COVID-19 rebound possible after taking Paxlovid, but no further treatment necessary: CDC

The Facilities for Illness Management and Prevention (CDC) warns of the potential for “COVID-19 rebound” after sufferers take the oral antiviral drug known as Paxlovid. The therapy is allowed underneath emergency use by the Meals and Drug Administration for grownup and pediatric sufferers with mild-to-moderate COVID-19 who’re in danger for extreme illness.

“Should you take Paxlovid, you may get signs once more,” CDC director Dr. Rochelle Walensky mentioned. “We’ve not but seen anyone who has returned with signs needing to go to the hospital. So, typically, a milder course.”

COVID-19 rebound is a return of COVID-19 signs or a brand new optimistic viral take a look at (after testing destructive) between two and eight days after getting higher. 

However the company famous some individuals might expertise the transient rebound of signs as a part of the pure course of the illness and “impartial of therapy with Paxlovid and no matter vaccination standing,” in line with a current CDC Well being Alert Community Well being Advisory.

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The company continues to advocate the antiviral therapy as Paxlovid helps stop hospitalization and demise attributable to COVID-19. It needs to be taken inside 5 days of symptom onset.  

“Each the recurrence of sickness and optimistic take a look at outcomes improved or resolved (median of three days) with out further anti-COVID-19 therapy. Based mostly on info from the case stories, COVID-19 rebound didn’t symbolize reinfection with SARS-CoV-2 or the event of resistance to Paxlovid; additionally, no different respiratory pathogens had been recognized amongst recognized instances,” the CDC mentioned.

The Heart for Illness Management and Prevention (CDC) has been criticized and mocked from all sides after a collection of muddled messages have baffled People amid a file surge in COVID-19 instances and the unfold of the omicron variant. 
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It’s potential to transmit the an infection whereas experiencing COVID-19 rebound, but it surely’s unknown at this level how the probability of transmission throughout rebound compares to the probability of transmission through the preliminary an infection.

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The company added there isn’t a proof Paxlovid must be prolonged or every other antiviral therapies are wanted for COVID-19 rebound, however the danger of transmission throughout this era will be managed by following CDC’s steerage on isolation.

For many who expertise COVID-19 rebound, Walensky suggested: “They need to take a look at. They need to put their masks again on. And if their take a look at is optimistic, restart the isolation protocol.”