Health
‘Dual-action’ weight-loss pill helps people drop 13% of body weight in three months in early trials
An experimental weight-loss pill is showing promising results, helping people drop 13% of their body weight in a three-month period.
The results from early clinical trials were presented by Novo Nordisk — the Danish drugmaker behind Ozempic and Wegovy — at the European Association for the Study of Diabetes (EASD) annual meeting in Madrid this week.
The drug, amycretin, works by replicating two hunger hormones — amylin, which regulates appetite and creates a feeling of fullness, and glucagon-like peptide 1 (GLP-1), the same hormone that is used in Ozempic and Wegovy to suppress appetite and boost insulin secretion.
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“Amycretin is the first treatment to harness the two distinct biological pathways stimulated by amylin and GLP-1 in a single molecule,” Martin Holst Lange, executive vice president and head of development at Novo Nordisk, said in a statement sent to Fox News Digital.
An experimental weight-loss pill is showing promising results, helping people drop 13% of their body weight in a three-month period. (iStock)
“We are proud to present the phase 1 study results at EASD, showing that the mean change in percentage body weight was -13.1% with amycretin after 12 weeks of treatment.”
While Ozempic and Wegovy are administered via injection, amycretin is given as a 50-milligram oral pill.
The clinical trial included participants who were obese or overweight but did not have diabetes. Those who took amycretin for 12 weeks lost more weight than those on a placebo — and higher doses led to more weight loss, according to Novo Nordisk.
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Taking the pill once a day led to around 10% weight loss, and those who doubled the dose lost 13%.
Another benefit the researchers highlighted is that people taking amycretin did not appear to hit a “weight loss plateau,” continuing to shed pounds as long as they took it.
Novo Nordisk — the Danish drugmaker behind Ozempic and Wegovy — presented the findings at the European Association for the Study of Diabetes annual meeting in Madrid this week. (iStock)
“The lack of weight loss plateauing indicates the possibility of achieving further weight reductions with extended treatment,” Agnes Gasoirek, a senior clinical pharmacology specialist at Novo Nordisk, wrote in the study findings.
‘Dual effect’
Dr. Christine Ren-Fielding, director and chief of bariatric surgery at the NYU Langone Weight Management Program, commented on the drug’s effectiveness.
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“GLP-1-based treatments, like Ozempic, have already shown impressive weight loss results by helping patients feel fuller for longer and reducing appetite,” the doctor, who was not involved in the study, told Fox News Digital.
“Adding amylin, another hormone that plays a crucial role in regulating insulin and hunger signals, amplifies this effect.”
Adding amylin, a hormone that plays a crucial role in regulating insulin and hunger signals, amplifies the effect of GLP-1 drugs like Ozempic, a doctor said. (Reuters)
This “dual action” creates a more powerful tool to manage cravings and caloric intake, according to Ren-Fielding.
“It’s particularly interesting because it addresses weight management through multiple physiological pathways, making it more comprehensive and potentially more effective than conventional treatments that typically focus on a single mechanism,” she added.
Potential risks or side effects
The most commonly reported side effects of amycretin include gastrointestinal issues like nausea and vomiting, more so with higher doses, according to Novo Nordisk.
“These adverse effects are not unusual with GLP-1 receptor agonists, which are known to affect gastric motility,” Ren-Fielding noted.
“It addresses weight management through multiple physiological pathways.”
It’s important to monitor these side effects closely, she advised, as GI issues are common among patients with obesity.
“While the initial weight loss outcomes are indeed encouraging, further studies are needed to ensure that the therapeutic benefits consistently outweigh the potential risks, especially with long-term administration,” Ren-Fielding added.
‘Not a cure-all’
While GLP-1 based drugs — including this new experimental pill — may show promising results, Ren-Fielding emphasized that they’re “not a cure-all for obesity.”
“Obesity is a chronic, multifactorial disease that requires a comprehensive, long-term approach,” she told Fox News Digital.
“Pharmacological treatments can play a significant role in managing the condition, but they are often most effective when combined with other interventions.”
“Obesity is a chronic, multifactorial disease that requires a comprehensive, long-term approach,” a doctor told Fox News Digital. (iStock)
Some patients may benefit from surgical interventions, the doctor said, along with lifestyle changes such as regular exercise, healthy eating and psychological support to address underlying behavioral factors.
“It’s important to recognize that obesity is not just about weight loss — it’s a lifelong condition that requires ongoing management, much like any other chronic disease,” she added.
Next steps
The results of the study are considered preliminary, as they have not yet been published in a peer-reviewed medical journal.
The researchers will continue to conduct research on amycretin in the coming months, according to Novo Nordisk.
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“The safety and tolerability profiles and the magnitude of weight loss support further development of amycretin, and we are awaiting data from the ongoing phase 1 trial with subcutaneous amycretin, with expected read-out in 2025,” Lange said.
