Health
Pop singer Lance Bass has type 1.5 diabetes, here’s what to know about the disease
Pop singer Lance Bass recently shared on social media that he has type 1.5 diabetes, also known as latent autoimmune diabetes in adults (LADA).
The former NSYNC member was initially diagnosed with type 2 diabetes a few years ago, he wrote in an Instagram post.
“But when I was first diagnosed, I had a difficult time getting my glucose levels under control even though I made adjustments to my diet, my medications and my workout routine,” he said. “Things just weren’t adding up.”
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Bass then revealed what he referred to as a “plot twist.”
“I recently discovered that I was misdiagnosed and I actually have type 1.5, or latent autoimmune diabetes of adults [LADA].”
Fox News Digital reached out to Bass for comment.
What is type 1.5 diabetes?
Type 1.5 diabetes is considered an autoimmune disease in which the body’s immune system mistakenly attacks cells in the pancreas — called beta cells — that secrete insulin, a hormone that helps to regulate glucose levels in the body, according to experts.
The condition is typically diagnosed in individuals age 30 and older and progressively worsens over time.
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“Like type 1 diabetes (T1DM), LADA is an autoimmune disease, but unlike T1DM, the decline in beta-cell function occurs much more slowly,” Dr. Silvana Obici, chief of the Division of Endocrinology at Stony Brook Medicine on Long Island, New York, told Fox News Digital in an email.
The American Diabetes Association (ADA) classifies LADA as a subset of Type 1 — “because they are all characterized by autoimmunity and only differ in the rate of beta cell destruction,” said Obici, who has not treated Bass.
The symptoms of type 1.5 diabetes are similar to those of type 1 and type 2 diabetes, but there are also some differences.
“Although type 1 is often associated with increased thirst, increased urination, increased hunger and weight loss, these symptoms are less common in both LADA and type 2 diabetes,” Dr. Kevin Peterson, vice president of primary care for the ADA, who also has not treated Bass, told Fox News Digital.
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“Both of these conditions can have a slow onset that is characterized by fatigue, urinary tract infections, blurred vision and mild problems that can sometimes be ignored.”
Unlike type 2 diabetes, LADA is associated with a progressive loss of insulin that can’t be controlled by lifestyle changes like diet and exercise, and may not respond to medicines used to treat type 2 diabetes, Peterson added.
Chance of misdiagnosis
Some 10% of adults with type 1.5 diabetes are initially misdiagnosed as having type 2 diabetes, studies show.
With LADA, “the presentation is often slow, making it difficult to distinguish between the two conditions, especially early in the diagnosis,” said Peterson.
Blood tests are available that can identify the type of diabetes, he noted.
Dr. David Lam, an associate professor in the division of endocrinology, diabetes and bone diseases at the Icahn School of Medicine at Mount Sinai in New York, did not comment on Bass’ case, but agreed that type 1.5 diabetes can be misdiagnosed.
Over 1 million Americans are diagnosed with diabetes every year, with approximately 10% of those having type 1.5.
“Testing for the autoantibodies is not standardized for all patients newly diagnosed with diabetes — it typically occurs because the clinician has a degree of suspicion of the diagnosis,” Lam told Fox News Digital.
“This is typically based on elements of the person’s clinical history, such as onset of diabetes at a younger age, lower body mass index, or a family or personal history of other autoimmune conditions,” he added.
Treatment and intervention
Although LADA shares some of the same symptoms as type 1 and type 2 diabetes, experts noted that its treatment can be different.
“Early in the course of type 1.5 diabetes, the pancreas may still make enough insulin, so there may be only mild glucose abnormalities,” Lam told Fox News Digital.
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During this period, treatments traditionally used for type 2 diabetes may work, he noted — “but as the condition progresses, and the pancreas’ ability to produce insulin significantly decreases, injected insulin therapy becomes necessary to control blood glucose levels.”
Treatment is also challenging because type 1.5 diabetes progresses at different rates for each individual and can be difficult to predict, Lam noted.
Specific medications for the disease will depend on the severity of the beta cells’ deficiency, Obici said.
“If the amount of insulin produced by the beta cells is very low, these individuals will require insulin, as with type 1 diabetes,” he told Fox News Digital.
“On the other hand, if the beta cells produce some or a substantial amount of insulin, LADA can be treated with a combination of insulin and other medications used for type 2 diabetes, such as metformin, GLP-1 receptor agonists and DPPIV inhibitors.”
All types of diabetes must be managed with dietary intervention, according to Obici.
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“In T1DM and LADA, dietary intervention is focused on helping to keep glycemia under control and to avoid hypoglycemia,” he said.
“In T2DM, diet and lifestyle modification is focused not only on glycemic control, but also on promoting weight loss.”
Dr. Brian Burtch, an endocrinologist at University Hospitals in Cleveland, Ohio, who was not involved in Bass’ care, told Fox News Digital that his practice sees at least one case of type 1.5 diabetes each month.
For those who are told they have type 2 diabetes and are young, not overweight and not responding to pills, Burtch typically recommends they ask about being tested for type 1.5.
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“As a physician, it is important to always consider this diagnosis in diabetes patients,” he advised.
