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Trying to lose weight? Here’s why your genetics could be just as important as your exercise regime

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Trying to lose weight? Here’s why your genetics could be just as important as your exercise regime

Weight loss is a complicated process. There are so many factors involved including your diet, how much sleep you get each night and the kind of exercise you do. Our recent study shows that your specific genetic profile may also have a dominant effect on how well you lose weight through exercise. This might explain why two people who do an identical workout will see very different results.

We identified 14 genes that appeared to significantly contribute to how much weight a person lost through running. This suggests that some of us have a natural talent when it comes to burning fat and losing weight through exercise.

To conduct our study, we recruited 38 men and women born in the UK aged between 20 and 40. None of the participants regularly exercised at the start of the study. The group was randomly divided, with one half following a strict eight-week endurance programme that consisted of three weekly runs of 20-30 minutes.

The other group acted as a control. They were instructed to refrain from exercise and continue their daily routines as normal over this study period, including diet and lifestyle habits.

All participants conducted a running test to see how far they could run in 12 minutes, and were weighed before and after the study period. This was to gauge their initial fitness level and see how much they changed over the duration of the study. Body mass index (BMI) was also calculated.

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Additionally, a saliva sample was collected from each person with a DNA test kit at the end of the study to assess their unique genetic profile.

It’s important to note that everyone who participated in the study had a similar body weight, BMI and aerobic fitness level at the start of the study. This is beneficial for multiple reasons. It meant everyone was at the same starting point, and some confounding variables were already controlled for such as fitness level. This ultimately improves accuracy in interpreting the results.

Exercise genes

Everyone in the exercise group managed to lose weight – around 2kg on average. The control group, on the other hand, put on a little bit of weight.

While a 2kg weight loss may not sound like a lot, it’s significant considering the exercise regime only lasted eight weeks and participants made no changes to their diet.

More significant, however, was the large variation in results among those that exercised – with an up to 10kg difference in weight loss between some of the participants. In fact, everyone within the exercise group improved at different rates.

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Since we controlled for factors such as the intensity, duration and frequency of the exercises and used participants who’d had a similar body weight and fitness level at the start of the study, this suggests that some people naturally benefited more than others from endurance training.

When we looked at the genetic profiles of our participants, we found that differences in each person’s response to the exercise was strongly associated with their specific genetics.

We showed there was a strong linear correlation between the amount of weight participants lost and 14 genes that have previously been shown to be associated with body weight, metabolism or psychological conditions that affect BMI. The greater number of these genes a participant had, the more weight they lost. Our results also revealed that around 63% of the variance in weight lost among participants were explained by the genes identified.

For example, research has shown the PPARGC1A gene plays a role in metabolism and the use of fats for energy while exercising. Our study found that all participants who lost more than 1.5kg from exercise had this gene. Those who lost less than this did not have this gene.

Genes are only one part of the equation, however.
EvMedvedeva/ Shutterstock

Our findings align with what previous studies have shown. But while previous papers have only looked at the link between individual genes and weight loss, ours is the first to show that 14 different genes appear to work in combination to affect whether a person loses weight from endurance exercise.

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Piece of the puzzle

Our study also suggests that while some people possess genes that make it easier for them to get fit and lose weight, people with these favourable genetics can only flourish if they actually exercise. In fact, our control group also had a number of these listed genes, but without exercise these genes could not activate, and so the participants did not lose any weight.

While our study provides compelling findings, it’s not without limitations. Since we only looked at endurance-based exercise, it will be important for future studies to investigate whether there are similar links between weight loss, genetics and combinations of different types of training (such as a mixture of endurance and strength sessions into a training plan).

It’s also worth mentioning that exercise is only one piece of the puzzle when it comes to weight loss. So even if you have all 14 of these genes, you won’t lose any weight or get fit if you don’t exercise and maintain a healthy diet and sleep pattern.

On the flip side, someone that only has a few of these favourable genes can still benefit if they exercise and are mindful of other aspects of their lifestyle.

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How Jackass Star Chris Pontius’ Simple ‘1-Rep’ Rule Keeps Him Jacked at 51 – and Why it’s so Effective

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How Jackass Star Chris Pontius’ Simple ‘1-Rep’ Rule Keeps Him Jacked at 51 – and Why it’s so Effective

You might know Chris Pontius as ‘Party Boy’ from the Jackass films and TV series that defined the early 2000s. Now 51, he’s back on our screens for Jackass: Best and Last, the fifth and final instalment in the franchise. Away from the stunts, though, Pontius has also become an unlikely source of practical fitness advice, regularly sharing workouts from his home gym.

