Health
‘Dual-action’ weight-loss pill helps people drop 13% of body weight in three months in early trials
An experimental weight-loss pill is showing promising results, helping people drop 13% of their body weight in a three-month period.
The results from early clinical trials were presented by Novo Nordisk — the Danish drugmaker behind Ozempic and Wegovy — at the European Association for the Study of Diabetes (EASD) annual meeting in Madrid this week.
The drug, amycretin, works by replicating two hunger hormones — amylin, which regulates appetite and creates a feeling of fullness, and glucagon-like peptide 1 (GLP-1), the same hormone that is used in Ozempic and Wegovy to suppress appetite and boost insulin secretion.
‘SIX-PACK SURGERY’ GAINING POPULARITY AMONG MEN, SAY PLASTIC SURGEONS
“Amycretin is the first treatment to harness the two distinct biological pathways stimulated by amylin and GLP-1 in a single molecule,” Martin Holst Lange, executive vice president and head of development at Novo Nordisk, said in a statement sent to Fox News Digital.
An experimental weight-loss pill is showing promising results, helping people drop 13% of their body weight in a three-month period. (iStock)
“We are proud to present the phase 1 study results at EASD, showing that the mean change in percentage body weight was -13.1% with amycretin after 12 weeks of treatment.”
While Ozempic and Wegovy are administered via injection, amycretin is given as a 50-milligram oral pill.
The clinical trial included participants who were obese or overweight but did not have diabetes. Those who took amycretin for 12 weeks lost more weight than those on a placebo — and higher doses led to more weight loss, according to Novo Nordisk.
OZEMPIC PUSH FOR SENIORS? SOME DOCTORS SAY MORE PEOPLE AGE 65 AND OVER SHOULD BE ON IT
Taking the pill once a day led to around 10% weight loss, and those who doubled the dose lost 13%.
Another benefit the researchers highlighted is that people taking amycretin did not appear to hit a “weight loss plateau,” continuing to shed pounds as long as they took it.
Novo Nordisk — the Danish drugmaker behind Ozempic and Wegovy — presented the findings at the European Association for the Study of Diabetes annual meeting in Madrid this week. (iStock)
“The lack of weight loss plateauing indicates the possibility of achieving further weight reductions with extended treatment,” Agnes Gasoirek, a senior clinical pharmacology specialist at Novo Nordisk, wrote in the study findings.
‘Dual effect’
Dr. Christine Ren-Fielding, director and chief of bariatric surgery at the NYU Langone Weight Management Program, commented on the drug’s effectiveness.
OBESITY MAKES PEOPLE MORE LIKELY TO CATCH COVID, STUDY SUGGESTS: ‘INDISPUTABLE RELATIONSHIP’
“GLP-1-based treatments, like Ozempic, have already shown impressive weight loss results by helping patients feel fuller for longer and reducing appetite,” the doctor, who was not involved in the study, told Fox News Digital.
“Adding amylin, another hormone that plays a crucial role in regulating insulin and hunger signals, amplifies this effect.”
Adding amylin, a hormone that plays a crucial role in regulating insulin and hunger signals, amplifies the effect of GLP-1 drugs like Ozempic, a doctor said. (Reuters)
This “dual action” creates a more powerful tool to manage cravings and caloric intake, according to Ren-Fielding.
“It’s particularly interesting because it addresses weight management through multiple physiological pathways, making it more comprehensive and potentially more effective than conventional treatments that typically focus on a single mechanism,” she added.
Potential risks or side effects
The most commonly reported side effects of amycretin include gastrointestinal issues like nausea and vomiting, more so with higher doses, according to Novo Nordisk.
“These adverse effects are not unusual with GLP-1 receptor agonists, which are known to affect gastric motility,” Ren-Fielding noted.
“It addresses weight management through multiple physiological pathways.”
It’s important to monitor these side effects closely, she advised, as GI issues are common among patients with obesity.
“While the initial weight loss outcomes are indeed encouraging, further studies are needed to ensure that the therapeutic benefits consistently outweigh the potential risks, especially with long-term administration,” Ren-Fielding added.
‘Not a cure-all’
While GLP-1 based drugs — including this new experimental pill — may show promising results, Ren-Fielding emphasized that they’re “not a cure-all for obesity.”
“Obesity is a chronic, multifactorial disease that requires a comprehensive, long-term approach,” she told Fox News Digital.
“Pharmacological treatments can play a significant role in managing the condition, but they are often most effective when combined with other interventions.”
