A new drug for pancreatic cancer is showing promise in early testing.

Daraxonrasib is a daily pill designed to block cancer signals linked to the RAS gene. It has now finished an early-stage clinical trial — the first time it was tested in people — to evaluate both its safety and effectiveness.

The clinical trial, led by the Dana-Farber Cancer Institute and published in The New England Journal of Medicine, tested the drug in 168 patients with advanced pancreatic cancer whose tumors had mutations in the RAS gene. All study participants had previously received at least one chemotherapy treatment.

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The drug is designed to block multiple active cancer signals that help tumor cells grow. This is especially important because more than 90% of pancreatic cancers carry these harmful mutations, researchers said.

Existing and older drugs that target RAS mutations only work on certain types that are uncommon in pancreatic cancer, such as KRAS mutations.

At the 300-milligram dose — the amount that will be used in larger phase 3 trials — about 30% of patients saw a positive response, researchers noted. Overall, about 90% of patients had their cancer either shrink or stop getting worse.

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There were some side effects reported — most commonly rash, mouth inflammation, nausea and diarrhea.

Lead investigator Dr. Brian Wolpin, director of the Hale Family Center for Pancreatic Cancer Research at Dana-Farber, commented in a press release statement that this development could change the future of cancer care.

“If supported by data from future clinical trials, daraxonrasib would be a targeted therapy relevant to nearly all patients with advanced pancreatic cancer,” he said.

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“This trial provides the first published data showing the safety and broad activity of a RAS(ON) multi-selective inhibitor in pancreatic cancer,” Wolpin went on. “If it proves effective in larger clinical trials, it would signify a substantial shift in how this disease is treated.”

In an interview with Fox News Digital, the researcher claimed that daraxonrasib represents “one of the most promising therapy advances we’ve seen in pancreatic cancer.”

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This is especially significant since pancreatic cancer has had “very few effective therapies” in the past, Wolpin noted.

“The study also showed disease control in approximately 90% of patients with metastatic pancreatic cancer, which is extremely exciting,” he added.

Wolpin noted that while side effects were common, most patients were able to tolerate treatment with “supportive care measures, and very few patients needed to stop therapy due to side effects.”

As this was a phase 1/2 study, it does not “definitively prove” the superiority of daraxonrasib compared to chemotherapy, Wolpin added.

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“The study did not include a randomized control arm that directly compared daraxonrasib with chemotherapy,” he said. “That being said, the results for daraxonrasib looked substantially better than what we have seen in prior clinical trials of chemotherapy in patients with previously treated metastatic pancreatic cancer.”

It also remains unclear how the drug may perform earlier in the disease, as the trial included patients who had already received prior treatments.

For patients and families affected by pancreatic cancer, Wolpin noted that daraxonrasib signals “real momentum” toward effective treatments, but it is still investigational and is not a cure.

“Pancreatic cancer remains a challenging disease, and additional research is needed to determine how best to sequence or combine therapies to provide the most durable responses and cures,” he said.

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Brian Slomovitz, director of gynecologic oncology and co-chair of the Cancer Research Committee at Mount Sinai Medical Center in Miami Beach, applauded this development in a separate interview with Fox News Digital.

“We are anxiously awaiting the upcoming plenary presentation of RASolute 302 at the ASCO meeting later this month,” said the expert, who was not involved in the study. “Greater than 90% of pancreatic cancers have activation of kRAS, which is a major factor in the development and progression of these cancers.” 

“Doubling the survival time in pretreated patients is unprecedented.”

“If the full dataset results that will be reported later this month confirm what was earlier released, I believe this will be one of the most important breakthroughs in all solid tumors,” Slomovitz went on. “Doubling the survival time in pretreated patients is unprecedented.”

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The doctor added that the “magnitude of benefit” could “reshape the treatment landscape” and “establish a new standard of care.”

“We will need to evaluate the full dataset for efficacy and safety,” Slomovitz added. “I am more than cautiously optimistic, and I am truly excited for our patients and their families that suffer from this dreadful disease.”

People who regularly visit museums or participate in creative activities may be aging more slowly on a biological level, according to a new study from the United Kingdom.

Researchers from University College London analyzed data from more than 3,500 adults and found that people who frequently engaged in arts and cultural activities showed signs of slower biological aging in several DNA-based measurements.

The findings were published in the journal Innovation in Aging.

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The study examined activities including painting, photography, dancing, singing, visiting museums and attending cultural events or historic sites.

Researchers compared participation in those activities with “epigenetic clocks,” scientific tools that examine chemical changes in DNA over time.

