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Breast cancer drug could help prolong survival for children with brain tumors, study finds

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Breast cancer drug could help prolong survival for children with brain tumors, study finds

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A drug called ribociclib, currently used to treat breast cancer, could slow the progression of certain pediatric high-grade gliomas, an aggressive type of childhood brain cancer, a new study has found.

Ribociclib (brand name Kisqali) is a CDK4/6 inhibitor, a type of drug that targets specific enzymes — including the protein CDK6 — to stop cancer cells from growing.

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In the study, which was published in the journal Cancer Cell, a 10-year-old patient who had experienced a second relapse of pediatric high-grade glioma — and had no other treatment options — experienced 17 months of “progression-free survival” after taking ribociclib.

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The patient had a diffuse hemispheric glioma (DHG), which typically develops in the frontal, parietal and temporal lobes of the brain.

“These very early results are remarkable given the typically poor prognosis for children diagnosed with these aggressive brain tumors,” according to a press release from the Institute of Cancer Research (ICR) in London.

A drug called ribociclib, which is currently used to treat breast cancer, could slow the progression of certain pediatric high-grade gliomas. (iStock)

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This type of tumor usually progresses within 3½ months of recurrence.

It has been four years since the female patient received her diagnosis. She is currently receiving further treatment, the release stated.

“We are finally starting to see more targeted therapies come out for different forms of brain cancer.”

“Ribociclib was chosen based on the genetic profile of the patient’s tumor, which demonstrated relevant markers,” said Dr. Gregory Nalesnik, a pediatric oncologist at Memorial Sloan Kettering Cancer Center in New York, who was not involved in the study but reviewed the findings.

The drug was also shown to be effective in mice — 100% of the mice treated with ribociclib survived for 110 days after treatment, compared to only 25% of the mice who received a placebo.

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High-grade gliomas (HGGs) are aggressive tumors in the brain and spinal cord that can occur in children and adults. (iStock)

The study, which was led by ICR and the Dana-Farber Cancer Institute in Boston, was partly funded by The Brain Tumour Charity and Cancer Research UK.

“We are finally starting to see more targeted therapies come out for different forms of brain cancer,” says senior author Mariella Filbin, M.D., PhD, co-director of the Brain Tumor Center of Excellence at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, in the press release.

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“Our patients really need these new treatment options.”

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Ribociclib was approved by the U.S. Food and Drug Administration (FDA) in March 2017 for the treatment of certain types of advanced or metastatic breast cancer in postmenopausal women.

What to know about high-grade gliomas

High-grade gliomas (HGGs) are aggressive tumors in the brain and spinal cord that can occur in children and adults.

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This type of tumor makes up some 10% of pediatric brain tumors, according to the American Brain Tumor Association (ABTA).

They are generally difficult to treat because they often grow into the tissue of the central nervous system.

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A 10-year-old patient (not pictured) who had experienced a second relapse of pediatric high-grade glioma — and had no other treatment options — experienced 17 months of “progression-free survival” after taking ribociclib. (iStock)

In children who are diagnosed with a high-grade glioma, the overall survival rate is less than two years, with less than 30% of patients surviving for five years.

Current treatments include surgery, radiation and chemotherapy, although these drugs have proven more effective for adults than children, noted the ABTA.

Results show promise, more research is needed

Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, was not involved in the study but shared his opinions on the drug’s potential.

“This is a targeted therapy that has been used in breast cancer to attack growth factors on the surface of the cancer,” he told Fox News Digital. 

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“It is now showing some promise in slowing progression of several months in a rare but deadly childhood glioma (malignancy in support cells of the brain).” 

“This research helps us have a better understanding of what is driving this devastating disease in children.”

On a wider scale, the drug could target more growth factor proteins on cancer cells, Siegel noted.

“This approach may be combined with other treatments, including surgery and radiation, to help prolong life,” he added.

In children diagnosed with a high-grade glioma, the overall survival rate is less than two years, with less than 30% of patients surviving for five years. (iStock)

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The study highlights the growing prevalence of targeted therapy, Nalesnik commented.

“The use of therapy guided by molecular tumor markers is becoming more and more prevalent in the world of oncology,” he told Fox News Digital. 

      

“Sometimes called ‘targeted therapies,’ these treatments are much more specific than traditional chemotherapies, which are globally cytotoxic (toxic to living cells) in general.” 

“This research helps us have a better understanding of what is driving this devastating disease in children,” a scientist said. (iStock)

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Targeted therapies like ribociclib, which are designed to address the root cause of a cancer cell’s harmful behavior, often have fewer side effects than conventional chemotherapy, according to Nalesnik.

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While targeted therapies show promise in treating aggressive cancers, experts agree that more research is needed.

