Health
Ancient 'pharaoh's curse' fungus shows promise in killing cancer cells
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A potentially deadly fungus known as “pharaoh’s curse fungus” could offer an unexpected path to fighting cancer, recent research shows.
Scientists from the University of Pennsylvania modified molecules from the fungus — which is officially called Aspergillus flavus — to create a new compound and enhance its cancer-killing properties.
“Fungi gave us penicillin,” said Dr. Xue (Sherry) Gao, an associate professor at UPenn and leader of the study, in a press release. “These results show that many more medicines derived from natural products remain to be found.”
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The findings were published in the journal Nature Chemical Biology.
Aspergillus flavus is found in decaying leaves and compost, as well as on trees, plants and some crops, according to Mayo Clinic.
A sample of Aspergillus flavus cultured in the Gao Lab at the University of Pennsylvania. (Bella Ciervo / UPenn)
While the fungus doesn’t endanger most healthy people, it can cause respiratory issues for those who have weakened immune systems or are taking certain medications.
Some of the more severe complications of the fungus can include bleeding in the lungs and life-threatening infections in the brain, heart and kidneys, Mayo Clinic stated.
History of the ‘curse’
After archaeologists opened King Tut’s tomb in the 1920s, multiple members of the excavation team died suddenly, fueling rumors of a “curse” upon those who dared interfere with the pharaoh’s rest, according to the UPenn press release.
After archaeologists opened King Tut’s tomb in the 1920s, members of the excavation team died suddenly, fueling rumors of a “curse” upon those who disturbed the pharaoh’s rest. (Historica Graphica Collection/Heritage Images/Getty Images)
Decades later, doctors hypothesized that fungal spores, which had been dormant for thousands of years, could have infected the team.
In the 1970s, it happened again, the university stated.
A dozen scientists entered another tomb, this time in Poland — and 10 died within a few weeks. Later investigations were said to reveal the presence of Aspergillus flavus in the tomb.
Cancer-fighting potential
Now, the same fungus linked to King Tut’s tomb could have the capability to fight leukemia in a new form of cancer therapy.
“There are a variety of compounds able to be produced by fungus,” Gao told Fox News Digital.
These compounds can be toxic to different cells, she noted, depending on the “biological management we are able to mitigate.”
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The study aimed to find a specific kind of compound — ribosomally synthesized and post-translationally modified peptides, or “RiPPs” — within Aspergillus flavus, which was previously shown to be a good source.
When this compound is able to enter cancer cells, Gao said, it may be able to stop their growth.
“Cancer cells divide uncontrollably,” Gao said in the release. “These compounds block the formation of microtubules, which are essential for cell division.”
First author Qiuyue Nie and coauthor Maria Zotova, from left, purify samples of the fungus in the UPenn lab. (Bella Ciervo / UPenn)
When mixed with human cancer cells, two variants of the molecules within these RiPPS were found to have potent effects against leukemia cells, the researchers found.
Another variant performed as well as two FDA-approved drugs that have been used for decades to treat leukemia (cytarabine and daunorubicin).
Potential limitations
Tiffany Troso-Sandoval, M.D., a medical oncologist and cancer care consultant based in New York, cautioned that this study, which was performed on cell cultures, is still in the very early stages.
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“It’s still very far away from being applicable to use in humans with leukemia,” Troso-Sandoval, who was not involved in the study, told Fox News Digital.
Speaking about RiPPs, the doctor told Fox News Digital, “What they’re referring to [in the study] is basically a rare type of bioactive molecule that they have isolated from this fungus.”
There are multiple subtypes of leukemia, Troso-Sandoval pointed out, including acute and chronic forms.
“One treatment might not work on [another] type of leukemia,” she noted. Further testing is needed to determine which subtypes may contain the active molecule.
Acute myeloid leukemia (AML) is a type of blood cancer. Once the identified compound is able to enter cancer cells, it may be able to stop their uncontrolled growth, the researchers said. (iStock)
The compound explored in the study had little to no effect on breast, liver or lung cancer cells, the researchers noted.
This suggests that its disruptive effects only work on certain types of cells, which will be an important consideration when developing medications.
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Looking ahead, the researchers plan to test the fungus’ potential in animal models and, ultimately, human trials.
Gao told Fox News Digital she is “excited about what nature can create and how it can benefit our society.”
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The study received support from the National Institutes of Health, the University of Pennsylvania, the Welch Foundation, the Houston Area Molecular Biophysics Program, the Cancer Prevention and Research Institute of Texas and the National Science Foundation.
Health
Common household chemicals linked to increased risk of serious neurological condition
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A study from Sweden’s Uppsala University discovered a link between microplastics and multiple sclerosis (MS).
The research, published in the journal Environmental International, discovered that exposure to two common environmental contaminants, PFAS and PCBs, could increase the risk of the autoimmune disease.
PFAS, or per- and polyfluoroalkyl substances, known as “forever chemicals,” are used in some common household products, such as non-stick cookware, textiles and cleaning products. They have also been found in drinking water throughout the U.S., according to the U.S. Environmental Protection Agency.
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PCBs, or polychlorinated biphenyls, are toxic industrial chemicals once widely used in electrical equipment before being banned decades ago, as stated by the National Institute of Environmental Health Sciences.
The new study findings were based on blood samples of 1,800 Swedish individuals, including about 900 who had recently been diagnosed with MS, according to a university press release.
PFAS, or per- and polyfluoroalkyl substances, known as “forever chemicals,” are used in some common household products, including non-stick cookware. (iStock)
The first phase of the trial studied 14 different PFAS contaminants and three substances that appear when PCBs are broken down in the body. These were then investigated for a link to the odds of diagnosis.
