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Heart attack risk could rise with artificial sweetener consumption, study finds

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Heart attack risk could rise with artificial sweetener consumption, study finds

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A common artificial sweetener has been linked to an increased risk of heart attacks and strokes, according to a new study from Cleveland Clinic.

Erythritol, a sugar alcohol that is used to sweeten many low-sugar, reduced-calorie drinks and foods — particularly in low-carb or “keto” diets — was found to cause a spike in blood platelets and blood clot formation, researchers say.

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The findings were published in the journal Arteriosclerosis, Thrombosis and Vascular Biology.

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The team’s previous study, which appeared in Nature Medicine, found that heart patients with high levels of erythritol in their system had double the risk of experiencing a major cardiac event within three years.

“In this study, we directly compared drinking a sweetened drink with either 30 grams of glucose, which is sugar, or 30 grams of erythritol,” senior author Stanley Hazen, M.D., PhD, co-section head of preventive cardiology at Cleveland Clinic, said in a video provided to Fox News Digital.

A common artificial sweetener has been linked to an increased risk of heart attacks and strokes, according to a new study from Cleveland Clinic. (iStock)

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The small study consisted of 20 healthy volunteers, averaging 30 years of age, whose blood was drawn after an overnight fast.

The participants drank water mixed with either 30 grams of erythritol (comparable to the dose in an artificially sweetened soda or baked good) or 30 grams of glucose.

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After 30 minutes, another blood draw assessed the participants’ plasma levels of erythritol as well as platelet function.

Those who consumed the artificial sweetener were found to have more than 1,000 times the erythritol level of those who consumed sugar.

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Erythritol, a sugar alcohol that is used to sweeten many low-sugar, reduced-calorie drinks and foods, was found to cause a spike in blood platelets and blood clot formation. (iStock)

“There is every reason to believe that after drinking the erythritol, there is a heightened risk of clotting, or thrombosis” — which could heighten the chances of heart attack or stroke, Hazen said.

That effect was not seen with the patients who drank glucose.

“It looks like it’s safer to drink a glucose-sweetened drink rather than an erythritol-sweetened drink.”

“Based on the current data, it looks like it’s safer to drink a glucose-sweetened drink rather than an erythritol-sweetened drink,” Hazen said.

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“I recommend my patients avoid the artificial sweeteners and sugar substitutes, to try to eat whole foods, to stay away from processed foods and to shop the produce section.”

Approximately 65% of adults in the United States consume sugar-sweetened beverages daily, statistics show. (iStock)

For those who do want to sweeten a food or drink, Hazen would recommend — based on the data — using honey or fruit instead of artificial sweetener.

This same effect has been observed with other sugar alcohols, the doctor noted.

Erythritol is classified by the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority as GRAS (“generally recognized as safe”).

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Other than the “bare minimum,” there is no mandate in place for this to be tested for safety, Hazen said.

“I would like to see regulatory bodies reevaluate the safety of the use of sugar alcohols.”

Further clinical studies are needed to measure the long-term cardiovascular safety of erythritol, according to the researchers.

“I recommend my patients avoid the artificial sweeteners and sugar substitutes, to try to eat whole foods, to stay away from processed foods and to shop the produce section,” the lead researcher said. (iStock)

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Dr. Bradley Serwer, a cardiologist and chief medical officer at VitalSolution, a Cincinnati, Ohio-based company that offers cardiovascular and anesthesiology services to hospitals, was not involved in the study but said that it raises “significant concerns.”

“Many artificial sweeteners have been studied and historically have been sold as healthy alternatives to sugar, but they have often been found to have significant side effects,” he told Fox News Digital. 

POPULAR ARTIFICIAL SWEETENER, ERYTHRITOL, COULD RAISE RISK OF HEART ATTACK AND STROKE: STUDY

“There have been other studies showing that erythritol increases platelet activity, which leads to abnormal blood clot formation.”

Several other sugar substitutes, such as xylitol, have also been linked to adverse health consequences, according to Serwer.

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“In addition to increasing the risk of cardiovascular events, these artificial sugars often trick the body into producing more insulin,” he noted. 

Several other sugar substitutes, such as xylitol, have also shown adverse health consequences, according to a cardiologist. (iStock)

“Insulin increases sweet cravings, so people crave more sugar after eating artificial sweeteners, thus causing a negative impact that can lead to metabolic syndrome.”

In his cardiology practice, Serwer said his patients often seek healthier alternatives to high-calorie, sugary foods.

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“It is important to inform them that it may be better to avoid these sugar alcohols altogether,” the cardiologist said.

He said he hoped “this data will cause the FDA to reevaluate the safety of erythritol.”

Industry group urges ‘extreme caution’

The Calorie Control Council (CCC), an international association that represents the low- and reduced-calorie food and beverage industry, advised consumers to interpret Cleveland Clinic’s study with “extreme caution.”

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“The limited number of participants were given an excessive amount of erythritol, nearly double to triple the maximum amount approved in any single beverage in the United States based on a standard 8-16 oz serving,” Carla Saunders, president of the Washington, D.C.-based CCC, said in a statement sent to Fox News Digital.