“Obesity is a chronic, multifactorial disease that requires a comprehensive, long-term approach,” a doctor told Fox News Digital. (iStock)
Some patients may benefit from surgical interventions, the doctor said, along with lifestyle changes such as regular exercise, healthy eating and psychological support to address underlying behavioral factors.
“It’s important to recognize that obesity is not just about weight loss — it’s a lifelong condition that requires ongoing management, much like any other chronic disease,” she added.
Next steps
The results of the study are considered preliminary, as they have not yet been published in a peer-reviewed medical journal.
The researchers will continue to conduct research on amycretin in the coming months, according to Novo Nordisk.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
“The safety and tolerability profiles and the magnitude of weight loss support further development of amycretin, and we are awaiting data from the ongoing phase 1 trial with subcutaneous amycretin, with expected read-out in 2025,” Lange said.
“If further research supports these initial findings, I can envision it becoming a viable option for those struggling with obesity.”
Ren-Fielding said there is “certainly potential” for the new drug to get FDA approval, especially considering the effectiveness of GLP-1-based drugs in recent years — but confirmed that much more testing is needed.
“The current clinical trials are promising, but we need larger, long-term studies to really assess the safety and overall benefits of the drug,” she told Fox News Digital.
For more Health articles, visit www.foxnews.com/health
“If further research supports these initial findings, I can envision it becoming a viable option for those struggling with obesity,” she went on.
“While I’m cautiously optimistic, there’s still a road ahead before we see widespread availability.”
Health
How Well Will You Age? Take Our Quiz to Find Out.
Every day we’re faced with a zillion small choices: Go to sleep early, or watch one more episode of that Netflix drama. Call an old friend to catch up, or cruise social media. Of course, no single action will guarantee a long, healthy life or doom you to an early grave. But those little daily decisions do add up, and over the long term they can make a difference when it comes to both your longevity and your health span, the amount of life spent in relatively good health.
Scroll through this theoretical “day in the life” and select the option that best fits your typical day. Not every situation will apply perfectly, but think about which choice you’d be most likely to make. This isn’t a formal scientific assessment. The goal here isn’t to assign you a “good” or “bad” score, but to help you understand the central factors that shape the way we age and how long we live.
Health
Red hair may be increasing as study points to surprising evolution trend
NEWYou can now listen to Fox News articles!
A study from Harvard Medical School indicates natural selection has favored the red hair gene, resulting in a potential increase in the number of redheaded people as humanity continues to evolve.
By analyzing nearly 16,000 ancient genomes spanning 10,000 years, researchers identified a list of traits that nature is actively pushing forward. Among the most prominent were the genetic variants for red hair.
“Perhaps having red hair was beneficial 4,000 years ago, or perhaps it came along for the ride with a more important trait,” the authors noted.
22 HEALTH CARE PREDICTIONS FOR 2025 FROM MEDICAL RESEARCHERS
The study, published in the journal Nature, relied on a large database of ancient DNA from West Eurasia. Using new computing methods, the team was able to filter out random fluctuations in DNA to identify what it called “directional selection.”
Directional selection happens when a particular version of a gene gives an organism a strong survival or reproductive advantage, causing it to become more common in a population faster than it would by chance, according to experts.
Directional selection is when a specific gene provides such significant benefits that it rises in frequency across a population much faster than random chance. (iStock)
Prior to this study, scientists only knew of about 21 such instances in human history, one of which was lactose tolerance. This new research uncovered hundreds more.
“With these new techniques and a large amount of ancient genomic data, we can now watch how selection shaped biology in real time,” Ali Akbari, first author of the study and senior staff scientist in the lab of Harvard geneticist David Reich, said in a press release.
COMMON EATING HABIT MAY TRIGGER PREMATURE IMMUNE SYSTEM AGING, STUDY FINDS
The data showed that genetic markers for red hair are among 479 gene variants that have been strongly favored over the past 10,000 years. One likely explanation, the researchers said, is a major shift in human history: the transition to farming.
Scientists have long pointed to vitamin D synthesis as a likely driver for the rise of traits like fair skin and light hair. (iStock)
As humans moved away from hunting and gathering and settled into agricultural societies, their environment and behavior changed radically, triggering an evolutionary “acceleration.”
CLICK HERE FOR MORE HEALTH STORIES
While the Harvard study provides the first definitive statistical proof that red hair was actively selected during the rise of farming, the researchers noted that the exact prehistoric benefit still requires more study.