Adults who participated more often, and in a wider variety of activities, tended to show slower aging scores compared to people who rarely engaged in arts or cultural experiences.

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The association appeared even stronger among adults over age 40.

Researchers also noted that the effect sizes were comparable to those linked to physical activity, one of the most widely studied behaviors associated with healthy aging.

Jessica Mack, a health and wellness expert and founder of The Functional Consulting Group who was not involved in the study, said the findings reflect a growing understanding that health is influenced by more than exercise and nutrition alone.

“Arts and cultural engagement may be associated with slower epigenetic aging, with effects comparable in some measures to physical activity,” Mack told Fox News Digital.

She said activities such as visiting museums and engaging with music or art may help reduce stress, improve emotional regulation and increase social connection.

“These are not ‘extra’ lifestyle activities,” Mack said. “They may be deeply connected to how the body manages inflammation, stress hormones, mood and overall resilience.”

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Mack added that people experiencing stress, social isolation, retirement or caregiving responsibilities may especially benefit from meaningful cultural engagement.

Experts cautioned, however, that the study does not prove arts engagement directly slows aging.

“This is an observational study, not an experiment,” Professor Steve Horvath of UCLA, a longevity researcher and pioneer in epigenetic aging research who was not involved in the study, told Fox News Digital.

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“So when researchers find that the people who go to museums have younger epigenetic age, we cannot tell whether the museum visits slowed their aging, or whether their slower aging is what allowed them to keep visiting museums,” he said.

Horvath said both explanations may be true to some degree, though he described the research as “methodologically careful” and worthy of further study.

The findings remained consistent even after accounting for factors such as smoking, income, body weight and other lifestyle habits.

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He added that regardless of whether arts engagement is directly slowing biological aging, staying socially and mentally active is still associated with healthier aging overall.

“The prescription is the same,” he said. “Keep going.”

Fitness influencer and trainer Mark Langowski, known on social media as @bodybymark, hosted a pushup and plank competition in New York City this week, where he urged the public to get up and get moving.

On his platform of nearly two million Instagram followers, Langowski asks fit people to share their workout routines. He was able to meet more in-shape New Yorkers at his Washington Square Park meet-up, in partnership with Oikos yogurt on May 12.

A male and a female winner who achieved the most pushups or held a plank the longest were gifted $500 each.

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Besides the cash prize, the inspiration was to get more people moving, Langowski shared during an interview with Fox News Digital.

“[It’s] a way to encourage strength and overall fitness in New York City and all around the country,” he said.

“We got together and we’re doing a plank competition, pushup competition. We had a guy just do 111 pushups. We’re just getting people moving.”

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Langowski said the attributes of a great competitor include strength, humility and confidence.

“The people who … did the most, they didn’t say they were going to do the most,” he said. “And there were other people who said they could do 150, and they did 70.”

Having a bit of humility helps make a good competitor, the trainer added.

Pushups and planks mark a “good general baseline” for measuring fitness level, according to Langowski. Some other basics include pull-ups, squats and endurance challenges, like running a mile — the kind of basics included in an elementary school fitness assessment.

For those who haven’t yet mastered these basics but want to get in better shape, Langowski shared some advice on how to get started.

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“Get with a trainer or someone who knows how to progress you,” he advised. “A lot of people are like, ‘I can’t do a pushup, so I’m never going to do one.’ That’s not the way.”

Langowski recommends starting with pushups on your knees or against a wall, then gradually progressing to standard pushups by moving onto your toes and lowering yourself fully to the ground before pushing back up.

“You’ll be surprised after you do that for a couple weeks, a couple months, a couple years – you’re going to be able to do a lot,” he said. “Nobody was born being able to do 111 pushups. They put in the work and they started somewhere.”

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The trainer noted that in addition to practicing, it’s just as important to give the body rest and to support muscle growth with proper protein intake and an overall healthy diet.

But perhaps the most crucial step toward getting in shape, according to Langowski, is having the motivation to get started

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“I know that’s easy for me to say – I’ve been in fitness and been relatively fit most of my life,” he said. “And I know a lot of people are sitting on the couch and they either feel sorry for themselves or they’re going through a tough time … You’ve just got to get out there.”

The trainer suggested starting with a simple walk — even just around the block — with no gym equipment required.

“You don’t need an expensive gym membership to get in good shape,” he said. “Most of the people that I stop on the street, they don’t have a gym membership at all. They do it in their living room.”

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“And that’s where you can do the exercises I mentioned – the squats, the lunges, the pushups,” Langowski went on.

“So, I would encourage people just to start, but also to get some friends or get a trainer, someone to support you and do it safely.”