Approximately 1.2 million Americans are diagnosed with diabetes every year, with some 10% of those having type 1.5, according to the ADA.
Health
Words and game of Scrabble keep married couple in wedded bliss for decades
A married couple who have long enjoyed the game of Scrabble both together and separately before they even met are never at a loss for words — and attribute their wedded bliss in part to their love of the nostalgic game.
They’re still playing in tournaments built around the game decades after they began doing so.
Graham Harding and his wife Helen Harding, both in their 60s, have been married for over 20 years.
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They met in the 1990s at Scrabble tournaments, as news agency SWNS reported.
But it was a “special match” in 2000 that brought the couple together — and has kept them together now.
Graham Harding is from the East Berkshire Scrabble Club, while his wife Helen is from the Leicester Scrabble Club in the U.K.
They have been taking part in the UK Open Scrabble Championship in Reading this week.
“The more words you know, the more ammunition you’ve got.”
“Scrabble is all about having a good vocabulary,” said Graham Harding, SWNS noted.
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“But it is a Scrabble vocabulary — not necessarily everyday English.”
Added Helen Harding, “The more words you know, the more ammunition you’ve got.”
The couple said they were “vague acquaintances” for about five years after they first met.
Then they got together after a special match in Swindon.
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They maintained a long-distance relationship before they got married in 2004.
The couple even brought their Scrabble board to their wedding.
It featured a message with Scrabble pieces that said, “Congratulations on your wedding day” — while their wedding cake said, in Scrabble letters, “Helen and Graham.”
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They each took up the hobby early in life well before they met each other.
The tournament that’s been taking place this week is the first since the COVID pandemic after a five-year break — and the couple has played some two dozen games in it as of Friday, SWNS reported.
Health
Deep sleep can keep two big health problems at bay, new studies suggest
It might be worth working a little bit harder to get that much-desired, but often elusive, good night’s sleep.
Deep sleep clears the mind of waste just as a “dishwasher” cleans dirty plates and glasses, just-published research suggests — and there’s more.
The findings also offer insights into how sleeping pills may disrupt the “brainwashing” system — potentially affecting cognitive function for people over the long run.
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Study senior author professor Maiken Nedergaard of the University of Rochester and the University of Copenhagen said norepinephrine (a neurotransmitter and hormone) triggers blood vessels to contract — generating slow pulsations that create a rhythmic flow in the surrounding fluid to carry away waste, news agency SWNS noted.
Said Nedergaard, “It’s like turning on the dishwasher before you go to bed and waking up with a clean brain. . . . We’re essentially asking what drives this process and trying to define restorative sleep based on” this “glymphatic clearance.”
The brain has a built-in waste removal process – the glymphatic system – that circulates fluid in the brain and spinal cord to clear out waste, according to the scientists.
The process helps remove toxic proteins that form sticky plaques linked to neurological disorders, such as Alzheimer’s disease.
But the scientists indicated that what drives the system was unclear until now, according to the study.
Is all sleep created equal? The researchers wanted to find out.
To find clues, Nedergaard and her team looked into what happens in mice when their brains sleep, as SWNS reported of the study. The team focused on the relationship between norepinephrine and blood flow during deep sleep.
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They found that norepinephrine waves correlate to variations in brain blood volume — suggesting that norepinephrine triggers a rhythmic pulsation in the blood vessels. The researchers then compared the changes in blood volume to brain fluid flow.
The brain fluid flow fluctuates in correspondence to blood volume changes, suggesting the vessels act as pumps to propel the surrounding brain fluid to flush out waste.
Natalie Hauglund of the University of Copenhagen and the University of Oxford, the study’s lead author, said, “You can view norepinephrine as [the] conductor of an orchestra.”
She added, “There’s a harmony in the constriction and dilation of the arteries, which then drives the cerebrospinal fluid through the brain to remove the waste products.”
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Hauglund said she wanted to understand whether all sleep is created equal.
To find out, the research team administered zolpidem, a common drug to aid sleep, to mice.
“If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.”
They found that the norepinephrine waves during deep sleep were 50% lower in zolpidem-treated mice than in naturally sleeping mice.
Although the zolpidem-treated mice fell asleep more quickly — fluid transport into the brain dropped more than 30%, as SWNS reported.
The researchers say their findings, published in the journal Cell, suggest that the sleeping aid may disrupt the norepinephrine-driven waste clearance during sleep.
Hauglund said, “More and more people are using sleep medication, and it’s really important to know if that’s healthy sleep. If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.”
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The research team said the findings likely apply to humans, who also have a glymphatic system, although it requires further testing.
Nedergaard added, “Now we know norepinephrine is driving the cleaning of the brain, we may figure out how to get people a long and restorative sleep.”
For more Health articles, visit www.foxnews.com/health
Meanwhile, a lack of sleep may be doing more damage than just making people groggy.
It could be sabotaging the brain’s ability to keep intrusive thoughts at bay.
Another new study, this one published in the Proceedings of the National Academy of Sciences, found that sleep deprivation weakens the brain’s defense against unwanted memories, allowing them to flood the mind, according to the New York Post.
“We show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep,” the scientists said.
Health
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