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Higher-dose naloxone spray doesn't increase overdose survival, study finds

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Higher-dose naloxone spray doesn't increase overdose survival, study finds
  • A study comparing a new, higher-dose nasal spray for opioid overdoses to the standard dose found no increase in survival rates but more side effects.
  • The 8-milligram naloxone spray, approved two years ago, was compared to the previous standard dose in rural parts of New York.
  • The study, published by the CDC, found no added benefit from the higher dose, with survival rates remaining the same.

A new, higher-dose nasal spray for reversing opioid overdoses did not save more lives than the previous standard dose, but it did cause more vomiting and other side effects, researchers wrote in a study published Thursday.

The 8-milligram naloxone spray — twice as potent as the highest dose previously available — was approved two years ago after pressure from experts and patient advocates who noted lower-dose antidotes often were being given multiple times to people suffering overdoses.

The new study, which was limited to more rural parts of New York state, is being called the first to provide real-world data on the differences between the two sprays. The paper was published by the Centers for Disease Control and Prevention, but the federal health agency was not involved in the research.

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The higher-dose “did not provide added benefit,” the authors wrote.

Naloxone, used to treat narcotic overdoses, is seen at a safe injection site at OnPoint NYC on Jan. 24, 2022 in New York, NY. A new, higher-dose nasal spray for reversing opioid overdoses did not save more lives than the previous standard dose, but it did cause more vomiting and other side effects. (Kent Nishimura / Los Angeles Times via Getty Images)

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“What was really remarkable was the survival was the same, but the amount of withdrawal symptoms was significantly larger in the people that got the 8-milligram dose,” said one of the authors, Dr. Michael Dailey of Albany Medical College.

Dailey said the study did not lead him to endorse one product over another. But, he said, “its important for us to recognize that the potential for increased side effects is real.”

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The researchers worked with the New York State Police, who respond to emergencies along highways and in rural areas.

Three troops in eastern New York were given 8-milligram sprays. Eight troops based further away from Albany were stocked with 4-milligram doses. The study results were based on 354 instances in which troopers administered naloxone sprays from late March 2022 to mid-August 2023.

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In cases where overdose patients were still alive when troopers arrived, 99% survived after getting naloxone, no matter which dose was given.

People who got 4-milligram sprays usually got more than one dose — 1.67 doses on average, equivalent to 6.7 milligrams. But so too did those treated with the 8-milligram sprays, who got 1.58 doses, or 12.6 milligrams, on average.

In both groups, disorientation and lethargy were common when people came to.

But other problems were significantly more common in the patients who got the higher-dose sprays. About 38% experienced signs and symptoms of withdrawal, including vomiting, abdominal pain, sweating, shaking and diarrhea. Only 19% of those getting the lower dose had those problems, the study found.

NALOXONE GROWING ON COLLEGE CAMPUSES AS OPIOID OVERDOSES CONTINUE

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That’s a concern because it could actually contribute to future overdose deaths, said Dr. Alexander Walley, a Boston Medical Center addiction specialist who also works with the Massachusetts health department.

If someone has extra withdrawal symptoms when they are rescued from an overdose, they may remember the pain and discomfort of that experience and — experts fear — might actually avoid having someone with naloxone around when they take drugs in the future, Walley said.

The study is limited and imperfect in how it randomized who got which doses, Walley said, but it’s nevertheless “good quality evidence.”

“The solution to a more potent (illicit) drug supply is not necessarily a more potent naloxone,” he said. “It’s having people be witnessed when they use the drugs, and have that witness be someone who can administer naloxone and call for help.”

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day


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Eat More To Lose Weight? How Small Meals Boost Fat Burn




















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Intermittent fasting’s real benefit may come after you start eating again

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Intermittent fasting’s real benefit may come after you start eating again

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Research continues to uncover new details on how fasting may help extend life.

A new study published in the journal Nature Communications investigated how intermittent fasting can boost longevity in small worms often used in aging research.

