Health
Endometrial cancer patients see new hope as FDA approves 'transforming' immunotherapy drug
The U.S. Food and Drug Administration (FDA) has approved a new drug for certain adult patients with endometrial cancer.
Jemperli (dostarlimab-gxly) — made by British pharmaceutical company GSK — is intended for people with primary advanced or recurrent forms of the cancer, according to the FDA’s Aug. 1 announcement.
It is an immunotherapy-based drug, which means it leverages the body’s immune system to attack cancer cells.
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In clinical trials, Jemperli showed an improved progression-free survival and overall survival for all patients, according to Dr. Brian Slomovitz, director of gynecologic oncology and co-chair of the Cancer Research Committee at Mount Sinai Medical Center in Florida.
“This class of drugs has been used in the second-line setting,” Slomovitz said — meaning they were only used if a first-line (primary) treatment was not effective or had intolerable side effects.
The FDA has approved a new drug for certain adult patients with endometrial cancer. (iStock)
“Moving them to first-line [status] here will yield better outcomes.”
This is the third FDA approval this year for immunotherapy in endometrial cancer, the doctor noted.
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“This is great news for our patients,” Slomovitz told Fox News Digital.
“Endometrial cancer has become the leading cause of death over all other gynecologic cancers, including ovarian cancer.”
Jemperli (dostarlimab-gxly) — made by British pharmaceutical company GSK — is intended for people who have primary advanced or recurrent forms of the cancer. (iStock)
Before the immunotherapy options became available, the only treatment for endometrial cancer was chemotherapy alone, Slomovitz said.
“These results are game-changing — it is unprecedented to have three approvals in such a short period of time.”
The most common side effects of all immunotherapy drugs are gastrointestinal, endocrine and dermatologic toxicities, the doctor noted.
“These results are game-changing — it is unprecedented to have three approvals in such a short period of time.”
“Patients should understand that adding immunotherapy to traditional chemotherapy has better results and the toxicity profile is manageable,” he added.
For doctors, Slomovitz emphasized the need to adjust quickly and make the newly approved drug a first-line treatment option for their patients.
GlaxoSmithKline (GSK) is the U.K.-based pharmaceutical company that makes Jemperli. (REUTERS/Dado Ruvic/Illustration/File Photo)
In June, the FDA approved Merck’s Keytruda (pembrolizumab) to be used in combination with chemotherapy for adult patients with primary advanced or recurrent endometrial cancer.
“The Merck trial (pembrolizumab) showed a significant improvement in progression-free survival for all patients,” Slomovitz said.
In that same month, AstraZeneca’s Imfinzi (durvalumab) was approved for patients with advanced or recurrent disease who have a certain biomarker.
The AstraZeneca trial also showed improved progression-free survival for all patients.
All trials for the new cancer drugs were run through the GOG Foundation, which is the largest cooperative group for all gynecologic oncology research, Slomovitz noted.
“The addition of immunotherapy to chemotherapy provided improvement in survival outcomes without a negative impact on quality of life,” an oncologist said. (iStock)
In the trials, the use of immunotherapy drugs in combination with chemotherapy reduced the risk of disease progression by approximately 70% in patients whose tumors had certain biomarkers.
In other patients without that biomarker, there was still a “clinically and statistically significant improvement in time to progression, which is meaningful for our patients and has now led to FDA approvals in both biomarker settings,” Kathleen N. Moore, M.D., co-director of the Stephenson Cancer Center at the University of Oklahoma Health Sciences Center, told Fox News Digital.
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“These studies have transformed outcomes for patients with endometrial cancer and are poised to change the treatment landscape for the better into the future,” she added.
Shannon N. Westin, medical director of the Gynecologic Oncology Center at the University of Texas MD Anderson Cancer Center, said she is “thrilled” to have multiple new options for patients with advanced and recurrent endometrial cancer after years with no new therapies.
This is the third FDA approval this year for immunotherapy in endometrial cancer, the doctor noted. “This is great news for our patients,” an oncologist told Fox News Digital. (iStock)
“We no longer have to treat everyone in the same cookie-cutter fashion, and can instead employ precision medicine to improve survival for these survivors.”
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“The addition of immunotherapy to chemotherapy provided improvement in survival outcomes without a negative impact on quality of life,” she went on.
