidence now that if you change the walkability of a community, people will get more physical activity,” Dr. Brownson said. “There aren’t going to be health clubs in rural communities, but there is nature and the ability to have walking trails, and land is relatively cheap.”
With C.D.C. support, in Rochester, N.Y., people who are deaf and hard-of-hearing are being trained to lead exercise and wellness programs for other hearing-impaired people who can’t easily participate in other gym classes.
In San Diego, researchers are testing ways to protect farm workers from exposure to ultraviolet rays and heat-related illnesses.
“Once they are up and started, they are community-driven and don’t depend on the government,” said Allison Bay, who recently lost her job managing such projects at the C.D.C.
The C.D.C.’s reorganization also eliminated lead poisoning programs. Lead poisoning is also “one of our greatest public health threats in the city of Cleveland,” said Dr. David Margolius, director of public health for the city.
The C.D.C. does not directly fund Cleveland’s lead programs — the funding comes from the state. “But just having the federal expertise to call on to help lead us toward a lead-free future, I mean, yeah, that has a big impact on us,” he said.
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South Carolina is facing a major measles outbreak, resulting in the quarantine of hundreds of residents.
The South Carolina Department of Health (DPH) reported in a media briefing on Wednesday that the current number of measles cases has reached 111 as part of the current Spartanburg County outbreak.
DPH first reported a measles outbreak in the Upstate region on Oct. 2.
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The health department confirmed that 254 people are currently in quarantine and 16 are in isolation to prevent further spread.
The health department confirmed that 254 people are currently in quarantine in the upstate region. (Getty Images)
“This significant jump in cases is unfortunate,” a DPH spokesperson commented on the outbreak.
Public exposure was identified at Inman Intermediate School, with 43 of their students in quarantine.
“This significant jump in cases is unfortunate.”
Eight other intermediate and middle schools in the area are also reportedly undergoing quarantine. The DPH said multiple students have had to quarantine twice due to repeat exposure.
“Vaccination continues to be the best way to prevent the disruption that measles is causing to people’s education, to employment and other factors in people’s lives and our communities,” the spokesperson said.
“This significant jump in cases is unfortunate,” a DPH spokesperson commented on the current outbreak. (iStock)
Out of the 111 confirmed cases, 105 were unvaccinated. Receiving a vaccination within 72 hours has been shown to prevent measles infection, the DPH spokesperson noted.
Some cases are related to travel exposure, while others are from an unknown source, suggesting that measles is circulating in the community, the DPH noted.
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Connecticut has also reported its first measles case in four years, according to the Connecticut Department of Public Health.
The department confirmed on Thursday that an unvaccinated child in Fairfield County, under the age of 10, was diagnosed with measles after recently traveling internationally.
“Vaccination continues to be the best way to prevent the disruption that measles is causing,” a DPH spokesperson said. (iStock)
The child began to show symptoms several days later, including a runny nose, cough, congestion, fever and a rash starting at the head and spreading to the rest of the body.
The Connecticut DPH noted that measles is “highly contagious” and can spread quickly through the air via coughing or sneezing. The CDC has estimated that nine out of 10 unvaccinated individuals who encounter an infected person will develop the measles virus.
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According to the International Vaccine Access Center, more than 1,800 cases of measles have been reported in 2025, which is the most since the U.S. declared the virus eliminated in 2000. It is also the most cases recorded in three decades.
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“The single best way to protect your children and yourself from measles is to be vaccinated,” DPH Commissioner Manisha Juthani, M.D., wrote in a statement. “One dose of measles vaccine is about 93% effective, while two doses are about 97% effective.”
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A sperm donor whose samples helped conceive nearly 200 children across Europe unknowingly carried a cancer-causing genetic mutation — a hidden risk now tied to multiple childhood illnesses and early deaths.
An investigation led by the BBC and many other public service broadcasters revealed that the donations were made to Denmark’s European Sperm Bank (ESB). Those donations were then used by 67 fertility clinics in 14 countries over a 17-year span.
The donor, who was not identified, was paid to donate as a student beginning in 2005, according to the report.
