Health
Endometrial cancer patients see new hope as FDA approves 'transforming' immunotherapy drug
The U.S. Food and Drug Administration (FDA) has approved a new drug for certain adult patients with endometrial cancer.
Jemperli (dostarlimab-gxly) — made by British pharmaceutical company GSK — is intended for people with primary advanced or recurrent forms of the cancer, according to the FDA’s Aug. 1 announcement.
It is an immunotherapy-based drug, which means it leverages the body’s immune system to attack cancer cells.
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In clinical trials, Jemperli showed an improved progression-free survival and overall survival for all patients, according to Dr. Brian Slomovitz, director of gynecologic oncology and co-chair of the Cancer Research Committee at Mount Sinai Medical Center in Florida.
“This class of drugs has been used in the second-line setting,” Slomovitz said — meaning they were only used if a first-line (primary) treatment was not effective or had intolerable side effects.
“Moving them to first-line [status] here will yield better outcomes.”
This is the third FDA approval this year for immunotherapy in endometrial cancer, the doctor noted.
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“This is great news for our patients,” Slomovitz told Fox News Digital.
“Endometrial cancer has become the leading cause of death over all other gynecologic cancers, including ovarian cancer.”
Before the immunotherapy options became available, the only treatment for endometrial cancer was chemotherapy alone, Slomovitz said.
“These results are game-changing — it is unprecedented to have three approvals in such a short period of time.”
The most common side effects of all immunotherapy drugs are gastrointestinal, endocrine and dermatologic toxicities, the doctor noted.
“These results are game-changing — it is unprecedented to have three approvals in such a short period of time.”
“Patients should understand that adding immunotherapy to traditional chemotherapy has better results and the toxicity profile is manageable,” he added.
For doctors, Slomovitz emphasized the need to adjust quickly and make the newly approved drug a first-line treatment option for their patients.
In June, the FDA approved Merck’s Keytruda (pembrolizumab) to be used in combination with chemotherapy for adult patients with primary advanced or recurrent endometrial cancer.
“The Merck trial (pembrolizumab) showed a significant improvement in progression-free survival for all patients,” Slomovitz said.
In that same month, AstraZeneca’s Imfinzi (durvalumab) was approved for patients with advanced or recurrent disease who have a certain biomarker.
The AstraZeneca trial also showed improved progression-free survival for all patients.
All trials for the new cancer drugs were run through the GOG Foundation, which is the largest cooperative group for all gynecologic oncology research, Slomovitz noted.
In the trials, the use of immunotherapy drugs in combination with chemotherapy reduced the risk of disease progression by approximately 70% in patients whose tumors had certain biomarkers.
In other patients without that biomarker, there was still a “clinically and statistically significant improvement in time to progression, which is meaningful for our patients and has now led to FDA approvals in both biomarker settings,” Kathleen N. Moore, M.D., co-director of the Stephenson Cancer Center at the University of Oklahoma Health Sciences Center, told Fox News Digital.
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“These studies have transformed outcomes for patients with endometrial cancer and are poised to change the treatment landscape for the better into the future,” she added.
Shannon N. Westin, medical director of the Gynecologic Oncology Center at the University of Texas MD Anderson Cancer Center, said she is “thrilled” to have multiple new options for patients with advanced and recurrent endometrial cancer after years with no new therapies.
“We no longer have to treat everyone in the same cookie-cutter fashion, and can instead employ precision medicine to improve survival for these survivors.”
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“The addition of immunotherapy to chemotherapy provided improvement in survival outcomes without a negative impact on quality of life,” she went on.
“This is the ideal scenario.”
Fox News Digital reached out to GSK for comment.
Health
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Health
West Nile death reported in Texas as health officials warn residents to safeguard against mosquitoes
A woman in Dallas County, Texas, has died after being diagnosed with West Nile virus.
The patient, whose name and age were not released, contracted a severe neuroinvasive form of the disease, according to a Tuesday press release from the Dallas County Health and Human Services (DCHHS).
The female patient had “underlying health issues,” officials stated.