“If further research supports these initial findings, I can envision it becoming a viable option for those struggling with obesity.”
Ren-Fielding said there is “certainly potential” for the new drug to get FDA approval, especially considering the effectiveness of GLP-1-based drugs in recent years — but confirmed that much more testing is needed.
“The current clinical trials are promising, but we need larger, long-term studies to really assess the safety and overall benefits of the drug,” she told Fox News Digital.
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“If further research supports these initial findings, I can envision it becoming a viable option for those struggling with obesity,” she went on.
“While I’m cautiously optimistic, there’s still a road ahead before we see widespread availability.”
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At 93, sprightly referee Frank Foster is still brandishing red and yellow cards and running the field three times a week for his local soccer association.
Having taken charge of around 5,500 matches over a 46-year officiating career, the great-grandfather credits his longevity and match-day stamina to a lifetime of healthy habits and a foundational diet, news agency SWNS reported.
Foster puts his remarkable fitness down to the strict wartime rations he was fed as a teenager, noting that it ensured he grew up eating “healthy food” rather than “sweets and cakes.”
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Decades later, his game-day preparation is still fueled by wholesome nutrition, always starting with a morning bowl of oatmeal, cereal or marmalade on toast to give him the energy to last the full 90 minutes.
The meal keeps him active enough to referee men’s, women’s and children’s games, a hobby he jokes he will never blow the final whistle on.
Frank Foster started refereeing in 1980. Today, he still officiates men’s, women’s and children’s games around three times a week. (SWNS)
His sharp mind and authoritative presence on the field are just as strong as his physical endurance.
A military veteran who aced his referee exam in 1980 with a 98% score, Foster relies on old-school discipline to keep matches under control, SWNS reported.
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He believes modern elite officials are too “soft” and allow player antics to ruin the sport. To maintain order and keep players from acting out, he lays down strict ground rules before kickoff. He has no patience for intimidation or theatrical diving. “Those who go down like they have been shot, well, I would just book them,” he said.
He is equally uncompromising when squads try to crowd him on the field.
Frank Foster is pictured before he became a referee. (Frank Foster/SWNS)
“I wouldn’t let them surround me at all,” Foster told SWNS.
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“I would say to the players, ‘Stay where you are,’ and ‘If you move one more inch, I will give you a yellow card.’ You need to stamp your authority and let them know who is in control.”
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He also avoids the modern stress of video-reviewing plays, which he believes creates unnecessary “aggression and disappointment” over microscopic offside calls, adding, “I think it spoils the game.”
Foster credits his longevity to wartime rations, adding that he avoided sweets. (SWNS)
“Sometimes it is only the player’s toe that is offside — it is ridiculous.”
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Foster says he “never thought” he’d still be doing this at age 93, but he makes the most of that gift.
He keeps his kit freshly washed, making sure it is “neat and tidy” for when he gets on that field.
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Foster, of South Yorkshire, England, also scrubs his black Adidas boots after every game, making sure they are “nice and clean” for his next match.
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Summer fun in the sun is being taken to a new extreme.
“Tanmaxxing” is a social media trend that involves maximizing sun exposure and tanning the skin more intensely.
Popular among Gen Z, the practice combines time spent in direct sunlight with a variety of tanning products like oils, bronzers and gels.
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Creators on social media are showing off their dramatic tan lines and outdoor set-ups — some even forgoing sun protection or adding tanning bed sessions.
“Tanmaxxing” is trending on social media as a way of maximizing sun exposure. (iStock)
While spending time outdoors can help boost mood, support the body’s production of vitamin D and reduce screen time, dermatologists warn that excessive sun exposure — especially as promoted by the tanmaxxing trend — can be dangerous.
New York-based board-certified dermatologist Dr. Michael Tassavor, MD, emphasized that there is “no such thing as a safe, natural tan.”
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“Tanning is damage,” he said in an interview with Fox News Digital. “Tanfluencers sell a deep tan as a ‘wellness upgrade,’ but a tan isn’t a glow-up — it’s your skin’s visible distress signal that DNA damage has already happened.”
“As a skin cancer specialist, I’ve taken care of thousands of skin cancers on patients who ‘tanmaxxed’ before it had a name. Most regret it.”
Using a tanning bed before 35 years old can raise melanoma risk by about 75%, an expert warned. (iStock)
The World Health Organization classifies UV radiation and tanning beds as Group 1 carcinogens, which is the same category as tobacco and asbestos.
Using a tanning bed before age 35 can raise melanoma risk by about 75%, Tassavor noted.
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“The damage compounds silently and shows up years later, once the easy window to intervene has closed,” he said.
