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Aging may speed up after death of a loved one, study finds: 'Major life stressor'

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Aging may speed up after death of a loved one, study finds: 'Major life stressor'

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Experiencing the loss of a loved one not only has an emotional impact, but it may also speed up the aging process.

That’s according to a recent report from the Columbia University Mailman School of Public Health and Butler Columbia Aging Center in New York, in collaboration with the Carolina Population Center at University North Carolina Chapel Hill.

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Researchers found that people who suffered a loss of a close family member such as a parent, child or sibling appeared to have an older biological age compared to those who did not.

The study was recently published in JAMA Network Open.

LIFE EXPECTANCY IN HUMANS NOT LIKELY TO INCREASE MUCH MORE, STUDY SUGGESTS

“Although this study doesn’t offer definitive proof, it provides strong evidence of a link between experiencing loss and accelerated biological aging,” lead author Allison E. Aiello, PhD, a professor of epidemiology at Columbia University Irving Medical Center in New York, told Fox News Digital.

Researchers found that people who suffered a loss of a close family member such as a parent, child or sibling appeared to have an older biological age compared to those who did not. (iStock)

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Aiello defined biological age as “how old our bodies are at the cellular level, which may differ from our actual age.”

With a gradual decline in the function of cells, tissues and organs, there is an increased risk of developing diseases later in life, she said.

Details of the study

The team of researchers gathered data from the National Longitudinal Study of Adolescent to Adult Health, which began in 1994.

A total of 20,745 participants ranging from 12 to 19 years were tracked for a 24-year span, up until 2018, according to a Columbia press release.

AGING SLOWDOWN COULD BE SURPRISE BENEFIT OF EXISTING MEDICATION, RESEARCH SHOWS

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The researchers recorded any losses of close relatives. Nearly 40% of participants experienced at least one loss in adulthood.

Out of the original participants, 4,500 agreed to undergo additional home exams and blood tests, the study authors noted. 

DNA markers from the blood samples — also known as epigenetic clocks — were used to establish biological age.

“A greater number of losses was associated with more pronounced biological aging.”

Although a single loss was shown to speed up biological aging, two or more losses in adulthood had a more noticeable impact, the researchers found.

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“A greater number of losses was associated with more pronounced biological aging, further supporting the harmful effects of this exposure,” Aiello told Fox News Digital.

Health effects of grief

The trauma of losing a parent or sibling has already been linked to many types of health issues, according to the study authors.

Prior research has shown that stress is linked to negative health outcomes — and loss is a “major life stressor,” Aiello said, often associated with mental health issues, cognitive decline, increased risk of heart disease and even higher mortality rates. 

Although a single loss was shown to speed up biological aging, two or more losses in adulthood had a more noticeable impact, the researchers found. (iStock)

“The effects of such losses may not appear immediately, but can emerge over time,” she noted.

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Although loss can cause these health effects at any age, they may be more profound during key developmental times in a person’s life, the researchers determined.

AGING SPEEDS UP ‘MASSIVELY’ AT TWO POINTS IN ONE’S LIFETIME, STANFORD STUDY FINDS: ‘ABRUPT CHANGES’

Those who had losses during early adulthood — up to the early 40s — experienced a bigger increase in biological aging compared to those who lost loved ones during childhood or adolescence, Aiello told Fox News Digital.

“We observed a stronger impact from loss in older age, possibly due to resilience in younger individuals or because we had fewer cases of loss in younger age groups, which made it harder to detect significant effects,” she said.

More research needed, experts say

Daniel Tawfik, a molecular biologist and co-founder of Healthspan, a digital medical clinic based in Santa Monica, California, was not associated with the study but shared his insights on the findings.

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“The recent JAMA study highlighting that bereavement may accelerate biological aging aligns with our understanding of how stress impacts the body,” Tawfik told Fox News Digital. 

“It is essential for individuals in such circumstances to seek support, employ stress-reduction techniques and remain vigilant about their health,” a researcher said. (iStock)

The study’s exploration of the epigenetic markers offers an “intriguing insight into the molecular mechanisms underlying stress-related aging,” he said.

