Health
New cancer therapy hunts and destroys deadly tumors in major breakthrough study
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Scientists at UCLA have developed an “off-the-shelf” cell-based immunotherapy that was able to track down and kill pancreatic cancer cells even after they had spread to other organs.
In a mouse study, the treatment slowed cancer growth, extended survival and remained effective even within the harsh environment of solid tumors.
“Even when the cancer tries to evade one attack pathway by changing its molecular signature, our therapy is hitting it from multiple other angles at the same time. The tumor simply can’t adapt fast enough,” lead author Dr. Yanruide Li, a post-doctoral scholar at UCLA, said in a press release.
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To build the therapy, researchers took human stem cells and turned them into a special type of immune cell called an invariant natural killer T cell (or NKT cell).
Next, they genetically modified those cells by adding a CAR receptor (chimeric antigen receptor), which enables the cells to recognize and attack pancreatic cancer cells.
UCLA scientists created an off-the-shelf CAR-NKT cell therapy that killed pancreatic tumors in multiple pre-clinical models. (iStock)
NKT cells are naturally compatible with any immune system, which means they can enter the body without causing dangerous reactions, according to the researchers. They can also be mass-produced using any donated blood stem cells.
“One donor could provide sufficient cells for thousands of treatments,” potentially offering a more affordable and accessible approach, according to the press release.
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The team tested the therapy in several lab models. These included models where the cancer was placed directly into the pancreas and others designed to mimic how the disease spreads to other organs, like the liver and lungs.
The CAR-NKT cells were able to push their way into the tumor itself, rather than getting stuck on the outside like many immune treatments do, the researchers found.
Researchers emphasized that one dose could cost around $5,000, far lower than personalized CAR-T treatments. (iStock)
Once they got inside the body, these engineered immune cells could spot cancer cells in several different ways and kill them using multiple built-in attack methods.
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Most importantly, they stayed active. Many immune cells that enter a solid tumor quickly become overwhelmed and shut down, but these engineered cells kept working instead of burning out, allowing them to continue fighting the cancer for a longer period.
The findings were published in the journal PNAS (Proceedings of the National Academy of Sciences).
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“Developing a therapy that targets both the primary tumor and its metastases in pre-clinical studies — one that can be ready to use off-the-shelf — represents a fundamental shift in how we might treat this disease,” said senior author Dr. Lili Yang, a professor of microbiology, immunology and molecular genetics at UCLA, in the same press release.
The researchers noted that one dose could cost around $5,000, far lower than personalized CAR-T treatments.
The therapy can be mass-produced from donor stem cells, potentially lowering cost and expanding access. (iStock)
Pancreatic cancer is notoriously aggressive and difficult to treat, according to the researchers. Most patients aren’t diagnosed until the disease has already spread, and the tumor’s biology creates multiple physical and chemical barriers that weaken the impact of traditional treatments.
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Since the therapy targets a protein that is common in breast, ovarian and lung cancers, the same cell product could potentially treat multiple cancer types.
In separate studies, the team has already demonstrated the therapy’s effectiveness against triple-negative breast cancer and ovarian cancer.
Most patients aren’t diagnosed until the disease has already spread, and the tumor’s biology creates multiple physical and chemical barriers that weaken the impact of traditional treatments. (iStock)
Based on the early findings, the UCLA researchers are preparing to submit applications to the Food and Drug Administration to begin human trials.
“We’ve developed a therapy that’s potent, safe, scalable and affordable,” Yang said in the release. “The next critical step is proving it can deliver the same results in patients we’ve seen in our preclinical work.”
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All testing so far has been done in mice, as the researchers noted that solid tumors in humans are far more complex. Human tumors can evolve and lose the targets that treatments are designed to recognize, raising the risk of the cancer escaping detection and continuing to grow.
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Long-term safety and side effects in humans are unknown ahead of clinical trials.
The researchers also noted that making big batches of identical, safe cells poses logistical and regulatory challenges.
Ants can be a nuisance. Just ask officials at a hospital in Canada who are dealing with an “appearance of ants within the operating room” that has forced them to indefinitely suspend some surgeries there.
The ants appeared recently at Carman Memorial Hospital in Carman Manitoba, according to a statement from Southern Health-Santé Sud, the provincial authority that oversees the hospital.
It was not clear when the hospital would resume operations, but Southern Health said on Friday that a “limited number of elective surgeries” had been postponed and that the hospital was working with patients to reschedule them. Portage Online, a local news website, reported that 16 operations had been postponed, citing information from Southern Health.
It’s not the first time ants have disrupted operations at the hospital. The insects appeared there in August 2024, but “the issue resolved within a few weeks,” Southern Health said. They returned last summer. But with their reappearance this week, the hospital said it was taking more drastic measures. The hospital serves the area around Carman, a town with a population of around 3,000 residents about 47 miles southwest of Winnipeg.
“Any factor that could impact the safety or integrity of the operating room environment requires the suspension of surgical activity until the issue can be resolved,” Southern Health said. “The safety of patients, staff and physicians is paramount.”
The hospital is working with exterminators “to identify the source of the ants and implement additional measures and support a long-term resolution.” Southern Health told Portage Online that exterminators had “surveyed and cleaned drains, opened walls and sealed cracks.”
“Several methods have been used to bait the ants in an effort to find where they are originating from,” the authority said.