According to Tassavor, two common beliefs behind tanmaxxing are false: Skipping sunscreen does not produce a “better” tan, and a base tan does not protect the skin from future sunburns.
“Most of your vitamin D can come from diet and supplements, and your skin is efficient enough to top up what it needs from ordinary incidental exposure,” a dermatologist said. (iStock)
Sunlight “isn’t the enemy,” the dermatologist noted, but there’s no need to chase it.
“Most of your vitamin D can come from diet and supplements, and your skin is efficient enough to [get] what it needs from ordinary incidental exposure,” he said.
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“Vitamin D matters for bone density, and sun does give some people a genuine mood lift, but there’s no evidence that anyone has to go out of their way to sunbathe for it, and no evidence that diligent sunscreen use harms bone health.”
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To safely expose yourself to the sun, Tassavor recommends using SPF 30 sunscreen and reapplying every two hours. Tanning beds should be avoided “entirely,” he cautioned, because there is “no safe dose” of UV exposure and using them accelerates skin aging.
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The Great American State Fair was postponed Saturday after multiple people reportedly fainted the day before, forcing thousands of visitors to pivot during celebrations for America’s 250th anniversary.
Friday’s medical emergencies required onsite attention as crowds flocked to the nation’s capital for Independence Day.
The fair reopened later Friday evening but was postponed again Saturday.
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Fox News Digital asked attendees what it took to get to the capital and what they made of the closure.
“We are so blessed to live in the best country in the world,” Whitney Thomas, a mother from North Carolina who traveled with her family for the Great American State Fair, told Fox News Digital Friday.
An arch across the street from a 110-foot “Freedom 250” Ferris wheel during final preparations for the Great American State Fair on the National Mall June 22, 2026 in Washington, D.C. (Al Drago for The Washington Post via Getty Images)
Despite the weather closure, she said her family was able to enjoy the State Fair Thursday evening and planned to wait out the heat in nearby museums until the fair reopened.
“I wanted my kids, who are 9 and 10, to be able to experience this with us,” she said.
“You cannot tell me that America was won by shutting things down when it gets hot.”
Brad Shultis, a retired Marine who traveled from Stafford, Virginia, expressed frustration over the decision to halt festivities.
“You cannot tell me that America was won by shutting things down when it gets hot,” he told Fox News Digital.
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“It gets hot, and we shut it down because it’s hot? Who cares? If it’s too hot, stay home.”
Shultis noted that he drove to Springfield and took the Metro just to be turned away right after buying lunch. He questioned the decision to shut down the celebration of America’s 250th anniversary, arguing that if people find the weather too hot, they should simply stay home or seek medical help rather than forcing a mass evacuation for those who spent time and money to get there.
Whitney Thomas brought her children with her from North Carolina to Washington to experience the historic event as a family. (Fox News Digital)
Wendy Lamb, who traveled eight hours from Connecticut with her family to support the state’s booth, noted that organizers were likely worried about the intense conditions and simply did not want visitors to suffer.
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While disappointed that her home state did not send official representation due to budget issues, Lamb and her fellow travelers refused to let the heat ruin their first trip to Washington, D.C.
“We’ve had a really, really fun time so far,” added John, another member of the group.
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He said they plan to navigate the heat by moving from museum to museum and using the Metro system to stay cool until the gates reopen.
For these visitors, the setback was minor compared to the emotional weight of seeing the U.S. Capitol and the Rotunda.
Judy drove with her family from Connecticut to support the state after officials withdrew support prior to the fair opening. (Fox News Digital)
“I mean, we are so fortunate we are free, and yet we have people out there that hate our country. … it’s very emotional,” said Pat Lamb, who fanned her face to stop tears welling in her eyes as she described the pride she felt for the nation.
The decision to close the fairgrounds aligns with severe weather protocols designed to prevent mass casualty medical events.
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According to the Centers for Disease Control and Prevention, extreme heat can quickly impair the body’s ability to cool itself, causing internal temperatures to rise faster than they can dissipate.
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When exposure to extreme conditions triggers a heat-related illness, symptoms can escalate rapidly from heat exhaustion — marked by heavy sweating, dizziness, nausea and fainting — to a life-threatening medical emergency, according to the CDC.
Brad Shultis, a veteran, was turned away just after lunch due to extreme heat at The Great American State Fair. (Fox News Digital)
The most severe risk is heat stroke, which occurs when the body’s cooling mechanism fails entirely, potentially driving core body temperatures to 103 degrees Fahrenheit or higher within minutes.
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To prevent severe complications like permanent organ damage or death, the CDC advises that anyone exhibiting warning signs such as confusion, slurred speech or a loss of consciousness should receive immediate medical treatment.
Public health officials urge individuals in high-heat environments to seek shade, stay heavily hydrated and identify air-conditioned cooling centers.
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