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Although the donor passed the initial health screenings, he had hidden genetic mutations that damaged the TP53 gene, which helps to prevent cancer by repairing DNA damage or trigger the death of cancer cells.
When TP53 is mutated, those protective functions are lost, which can lead to uncontrolled cell division, accumulation of mutations and tumor growth, research has shown.
A sperm donor whose samples helped conceive nearly 200 children across Europe (not pictured) unknowingly carried a cancer-causing genetic mutation — a hidden risk now tied to multiple childhood illnesses and early deaths. (Getty Images)
Up to 20% of the man’s sperm would contain that mutated gene, and any children conceived from that affected sperm would have the mutation in every cell of their body, the BBC report stated.
As a result, these children would have a 90% risk of developing some type of cancer in their lifetime, including breast cancer, bone cancers, brain tumors and leukemia. This heightened risk is known as Li Fraumeni syndrome.
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Doctors raised these concerns at the annual congress of the European Society of Human Genetics (ESHG), which was held in Milan in May 2025.
At that conference, Edwige Kasper — a specialist in cancer genetics at Rouen University Hospital in France — presented the case of the sperm donor whose genetic material carried the harmful variant.
“This is the abnormal dissemination of genetic disease. Not every man has 75 children across Europe.”
It was reported that 23 children had been confirmed to have the variant at that time, 10 of which had already been diagnosed with cancer.
The actual number is likely much higher, the report surmised, as at least 197 children were born from the donated sperm — but not all data has been collected.
Kasper called for a limit on the number of births or families for a single donor in Europe.
“We can’t do whole-genome sequencing for all sperm donors — I’m not arguing for that,” she said. “But this is the abnormal dissemination of genetic disease. Not every man has 75 children across Europe.”
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She also recommended that children born from this donor’s sperm undergo genetic counseling.
“We have some children that have already developed two different cancers, and some of them have already died at a very early age,” Kasper recently told the investigators.
Up to 20% of the man’s sperm would contain that mutated gene, and any children conceived from that affected sperm would have the mutation in every cell of their body, the BBC report stated. (iStock)
There is no worldwide law that limits how many times a donor’s sperm can be used or how many children may be born from a single donor, according to the European Society of Human Reproduction and Embryology (ESHRE).
However, individual countries may have their own rules or guidelines surrounding sperm donor usage. The ESHRE recently proposed a cap of 50 families per donor as an international limit.
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Dr. Marc Siegel, Fox News senior medical analyst, commented on these developments to Fox News Digital.
“This awful story emphasizes the growing need for up-to-date genetic screening for all donors,” he said. “It also provides context for the idea that knowing the donor provides an advantage.”
“This awful story emphasizes the growing need for up-to-date genetic screening for all donors,” Dr. Marc Siegel said. (iStock)
“Genetic screening, including for oncogenes (genes that have the potential to cause cancer) is improving dramatically, and all use of sperm donations must include it,” Siegel went on.
He also called for AI to be used to improve and speed up the process.
“When a propensity for disease is suspected, the sperm must be discarded,” the doctor added.
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In a statement sent to Fox News Digital, the European Sperm Bank expressed “deepest sympathy” for the families involved.
“We are deeply affected by the case and the impact that the rare TP53 mutation has on a number of families, children and the donor. They have our deepest sympathy,” the ESP said.
The American Society of Reproductive Medicine provided its guidance on embryo and gamete donation, which stated in part that all prospective donors should undergo “appropriate genetic evaluation.” (iStock)
“ESB tests and performs an individual medical assessment of all donors in full compliance with recognized and scientific practice and legislation.”
In the case of this particular sperm donor with the TP53 mutation, the ESB noted that it occurs only in a small part of the donor’s sperm cells and not in the rest of the body.
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“In such cases, the donor himself and his family members are not ill, and a mutation of this type is not detected preventively by genetic screening,” the agency said.
When the ESB later confirmed the mutation in 2023, the donor was “immediately blocked” and authorities and clinics were notified.
“Donors should be healthy and have no history to suggest hereditary disease.”
“The clinics are responsible for informing the patients, partly because we as a sperm bank do not necessarily know the patients, and because the patients’ own treating physicians are best equipped to advise them in the specific situation,” the agency stated.