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“For 30 years, science has shown that erythritol is a proven safe and effective choice for sugar and calorie reduction,” stated the Calorie Control Council. (iStock)

Erythritol levels were only measured once after consumption, she pointed out. 

“The pilot lacked control over lifestyle factors that may affect the outcome, which could introduce confounding variables and impact the reliability of the findings,” Saunders added. 

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“Further, as erythritol levels were only measured at baseline and 30 minutes after consumption, there is no way to demonstrate any lasting effect of excessive consumption on any health outcome,” she also said. 

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“For 30 years, science has shown that erythritol is a proven safe and effective choice for sugar and calorie reduction.”

Fox News Digital contacted Cleveland Clinic for comment on the CCC’s position.

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How much red meat is too much? Experts weigh in on food pyramid updates

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How much red meat is too much? Experts weigh in on food pyramid updates

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The release of an updated food pyramid this week has sparked mixed reactions from doctors and dietitians.

One of the most noteworthy shifts in the 2025-2030 Dietary Guidelines for Americans — announced by HHS officials during a Jan. 7 press conference at the White House — is a greater emphasis on “high-quality proteins,” including red meat and eggs, as well as full-fat dairy.

The new guidelines focus on “real, whole, nutrient-dense foods,” and a dramatic reduction in highly processed foods, added sugars, refined carbohydrates and unhealthy fats.

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“Protein and healthy fats are essential and were wrongly discouraged in prior dietary guidelines,” Health Secretary Robert F. Kennedy Jr. said during the press conference. “We are ending the war on saturated fats.”

Nick Norwitz, a Harvard- and Oxford-trained researcher known for his work in metabolic health, shared his reaction to the new guidelines.

The release of an updated food pyramid this week has sparked mixed reactions from doctors and dietitians. (realfood.gov)

Despite how the new pyramid is presented, he noted, the actual guidelines for saturated fat consumption haven’t changed, as they still state that, “in general, saturated fat consumption should not exceed 10% of total daily calories.”

The intake of unprocessed whole foods rich in saturated fat, especially dairy fat, tends to be associated with improved health outcomes, according to Norwitz.

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“Full-fat dairy — especially cheese, for example — tends to be associated with lower BMI, reduced rates of diabetes and even reduced dementia risk,” he told Fox News Digital. “There are, of course, nuances — but ‘ending the war’ on saturated fat seems reasonable.”

Risks vary, experts say

Experts cautioned about the potential health risks of exceeding the recommended intake of saturated fat, including higher rates of LDL “bad” cholesterol, which is known to increase the risk of cardiovascular disease.

“The recommendation to limit saturated fat to 10% of total calories is based on the research showing that higher rates increase LDL cholesterol and associated risks for cardiovascular disease,” Sherry Coleman Collins, a food allergy dietitian and expert from the Atlanta metropolitan area, told Fox News Digital. 

One of the most noteworthy shifts in the 2025-2030 Dietary Guidelines for Americans is a greater emphasis on “high-quality proteins” — including red meat and eggs — as well as full-fat dairy. (iStock)

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Nutrition should be personalized and is dependent on multiple factors, she said, including age, gender, activity level and genetic risk factors.

“The total saturated fat an individual might safely consume is influenced by their size and total calorie needs, as well as potentially genetic differences,” Coleman Collins said.

Norwitz agreed, adding that “the specific food source and interaction with the unique host and their broader dietary context should take the spotlight.”

Dr. Pooja Gidwani, a double board-certified doctor of internal medicine and obesity medicine in Los Angeles, pointed out that not everyone has the same “tolerance” for saturated fats.

“If increasing saturated fat leads to a meaningful rise in LDL cholesterol or ApoB (Apolipoprotein B, a protein found on the surface of certain cholesterol-carrying particles in the blood), that intake level is excessive for that individual, regardless of improvements in weight or glucose metrics,” she said.

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“This personalized approach becomes increasingly important in midlife and beyond, when cardiovascular disease becomes the dominant driver of morbidity and mortality and when tolerance for cumulative atherogenic (artery-clogging) exposure is lower.”

For those who need to reduce LDL cholesterol or have a higher cardiovascular risk, the American Heart Association recommends an even lower amount of saturated fats — less than 6% of total daily calories.

Experts cautioned about the potential health risks of exceeding the recommended intake of saturated fat, including higher rates of LDL “bad” cholesterol. (iStock)

Gidwani also cautioned that diets emphasizing saturated fat could crowd out fiber and unsaturated fats, “both of which play independent roles in cholesterol clearance, insulin sensitivity, gut health and inflammation.”

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“Saturated fat-heavy patterns are also calorie-dense, which can quietly undermine long-term weight management if intake is not carefully regulated,” she added.

Not all saturated fats are equal, experts say

The effects of saturated fat depend on what specific foods are being consumed, according to experts.

