Health
For Alzheimer’s patients, eating pomegranates could help alleviate symptoms, study says: ‘Promising results’
Are pomegranates the next brain food?
The link between diet and dementia has been well-documented, and now researchers at the University of Copenhagen and the U.S. National Institute on Aging have found that eating more pomegranates, strawberries and walnuts could help improve memory among Alzheimer’s patients.
Those foods contain a substance called urolithin A, a compound created by gut bacteria.
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“Our study on mouse models with Alzheimer’s disease shows that urolithin A, which is a naturally occurring substance in pomegranates, can alleviate memory problems and other consequences of dementia,” said Vilhelm Bohr, affiliate professor at the Department of Cellular and Molecular Medicine at the University of Copenhagen, in a press release.
In patients with neurodegenerative diseases such as Alzheimer’s, the brain has trouble removing weak mitochondria, which builds up and impairs brain function.
Utolithin A has been shown to remove weak mitochondria from the brain, thus restoring cognitive function, the researchers found.
The study findings were published in the journal Alzheimer’s and Dementia.
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Researchers aren’t sure how much of the substance is needed to achieve positive results.
“We still cannot say anything conclusive about the dosage, but I imagine that it is more than a pomegranate a day,” Bohr said.
“However, the substance is already available in pill form, and we are currently trying to find the right dosage.”
Utolithin A could ideally be used as a safe way to prevent neurological diseases, he noted.
“The advantage of working with a natural substance is the reduced risk of side effects,” he said.
“Clinical trials with Urolithin A have been effective in muscular disease, and now we need to look at Alzheimer’s disease.”
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Based on the “promising results” seen in the mouse models, the researchers are planning to conduct clinical trials on humans.
Tanya Freirich, a registered dietitian nutritionist in Charlotte, North Carolina, was not involved in the study but shared comments on the findings.
“Long-term urolithin A treatment significantly improved learning, memory and olfactory function (smelling) in mice,” she told Fox News Digital.
“The advantage of working with a natural substance is the reduced risk of side effects.”
“As a dietitian, I always recommend that people discuss any supplement with their personal medical care provider before starting it.”
As the research is still very new and has only been done in mice so far, Freirich noted that the results “cannot be extrapolated to humans with certainty.”
She added, “I would certainly recommend to anyone that adding pomegranates, strawberries and walnuts to the diet is a great idea.”
“These are whole, unprocessed and very nutritious foods, high in antioxidants and, in the case of walnuts, omega 3s.”
These foods are unlikely to cause any harm if consumed in typical portion sizes, Freirich noted, unless there is an allergy or another specific reason to avoid them.
Other recommended foods for brain health include adequate dietary intake of omega 3s (salmon, walnuts, chia seeds, ground flaxseed, olive oil), green leafy vegetables, berries, and legumes (beans, lentils, chickpeas), according to Freirich.
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Maintaining at least 150 minutes of physical activity per week and keeping the brain sharp with activities and community engagement can also help mitigate Alzheimer’s symptoms, the nutritionist added.
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Erin Palinski-Wade, a New Jersey-based dietitian and author of the book “Belly Fat Diet For Dummies,” who was also not involved in the study, said the “promising” results support other research that has found an association between pomegranates and improved cognition and memory.
“More research needs to be done to identify how much would be needed to achieve cognitive benefits, but adding even small amounts of pomegranate to the diet can be beneficial to overall health,” she told Fox News Digital.
Pomegranates are also rich in antioxidants and fiber, Palinski-Wade noted, which can help to reduce inflammation in the body and lessen future disease risk.
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“Adding pomegranate arils into salads, smoothies or on top of yogurt or incorporating 100% pomegranate juice can be a great addition to your diet and an easy way to boost your overall intake of brain-benefiting nutrients,” the nutritionist said.
Fox News Digital reached out to the study researchers and to the Alzheimer’s Association requesting comment.
Health
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Health
One state leads country in human bird flu with nearly 40 confirmed cases
A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health (SFDPH).
As of Dec. 23, there had been 36 confirmed human cases of bird flu in the state, according to the California Department of Public Health (CDPH).
This represents more than half of the human cases in the country.
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The latest pediatric patient, who lives in San Francisco, experienced fever and conjunctivitis (pink eye) as a result of the infection.
