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Largest-ever COVID vaccine study links shot to small increase in heart and brain conditions

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Largest-ever COVID vaccine study links shot to small increase in heart and brain conditions

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The largest COVID vaccine study to date has identified some risks associated with the shot.

Researchers from the Global Vaccine Data Network (GVDN) in New Zealand analyzed 99 million people who received COVID vaccinations across eight countries.

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They monitored for increases in 13 different medical conditions in the period after people received a COVID vaccine.

The study, which was published in the journal Vaccine last week, found that the vaccine was linked to a slight increase in neurological, blood and heart-related medical conditions, according to a press release from GVDN.

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People who received certain types of mRNA vaccines were found to have a higher risk of myocarditis, which is inflammation of the heart muscle.

Some viral-vector vaccines were linked to a higher risk of blood clots in the brain, as well as an increased likelihood of Guillain-Barre syndrome, a neurological disorder in which the immune system attacks the nerves.

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Researchers from the Global Vaccine Data Network in New Zealand analyzed 99 million people who received COVID vaccinations across eight countries. (iStock)

Other potential risks included inflammation of part of the spinal cord after viral vector vaccines, and inflammation and swelling in the brain and spinal cord after viral vector and mRNA vaccines, the press release stated.

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“The size of the population in this study increased the possibility of identifying rare potential vaccine safety signals,” lead author Kristýna Faksová of the Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, said in the release.

“Single sites or regions are unlikely to have a large enough population to detect very rare signals.”

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Doctors react to the findings

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was not involved in the research but commented on the findings.

More than 80% of the U.S. population has received at least one dose of the COVID vaccine, per the CDC. (iStock)

“The massive study and review of the data reveals some rare association of the MRNA vaccines and myocarditis, especially after the second shot, as well as an association between the Oxford Astra Zeneca adenovirus vector vaccines and Guillain Barre syndrome,” he told Fox News Digital.

“But these risks are rare,” he added, “and other studies show that the vaccine decreases the risk of myocarditis from COVID itself dramatically.”

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Siegel noted that all vaccines have side effects.

“It always comes down to a risk/benefit analysis of what you are more afraid of — the vaccine’s side effects or the virus itself, which can have long-term side effects in terms of brain fog, fatigue, cough and also heart issues,” he said.

“Denying or exaggerating a vaccine’s side effects is not good science — nor is underestimating the risks of the virus, especially in high-risk groups,” Siegel added.

“It comes down to a risk/benefit analysis of what you are more afraid of — the vaccine’s side effects or the virus itself.”

The key is for doctors and their patients to carefully weigh the risks and benefits, the doctor emphasized.

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“This study does not really change anything; it just provides much further evidence of what we already know,” he said.

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Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, also reacted to the study’s findings. 

“This study is confirming in a much larger cohort what has been previously identified in the original studies during the pandemic — myocarditis and pericarditis as a rare side effect of mRNA vaccines and clots as a rare side effect of the viral vectored vaccines,” he told Fox News Digital.

Finley Martin, 14, is seen getting a shot of the Pfizer COVID-19 vaccine at the First Baptist Church of Pasadena, May 14, 2021, in Pasadena, California. (AP Photo/Marcio Jose Sanchez, File)

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“The odds of all of these adverse events are still much, much higher when infected with SARS-CoV-2 (COVID-19), so getting vaccinated is still by far the safer choice.”

This study was part of a more widespread research initiative, the Global COVID Vaccine Safety (GCoVS) Project.

The project is supported by Centers for Disease Control and Prevention (CDC), a component of the U.S. Department of Health and Human Services (HHS).

More than 80% of the U.S. population has received at least one dose of the COVID vaccine, per the CDC.

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Fox News Digital reached out to Pfizer and Moderna, makers of mRNA COVID vaccines, for comment.

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Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health

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Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health

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The key to feeling better in a fast, overstimulated world might be surprisingly simple: Live a little more like your grandparents.

A growing social media trend, dubbed “nonnamaxxing,” draws inspiration from the slower, more intentional rhythms associated with an Italian grandmother.

The lifestyle is often linked to activities like preparing home-cooked meals, spending time outdoors and making meaningful connections.

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“Nonnamaxxing is a 2026 trend that embraces the slower, more intentional lifestyle of an Italian grandmother (a Nonna). Think cooking from scratch, long family meals, daily walks, gardening and less screen time,” Erin Palinski-Wade, a New Jersey-based registered dietitian, told Fox News Digital.

Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)

Stepping away from screens and toward real-world interaction can have measurable benefits, according to California-based psychotherapist Laurie Singer.

“We know that interacting with others in person, rather than spending time on screens, significantly improves mental health,” she told Fox News Digital, adding that social media often fuels comparison and lowers self-esteem.

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Living more like previous generations isn’t purely driven by nostalgia. Cooking meals from scratch, for example, has been linked to better nutrition and more mindful eating patterns.

Adopting traditional mealtime habits can improve diet quality and support both physical and mental health, especially when meals are shared regularly with others, Palinski-Wade noted.

One longevity expert stresses that staying healthy isn’t just about food — it’s also about joy and community. (iStock)

There’s also a psychological benefit to slowing down and focusing on one task at a time. Anxiety often stems from unfinished or avoided tasks, Singer noted, and engaging in hands-on activities can counteract that.

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“Nonnamaxxing encourages us to be present around a task, like gardening, baking or knitting, or just taking a mindful walk, that delivers something ‘real,’” she said.

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Palinski-Wade cautions against turning the trend into another source of pressure, noting that a traditional “nonna” lifestyle often assumes a different pace of life.

The key, she said, is adapting the mindset, not replicating it perfectly.

Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)

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The goal is to reintroduce small, intentional moments that make you feel better.

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That might mean prioritizing a few shared meals each week, taking a walk without your phone or setting aside time for a simple hobby, the expert recommended.

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Singer added, “Having a positive place to escape to, through whatever activities speak to us and make us happy, isn’t generational – it’s human.”

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Loneliness may be silently eroding your memory, new research reveals

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Loneliness may be silently eroding your memory, new research reveals

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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.

Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.

Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.

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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.

Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)

“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.

The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.

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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.

Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)

Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.

About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.

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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.

The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.

Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)

Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.

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“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.

“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.

By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)

He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.

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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.

Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.

“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)

Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.

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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”

Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.

Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)

She said staying socially and mentally engaged is crucial for overall brain health.

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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”

The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.

Fox News Digital reached out to the researchers for comment.

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day


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Eat More To Lose Weight? How Small Meals Boost Fat Burn




















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