The band had been touring “The Final Domino? Tour” after a 14-year stay hiatus.
Collins, 71, has talked about nerve injury in his arms and has stated he has had bother drumming.
Collins’ son Nic stuffed in for his father throughout latest solo excursions.
The band carried out 23 songs on the ultimate night time.
Collins turned the lead vocalist of Genesis in 1975.
“Tonite [sic] marks the top of an period. To have witnessed this final present was really the reminiscence of a lifetime and an occasion I shall maintain in my coronary heart endlessly. Endlessly grateful would not start to do it justice.
“A lot love was left on that O2 stage and a good greater quantity shared between an viewers who did not need it to finish. Thanks @genesis_band for the reminiscences, thanks dad for being such an inspiration and thanks @nic_collins for making me the proudest sister there may be. 50 years of songs later and nonetheless generations extra to rejoice you lengthy after this tour has completed.”