However, scientists have long pointed to vitamin D synthesis as a likely driver for the rise of these light-pigmented traits in northern climates.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
While redheads remain a minority of the global population today, the Harvard study’s analysis suggests that they may not be an evolutionary accident.
While redheads remain a minority of the global population today, the Harvard study’s analysis suggests they may not be an evolutionary accident. (iStock)
Instead, the red hair trait was “boosted” by natural selection as humans adapted to the challenges of a modern world, according to the researchers.
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
The researchers urged caution in how these findings are interpreted.
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
“What a variant is associated with now is not necessarily why an allele propagated,” the authors noted.
Health
Aging in Place: How Technology Might Help You Grow Old at Home
Dr. Megan Jack, a neurosurgeon in Cleveland, often works 60 or 70 hours a week. And she’s completely unavailable when she’s in the operating room. That makes it tough to be a caregiver for her 76-year-old mother, who lives in a separate unit on Dr. Jack’s property, 30 minutes away from the hospital.
To help care for her mother, who has Alzheimer’s disease, Dr. Jack uses an array of high-tech tools, some of which didn’t exist just a few years ago. She manages her mother’s medications with a smart pill box. She changes her television channels with an app, sends appointment reminders through a digital message board — and, with her mother’s blessing, uses cameras for communication and monitoring.
“It’s been invaluable that I can both make sure she’s safe and make sure everything is going well,” Dr. Jack said, “but also give her the independence and the freedom that she still deserves.”
America is aging rapidly. Roughly 11,000 people are turning 65 each day in the United States. And many of them — 75 percent of people over 50, according to AARP’s most recent survey, from 2024 — hope to spend their remaining years in the comfort of their homes, rather than in assisted-living or other care facilities.
One thing that could help fulfill those wishes is the budding field of “age tech,” which encompasses tools that support older adults. Industry experts say that age tech is making homes safer for older adults and is easing the minds of their caregivers, especially those who live far away or work outside the home.
Dr. Jack said that age tech had “really allowed me to integrate caregiving into my life, as opposed to caregiving taking over my life.”
The age tech boom
If older adults don’t have loved ones who are both close by and able to help, they might believe they don’t have a ton of options. They can live independently, or, if they can afford it and qualify medically, they can move to an assisted-living facility or a nursing home, without a lot of choices in between. In-home help can be expensive without Medicaid and can also be difficult to find, given the serious shortage of home care workers.
Age tech can help bridge some important gaps, said Emily Nabors, the associate director of innovation at the National Council on Aging, a nonprofit advocacy group. Already, AARP reports that 25 percent of caregivers are remotely monitoring their loved ones with apps, videos or wearables, nearly double the percentage from five years ago.
“We used to say homes are the health care settings of the future, but they really are health care settings now,” Ms. Nabors said. “Aging in place is very realistic.”
More than 700 companies are in AARP’s AgeTech Collaborative, a group that connects businesses, nonprofits and funders to help get new technologies off the ground. Altogether, the collaborative’s start-ups have raised nearly $1 billion in the past four years.
The products include smart walkers, glasses with lenses that provide real-time captions of conversations for those with hearing issues, and a concierge service that connects older people to drivers and deliveries, even if they don’t have a smartphone.
Ms. Nabors does foresee some affordability and access barriers to age tech, including the lack of high-speed internet in rural areas, but she said one vital resource would be local aging agencies, which can offer advice and, sometimes, free support.
Janet Marasa leaned on the agency near her home in Rockland County, N.Y., to get a free robotic pet for her mother, Carol DeMaio, 80, who has dementia. The pets, manufactured by a company called Joy for All, aim to offer emotional support without the upkeep.
Ms. DeMaio named the robotic dog Sabrina, after a golden retriever who died. The new Sabrina stays at the foot of her bed at night. As soon as Ms. DeMaio stirs awake, the dog reacts. “She said it gives her a reason to get up in the morning,” Ms. Marasa said.
The dog has been a boon to her, too. “It provides comfort and interaction that I can’t provide every second,” said Ms. Marasa, who lives with her mother but works full time for the county government. “It gives her something that she can feel like is totally her own.”
In Broward County, Fla., where the population of residents over 85 is expected to nearly triple over the next few decades, the local agency on aging has used state and federal money and private grants to provide technologies to nearly 4,000 of the county’s seniors at no cost.
Its offerings include a company that uses radar to sense falls and a program that allows seniors to make video calls through their televisions.