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This was the county’s first West Nile death in 2024.
“We are deeply saddened by this loss,” said Dr. Philip Huang, director of DCHHS, in the release.
“This heartbreaking tragedy underscores the critical importance of safeguarding against mosquito bites, which can transmit several diseases, including West Nile virus.”
What to know about West Nile
Since the West Nile virus first entered the U.S. in 1999, it has become the leading cause of mosquito-borne disease in the country, according to the Centers for Disease Control and Prevention (CDC).
In most cases, the West Nile virus — a flavivirus in the same family as yellow fever, dengue fever, Japanese encephalitis and the Zika virus — is spread when Culex mosquitoes bite infected birds and then bite people and other animals, per the CDC’s website.
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The virus is not transmitted through eating or handling infected animals or birds — nor is it spread through physical contact, coughing or sneezing.
A vast majority — around 80% — of the people who contract the virus will not experience any symptoms, the CDC states on its website.
“It causes a rash and other symptoms, including swollen lymph nodes, which other viruses in its class do not exhibit,” Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, told Fox News Digital.
“It only affects the nervous system 1% of the time and is rarely fatal.”
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Around one in five people will develop febrile illness, which is marked by a fever along with body aches, headache, joint pain, diarrhea, rash and/or vomiting.
These symptoms usually go away on their own, but some people may have lingering weakness and fatigue months after infection.
In rare cases — about one in every 150 infected people — the virus can lead to serious conditions affecting the nervous system, such as encephalitis (inflammation of the brain) or meningitis (inflammation of the membranes that surround the brain and spinal cord), the CDC states on its website.
Those who develop serious illness may experience headache, stiff neck, high fever, disorientation, vision loss, muscle weakness, convulsions, tremors, coma or paralysis, which occur when there is viral infection of the central nervous system.
Among people who have this invasive form of the illness, around 10% will die.
“It affects the nervous system 1% of the time and is rarely fatal.”
While anyone can potentially develop severe illness, the highest-risk groups include those over 60 years of age, people who have had organ transplants and those with diabetes, cancer, high blood pressure, kidney disease, immune disorders and other certain medical conditions.
“The virus’ effects can be quite serious in the elderly,” Siegel noted.
Diagnosis and treatment
Those who think they might have been infected with WNV should be assessed by a health care provider, the CDC states.
Diagnosis of the infection can be made based on evaluation of symptoms, recent exposure to mosquitoes and testing of blood or spinal fluid.
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Health care providers will typically recommend treating symptoms with over-the-counter pain medications and getting plenty of rest and fluids.
Those who experience severe illness may need to be hospitalized for supportive care.
As of Aug. 6, there were 103 West Nile virus cases in the U.S. across 26 states, per the CDC.
Sixty-eight of those cases were neuroinvasive (severe).
Preventing the virus
There is currently no vaccine for West Nile virus.
“The virus can be contained through public health measures including more insect repellent with DEET, longer sleeves and less stagnant water in our backyards,” Siegel said.
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Trying to kill adult mosquitoes by spreading too much insecticide can be problematic, the doctor warned.
“Animals, people with asthma and insects that would otherwise kill the mosquitoes are affected.”
Dallas County health officials are urging local residents to take steps to protect themselves amid high mosquito activity, emphasizing the importance of the “four Ds” outlined below.
DEET: When spending time outdoors, people should apply insect repellent containing DEET or other EPA-approved ingredients.
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Dress: Minimize exposed skin by wearing long, loose clothing, officials recommend.
Drain: Eliminating any standing water can help prevent mosquitoes from breeding.
Dawn to dusk: Those at highest risk can minimize outdoor time during peak mosquito hours (just before and after sunset, and in the early morning before sunrise).
Health
Gallup poll reveals how teens cope with negative emotions — and why 'they want to be heard'
A new Gallup survey explored how young Americans cope with stress, anxiety and other big emotions – and the results were mostly positive.
The research was done in partnership with the Walton Family Foundation and Dr. Lisa Damour, a bestselling author and clinical adolescent psychologist who served as a consultant on Pixar’s movie “Inside Out 2.”