“I would recommend choosing minimally processed or unprocessed forms of foods,” said Tanya Freirich, a registered dietitian nutritionist in Charlotte, North Carolina. “For example, in place of a hot dog — which has additives, nitrites, sodium and fillers — consuming a chicken thigh would be a much better choice.”

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Gidwani reiterated that the amount of processing plays a big role.

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“Processed meats are consistently associated with worse cardiometabolic outcomes and represent the clearest category to limit,” she said. “The risk here is not only saturated fat, but also sodium load, preservatives and the broader dietary pattern they tend to accompany.”

“Full-fat dairy — especially cheese, for example — tends to be associated with lower BMI, reduced rates of diabetes and even reduced dementia risk,” an expert told Fox News Digital. (iStock)

Unprocessed red meat, the doctor said, can fit into an overall healthy diet in smaller amounts, particularly when consumed alongside fiber-rich plants and minimally processed foods.

“However, from a longevity perspective, it should be viewed as optional rather than foundational, especially for individuals with elevated cardiovascular risk,” she added.

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When it comes to dairy, Gidwani noted that fermented options are “metabolically more favorable” than butter or cream.

“However, saturated fat from dairy is still not necessary to prioritize for metabolic health or longevity,” she said. “Excessive reliance on dairy fat can displace healthier fat sources without offering clear long-term benefit.”

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Overall, the doctor recommends unsaturated fat sources, including extra virgin olive oil, nuts, seeds, avocado and omega-3-rich fish, as primary dietary fats.

“These consistently support lipid profiles, insulin sensitivity and vascular health,” Gidwani said. “Saturated fat can exist within a balanced diet, but it should remain secondary rather than emphasized.”

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Why the big picture matters

Saturated fat is just one piece of a much wider nutrition puzzle, the experts agreed.

Unprocessed red meat can fit into an overall healthy diet in smaller amounts, particularly when consumed alongside fiber-rich plants and minimally processed foods, one expert said. (iStock)

“Our heart health is not determined by one type of fat or one type of cholesterol, but the sum of many parts — our entire diet, our exercise habits, our stress and so much more,” Freirich said.

She recommends consulting a registered dietitian for guidance on unique dietary needs based on age, gender, activity level and medical history.

“Our heart health is not determined by one type of fat or one type of cholesterol, but the sum of many parts — our entire diet, our exercise habits, our stress and so much more,” said an expert.  (iStock)

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New Jersey-based dietitian Erin Palinski-Wade, author of “2-Day Diabetes Diet,” added that the message should be to focus more on overall patterns.

That means “plenty of fiber-rich plants, lean protein at every meal (including those that also contain fiber, such as nuts and seeds) and a reduction in overall intake of added sugars.”

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“That change will drive true health improvements,” she said.

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Missing sleep may take a hidden toll on your brain and longevity, research reveals

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Missing sleep may take a hidden toll on your brain and longevity, research reveals

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Missing out on adequate sleep could be taking years off your life.

New research from the Oregon Health & Science University (OHSU), published in the journal Sleep Advances, found that poor sleep may shorten life expectancy more than other lifestyle factors like diet, exercise and loneliness.

The researchers analyzed nationwide CDC survey data, identifying trends associated with average life expectancy by county, according to a press release.

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The study found that lack of adequate sleep led to higher mortality risk in every U.S. state and was the top behavioral driver compared to other factors, only behind smoking.

Senior study author Andrew McHill, Ph.D., associate professor and director of the Sleep, Chronobiology, and Health Laboratory in the OHSU School of Nursing, noted in a statement that he did not expect sleep to be “so strongly correlated” to life expectancy.

Poor sleep is directly correlated with shorter life expectancy, the study reveals. (iStock)

“We’ve always thought sleep is important, but this research really drives that point home: People really should strive to get seven to nine hours of sleep, if at all possible,” he said.

“This research shows that we need to prioritize sleep at least as much as we do [in] what we eat or how we exercise.”

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In a previous interview with Fox News Digital, Dr. Daniel Amen, psychiatrist and owner of Amen Clinics in California, emphasized how important sleep is for brain function and longevity.

Researchers suggest people should prioritize sleep just as much as diet and exercise. (iStock)

“Sleep is so important,” he said. “When you sleep, your brain cleans and washes itself. And if you don’t sleep seven to nine hours at night, your brain looks older than you are — there’s less blood flow, and it increases inflammation in the brain.”

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“Your brain doesn’t have enough time to get rid of the toxins that build up during the day.”

Lack of adequate sleep can lead to poor decisions and foster toxic cycles, the doctor warned. 

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“If your brain has less activity in the front part, not only are you tired, but you’re also hungrier, and you’re more likely to not make the best decisions,” he said. 

“Which, of course, will stress you out, and then you won’t sleep well the next night.”

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A doctor suggests being “purposeful” about going to bed and waking up each day. (iStock)

One small change to promote longevity and brain health is to try getting to bed 15 minutes earlier, Amen suggested.

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“Really be purposeful about not being distracted by Netflix or your phone,” he said.

“And when you get up in the morning, say to yourself, ‘Today is going to be a great day.’ The more positive you are, the better your brain.”

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