“Although more clinical trials are needed to lend evidence to efficacy and information about side effects (both short-term and long-term), I applaud the authors in their application of translational research and the use of targeted therapy for pediatric high-grade glioma,” Nalesnik added.

Looking ahead, the researchers hope that this study will pave the way to clinical trials that include more patients. (iStock)

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Looking ahead, the researchers hope that this study will pave the way to clinical trials that include more patients.

“This research helps us have a better understanding of what is driving this devastating disease in children,” said Dr. Simon Newman, chief scientific officer at The Brain Tumour Charity, in the press release. 

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“We know that current treatments are not effective and that finding vulnerabilities in cancer cells could lead to new, targeted treatments to help children live longer and better lives. Although this is very early days, we hope that it will provide some data to inform clinical trials in the future.”

Fox News Digital reached out to the study researchers and to ABTA for comment.

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Flu hospitalizations hit all-time weekly high in densely populated state, officials warn

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Flu hospitalizations hit all-time weekly high in densely populated state, officials warn

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The New York State Department of Health has announced the highest number of flu hospitalizations recorded in a single week.

The state confirmed the uptick in hospital visits in a press release on Jan. 2, as flu cases continue to rise in the region and nationwide.

New York State, including New York City, has consistently tracked the highest numbers of recorded respiratory illness cases in the country for the last few weeks, according to CDC data. Several other states have climbed to the “very high” category for respiratory activity as well, as of the week ending Dec. 27.

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The most recent data from the New York health department showed a total of 4,546 hospitalizations from Dec. 26, 2025, to Jan. 2, 2026 – a week-over-week increase of nearly 1,000. The prior week, the department announced the highest number of flu cases ever recorded in a single seven-day period.

The New York State Department of Health reported a total of 4,546 hospitalizations from Dec. 26, 2025, to Jan. 2, 2026. (iStock)

In a statement, New York’s Acting Commissioner of Health Dr. James McDonald noted the severity of this flu season compared to previous years.

“Almost 1,000 more people were admitted to a hospital during this most recent seven-day period compared to the prior week,” he confirmed. “There is still time to get a flu shot, and remember, flu can be treated with antiviral medication if started within 48 hours of symptom onset [as] your doctor deems appropriate.”

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Health officials are pushing for Americans to consider getting the flu vaccine, as experts consider it to be a top line of defense for preventing viral exposure and spread.

Flu symptoms can include fever, chills, headache, fatigue, cough, sore throat and runny nose. (iStock)

In a previous interview with Fox News Digital, Dr. Neil Maniar, professor of public health practice at Boston’s Northeastern University, emphasized that it’s not too late to get the flu vaccine, as peak season typically occurs in January.

“The vaccine still provides protection against serious illness resulting from the subclade K variant that seems to be going around,” he said.

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Even healthy individuals can become seriously ill from the flu, Maniar noted, “so a vaccine is beneficial for almost everyone.”

“Individuals typically start to develop some degree of protection within a few days and gain the full benefit within about two weeks, so now is the time for anyone who hasn’t gotten the vaccine yet.”

“The vaccine still provides protection against serious illness resulting from the subclade K variant that seems to be going around,” one doctor said. (iStock)

Flu symptoms can include fever, chills, headache, fatigue, cough, sore throat and runny nose.

A mutation of influenza A H3N2, called subclade K, has been detected as the culprit in rising global cases, causing more intense symptoms and higher risk of spread.

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“It’s becoming evident that this is a pretty severe variant of the flu,” Maniar said. “Certainly, in other parts of the world where this variant has been prevalent, it’s caused some severe illness, and we’re seeing an aggressive flu season already.”

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New York State recommends taking preventive actions to avoid flu infection. These include washing hands often; avoiding touching the eyes, nose and mouth; avoiding close contact with sick people; cleaning and disinfecting objects and surfaces; and staying home when feeling sick.

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Not all cancers should be treated right away, medical experts say — here’s why

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Not all cancers should be treated right away, medical experts say — here’s why

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When someone gets a cancer diagnosis, the initial reaction is usually to undergo treatment as quickly as possible — but for some types of disease, doctors may recommend a more conservative approach.

For certain cancers, immediate or aggressive treatment can cause more harm than good, according to multiple medical experts.

For example, treating slow-growing tumors with surgery, radiation or chemotherapy could create significant side effects without a survival benefit.

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“The fact that so many cancers will never kill you is not a justification for not knowing, because there is still plenty of room for ‘watchful waiting,’ as well as interventions that may improve quality of life even if they don’t extend life,” Dr. Marc Siegel, Fox News senior medical analyst, told Fox News Digital.

This is especially true as targeted cancer treatments emerge, which are more personalized and less likely to cause severe side effects, according to the doctor.

For precancerous, very early-stage breast conditions, careful monitoring may be more prudent than immediate surgery, research shows. (iStock)

“The fact that cancers are occurring earlier is a justification for heightened screenings, not the opposite,” Siegel added. “Information is power — what you do with that information is based on clinical judgment and the art of medicine.”