In a recent Instagram Reel, he shared: ‘I have a very simple exercise tip for people who are having trouble getting motivated to exercise. Just lift the weight one time, do one rep, one push-up, whatever it is, and once you’ve started you kind of go, “Well, I might as well just keep going”.’

‘So try it, it’s worked for me every time and it’ll probably work for you,’ he says.

The advice is grounded in behavioural science. By taking one small step towards your workout, you’re more likely to overcome the initial mental resistance because the task feels more achievable. Once you’ve started, it’s far easier to build momentum and complete the rest of your session.

Our Fitness Director Explains Why This Method Works

‘There’s a bit of science behind this, too,’ says Andrew Tracey. ‘Behaviour-change researchers have looked at “all-or-nothing thinking” around exercise – basically, the idea that if you can’t do the full session, exactly as planned, you may as well sack it off completely. Giving yourself permission to do the smallest possible version of the workout is a way around that.

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‘Tell yourself you’re only doing the warm-up. Or one round. Or five minutes. You’re allowed to stop there. But often, once you’ve started, you realise the hard part wasn’t the workout itself. It was getting going. Research also shows that the way a workout feels can affect whether you come back for more. So a small win that feels doable is almost always better than the perfect session you never start. So while the “minimum dose” might feel like a cop-out, it could actually be a way in.’


If there’s one thing Kori Sampson knows, it’s how to optimise your body composition for performance. To tap into his knowledge as an elite athlete and coach, we asked him to create a 4-week plan to help you move faster, recover quicker and keep pushing when the fatigue sets in – all while improving your muscle-to-fat ratio.

Ready to build muscle, burn fat and come out the other side looking, feeling and performing better? Click here to get 14 days of free access to the plan via the Men’s Health app.

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“Forget living longer, exercise can make life easier right now”—a 72-year-old fitness influencer and marathon runner shares two accessible ways to start moving

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“Forget living longer, exercise can make life easier right now”—a 72-year-old fitness influencer and marathon runner shares two accessible ways to start moving

Retirement is often a time when people slow down, but in Christine Hobson’s case, she’s speeding up. When her daughter persuaded her to join a running club so she wouldn’t get bored, she had no idea she’d get the fitness bug and run 125 marathons in total, visiting all seven continents.

And the 72-year-old former teacher has plans to run the North Pole marathon in 2027.

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Why 21-15-9 Might be the Smartest Workout Format in Fitness – and How to Use it to Drive Muscle Growth

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Why 21-15-9 Might be the Smartest Workout Format in Fitness – and How to Use it to Drive Muscle Growth

CrossFit means a lot of things to a lot of people – because it’s made up of a lot of things.

Since the rise of the fitness giant, countless brands, events and training methods have sprung up around it – not claiming to be CrossFit, but looking suspiciously CrossFit-esque.

There are, however, a handful of things that are uniquely CrossFit: the ‘Girls’ benchmark workouts. The Hero WODs and, of course, its signature rep schemes.

Chief among them is ’21-15-9′.

The 21-15-9 rep scheme may just be the single most CrossFit thing in existence. But what exactly is it? Where did it come from? And why might it actually be better at building muscle in a hurry than its conditioning roots would have you believe?

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Let’s have a look.

What Is 21-15-9?

If you’ve never encountered it before, the format couldn’t be simpler. Choose two exercises (occasionally more) and perform 21 reps of each, then 15 reps of each, then nine reps of each, completing the entire workout as quickly as possible – with good form.

Probably the best-known example is ‘Fran’: 21 thrusters and pull-ups, followed by 15 of each, then nine. On paper it doesn’t look especially intimidating. In practice, it’s one of the most feared benchmark workouts in fitness.

Where Did it Come From?

Unlike many modern training methods, 21-15-9 didn’t come out of a study. It came from the gym floor.

CrossFit founder Greg Glassman has explained that the format emerged through years of coaching and experimentation in the 1990s. Rather than chasing a perfect sets-and-reps prescription, he was looking for a workout that allowed athletes to maintain a high power output from start to finish.

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The thinking is surprisingly elegant. You begin with 21 reps while fresh. By the time you reach the set of 15, your ability to produce force has already fallen. By the final nine, you’re significantly more fatigued – but the workload has dropped by almost the same amount.

Instead of grinding through increasingly miserable sets of the same length, the workout ‘meets you where you are’, reducing the work required as your capacity declines. The result is a workout that encourages you to keep moving instead of standing around trying to recover.

The numbers themselves are also remarkably practical. Forty-five total reps per movement provides plenty of training volume without turning the session into an endurance slog, while every set divides neatly into thirds if you need to break it up.

