Health
Expert warns of ‘silent epidemic’ that puts men’s health at serious risk
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While gastroesophageal reflux disease (GERD) affects both men and women, men tend to experience more severe symptoms and complications.
Studies show that men have higher acid exposure and are nearly twice as likely to develop Barrett’s esophagus, a condition that can lead to esophageal cancer if left untreated.
Esophageal cancer is up to nine times more common in men, making them far more likely to progress from chronic reflux to serious outcomes.
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Dr. Daryl Gioffre, gut health specialist, certified nutritionist and author of “Get Off Your Acid” and “Get Off Your Sugar,” spoke with Fox News Digital about how acid reflux is becoming a “silent epidemic” among men — and what they can do about it.
“This isn’t just about heartburn, but about systemic inflammation that starts in the gut and spreads throughout the body,” Gioffre said.
While gastroesophageal reflux disease (GERD) affects both men and women, men tend to experience more severe symptoms and complications. (iStock)
“Acid reflux is the body’s alarm system, warning that the gut, metabolism and stress response are all out of balance.”
‘The perfect storm’
Men today are living in a “pressure cooker,” Gioffre warned. “Chronic stress, poor sleep, processed foods, alcohol and medication overuse are destroying gut health and digestion,” he said.
“Combine that with typical diets heavier in meat, alcohol and ultraprocessed foods, and a greater tendency to ignore symptoms, and you’re breeding a perfect storm for chronic inflammation and increased risk of reflux compared to women.”
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Late-night eating, larger portions, less fiber and high caffeine intake also stack the deck against men, he said. In addition to dietary choices, men’s lifestyle behaviors can also impact digestion.
Late-night eating and larger portions are part of what make men more prone to acid reflux and other digestive issues. (iStock)
“Many men skip meals, eat too quickly and rely on convenience foods stripped of minerals and fiber,” Gioffre said.
Over time, this “ongoing acid assault” erodes the gut lining, drives acid upward and turns normal esophageal cells into precancerous Barrett’s cells, increasing cancer risk dramatically, he warned.
Biggest food culprits
When it comes to ultraprocessed foods, Gioffre called out three specific components that worsen acid reflux: refined salt, sugar and seed oils.
“Together, they inflame the gut and weaken both digestion and the lower esophageal sphincter, the valve that keeps acid in the stomach where it belongs,” he said.
“Men need to slow down, eat foods that support digestion and strengthen the gut, and stop relying on quick fixes.”
Men also tend to drink more coffee than women, often two to three cups a day, usually on an empty stomach, Gioffre pointed out.
“That constant caffeine hit strips minerals, dehydrates the body and spikes acidity — all of which increase the risk of reflux.”
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Ultimately, he said, “men need to slow down, eat foods that support digestion and strengthen the gut, and stop relying on quick fixes. Otherwise, reflux will only keep getting worse and harder to treat.”
Biological differences
There are some biological differences between the genders that contribute to men’s higher risk of severe gastrointestinal conditions, according to Gioffre.
“Men produce less protective mucus and saliva — the body’s natural defense system that buffers acid when it backflows into the esophagus. So when acid reflux strikes, it hits harder,” he said.
Some examples of alkaline-rich foods include leafy greens, vegetables, fruits, nuts and seeds, and mineral water or spring water. (iStock)
“That acid burns and erodes tissue that was never designed to handle acid in the first place, setting the stage for inflammation, damage and long-term complications.”
Younger men also tend to carry more visceral (abdominal) fat, Gioffre noted, which increases pressure in the stomach and forces acid up into the esophagus.
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Hormones also play a role.
“Estrogen in women appears to protect the esophagus by improving blood flow and mucosal repair, protection men have much less of,” the doctor said. “Without lower levels than women, their tissue where reflux hits doesn’t recover as quickly from repeated acid exposure.”
7 things to start doing right now
Gioffre recommends that men take the following simple steps to immediately begin lowering their risk.
No. 1: Stop eating three hours before bed
“One of the biggest and most overlooked causes of acid reflux is eating too close to bedtime,” Gioffre said. “When you lie down after a meal, gravity is no longer helping to keep acid in your stomach where it belongs, so it’s much easier for it to travel up the wrong way into your esophagus.”
Reflux symptoms often get worse at night, the doctor noted — “and it’s why so many men wake up coughing, choking or with a burning throat, hoarse voice or sour taste in their mouth.” (iStock)
This is why reflux symptoms often get worse at night, he noted — “and it’s why so many men wake up coughing, choking or with a burning throat, hoarse voice or sour taste in their mouth.”
