Health
Chronic back pain may have met its match with hormone treatment, scientists say
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A hormone traditionally used to treat bone loss may hold the key to stopping chronic back pain at its source, according to a new study.
Chronic back pain is often linked to the deterioration of spinal discs and vertebral end plates, which are the thin layers of tissue separating the discs from the vertebrae, according to medical sources.
When these break down, they become porous, allowing nerves that aren’t usually impacted to enter the spinal center, leading to frequent discomfort.
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Research led by Dr. Janet L. Crane at Johns Hopkins University found the parathyroid hormone (PTH) could prevent and even reverse the growth of pain-sensing nerves into damaged areas of the spine.
Parathyroid glands naturally produce PTH, which experts say plays a key role in regulating calcium levels and bone remodeling.
Research suggests a parathyroid hormone can prevent the growth of pain-sensing nerves into damaged areas of the spine. (iStock)
These findings could shift the focus of back pain treatment from managing symptoms to modifying the underlying issue, according to scientists.
“During spinal degeneration, pain-sensing nerves grow into regions where they normally do not exist. Our findings show that parathyroid hormone can reverse this process by activating natural signals that push these nerves away,” Crane said in a press release.
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Synthetic versions of PTH are already used to treat osteoporosis. Earlier research hinted that these treatments might also reduce bone-related pain, but the underlying biological mechanism was not well understood.
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Using animal models, the Johns Hopkins researchers found that one to two months of PTH treatment led to denser, more stable vertebral endplates.
More significantly, the treatment triggered bone-building cells, known as osteoblasts, to produce a protein called Slit3, the study detailed.
These findings could shift the focus of back pain treatment from managing symptoms to modifying the underlying issue, according to scientists. (iStock)
The study found that this protein repels growing nerve fibers, preventing them from infiltrating sensitive regions of the spine.
When the researchers removed Slit3 from mice, the hormone’s pain-relieving effects disappeared, confirming the protein’s critical role in the process.
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PTH is already approved by the Food and Drug Administration to treat osteoporosis. Some patients receiving the hormone for bone density have reported unexpected relief from back pain, a phenomenon this study could help explain.
This study lays a foundation for future clinical trials to explore the efficacy of PTH as a disease-modifying and pain-relieving treatment for spinal degeneration, the researchers say. (iStock)
“Our study suggests that PTH treatment of [lower back pain] during spinal degeneration may reduce aberrant innervation (abnormal nerve growth),” Crane concluded.
The doctor said this research lays the foundation for future clinical trials that will explore PTH’s effectiveness as a disease-modifying and pain-relieving treatment for spinal degeneration.
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Researchers noted several limitations, including the possibility that PTH treatment could affect the central nervous system in ways not fully explored in this study.
Because the study focused specifically on the Slit3 protein, further research is needed to determine how other genetic factors and bone-forming processes might influence spinal nerve growth and pain relief.
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The study was published in the journal Bone Research.
Health
Giant golden spiders could spread this summer; experts downplay health risk
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Large, palm-sized spiders are spinning massive golden webs across porches and power lines, and, according to experts, they’re here to stay.
The Joro spider, which has a leg span up to 4 inches and markings of neon yellow, blue-black and red, was first recorded in Georgia in 2013.
Since its arrival — likely as a hitchhiker on a shipping container or an airplane from Asia, experts say — the arachnid has been steadily marching north.
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The spiders have so far been spotted in Georgia, North Carolina, South Carolina and Tennessee.
They are expected to spread throughout eastern North America, at least as far north as Pennsylvania and possibly further in warmer, coastal areas, according to Penn State.
Joro spiders can “fly” by shooting out silk parachutes that carry them on the wind. (Stuart Cahill/Boston Herald)
To travel, the spider uses a technique called “ballooning,” in which hatchlings release fine silk threads that catch air currents and carry them over long distances.