(Although I’ve got to be honest, I’m a 20-15-10-5 man myself, just for the sake of round numbers.)

Why Does it Work So Well?

Although there isn’t research showing that 21-15-9 is somehow the magic formula, there are obvious reasons why it consistently produces brutally effective workouts.

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Descending reps help maintain intensity. As fatigue accumulates, reducing the target allows movement quality, bar speed and overall work rate to stay higher than they would if you simply repeated the same number of reps over and over.

It also tends to land in a physiological sweet spot. Most 21-15-9 workouts take between three and eight minutes, depending on the movements and the athlete. That’s long enough to create a serious cardiovascular challenge while still requiring meaningful force production throughout. You’re taxing your anaerobic systems hard while relying on your aerobic system to help you recover just enough to keep going.

Finally, there’s the psychological trick. The hardest-looking part comes first. Once you’ve survived the opening 21, every remaining round appears more manageable. ‘Only 15 left.’ Then, ‘Just nine.’ In reality, you’re becoming more fatigued with every rep, but the shrinking target keeps you attacking the workout instead of pacing too conservatively.

Why it Might be Surprisingly Good for Building Muscle

Perhaps the biggest misconception about 21-15-9 is that it’s ‘just cardio with weights’.

Choose the right load and something interesting happens. Very few athletes complete every round unbroken. Instead, the workout naturally evolves into a series of short, broken sets separated by only a few seconds of rest.

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Your 21 might become 11-5-5. Your 15 becomes 8-4-3. Your final nine might stay unbroken – or become 5-4.

In effect, you’ve accidentally turned the workout into a form of rest-pause training.

Those brief pauses allow just enough recovery to squeeze out more high-quality repetitions before fatigue catches up again. By the latter stages of each mini-set, you’re repeatedly working very close to failure, recruiting the high-threshold motor units with the greatest potential for muscle growth.

It’s a similar principle to rest-pause training, myo-reps and cluster sets: all methods used to accumulate hypertrophy-friendly volume while keeping the load relatively heavy and the rest periods brutally short.

You’re basically speed-running a large number of hard, growth-stimulating reps in a very small window of time. Could this help explain why elite CrossFit athletes often carry an impressive amount of muscle despite spending relatively little time performing traditional bodybuilding splits?

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It’s certainly plausible, although the ‘elite’ part often selects for athletes with the greatest muscle-building potential.

Much of their training isn’t simply conditioning. It’s high-density resistance training performed under accumulating fatigue, with only fleeting recovery between efforts. In other words, they’re often doing something bodybuilders have deliberately programmed for decades: packing a lot of hard work into a very short period of time.

That’s not to say 21-15-9 is superior to a well-designed hypertrophy programme. If your sole goal is building muscle, there are more efficient ways to do it.

But if you’re looking for a workout that develops fitness, tests your mettle and still provides a meaningful stimulus for strength and size, it’s easy to see why this deceptively simple rep scheme has remained one of CrossFit’s defining fingerprints for more than 20 years.

Best Bodyweight 21-15-9 Workout: ‘JT’

If you’re looking for an interesting twist on the 21-15-9 format, look no further than Hero WOD ‘JT’, which concentrates the muscle-building potential of the format into a brutal upper-body workout.

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Created in honour of Petty Officer 1st Class Jeff Taylor, who was killed in Afghanistan in 2006, the workout strips away barbells altogether and relies solely on three bodyweight movements:

21-15-9 reps of:

Don’t let the lack of equipment fool you. The volume – 45 reps of each movement, 135 reps in total – combined with the descending rep scheme makes this a brutal upper-body test, hammering the shoulders, chest and triceps while demanding serious muscular endurance.

Better still, it perfectly demonstrates one of the biggest strengths of 21-15-9. As fatigue mounts and the sets naturally fragment, the workout begins to resemble one giant rest-pause set, allowing you to accumulate a huge number of hard, near-failure reps in less than 10 minutes.

If your goal is building an impressive upper body while developing serious work capacity, there are few bodyweight workouts that deliver quite so much bang for your buck, making ‘JT’ one of my personal favourites.

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fitness magazine cover featuring a muscular man with kettlebells

If there’s one thing Kori Sampson knows, it’s how to optimise your body composition for performance. To tap into his knowledge as an elite athlete and coach, we asked him to create a 4-week plan to help you move faster, recover quicker and keep pushing when the fatigue sets in – all while improving your muscle-to-fat ratio.

Ready to build muscle, burn fat and come out the other side looking, feeling and performing better? Click here to get 14 days of free access to the plan via the Men’s Health app.


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