More research is needed to determine whether the age-related effects of losing a loved one are temporary or permanent, according to Tawfik.

“Epigenetic aging is dynamic, so there’s good reason to believe these changes can be reversed.”

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“With only a single assessment point, it remains unclear how long these biological changes persist, the extent to which individuals can recover over time, and what specific interventions might mitigate these effects,” he said.

      

“Epigenetic aging is dynamic, so there’s good reason to believe these changes can be reversed.”

Aiello reiterated that additional research would help to confirm these findings.

“We need more data … in younger individuals and longer-term studies to better understand the immediate and long-lasting effects of loss on biological aging,” she said.

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Healthy coping strategies

Aiello and Tawfik agreed that the study highlights the importance of effective coping strategies after the loss of a loved one.

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“It is essential for individuals in such circumstances to seek support, employ stress-reduction techniques and remain vigilant about their health,” Tawfik told Fox News Digital. 

“Proactive management may help alleviate some of the physiological burdens associated with bereavement.”

More research is needed to determine whether the age-related effects of losing a loved one are temporary or permanent, according to a researcher. (iStock)

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Future studies should focus on how specific coping strategies and support systems could help decrease the impact a loss has on the biological aging process, according to Aiello. 

This could then guide medical professionals and public health strategies to improve outcomes after a loss, she said.

For more Health articles, visit www.foxnews.com/health

The study was supported by the National Institute on Minority Health and Health Disparities, Add Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institute on Aging, the Carolina Population Center, and other federal agencies and foundations.

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Punch the monkey, viral star, experiences dramatic breakthrough among zoo mates

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Punch the monkey, viral star, experiences dramatic breakthrough among zoo mates

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In a dramatic turn of events that’s captured the attention of animal lovers worldwide, Punch — the young macaque at a zoo in Japan famous for his inseparable bond with a stuffed orangutan toy — has reached a major milestone in his journey toward social integration.

On Thursday, visitors and staff at the Ichikawa Zoological and Botanical Garden witnessed a breakthrough: Punch was seen cuddling with and hitching a ride on the back of a fellow macaque.

Punch’s story began with hardship. He was abandoned by his mother shortly after his birth in July 2025 — and to ensure his survival, zookeepers stepped in to hand-rear the primate.

On Jan. 19, 2026, the zoo officially began the process of reintegrating Punch into the “monkey mountain” enclosure.

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The transition was initially fraught with tension. 

Punch’s story began with hardship when he was abandoned by his mother shortly after he was born. To help him, zookeepers gave him a stuffed toy that he began dragging around everywhere he went.  (David Mareuil/Anadolu via Getty Images)

As a hand-reared infant, Punch was bullied and ignored by the established group of monkeys.

He was often seen huddled alone with his orange plush companion while the rest of the troop interacted.

BABY MONKEY CARRIES FAITHFUL STUFFED COMPANION EVERYWHERE HE GOES, DRAWING CROWDS AT ZOO

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In an official statement released Feb. 27, the Ichikawa Zoological and Botanical Garden detailed the meticulous care behind this process.

Previous viral videos showed Punch bullied by the rest of the troop, running to his plushy toy for comfort. (David Mareuil/Anadolu via Getty Images)

“From an animal welfare perspective, our primary goal is to reintegrate Punch with the troop,” the zoo said. 

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The strategy involved nursing Punch within the enclosure, so the troop could recognize him as one of their own, and pairing him with a gentle young female macaque prior to his full release to build his confidence.

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The latest footage, captured by X user @tate_gf, suggested the zoo’s patience is paying off. 

The video shows Punch seeking physical contact not from his toy, but from another monkey — eventually climbing onto its back for a vital social behavior for young macaques: the “piggyback ride.”

The zoo’s strategy appears to be paying off: Punch, shown at far left, was recently seen riding on the back of a fellow macaque. (David Mareuil/Anadolu via Getty Images)

While Punch still carries his stuffed toy for comfort during moments of perceived danger, the zoo remains optimistic about his progress. 