Ohio-based Damour and the rest of the team dove deep into the Gen Z experience, exploring the relationship between teens and their parents and other support systems.
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The researchers surveyed 1,675 children between ages 10 and 18, along with their parents or guardians.
The data revealed that young Gen Zers are using a “range of healthy coping mechanisms” to deal with challenging feelings, according to a press release.
More than half of Gen Z respondents reported listening to music as a coping mechanism, while 45% said they play video games, 45% connect with friends and 39% talk about their feelings.
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Only 20% of teens reported that they turn to social media when upset.
The emotional lives of preteens and teens are “marked by more ups than downs,” according to the Gallup poll.
A whopping 94% of teens said they felt happiness “a lot on the prior day” — while 45% said they also felt stressed, 38% felt anxious and 23% felt sad.
Helping teens handle emotions
The survey explored how parents and guardians can help teens manage their emotions as they start to seek more independence.
More than 60% of Gen Zers said they want their parents to listen to them when upset. Only 28% want their parents to give advice.
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Younger Gen Z respondents are more likely to search for parental reassurance and physical comfort — but teenagers are 20% more likely to want their parents to give them space when they are upset, the survey found.
Young people who feel the need to be perfect are 23% to 30% more likely to feel anxious, sad and stressed.
Among the parents surveyed, 35% reported their teens having “very intense emotions,” but more than eight in 10 parents said they feel “confident in their ability to comfort and communicate with their children.”
The survey also found that one-third of Gen Z kids feel pressure to be perfect, a sentiment that is particularly higher among 13- to 15-year-olds (38%) and girls (40%).
Young people who feel the need to be perfect are 23% to 30% more likely to feel anxious, sad and stressed, the research found.
“These new findings suggest that the negative emotions many Gen Zers feel are closely related to the pressure they feel to be perfect,” Stephanie Marken, Gallup senior partner, wrote in a statement.
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“Prior Gallup research has found that children who frequently experience negative emotions are more likely to say that they also struggle in school, so helping Gen Z to cope with these emotions – as well as their underlying causes – is critically important to their academic and future success,” Marken added.
‘Surprisingly’ positive
In an interview with Fox News Digital, Damour expressed her surprise at the large number of young Gen Zers who reported positive emotions and coping techniques.
“I think our results will surprise a lot of people, because the headlines over the last several years have focused on mental health concerns and unwanted emotions,” she said.
“We are hearing from young people that, above all, they want to be heard and taken seriously.”
While 23% of children reported feeling envy and sadness, 29% experienced anger, 38% reported anxiety and worry, and 45% said they were stressed, a majority reported feeling enjoyment (91%) and happiness (94%).
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“The takeaway here is that teenagers have downs, but they also have ups,” Damour said. “And in terms of what they’re telling us, their ups are far more common than their downs.”
While teenagers tend to have complicated emotions and intense feelings, they’re not always negative, she pointed out.
The expert also offered guidance for parents whose teens may have perfectionist tendencies.
“We want to go out of our way as adults to remind young people that everyone has shortcomings,” she said. “The goal is not to be perfect, but to acknowledge and work on our shortcomings while still feeling good about ourselves overall.”
‘Listening goes a long way’
As the new school year kicks off, Damour encouraged parents to focus on listening rather than always providing solutions.
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“Well-meaning adults will often lead with some suggestions or guidance when a teenager brings painful emotions their way – and though it may come from a loving place, we are hearing from young people that, above all, they want to be heard and taken seriously,” she said.
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“Listening to teenagers and taking their feelings very seriously goes a long way to helping them feel better,” Damour added.
By stepping back instead of rushing in to help, adults may find that teenagers can effectively manage their own upset feelings, she said.
“We’re in a moment where parents are very, very anxious about teenagers and very, very anxious about their kids becoming teenagers,” the psychologist noted.
“Teenagers want to be heard by and taken seriously by adults, they are very thoughtful about how they manage emotions, and they know what doesn’t help them feel better.”
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