Below are some types of cancer that may not warrant treatment, according to research and doctors’ guidance.

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No. 1: Prostate cancer (low-risk)

While some types of prostate cancer should be treated right away, others are better addressed by “watchful waiting,” according to Sanoj Punnen, M.D., a urologic oncologist with Sylvester Comprehensive Cancer Center, part of the University of Miami Health System. 

“With respect to prostate cancer, for most low-risk cancers (Gleason 6 or grade group 1), we recommend initial observation and surveillance rather than immediate treatment,” he told Fox News Digital.

NEW PROSTATE CANCER TEST PINPOINTS DISEASE BETTER THAN PSA OPTION, STUDY FINDS

The Gleason score is a grading system that ranks prostate cancer cells in terms of how abnormal they are, with 6 being the lowest grade and 10 being the highest grade (barely resembling normal cells).

“For high-grade tumors like Gleason 8, 9 or 10, we believe they progress quickly, so we recommend treatment to prevent the risk of metastasis,” said Punnen, who is also vice chair of research and a professor with the Desai Sethi Urology Institute at UHealth. “For low-risk tumors, we think they pose little risk, so we recommend just observation.”

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“The fact that cancers are occurring earlier is a justification for heightened screenings, not the opposite.”

“But in the end, we can’t be sure, so our approach to observation includes serial monitoring of cancer status with PSA, MRI and occasional biopsy to ensure the tumor isn’t progressing.”

No. 2: Ductal carcinoma in situ (DCIS) 

Also known as stage 0 breast cancer, DCIS is a non-invasive disease marked by abnormal cells in the lining of the breast milk ducts. The “in situ” is Latin for “in the original place,” which indicates that the cancer has not spread outside the milk ducts.

For this precancerous, very early-stage breast condition, careful monitoring may be more prudent than immediate surgery, research shows.

While some types of prostate cancer should be treated right away, others are better addressed by “watchful waiting,” according to a urologic oncologist. (iStock)

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A 2024 study by the Dana-Farber Cancer Institute found that active monitoring for DCIS resulted in similar quality of life, mental health and symptom progression over a two-year period compared to a standard surgical approach.

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“These results suggest that in the short term, active monitoring is a reasonable approach to management of low-risk DCIS,” the lead researcher said in a press release. “If longer-term follow-up supports the safety of active management from a cancer outcome standpoint, this approach could be considered as an option for women with this condition.”

“But it is also critical that we understand how women feel when they are living with this ‘watch and wait’ approach and how it impacts their overall quality of life.”

Other research has suggested that women with low-risk DCIS did not have a higher rate of invasive cancer after two years of active monitoring, although each patient should discuss their individual risk level with an oncologist.

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No. 3: Indolent (slow-growing) lymphomas

Non-Hodgkin lymphoma (NHL) is a type of cancer that starts in the lymphatic system, which includes the lymph nodes, spleen, thymus, bone marrow and other tissues. 

Indolent lymphomas are those that “grow and spread slowly,” according to the American Cancer Society.

THE DEADLY CANCER HIDING IN PLAIN SIGHT — AND WHY MOST PATIENTS NEVER GET SCREENED

The National Comprehensive Cancer Network (NCCN) recommends watchful waiting for asymptomatic, slow-growing follicular lymphoma, as a means of avoiding the toxicity of chemotherapy and immunotherapy until it’s absolutely necessary.

The Lymphoma Research Foundation confirms that doctors recommend “active surveillance” for some patients with slow-growing lymphoma.

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Indolent lymphomas are those that “grow and spread slowly,” according to the American Cancer Society. (iStock)

“This approach may be started after the initial diagnosis or after relapse, depending on the situation,” the foundation states on its website. “Active treatment is started if the patient begins to develop lymphoma-related symptoms or if there are signs that the disease is progressing.”

Treatment should be started right away for aggressive (fast-growing) lymphomas.

No. 4: Chronic lymphocytic leukemia

One of the most common adult leukemias, chronic lymphocytic leukemia (CLL) originates in white blood cells (lymphocytes) in the bone marrow and then spreads to the bloodstream, according to the American Cancer Society.

CLL tends to grow slowly, with many patients experiencing no symptoms for years. Eventually, the cancer calls can spread to the lymph nodes, liver and spleen.

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BREAKTHROUGH BLOOD TEST COULD SPOT DOZENS OF CANCERS BEFORE SYMPTOMS APPEAR

Some studies have shown that early treatment for CLL does not improve survival rates compared to observation, and that the benefits may not outweigh the risks.

In a 2023 study presented at the European Hematology Association 2023 Congress in Frankfurt, Germany, researchers found that early treatment did not prolong overall survival compared to a placebo in patients with early, asymptomatic CLL.