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The organization cited the successful 2009 case of Otome, another hand-reared macaque who eventually outgrew her stuffed toy, successfully integrated — and went on to raise four offspring of her own.

The zoo has had crowds coming to see Punch, with hundreds of people lining up to get inside to see the young star, according to reports. 

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“I’m hoping Punch has a good life like everybody else does, and think he’s a cute little guy,” one person commented online. 

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“Such a precious baby,” another person wrote. 

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ChatGPT could miss your serious medical emergency, new study suggests

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ChatGPT could miss your serious medical emergency, new study suggests

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This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255).

Artificial intelligence has been touted as a boon to healthcare, but a new study has revealed its potential shortcomings when it comes to giving medical advice.

In January, OpenAI launched ChatGPT Health, the medical-focused version of the popular chatbot tool. 

The company introduced the tool as “a dedicated experience that securely brings your health information and ChatGPT’s intelligence together, to help you feel more informed, prepared and confident navigating your health.”

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But researchers at the Icahn School of Medicine at Mount Sinai have found that the tool failed to recommend emergency care for a “significant number” of serious medical cases.

The study, published in the journal Nature Medicine on Feb. 23, aimed to explore how ChatGPT Health — which is reported to have about 40 million users daily — handles situations where people are asking whether to seek emergency care.

Artificial intelligence has been touted as a boon to healthcare, but a new study has revealed its potential shortcomings when it comes to giving medical advice. (iStock)

“Right now, no independent body evaluates these products before they reach the public,” lead author Ashwin Ramaswamy, M.D., instructor of urology at the Icahn School of Medicine at Mount Sinai in New York City, told Fox News Digital.

“We wouldn’t accept that for a medication or a medical device, and we shouldn’t accept it for a product that tens of millions of people are using to make health decisions.”

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Emergency scenarios

The team created 60 clinical scenarios across 21 medical specialties, ranging from minor conditions to true medical emergencies.

Three independent physicians then assigned an appropriate level of urgency for each case, based on published clinical practice guidelines in 56 medical societies.

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The researchers conducted 960 interactions with ChatGPT Health to see how the tool responded, taking into account gender, race, barriers to care and “social dynamics.”

While “clear-cut emergencies” — such as stroke or severe allergy — were generally handled well, the researchers found that the tool “under-triaged” many urgent medical issues.  

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The team created 60 clinical scenarios across 21 medical specialties, ranging from minor conditions to true medical emergencies. (iStock)

For example, in one asthma scenario, the system acknowledged that the patient was showing early signs of respiratory failure — but still recommended waiting instead of seeking emergency care.

“ChatGPT Health performs well in medium-severity cases, but fails at both ends of the spectrum — the cases where getting it right matters most,” Ramaswamy told Fox News Digital. “It under-triaged over half of genuine emergencies and over-triaged roughly two-thirds of mild cases that clinical guidelines say should be managed at home.”

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Under-triage can be life-threatening, the doctor noted, while over-triage can overwhelm emergency departments and delay care for those in real need.

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Researchers also identified inconsistencies in suicide risk alerts. In some cases, it directed users to the 988 Suicide and Crisis Lifeline in lower-risk scenarios, and in others, it failed to offer that recommendation even when a person discussed suicidal ideations.

“ChatGPT Health performs well in medium-severity cases, but fails at both ends of the spectrum.”

“The suicide guardrail failure was the most alarming,” study co-author Girish N. Nadkarni, M.D., chief AI officer of the Mount Sinai Health System, told Fox News Digital.

ChatGPT Health is designed to show a crisis intervention banner when someone describes thoughts of self-harm, the researcher noted.

OpenAI launched ChatGPT Health, the medical-focused version of the popular chatbot tool, in January 2026. (Gabby Jones/Bloomberg via Getty Images)

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“We tested it with a 27-year-old patient who said he’d been thinking about taking a lot of pills,” Nadkarni said. “When he described his symptoms alone, the banner appeared 100% of the time. Then we added normal lab results — same patient, same words, same severity — and the banner vanished.” 