Researchers from the University of Texas Southwestern Medical Center in Dallas compared worms that were fed normally to those that underwent a 24-hour fast in early adulthood and were then fed again, according to a press release.

POPULAR INTERMITTENT FASTING DIETS MAY NOT DELIVER THE HEALTH BENEFITS MANY EXPECT

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The scientists measured a variety of factors, including stored fat, gene activity related to fat metabolism and lifespan.

The results showed that the life-boosting benefit did not depend on the fasting itself but on the body’s behavior after eating again.

Experts say sustainability is key when choosing a long-term weight-loss strategy. (iStock)

Study lead Peter Douglas, associate professor of molecular biology and a member of the Hamon Center for Regenerative Science and Medicine at UT Southwestern, suggested that these discoveries “shift the focus toward a neglected side of the metabolic coin – the re-feeding phase.”

“Our data suggest that the health-promoting effects of intermittent fasting are not merely a product of the fast itself, but are dependent on how the metabolic machinery recalibrates during the subsequent transition back to a fed state,” he said.

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“Our findings bridge a gap between lipid metabolism and aging research,” he added. “By targeting aging, the single greatest risk factor for human disease, we move beyond treating isolated conditions toward a preventive model of medicine that enhances quality of life for all individuals.”

Lauri Wright, director of nutrition programs at the University of South Florida’s College of Public Health, called this a “high-quality” study that adds an “important nuance to how we think about fasting and longevity.”

Intermittent fasting typically involves limiting meals to an eight-hour daily window or fasting every other day. (iStock)

The benefits of the refeeding phase after fasting were “especially interesting,” Wright, who was not involved in the study, told Fox News Digital.

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“The researchers showed that longevity was linked to the body’s ability to turn off fat breakdown after fasting, allowing cells to restore energy balance,” she reiterated.

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“From a scientific standpoint, that’s a meaningful shift because it suggests fasting is not just about burning fat, but about metabolic flexibility.”

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Fasting may support longevity through triggering metabolic switching, enhancing cellular repair and stress resistance and improving markers like insulin sensitivity, research shows.

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Limitations and cautions

Although this study provides “important insight” on the power of refeeding, Wright noted that the findings should be approached with caution, as the study was done on worms and cannot always be translated to humans.

“Additionally, it explains how a process might work in a controlled lab condition rather than real-world eating behaviors,” she added as a limitation. “Finally, the study is short-term and doesn’t give us the long-term translation on lifespan outcomes.”

The review found intermittent fasting was barely more effective than doing nothing, according to the study authors. (iStock)

Wright cautioned that fasting is “not a magic solution for longevity, and how you eat overall matters more than when you eat.”

“I advise, first and foremost, to focus on diet quality, including a variety of fruits and vegetables, healthy fats and minimally processed foods,” she said.

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For those who are considering fasting, it’s better to stick with a moderate plan — like a 12- to 14-hour overnight fast — rather than going to extremes, Wright said. After fasting, she recommends focusing on well-balanced meals.

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Several groups of people should be cautioned against fasting, according to Wright, including those with diabetes who are on insulin or hypoglycemic medications, those who are pregnant or breastfeeding, anyone with a history of eating disorders and older adults at risk of malnutrition.

Anyone considering intermittent fasting should consult with a doctor before starting.

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Cheap surgery overseas may come with devastating complications, doctors warn

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Cheap surgery overseas may come with devastating complications, doctors warn

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More than three million people travel to undergo cosmetic surgery each year, statistics show — but the potential savings come at a cost.

Most people opting to pursue this so-called “medical tourism” are chasing budget-friendly price tags. 

International surgeries, such as hair transplants in Turkey, can cost as little as $4,000 to $5,000 compared to $20,000 to $30,000 in the U.S., but often come with extreme risks, according to board-certified plastic surgeon Dr. Sheila Nazarian of California.

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The doctor recently joined Lisa Brady on the “The FOX News Rundown” podcast to discuss the rising trend of medical tourism. One of the biggest risks, she said, is the lack of safety regulations in popular destinations like Mexico and Turkey.