“This is the ideal scenario.”
Fox News Digital reached out to GSK for comment.
Health
The Best Time To Take ‘Nature’s Ozempic’ Berberine for Weight Loss and Blood Sugar Control, According to an MD
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Health
Study reveals why chewing gum might actually help with focus and stress relief
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Humans have been chewing gum for thousands of years, long after the flavor fades and without any clear nutritional benefit.
The habit dates back at least 8,000 years to Scandinavia, where people chewed birchbark pitch to soften it into a glue for tools. Other ancient cultures, including the Greeks, Native Americans and the Maya, also chewed tree resins for pleasure or soothing effects, National Geographic recently reported.
In the late 19th and early 20th centuries, William Wrigley Jr. transformed chewing gum from a novelty into a mass consumer habit through relentless and innovative marketing. His brands, including Juicy Fruit and Spearmint, promoted gum as a way to calm nerves, curb hunger and stay focused.
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“Are you worried? Chew gum,” an article from 1916 said, according to Kerry Segrave’s book, “Chewing Gum in America, 1850-1920: The Rise of an Industry.” “Do you lie awake at night? Chew gum,” it continued. “Are you depressed? Is the world against you? Chew gum.”
Advertisements have long framed chewing gum as a tool for stress relief and mental sharpness. (Keystone View Company/FPG/Archive Photos/Getty Images)
In the 1940s, a study found chewing resulted in lower tension but couldn’t say why.
“The gum-chewer relaxes and gets more work done,” The New York Times wrote at the time about the study’s results.
Gum became an early form of wellness, and companies are trying to revive that idea today as gum sales decline, according to National Geographic.
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But only now are scientists finally beginning to understand the biology behind those long-standing beliefs.
Chewing gum may briefly affect attention and stress-related brain activity, according to studies. (iStock)
A 2025 review by researchers at the University of Szczecin in Poland analyzed more than three decades of brain-imaging studies to examine what happens inside the brain when people chew gum. Using MRI, EEG and near-infrared spectroscopy research, the authors found that chewing alters brain activity in regions tied to movement, attention and stress regulation.
The findings help clarify why the seemingly pointless task can feel calming or focusing, even once the flavor has faded.
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Chewing gum activated not only the brain’s motor and sensory networks involved in chewing, but also higher-order regions linked to attention, alertness and emotional control, the review found. EEG studies found brief shifts in brain-wave patterns linked to heightened alertness and what researchers call “relaxed concentration.”
Humans have chewed gum for pleasure for thousands of years, according to reports. (iStock)
“If you’re doing a fairly boring task for a long time, chewing seems to be able to help with concentration,” Crystal Haskell-Ramsay, a professor of biological psychology at Northumbria University, told National Geographic.
The review also supports earlier findings that gum chewing can ease stress, but only in certain situations. In laboratory experiments, people who chewed gum during mildly stressful tasks such as public speaking or mental math often reported lower anxiety levels than those who didn’t.
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Chewing gum did not, however, consistently reduce anxiety in high-stress medical situations, such as immediately before surgery, and it offered no clear benefit when participants faced unsolvable problems designed to induce frustration.
Some studies suggest chewing gum can reduce stress in mild situations but not extreme ones. (iStock)
Across multiple studies, people who chewed gum did not remember lists of words or stories better than those who didn’t, the researchers also found, and any boost in attention faded soon after chewing stopped.
Gum may simply feed the desire to fidget, experts suspect.
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“Although these effects are often short-lived, the range of outcomes … underscores chewing gum’s capacity to modulate brain function beyond simple oral motor control,” the researchers wrote.
“However, at this time, the neural changes associated with gum chewing cannot be directly linked to the positive behavioral and functional outcomes observed in studies,” they added.
A 2025 review analyzed decades of MRI, EEG and near-infrared spectroscopy studies on gum chewing. (iStock)
Future research should address longer-term impacts, isolate flavor or stress variables and explore potential therapeutic applications, the scientists said.
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The findings also come with caveats beyond brain science. Although sugar-free gum may help reduce cavities, Fox News Digital has previously reported that dentists warn acids, sweeteners and excessive chewing may harm teeth or trigger other side effects.
Fox News Digital has reached out to the study’s authors for comment.
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