“A safety feature that works perfectly in one context and completely fails in a nearly identical context … is a fundamental safety problem.”

CHATGPT HEALTH PROMISES PRIVACY FOR HEALTH CONVERSATIONS

The researchers were also surprised by the social influence aspect.

“When a family member in the scenario said ‘it’s nothing serious’ — which happens all the time in real life — the system became nearly 12 times more likely to downplay the patient’s symptoms,” Nadkarni said. “Everyone has a spouse or parent who tells them they’re overreacting. The AI shouldn’t be agreeing with them during a potential emergency.”

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Fox News Digital reached out to Open AI, creator of ChatGPT, requesting comment.

Physicians react

Dr. Marc Siegel, Fox News senior medical analyst, called the new study “important.” 

“It underlines the principle that while large language models can triage clear-cut emergencies, they have much more trouble with nuanced situations,” Siegel, who was not involved in the study, told Fox News Digital. 

ChatGPT and other LLMs can be helpful tools, a doctor said, but they “should not be used to give medical direction.” (iStock)

“This is where doctors and clinical judgment come in — knowing the nuances of a patient’s history and how they report symptoms and their approach to health.”

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ChatGPT and other LLMs can be helpful tools, Siegel said, but they “should not be used to give medical direction.”

“Machine learning and continued input of data can help, but will never compensate for the essential problem – human judgment is needed to decide whether something is a true emergency or not.”

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Dr. Harvey Castro, an emergency physician and AI expert in Texas, echoed the importance of the study, calling it “exactly the kind of independent safety evaluation we need.”

“Innovation moves fast. Oversight has to move just as fast,” Castro, who also did not work on the study, told Fox News Digital. “In healthcare, the most dangerous mistakes happen at the extremes, when something looks mild but is actually catastrophic. That’s where clinical judgment matters most, and where AI must be stress-tested.”

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Study limitations

The researchers acknowledged some potential limitations in the study design.

“We used physician-written clinical scenarios rather than real patient conversations, and we tested at a single point in time — these systems update frequently, so performance may change,” Ramaswamy told Fox News Digital.

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Additionally, most of the missed emergencies happened in situations where the danger depended on how the condition was changing over time. It’s not clear whether the same problem would happen with acute medical emergencies.

Because the system had to choose just one fixed urgency category, the test may not reflect the more nuanced advice it might give in a back-and-forth conversation, the researchers noted. 

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ChatGPT Health is designed to show a crisis intervention banner when someone describes thoughts of self-harm. (iStock)

Also, the study wasn’t large enough to confidently detect small differences in how recommendations might vary by race or gender.

“We need continuous auditing, not one-time studies,” Castro noted. “These systems update frequently, so evaluation must be ongoing.”

‘Don’t wait’

The researchers emphasized the importance of seeking immediate care for serious issues.

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“If something feels seriously wrong — chest pain, difficulty breathing, a severe allergic reaction, thoughts of self-harm — go to the emergency department or call 988,” Ramaswamy advised. “Don’t wait for an AI to tell you it’s OK.”

The researchers noted that they support the use of AI to improve healthcare access, and that they didn’t conduct the study to “tear down the technology.”

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“These tools can be genuinely useful for the right things — understanding a diagnosis you’ve already received, looking up what your medications do and their side effects, or getting answers to questions that didn’t get fully addressed in a short doctor’s visit,” Ramaswamy said. 

“That’s a very different use case from deciding whether you need emergency care. Treat them as a complement to your doctor, not a replacement.”

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“This study doesn’t mean we abandon AI in healthcare.”

Castro agreed that the benefits of AI health tools should be weighed against the risks.

“AI health tools can increase access, reduce unnecessary visits and empower patients with information,” he said. “They are not inherently unsafe, but they are not yet substitutes for clinical judgment.”

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“This study doesn’t mean we abandon AI in healthcare,” he went on. “It means we mature it. Independent testing and stronger guardrails will determine whether AI becomes a safety net or a liability.”

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