As demand spikes in these medical tourism “mills,” there have been reports of non-medically trained staff performing procedures like hair transplants.

Most people opting to pursue “medical tourism” are chasing budget-friendly price tags.  (iStock)

“I’ve heard that they [international clinics] are even recruiting people who maybe were taxi drivers and then putting them through their own training program … to become hair transplant technicians,” Nazarian said. “That’s how high the demand has become.”

In the U.S., medical school graduates are granted a “physician and surgeon” license, which means doctors — including pediatricians or OB-GYNs — can legally perform cosmetic surgeries, even if they didn’t receive specialized training for those procedures during residency, Nazarian noted.

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Instead of pinching pennies, the doctor recommended paying whatever amount is necessary to ensure quality treatment.

“People think of it as, you know, going to the mall. … It’s surgery, and surgery has risks,” she said. “You need to be with someone who not only can perform a beautiful surgery, but who can handle possible complications well.”

“You need to ask them: ‘What was your residency training in? And if you wanted to, would you be allowed to do this procedure in a hospital?’”

Aftercare is another critical factor in the success and safety of a cosmetic procedure, as the doctor emphasized that 20% of a surgical result depends on post-operative care.

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This can be difficult or even impossible to manage when a doctor is in a different time zone, she cautioned, or if the clinic disappears shortly after the procedure.

Nazarian also noted the importance of addressing the psychological component of plastic surgery, noting that no procedure will fix underlying unhappiness. The doctor said she uses screening questionnaires to ensure that patients are truly seeking self-improvement rather than a “cure” for deeper issues.

International surgeries, such as hair transplants in Turkey, can cost as little as $4,000 to $5,000 compared to $20,000 to $30,000 in the U.S., but often come with extreme risks. (iStock)

“If you’re not already generally very content with your life, a knife in my hand is not going to bring you there,” Nazarian said.

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“The analogy I always give is you don’t want a paisley couch — you want a neutral couch and you can put paisley pillows on it,” she said, noting that a procedure should “make you look normal, God-given, athletic. And then you can change your clothes when the trends come and go.”

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Samuel Golpanian, M.D., a double board-certified plastic surgeon in Beverly Hills, said he has also seen an increasing number of patients undergoing cosmetic procedures abroad, sometimes with “devastating consequences.”

“The key is being extremely careful before embarking on this journey.”

“I’ve seen a wide range of complications, including infections, poor wound healing, significant scarring and tissue necrosis (skin death),” he told Fox News Digital. “These complications often lead to prolonged pain, ongoing medical problems, and significant additional costs to repair the damage.”

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Golpanian said he’s treated patients who received unsafe or non-medical-grade injectable materials, which can lead to serious long-term health issues.

One surgeon said he’s treated patients who received unsafe or non-medical-grade injectable materials, which can lead to serious long-term health issues. (iStock)

“I’ve also seen damage to underlying structures, asymmetry and results that are extremely difficult — sometimes impossible — to correct.”

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“That said, I’ve also seen some good outcomes, so it’s not all bad,” he noted. “The key is being extremely careful before embarking on this journey.”

Quick tips for safe ‘medical tourism’

Fully vet the surgeon. “Most surgeons will provide information about their education and training, but it’s important not to accept these claims at face value,” Golpanian said. “Verify them directly by contacting the institutions where they trained.”

Ask for references from prior patients. Ideally, it’s best to get references from U.S.-based patients who can speak candidly about both their experience and their results, the surgeonsaid.

Think beyond the cost. Golpanian emphasized the adage “you get what you pay for.” “Cost should take a back seat to experience, training, judgment and proven results,” he advised.

Be cautious about relying on before-and-after photos. These can be selective or even enhanced, Golpanian warned.

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Keep aftercare in focus. “Make sure the practice emphasizes comprehensive follow-up care and has a clear, realistic post-operative plan in place.”

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