Health
Could cancer vaccines be next? New treatment cuts melanoma risk by nearly 50%
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A new injectable therapy is showing positive results in reducing melanoma throughout a five-year period.
The personalized mRNA cancer therapy, called intismeran autogene, combined with the cancer immunotherapy drug KEYTRUDA (pembrolizumab), is a collaboration between Merck and Moderna.
The results from the phase 2b KEYNOTE-942 study were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago on May 27.
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After about a five-year follow-up, the combo drug was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone.
The researchers analyzed data from 157 patients with high-risk stage 3 and 4 melanoma whose cancer had been removed via surgery. The participants were split into two groups — one received the combo therapy and the other only received pembrolizumab, according to a press release.
The therapy was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone after a five-year follow-up. (iStock)
The findings revealed that the combination group saw benefits that were “sustained and durable over time.”
Intismeran autogene is designed using mutations identified in a patient’s own tumor, with the intention of teaching the immune system what the cancer looks like so that it can recognize and attack it.
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According to the researchers, intismeran is “well-tolerated” with a “manageable” safety profile.
The most commonly cited side effects of the personalized mRNA vaccine plus KEYTRUDA were fatigue, injection-site pain, chills, fever and headache. The researchers reported no new long-term safety concerns and no severe vaccine-related adverse events.
The combination therapy is currently being evaluated in a phase 3 study — the final confirmation stage.
Patients with late-stage melanoma have a “significant risk” of cancer recurrence, according to an expert. (iStock)
In a Merck press release from January, Kyle Holen, MD, Moderna’s senior vice president and head of development, oncology and therapeutics, noted that this data highlights the “potential of a prolonged benefit … in patients with resected high-risk melanoma.”
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“We continue to invest in our platform in oncology because of encouraging outcomes like these, which illustrate mRNA’s potential in cancer care,” he said.
Dr. Marjorie Green, senior vice president and head of oncology, global clinical development at Merck Research Laboratories, also commented that for many patients with stage 3 or 4 melanoma, there is a “significant risk of recurrence following surgery.”
Researchers confirmed that the combination therapy is currently being evaluated in a phase 3 study. (iStock)
“As such, demonstrating the longer-term potential of intismeran autogene and KEYTRUDA to reduce the risk of recurrence for certain patients with melanoma is a meaningful milestone,” she said.
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The company cited encouraging five-year follow-up data and pointed to upcoming late-stage INTerpath trial results with Moderna in several hard-to-treat cancers.
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Veterans face surprising threat after cancer diagnosis, study reveals
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This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the National Suicide Prevention Lifeline at 1-800-273-TALK (8255).
Veterans with cancer face a higher risk of suicide attempts, according to new research from Oregon Health & Science University (OHSU).
The risk is especially prevalent in the months following diagnosis and can persist for years, states the study, which was published in JAMA Oncology.
The researchers analyzed Veterans Health Administration data from more than 292,000 veterans with cancer from 2014 to 2023.
GRIEVING MOM HOSPITALIZED WITH RARE ‘BROKEN HEART SYNDROME’ AFTER VETERAN SON’S SUICIDE
The data was measured against the rate of suicidal self-directed violence (SSDV), including both fatal and nonfatal suicide attempts, the study stated.
Veterans with cancer experienced suicide attempts at a rate of 203 per 100,000, which the researchers noted is “significantly higher than the general population.”
Those with higher SSDV rates included veterans with severe frailty, chronic mental illness, advanced cancer and high pain scores. (iStock)
The study also found that overwhelming distress tied to disease diagnosis, treatment and long-term effects puts patients at risk “well into survivorship,” or long after active treatment is over.
The risk was highest in the first six months after diagnosis, but persisted for up to five years.
VETERANS’ PTSD SYMPTOMS COULD IMPROVE WITH HYPERBARIC OXYGEN THERAPY, STUDY SHOWS
Those with higher SSDV rates included veterans with severe frailty, chronic mental illness, advanced cancer and high pain scores.
High rates of nonfatal attempts were recorded most in veterans under the age of 45, females, and veterans with central nervous system cancer or thyroid cancer.
Suicide risk was most prevalent six months after cancer diagnosis, but remained elevated for up to five years. (iStock)
Prescription medications were the most common method used in nonfatal suicide attempts, including opioids, while firearms were most common in fatal attempts.
As the study was observational, the results show an association but don’t prove that cancer directly caused the suicidal behavior.
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Lead study author Donald R. Sullivan, MD, associate professor of medicine at the OHSU School of Medicine, commented that this is a “concerning public health crisis that disproportionately affects America’s servicemen and servicewomen.”
“We hope to raise awareness and inform the development of approaches to better support veterans and mitigate the impact of a cancer diagnosis on their well-being,” he said in a statement sent to Fox News Digital.
“We need to combine efforts in research, outreach and care.”
In a press release statement, Sullivan added that a cancer diagnosis is often a “profound shock.”
“Even cancers with good survival rates can trigger an immediate fear of death,” he said. “That initial moment, combined with pain, treatment side effects, anxiety or depression, can be incredibly destabilizing.”
“We hope to raise awareness and inform the development of approaches to better support veterans,” said the lead researcher. (iStock)
Jim Whaley, CEO of Mission Roll Call — a nonprofit veteran advocacy group — reflected on these findings in an interview with Fox News Digital.
“The study shows that more investigation and action is needed to medicate the higher percentage of veterans diagnosed with cancer committing suicide,” said Whaley, who was not involved in the study.
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“Understanding the chain of events and upstream factors is vital, as is sharing the study results and recommendations with veteran support organizations involved in these efforts on the ground in communities across the nation.”
Whaley also stressed the importance of recognizing that health encompasses both mental and physical well-being, especially for military service members.
An expert stressed the importance of recognizing that health encompasses both mental and physical well-being, especially for military service members. (iStock)
“Just as we trained in physical fitness daily, we must exercise our mental health in the same manner,” he said. “Veterans sometimes need the tools to do that.”
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While veterans are “great” at helping other veterans, Whaley suggested that they’re “not so good at asking for help.” It’s imperative that loved ones and people within the veteran community watch for warning signs of mental health decline, he added.
The number of veteran suicides is 425% higher than the number of combat deaths since 9/11, he noted.
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“Despite good intentions, the decline in the number of suicides is not dropping enough to end this scourge,” Whaley said. “We need to combine efforts in research, outreach and care … It is a national crisis that needs a national-level task force.”
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