Gioffre said it’s best to stop eating three hours before bed, which gives the body time to fully digest, empty the stomach and drop acid levels before lying down.
No. 2: Remove common reflux triggers
Common triggers include garlic, onions, spicy foods, alcohol, chocolate, caffeine, citrus fruits and carbonated water, according to Gioffre.
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“All of these weaken the lower esophageal sphincter, the valve that keeps stomach acid where it belongs,” he said. “Once that muscle relaxes, acid flows upward, causing heartburn by inflaming and irritating the esophageal and throat lining.”
“If you want to heal reflux naturally, you can’t just change what you eat — you have to change how you live.”
The doctor also recommends adding back alkaline minerals, digestive enzymes and a high-quality probiotic. Some examples of alkaline-rich foods include leafy greens, vegetables, fruits, nuts and seeds, and mineral water or spring water.
No. 3: Stay hydrated
Gioffre recommends starting the morning with warm lemon water with a teaspoon of local honey, or a tea with slippery elm.
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“This helps soothe and calm the upper GI tract and eases reflux,” he said. It’s also important to stay hydrated throughout the day, the doctor added.
No. 4: Stay grounded
Simple grounding practices, like walking barefoot in the grass, doing deep breathing or just stepping outside to reconnect with nature, can help promote gut health.
Esophageal cancer is up to nine times more common in men, making them far more likely to progress from chronic reflux to serious outcomes. (iStock)
“These activate your parasympathetic ‘rest-and-digest’ system, calm your gut and keep acid levels in check naturally,” Gioffre said. “Get outside and move after meals, and swap your late-night snack for deep breathing or stretching.”
No. 5: Manage stress and sleep
When men don’t sleep well, the body produces more cortisol, which is the main stress hormone.
“High cortisol keeps you locked in a constant state of fight-or-flight, and when you’re in that mode, your body isn’t focused on rest, digest or repair — it’s focused on survival,” Gioffre said.
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In this state, blood flow is pulled away from the gut and sent to the muscles and brain, he noted, which means digestion slows down, stomach acid production drops and food sits in the stomach for too long, which leads to bloating, gas and more reflux.
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“If you want to heal reflux naturally, you can’t just change what you eat — you have to change how you live,” Gioffre said. “Quality sleep and stress management are non-negotiable if you want to restore your gut and calm acid at its root cause.”
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South Carolina is facing a major measles outbreak, resulting in the quarantine of hundreds of residents.
The South Carolina Department of Health (DPH) reported in a media briefing on Wednesday that the current number of measles cases has reached 111 as part of the current Spartanburg County outbreak.
DPH first reported a measles outbreak in the Upstate region on Oct. 2.
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The health department confirmed that 254 people are currently in quarantine and 16 are in isolation to prevent further spread.
The health department confirmed that 254 people are currently in quarantine in the upstate region. (Getty Images)
“This significant jump in cases is unfortunate,” a DPH spokesperson commented on the outbreak.
Public exposure was identified at Inman Intermediate School, with 43 of their students in quarantine.
“This significant jump in cases is unfortunate.”
Eight other intermediate and middle schools in the area are also reportedly undergoing quarantine. The DPH said multiple students have had to quarantine twice due to repeat exposure.
“Vaccination continues to be the best way to prevent the disruption that measles is causing to people’s education, to employment and other factors in people’s lives and our communities,” the spokesperson said.
“This significant jump in cases is unfortunate,” a DPH spokesperson commented on the current outbreak. (iStock)
Out of the 111 confirmed cases, 105 were unvaccinated. Receiving a vaccination within 72 hours has been shown to prevent measles infection, the DPH spokesperson noted.
Some cases are related to travel exposure, while others are from an unknown source, suggesting that measles is circulating in the community, the DPH noted.
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Connecticut has also reported its first measles case in four years, according to the Connecticut Department of Public Health.
The department confirmed on Thursday that an unvaccinated child in Fairfield County, under the age of 10, was diagnosed with measles after recently traveling internationally.
“Vaccination continues to be the best way to prevent the disruption that measles is causing,” a DPH spokesperson said. (iStock)
The child began to show symptoms several days later, including a runny nose, cough, congestion, fever and a rash starting at the head and spreading to the rest of the body.
The Connecticut DPH noted that measles is “highly contagious” and can spread quickly through the air via coughing or sneezing. The CDC has estimated that nine out of 10 unvaccinated individuals who encounter an infected person will develop the measles virus.
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According to the International Vaccine Access Center, more than 1,800 cases of measles have been reported in 2025, which is the most since the U.S. declared the virus eliminated in 2000. It is also the most cases recorded in three decades.