“The possibilities are endless,” Charlotte Mather-Taylor, the agency’s chief executive, said. “It’s pretty great to see all the new technology coming out so quickly, and I think that can only benefit our older population and also our caregivers.”
Here comes A.I.
Even technologies not specifically marketed as age tech can help older adults maintain their independence, said Laurie Orlov, founder of the blog Aging and Health Technology Watch. She pointed to video-calling and telehealth platforms; remotely controlled thermostats and lights; and smart speakers, doorbells and watches.
“All technology can be customized to help older adults stay longer in their homes and help their family members feel good about it, or at least tolerate it,” Ms. Orlov said.
That will only become more true with the continued proliferation of artificial intelligence, Ms. Orlov added. Some older adults are already using conversational A.I. to get answers about things like the weather or their medications. (Relying too heavily on A.I. can, however, have negative consequences because chatbots often give flawed medical advice and can lead patients astray.) A.I. can also assist in pattern detection: alerting caregivers to signals that might indicate declines in someone’s cognition or mental health, such as changing their speech pattern or leaving the house less frequently.
One A.I.-powered age tech tool is ElliQ, a tabletop companion robot that looks like a sleek silver desk lamp with a screen. About a year and a half ago, Camille Wolsonovich got one for free, thanks to a local nonprofit, for her 90-year-old father, Bill Castellano. He lives alone in a senior community.
Ms. Wolsonovich, who runs a consulting business, relies on ElliQ to lead her father in exercises and remind him to take his pills and drink water. The robot also asks her father about his sleep and mood via automated check-ins.
“Everything’s just another layer that gives us more confidence, from a caregiving standpoint, that he’s good,” Ms. Wolsonovich said. “I don’t have to necessarily track everything all the time and be overbearing.”
As for Mr. Castellano? He plays trivia digitally and converses daily with ElliQ. The robot, which has a friendly female voice, asks questions, cracks jokes and remembers his likes, dislikes and friends. “She’s great company,” he said. “Everybody around me wants one.”
What about ethical concerns?
Clara Berridge studies the ethics of age tech at the University of Washington.
She has many privacy concerns, namely that most direct-to-consumer products aren’t subject to medical privacy laws, despite being privy to sensitive health information. Though she hopes the federal government will eventually step in to regulate these products, as it has in other countries, the onus remains on the consumer for now.
And even if an age tech product isn’t selling mom’s personal data to the lowest bidder, Dr. Berridge said there’s still the question of whether certain tools are ethical.
“It’s really important for caregivers to recognize that using these new technologies that give them more information about someone can represent greater intrusion into someone’s life,” she said.
What may be well-intentioned monitoring could reveal information that an older adult would rather keep private, such as issues with incontinence, or the comings and goings of a romantic partner.
“It can lead to somebody feeling infantilized,” Dr. Berridge said. “Like there’s not a place to hide within your own home.”
Her research shows that adult children often underestimate how much their parents can understand about technology and how much they want to be involved in tech-related decisions.
She encouraged caregivers to have transparent conversations about privacy implications and to avoid ultimatums or the idea that any decision must be permanent. She said caregivers should put themselves in their parents’ shoes: Is this something they’d want their own children monitoring?
Dr. Berridge is working on an advanced directive for technology, which outlines older people’s wishes for how technology is used in their care. Ultimately, she hopes that questions about age tech will become a standard part of planning for the future.
“If you’re at the start of what, for many people, ends up being a long road of supporting someone potentially through the end of their life,” she said, “seeking to understand each other’s concerns and priorities better is time very well spent.”
-
Alabama3 minutes agoAlabama QB Ty Simpson says faith in Jesus Christ fuels confidence heading into 2026 NFL Draft
-
Alaska9 minutes agoHawaiian and Alaska Airlines officially integrate digital services
-
Arizona15 minutes agoArizona Lottery Powerball, The Pick results for April 22, 2026
-
Arkansas21 minutes agoArkansas’ congressional delegation updates state business leaders on legislative priorities | Northwest Arkansas Democrat-Gazette
-
California27 minutes agoTop California governor candidates debate in San Francisco as field narrows
-
Colorado33 minutes agoRockies’ Tomoyuki Sugano shuts down Padres in 8-3 Colorado win
-
Connecticut39 minutes agoCT Lottery Powerball, Cash 5 winning numbers for April 22, 2026
-
Delaware45 minutes agoBody found near Bowers Beach – 47abc