In a separate statement to the CBC, Southern Health said that it believed that an ant colony had made its home near the hospital and that they appeared to be “simply seeking food sources inside buildings as ants are known to do.”
The hospital also told the CBC that the ant problem at the hospital did not amount to an “infestation.”
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The U.S. government is moving to evacuate American passengers from a cruise ship linked to a deadly hantavirus outbreak, with plans to transport them to a military base in Nebraska for quarantine and monitoring, federal health officials said Friday.
The Centers for Disease Control and Prevention said the risk to the American public remains extremely low as officials move forward with a medical repatriation flight for passengers aboard the M/V Hondius.
President Donald Trump said earlier Friday that the situation appears to be under control, pointing to the virus being difficult to transmit.
“We have very good people looking at it. It seems to be okay. They know the virus very well. They’ve worked with it for a long time. They know it very well. Not easy to pass on. So we hope that’s true,” he said.
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Health workers in protective gear evacuate patients from the MV Hondius cruise ship at a port in Praia, Cape Verde, on May 6, 2026. (Misper Apawu/AP)
“We seem to have things under very good control. They know that virus very well. It’s been around a long time. Not easily transferable, unlike COVID. But we’ll see. We have very good people studying it very closely.”
The outbreak has escalated over several weeks, beginning with a passenger who became sick in early April and later resulting in at least three deaths, according to the World Health Organization.
Cases are now reported across multiple countries after passengers disembarked in Africa and Europe, prompting health officials to trace contacts globally.
Authorities in Cape Verde at one point blocked passengers from leaving the ship, underscoring concerns about containment.
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An ambulance evacuates patients from the MV Hondius cruise ship to the airport in Praia, Cape Verde, on May 6, 2026. (Misper Apawu/AP)
Hantavirus is a rare but potentially deadly disease typically spread through contact with infected rodents or their droppings, according to the CDC. While most strains do not spread between people, health officials say the Andes virus — identified in some cases linked to the cruise ship — is the only known strain capable of limited person-to-person transmission.
The vessel is expected to dock in Spain’s Canary Islands, where international teams are coordinating next steps for passengers and crew.
A CDC team has been deployed to the Canary Islands to assess potential exposure among American passengers and determine monitoring needs.
Returning passengers are expected to be flown on a U.S. government medical repatriation flight to Offutt Air Force Base in Omaha, Nebraska.
Health workers in protective gear evacuate patients from the MV Hondius cruise ship into an ambulance at a port in Praia, Cape Verde, on May 6, 2026. (Misper Apawu/AP)
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They will then be transported to the National Quarantine Center at the University of Nebraska Medical Center for further monitoring.
Additional CDC personnel will be stationed at Offutt Air Force Base to support health assessments.
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From tracking sleep and steps to monitoring heart rate, temperature and stress levels, wearable devices like smartwatches and rings are growing in popularity as wellness tools.
Fox News’ Brian Kilmeade recently used one of these — an Oura ring — to track his metrics from the early morning hours through a demanding work schedule and reported the results live on “Fox & Friends.”
“I just got four hours and one minute [of sleep], but I have some REM sleep, 14%, over 20% of deep sleep. Feeling pretty good, I feel pretty fresh,” Kilmeade shared during his first early morning update, reviewing the stats from his ring.
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Throughout the day, the wearable tracked his physiological responses to various environments, from the stress of a live television broadcast to the physical exertion of a workout.
Wearable devices are changing cardiology’s landscape, helping detect conditions like atrial fibrillation early, a cardiologist said. (iStock)
Kilmeade observed the data in real time, noting, “You see the stress level spike just a little bit … as I make my way over to radio, my activity is going to pick up.”
By the end of his day, which included a trip to West Point and hours spent in a car, the device provided a summary of Kilmeade’s activity levels and heart rate stability.
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Dr. Craig Basman, a New Jersey cardiologist, joined the program to interpret the data and discuss the clinical implications of such technology.
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Basman immediately addressed Kilmeade’s limited rest. “Well, I don’t think you have to be a cardiologist to diagnose him with suboptimal sleep,” he said.
The cardiologist urged users to treat the data as a catalyst for lifestyle changes. (iStock)
However, the doctor highlighted the broader potential of these tools, explaining that “these wearable devices are changing the landscape of cardiology” and that “the future is bright, not just for preventative care … but also screening and detection of actual cardiovascular pathology.”
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The cardiologist urged users to treat the data as a catalyst for lifestyle changes, noting that he wouldn’t recommend detection tools unless you’re “going to do something about it.”
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Regarding the accuracy of the technology, Basman said there is “robust data” to suggest that the numbers are “incredibly accurate” for a lot of the metrics people are viewing, specifically data like resting heart rate and heart rate variability.
Wearable health tech like watches and rings can track sleep, heart rate and stress. (iStock)
He also mentioned that some devices can detect serious conditions like atrial fibrillation, which affects millions and can often go undetected during a standard physical exam.
For younger individuals, wearables can serve as a “great primary prevention tool,” according to the doctor, given that plaque can begin to develop in the arteries as early as the 20s and 30s.
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For the older population, the devices act more as a “screening tool for actual existing cardiac pathology,” he added.
Anyone concerned about wearable health data should consult a doctor for medical guidance.
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