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When contacted by Fox News Digital, the American Society of Reproductive Medicine (ASRM) provided its guidance on embryo and gamete donation, which stated in part that all prospective donors should undergo “appropriate genetic evaluation.”
“Donors should be healthy and have no history to suggest hereditary disease,” the ASRM continued.
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Parents with concerns are encouraged to contact both their treating clinic and the relevant fertility authority in that country.
GLP-1 weight loss pill in development
Fox News senior medical analyst Dr. Marc Siegel discusses advancements in weight loss drugs, safety concerns surrounding nicotine patches and his interview with FDA Commissioner Dr. Marty Makary on vaccine protocol.
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Scientists in Sweden have created a new pill designed to help the body burn fat and control blood sugar in a different way than popular GLP-1 drugs, like Ozempic.
While injectable GLP-1s work by suppressing appetite, this new treatment boosts metabolism in the muscles.
A study led by researchers at Karolinska Institutet and Stockholm University included both an early animal study and a human clinical trial with 48 healthy adults and 25 people with type 2 diabetes, according to a press release.
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The new oral medication was found to successfully control blood glucose, boost fat burning and retain muscle mass in animals, while getting high marks for tolerability and safety in humans.
It was also found to have fewer side effects than GLP-1s like semaglutides and tirzepatides, which are known to cause appetite loss, gastrointestinal distress and muscle wasting, the researchers noted.
While injectable GLP-1s work by suppressing appetite, this new treatment boosts metabolism in the muscles. (iStock)
The experimental medication uses a new form of beta-2 agonist that benefits muscle function while also avoiding overstimulation of the heart, which has been identified as a potential safety concern of older versions.
The findings were published this week in the journal Cell.
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Because the new oral drug acts via a different mechanism than appetite-suppressing medications, it could be used alone or in combination with GLP-1s, the researchers noted.
“Our results point to a future where we can improve metabolic health without losing muscle mass,” said Tore Bengtsson, professor at the Department of Molecular Bioscience at Wenner-Gren Institute, Stockholm University, in the release. “Muscles are important in both type 2 diabetes and obesity, and muscle mass is also directly correlated with life expectancy.”
“Muscles are important in both type 2 diabetes and obesity, and muscle mass is also directly correlated with life expectancy.” (iStock)
This medication has the potential to be of “great importance” for patients with type 2 diabetes and obesity, according to Shane C. Wright, assistant professor at the Department of Physiology and Pharmacology at Karolinska Institutet.
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“Our substance appears to promote healthy weight loss and, in addition, patients do not have to take injections,” he added.
Dr. Trey Wickham, interim chief of the Division of Endocrinology, Diabetes & Metabolism at VCU Health in Richmond, Virginia, was not involved in the study but shared his reaction to the publication in the journal Cell.
“Our results point to a future where we can improve metabolic health without losing muscle mass.”
“This compound’s mechanism of action could address some specific metabolic concerns with previous weight reduction therapies, such as the loss of both muscle and fat tissue,” Wickham told Fox News Digital.
“Although the reported preliminary results are interesting, rigorous testing involving larger longitudinal trials are necessary to ensure human long-term safety and understand the potential role of this compound in the comprehensive, evidence-based treatment of obesity and diabetes.”
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The study had some limitations, the researchers noted, chiefly that the preclinical studies in mice fail to capture the “complex nature of these diseases” in humans.
Structural studies are needed to understand exactly how the drug works.
“This compound’s mechanism of action could address some specific metabolic concerns with previous weight reduction therapies, such as the loss of both muscle and fat tissue,” a doctor said. (iStock)
“Our phase 1 data show that compound 15 is well-tolerated; however, conclusive clinical efficacy data (on how the drug controls glucose metabolism) are currently still lacking.”
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Looking ahead, the company that developed the drug, Atrogi AB, plans to conduct a larger phase 2 clinical trial with a larger, more diverse population, including people with obesity.
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The study was supported in part by the Swedish Research Council, the Swedish Society for Medical Research and the Novo Nordisk Foundation.
Uppsala University, University of Copenhagen, Monash University and University of Queensland all collaborated with the lead researchers.
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