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“The single best way to protect your children and yourself from measles is to be vaccinated,” DPH Commissioner Manisha Juthani, M.D., wrote in a statement. “One dose of measles vaccine is about 93% effective, while two doses are about 97% effective.”
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A sperm donor whose samples helped conceive nearly 200 children across Europe unknowingly carried a cancer-causing genetic mutation — a hidden risk now tied to multiple childhood illnesses and early deaths.
An investigation led by the BBC and many other public service broadcasters revealed that the donations were made to Denmark’s European Sperm Bank (ESB). Those donations were then used by 67 fertility clinics in 14 countries over a 17-year span.
The donor, who was not identified, was paid to donate as a student beginning in 2005, according to the report.
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Although the donor passed the initial health screenings, he had hidden genetic mutations that damaged the TP53 gene, which helps to prevent cancer by repairing DNA damage or trigger the death of cancer cells.
When TP53 is mutated, those protective functions are lost, which can lead to uncontrolled cell division, accumulation of mutations and tumor growth, research has shown.
A sperm donor whose samples helped conceive nearly 200 children across Europe (not pictured) unknowingly carried a cancer-causing genetic mutation — a hidden risk now tied to multiple childhood illnesses and early deaths. (Getty Images)
Up to 20% of the man’s sperm would contain that mutated gene, and any children conceived from that affected sperm would have the mutation in every cell of their body, the BBC report stated.
As a result, these children would have a 90% risk of developing some type of cancer in their lifetime, including breast cancer, bone cancers, brain tumors and leukemia. This heightened risk is known as Li Fraumeni syndrome.
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Doctors raised these concerns at the annual congress of the European Society of Human Genetics (ESHG), which was held in Milan in May 2025.
At that conference, Edwige Kasper — a specialist in cancer genetics at Rouen University Hospital in France — presented the case of the sperm donor whose genetic material carried the harmful variant.
“This is the abnormal dissemination of genetic disease. Not every man has 75 children across Europe.”
It was reported that 23 children had been confirmed to have the variant at that time, 10 of which had already been diagnosed with cancer.
The actual number is likely much higher, the report surmised, as at least 197 children were born from the donated sperm — but not all data has been collected.
Kasper called for a limit on the number of births or families for a single donor in Europe.
“We can’t do whole-genome sequencing for all sperm donors — I’m not arguing for that,” she said. “But this is the abnormal dissemination of genetic disease. Not every man has 75 children across Europe.”
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She also recommended that children born from this donor’s sperm undergo genetic counseling.
“We have some children that have already developed two different cancers, and some of them have already died at a very early age,” Kasper recently told the investigators.
Up to 20% of the man’s sperm would contain that mutated gene, and any children conceived from that affected sperm would have the mutation in every cell of their body, the BBC report stated. (iStock)
There is no worldwide law that limits how many times a donor’s sperm can be used or how many children may be born from a single donor, according to the European Society of Human Reproduction and Embryology (ESHRE).
However, individual countries may have their own rules or guidelines surrounding sperm donor usage. The ESHRE recently proposed a cap of 50 families per donor as an international limit.
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Dr. Marc Siegel, Fox News senior medical analyst, commented on these developments to Fox News Digital.
“This awful story emphasizes the growing need for up-to-date genetic screening for all donors,” he said. “It also provides context for the idea that knowing the donor provides an advantage.”
“This awful story emphasizes the growing need for up-to-date genetic screening for all donors,” Dr. Marc Siegel said. (iStock)
“Genetic screening, including for oncogenes (genes that have the potential to cause cancer) is improving dramatically, and all use of sperm donations must include it,” Siegel went on.
He also called for AI to be used to improve and speed up the process.
“When a propensity for disease is suspected, the sperm must be discarded,” the doctor added.
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In a statement sent to Fox News Digital, the European Sperm Bank expressed “deepest sympathy” for the families involved.
“We are deeply affected by the case and the impact that the rare TP53 mutation has on a number of families, children and the donor. They have our deepest sympathy,” the ESP said.
The American Society of Reproductive Medicine provided its guidance on embryo and gamete donation, which stated in part that all prospective donors should undergo “appropriate genetic evaluation.” (iStock)
“ESB tests and performs an individual medical assessment of all donors in full compliance with recognized and scientific practice and legislation.”
In the case of this particular sperm donor with the TP53 mutation, the ESB noted that it occurs only in a small part of the donor’s sperm cells and not in the rest of the body.