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“We saw that several individual substances, such as PFOS and two hydroxylated PCBs, were linked to increased odds for MS,” lead study author Kim Kultima said in a statement. “People with the highest concentrations of PFOS and PCBs had approximately twice the odds of being diagnosed with MS, compared to those with the lowest concentrations.”
The researchers then examined the combined effects of these substances and found that the mixture was also linked to increased risk.
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Fellow researcher Aina Vaivade noted that risk assessments should consider chemical mixtures, not just individual exposures, because people are typically exposed to multiple substances at the same time.
“We saw that several individual substances, such as PFOS and two hydroxylated PCBs, were linked to increased odds for MS,” the lead study author said. (iStock)
The final phase of the study investigated the relationship between inheritance, chemical exposure and the odds of MS diagnosis, revealing that those who carry a certain gene variant actually have a reduced MS risk.
However, individuals who carried the gene and had higher exposure to PFOS — a singular type of chemical in the PFAS family — had an “unexpected” increased risk of MS.
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“This indicates that there is a complex interaction between inheritance and environmental exposure linked to the odds of MS,” Kultima said.
“We therefore think it is important to understand how environmental contaminants interact with hereditary factors, as this can provide new knowledge about the genesis of MS and could also be relevant for other diseases.”
Multiple sclerosis is a disease that leads to the breakdown of the protective covering of the nerves, according to Mayo Clinic. (iStock)
Fox News senior medical analyst Dr. Marc Siegel commented on these findings in an interview with Fox News Digital.
“MS is a complex disease that is somewhat autoimmune and somewhat post-inflammatory,” said Siegel, who was not involved in the study. “Epstein-Barr virus infection greatly increases the risk of MS.”
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“There is every reason to believe that environmental triggers play a role, including microplastics, and this important study shows a correlation, but not causation — in other words, it doesn’t prove that the microplastics caused MS.”
The study had some limitations, the researchers acknowledged, including that the chemical exposure was measured only once, at the time of blood sampling. This means it may not accurately represent participants’ long-term or past exposure levels relevant to MS development.
“There is every reason to believe that environmental triggers play a role.”
Fox News Digital reached out to several industry groups and manufacturers requesting comment on the potential link between PFAS chemicals and multiple sclerosis.
Several have issued public statements, including the American Chemistry Council, which states on its website that “manufacturers and many users of today’s PFAS are implementing a variety of practices and technologies to help minimize environmental emissions.”
In April 2024, the EPA enacted a new federal rule that sets mandatory limits on certain PFAS chemicals in drinking water, aiming to reduce exposure. The agency also aims to fund testing and treatment efforts.
A woman working out outdoors takes a sip of water from a plastic bottle. (iStock)
Multiple sclerosis is a disease that leads to the breakdown of the protective coverings that surround nerve fibers, according to Mayo Clinic.
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The immune system’s attack on these nerve sheaths can cause numbness, weakness, trouble walking and moving, vision changes and other symptoms, and can lead to permanent damage.
There is currently no cure for MS, Mayo Clinic reports, but treatment is available to manage symptoms and modify the course of the disease.
Health
Natural Ozempic? 6 GLP-1 Foods That Work Just Like the Shot
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Health
Simple daily habit could help people with type 2 diabetes manage blood sugar
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Sitting next to a window may help people with type 2 diabetes control their insulin levels, according to new research.
The study, published in Cell Metabolism, found that exposure to natural light — even indoors next to a window — changes how the body processes glucose and uses energy.
People in Western societies spend 80% to 90% of their time under artificial lights, which are much dimmer and less dynamic than sunlight, the researchers noted. Natural daylight is a powerful cue for the body’s internal clock, also known as the circadian rhythm.
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The body’s internal clock influences many processes, including digestion, hormone release and metabolism, according to research. When it gets out of sync, it can worsen insulin resistance and blood sugar control, which are two of the main issues caused by type 2 diabetes.
Typical lighting in homes and offices is much dimmer and lacks the biological signals provided by natural daylight. (iStock)
To test the effects of daylight on blood sugar, scientists recruited 13 adults with type 2 diabetes. Each person spent two separate 4.5-day periods in a controlled office setting, according to a press release.
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In one period, they worked in front of large windows with natural daylight streaming in. In the other period, participants worked in the same room with the windows covered and were exposed only to typical indoor lighting.
Daylight isn’t a replacement for medication or traditional management strategies like diet and exercise, the researchers noted.
Everyone ate similar meals, followed the same schedule and continued their usual diabetes medications in both conditions.
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While average blood sugar levels didn’t differ drastically between the two conditions, people spent more time in the healthy glucose range when they were exposed to natural daylight — their blood sugar fluctuated less and stayed within a desirable range for a greater portion of the day.
Participants who were exposed to daylight burned more fat and fewer carbohydrates, a metabolic pattern linked to better blood sugar regulation. (iStock)
Exposure to natural light also affected metabolism. In daylight, participants burned more fat and fewer carbohydrates for energy.
Muscle biopsies and laboratory tests further showed that the genes responsible for the body’s cellular clocks were more synchronized under natural light conditions, the study revealed.
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Better alignment of these genes can improve nutrient processing and how cells respond to insulin, the researchers concluded.
Sitting near windows or spending more time outdoors could support diabetes management alongside standard treatments, researchers say. (iStock)
However, daylight isn’t a replacement for medication or traditional management strategies like diet and exercise, according to the team.
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The study did have some limitations, including that the group of patients was small. The researchers cautioned that larger studies are needed to confirm these results and determine how much natural light exposure is optimal.
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“This study also highlights the often unnoticed impact of the built environment on our health, and raises further concerns about the prevalence of office environments with poor (natural) daylight access,” the researchers noted.
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