The unnamed patient was not hospitalized and has fully recovered, according to the SFDPH.
The child tested positive for bird flu at the SFDPH Public Health Laboratory. The U.S. Centers for Disease Control and Prevention (CDC) will perform additional tests to confirm the result.
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It is not yet known how the child was exposed to the virus and an investigation is ongoing.
“I want to assure everyone in our city that the risk to the general public is low, and there is no current evidence that the virus can be transmitted between people,” said Dr. Grant Colfax, director of health, in the press release.
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“We will continue to investigate this presumptive case, and I am urging all San Franciscans to avoid direct contact with sick or dead birds, especially wild birds and poultry. Also, please avoid unpasteurized dairy products.”
Samuel Scarpino, director of AI and life sciences and professor of health sciences at Northeastern University in Boston, is calling for “decisive action” to protect individuals who may be in contact with infected livestock and also to alert the public about the risks associated with wild birds and infected backyard flocks.
“While I agree that the risk to the broader public remains low, we continue to see signs of escalating risk associated with this outbreak,” he told Fox News Digital.
Experts have warned that the possibility of mutations in the virus could enable person-to-person transmission.
“While the H5N1 virus is currently thought to only transmit from animals to humans, multiple mutations that can enhance human-to-human transmission have been observed in the severely sick American,” Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, told Fox News Digital.
“This highlights the requirement for vigilance and preparation in the event that additional mutations create a human-transmissible pandemic strain.”
As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture (CDFA).
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In the last 30 days alone, the virus has been confirmed in 84 dairy farms in the state.
Health
Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.
“In the beginning, everyone thought they were going to find this one breakthrough pain drug that would replace opioids,” Gereau said. Increasingly, though, it’s looking like chronic pain, like cancer, could end up having a range of genetic and cellular drivers that vary both by condition and by the particular makeup of the person experiencing it. “What we’re learning is that pain is not just one thing,” Gereau added. “It’s a thousand different things, all called ‘pain.’”
For patients, too, the landscape of chronic pain is wildly varied. Some people endure a miserable year of low-back pain, only to have it vanish for no clear reason. Others aren’t so lucky. A friend of a friend spent five years with extreme pain in his arm and face after roughhousing with his son. He had to stop working, couldn’t drive, couldn’t even ride in a car without a neck brace. His doctors prescribed endless medications: the maximum dose of gabapentin, plus duloxetine and others. At one point, he admitted himself to a psychiatric ward, because his pain was so bad that he’d become suicidal. There, he met other people who also became suicidal after years of living with terrible pain day in and day out.
The thing that makes chronic pain so awful is that it’s chronic: a grinding distress that never ends. For those with extreme pain, that’s easy to understand. But even less severe cases can be miserable. A pain rating of 3 or 4 out of 10 sounds mild, but having it almost all the time is grueling — and limiting. Unlike a broken arm, which gets better, or tendinitis, which hurts mostly in response to overuse, chronic pain makes your whole world shrink. It’s harder to work, and to exercise, and even to do the many smaller things that make life rewarding and rich.
It’s also lonely. When my arms first went crazy, I could barely function. But even after the worst had passed, I saw friends rarely; I still couldn’t drive more than a few minutes, or sit comfortably in a chair, and I felt guilty inviting people over when there wasn’t anything to do. As Christin Veasley, director and co-founder of the Chronic Pain Research Alliance, puts it: “With acute pain, medications, if you take them, they get you over a hump, and you go on your way. What people don’t realize is that when you have chronic pain, even if you’re also taking meds, you rarely feel like you were before. At best, they can reduce your pain, but usually don’t eliminate it.”
A cruel Catch-22 around chronic pain is that it often leads to anxiety and depression, both of which can make pain worse. That’s partly because focusing on a thing can reinforce it, but also because emotional states have physical effects. Both anxiety and depression are known to increase inflammation, which can also worsen pain. As a result, pain management often includes cognitive behavioral therapy, meditation practice or other coping skills. But while those tools are vital, it’s notoriously hard to reprogram our reactions. Our minds and bodies have evolved both to anticipate pain and to remember it, making it hard not to worry. And because chronic pain is so uncomfortable and isolating, it’s also depressing.
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