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“In such cases, the donor himself and his family members are not ill, and a mutation of this type is not detected preventively by genetic screening,” the agency said.
When the ESB later confirmed the mutation in 2023, the donor was “immediately blocked” and authorities and clinics were notified.
“Donors should be healthy and have no history to suggest hereditary disease.”
“The clinics are responsible for informing the patients, partly because we as a sperm bank do not necessarily know the patients, and because the patients’ own treating physicians are best equipped to advise them in the specific situation,” the agency stated.
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When contacted by Fox News Digital, the American Society of Reproductive Medicine (ASRM) provided its guidance on embryo and gamete donation, which stated in part that all prospective donors should undergo “appropriate genetic evaluation.”
“Donors should be healthy and have no history to suggest hereditary disease,” the ASRM continued.
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Parents with concerns are encouraged to contact both their treating clinic and the relevant fertility authority in that country.
GLP-1 weight loss pill in development
Fox News senior medical analyst Dr. Marc Siegel discusses advancements in weight loss drugs, safety concerns surrounding nicotine patches and his interview with FDA Commissioner Dr. Marty Makary on vaccine protocol.
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Scientists in Sweden have created a new pill designed to help the body burn fat and control blood sugar in a different way than popular GLP-1 drugs, like Ozempic.
While injectable GLP-1s work by suppressing appetite, this new treatment boosts metabolism in the muscles.
A study led by researchers at Karolinska Institutet and Stockholm University included both an early animal study and a human clinical trial with 48 healthy adults and 25 people with type 2 diabetes, according to a press release.
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The new oral medication was found to successfully control blood glucose, boost fat burning and retain muscle mass in animals, while getting high marks for tolerability and safety in humans.
It was also found to have fewer side effects than GLP-1s like semaglutides and tirzepatides, which are known to cause appetite loss, gastrointestinal distress and muscle wasting, the researchers noted.
While injectable GLP-1s work by suppressing appetite, this new treatment boosts metabolism in the muscles. (iStock)
The experimental medication uses a new form of beta-2 agonist that benefits muscle function while also avoiding overstimulation of the heart, which has been identified as a potential safety concern of older versions.
The findings were published this week in the journal Cell.
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Because the new oral drug acts via a different mechanism than appetite-suppressing medications, it could be used alone or in combination with GLP-1s, the researchers noted.
“Our results point to a future where we can improve metabolic health without losing muscle mass,” said Tore Bengtsson, professor at the Department of Molecular Bioscience at Wenner-Gren Institute, Stockholm University, in the release. “Muscles are important in both type 2 diabetes and obesity, and muscle mass is also directly correlated with life expectancy.”
“Muscles are important in both type 2 diabetes and obesity, and muscle mass is also directly correlated with life expectancy.” (iStock)
This medication has the potential to be of “great importance” for patients with type 2 diabetes and obesity, according to Shane C. Wright, assistant professor at the Department of Physiology and Pharmacology at Karolinska Institutet.
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“Our substance appears to promote healthy weight loss and, in addition, patients do not have to take injections,” he added.
Dr. Trey Wickham, interim chief of the Division of Endocrinology, Diabetes & Metabolism at VCU Health in Richmond, Virginia, was not involved in the study but shared his reaction to the publication in the journal Cell.
“Our results point to a future where we can improve metabolic health without losing muscle mass.”
“This compound’s mechanism of action could address some specific metabolic concerns with previous weight reduction therapies, such as the loss of both muscle and fat tissue,” Wickham told Fox News Digital.
“Although the reported preliminary results are interesting, rigorous testing involving larger longitudinal trials are necessary to ensure human long-term safety and understand the potential role of this compound in the comprehensive, evidence-based treatment of obesity and diabetes.”
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The study had some limitations, the researchers noted, chiefly that the preclinical studies in mice fail to capture the “complex nature of these diseases” in humans.
Structural studies are needed to understand exactly how the drug works.
“This compound’s mechanism of action could address some specific metabolic concerns with previous weight reduction therapies, such as the loss of both muscle and fat tissue,” a doctor said. (iStock)
“Our phase 1 data show that compound 15 is well-tolerated; however, conclusive clinical efficacy data (on how the drug controls glucose metabolism) are currently still lacking.”
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Looking ahead, the company that developed the drug, Atrogi AB, plans to conduct a larger phase 2 clinical trial with a larger, more diverse population, including people with obesity.
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The study was supported in part by the Swedish Research Council, the Swedish Society for Medical Research and the Novo Nordisk Foundation.
Uppsala University, University of Copenhagen, Monash University and University of Queensland all collaborated with the lead researchers.
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