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“I believe it’s fair to conclude that ‘watch-and-wait’ should remain the standard of care in the era of targeted drugs,” said researcher Petra Langerbeins, M.D., when presenting the findings.

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No. 5: Low-grade endometrial cancer

For most patients with endometrial cancer, surgery is the first treatment, which entails removing the uterus, fallopian tubes and ovaries, according to the American Cancer Society.

However, in certain patients with low-grade cancer, such as older people, those with “frailty” and people with major health issues, doctors may recommend deferring surgery, which can pose a high risk.

The American Thyroid Association’s guidelines officially recommend active surveillance for very low-risk microcarcinomas. (iStock)

In cases where the patient has medical comorbidities or wants to preserve fertility, hormone treatment may be used instead of surgery, per the ACS.

“It’s usually also considered for cancer that is lower-grade, low-volume and slow-growing,” the above source stated.

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No. 6: Some early kidney cancers

In cases of kidney cancer with small tumors (≤3 cm) or benign lesions, doctors may recommend monitoring them instead of undergoing surgery for removal.

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The American Urological Association confirms that active surveillance is an option for some small renal masses (localized tumors).

“I believe it’s fair to conclude that ‘watch-and-wait’ should remain the standard of care in the era of targeted drugs.”

Deferred treatment is particularly recommended for older patients or those with “significant comorbidities,” research shows.

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“Shared decision-making about active surveillance should consider risks of intervention/competing mortality versus potential oncologic benefits of intervention,” the UAU states in its guidance.

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Data from the Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry showed that patients with active surveillance had a 99% or greater cancer-specific survival rate — virtually the same as patients who received immediate treatment.

No. 7: Small papillary thyroid cancers

Papillary thyroid cancer (PTC), the most common type of thyroid cancer, may not warrant treatment for small tumors measuring 1 centimeter (10 mm) or less, which are called microcarcinomas.

A young multiracial female is undergoing a diagnostic medical imaging procedure in a state-of-the-art hospital setting with CT simulator. The image illustrates the use of cutting-edge technology for healthcare and treatment in a modern medical environment. The portrayal highlights precision, care, and the sophistication of contemporary medical practices. (iStock)

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Research found that when using active surveillance for 10 to 20 years, less than 10% experienced significant growth, only 5% developed lymph node spread and there were no thyroid-cancer deaths.

The American Thyroid Association’s guidelines officially recommend active surveillance for very low-risk microcarcinomas.

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While many patients with low-risk tumors can safely delay treatment, this does not apply to all cancers or all patients. 

As cancer behavior and personal health factors vary widely, patients should consult their doctor to determine the most appropriate course of care based on their individual risk level.

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Brain Health Challenge: Test Your Knowledge of Healthy Habits

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Brain Health Challenge: Test Your Knowledge of Healthy Habits

Welcome to the Brain Health Challenge! I’m Dana Smith, a reporter at The New York Times, and I’ll be your guide.

To live a healthy life, it’s crucial to have a healthy brain. In the short term, it keeps you sharp and firing on all cylinders. In the long term, it can reduce your risk of cognitive decline, dementia and stroke.

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Practicing basic healthy behaviors, like eating nutritious food and getting regular exercise, is the best way to enhance your brain power and protect the longevity of your neurons. These types of lifestyle habits can benefit the brain at any age. And while they won’t guarantee that you’ll never develop dementia or another brain disease, several clinical trials have shown that they can improve cognition or slow decline.

Every day this week, you’ll do an activity that’s good for your brain, and we’ll dig into the science behind why it works. Some of these activities can provide a small immediate cognitive benefit, but the bigger reward comes from engaging in them consistently over time. So along with the neuroscience lessons, we’ll include a few tips to help you turn these actions into lasting habits.

To keep you accountable, we’re encouraging you to complete this challenge with a friend. If you don’t have a challenge buddy, no problem: We’re also turning the comments section into one big support group.

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There are so many fascinating ways your daily behaviors affect your brain. Take sleep, for example.

Lots of studies have shown that getting a good night’s rest (seven to eight hours) is associated with better memory and other cognitive abilities. That’s because sleep, especially REM sleep, is when your brain transfers short-term memories — things you learned or experienced during the day — into long-term storage.

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Sleep is also when your brain does its daily housekeeping. While you rest, the brain’s glymphatic system kicks into high gear, clearing out abnormal proteins and other molecular garbage, including the protein amyloid, which is a major contributor to Alzheimer’s disease. A buildup of amyloid is one reason experts think that people who routinely get less sleep have a higher risk of dementia.

What other behaviors play a big role in brain health? For today’s activity, we’re going to test your knowledge with a quiz. Share your score with your accountability partner and in the comments below — I’ll be in there too, cheering you on.

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