Ian Williams, an entomologist with Orkin, said he counted 200 adult spiders by September of last year on his one-acre property near Atlanta.
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“They’re quite intimidating looking spiders, and they make very large webs,” he told Fox News Digital. “The webbing itself, if it catches the sunlight, has a golden hue to it. And it’s very strong.”
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Despite the arachnid’s striking appearance, experts agree that people shouldn’t panic. Research shows the Joro is among the “shyest” spiders ever documented. When disturbed, they often sits motionless for over an hour rather than attacking.
Joro spiders like to spin their webs up high near houses, trees and even power lines, an expert said. (Stuart Cahill/Boston Herald)
“While they’re large spiders, they don’t have large fangs. And, so, it’s difficult for them to bite humans,” Williams noted.
Even in the rare event of a nip, the expert said the venom is weak, comparable to a localized bee sting, and carries “no medical importance.”
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As an invasive species, the Joro’s impact is still being weighed by scientists.
“One of the big concerns is that they potentially out-compete native species of spiders,” Williams said.
Physical removal is more efficient than pesticides, according to an expert. (iStock)
A prolific hunter, the Joro spider catches everything from mosquitoes to large, meaty insects like cicadas. It is unclear whether it steals food from native garden spiders.
To prevent Joro spiders from nesting on your porch or property, experts recommend using a broom or long pole to knock the web down.
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“Spiders may get the message, ‘Hey, I’m not going to keep remaking my same web in the same area,’” Williams said.
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Physical removal is more effective than pesticides, which often miss the spiders in their high, open-air webs.
For those who spot a Joro spider in a new area, experts suggest logging the sighting on apps like iNaturalist to help researchers track their northern migration.
Health
Another state bans ‘gas station heroin’ as officials warn of deadly risks
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Top stories
→ ‘Gas station heroin’ banned in another state amid nationwide crackdowns
→ New COVID variant spreads across US as CDC raises concerns
→ The real reasons you’re still exhausted after 8 hours of sleep
FDA Commissioner Martin Makary says tianeptine poses a “dangerous and growing health trend.” (Markus Scholz/picture alliance via Getty Images)
Conversation-starters
→ March Madness sparks surprising surge in men’s sexual procedure
→ Cannabis benefits called into question in major study
→ ‘Call a Boomer’ payphones help cure loneliness across generations
Along a bustling sidewalk in Boston, a bright yellow payphone invites folks to “Call a Boomer.” (Matter Neuroscience)
Food for thought
→ Eating meat tied to lower dementia risk, study suggests
→ Stomach issues might have nothing to do with eating habits
→ Why your sugar cravings won’t go away, even after cutting sweets
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Health
Dementia risk signals could lie in simple blood pressure readings, researchers say
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Simple measurements taken during routine blood pressure checks could predict dementia risk years before symptoms appear.
That’s according to new research presented this week at the American College of Cardiology’s Annual Scientific Session in Louisiana.
The findings draw on two studies led by researchers at Georgetown University, which suggest that monitoring how blood vessels age and stiffen over time can provide a window into future cognitive health.
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Data shows rates of dementia and aging-related cognitive decline are expected to increase as populations age, and half of U.S. adults have high blood pressure (hypertension).
Scientists believe that efforts to better address hypertension, a key contributor to heart disease and a risk factor for dementia, could affect both cardiac and brain health.
Data shows rates of dementia and aging-related cognitive decline are expected to increase as populations age. Meanwhile, half of U.S. adults have high blood pressure. (iStock)
“Blood pressure management isn’t just about preventing heart attacks and strokes; it may also be one of the most actionable strategies for preserving cognitive health,” Dr. Newton Nyirenda, the study’s lead author and an epidemiologist at Georgetown University in Washington, said in a press release.
The research focused on two metrics, the pulse pressure-heart rate index and estimated pulse wave velocity. Both were calculated using data collected during standard doctor visits, such as heart rate, age and blood pressure.
“Blood pressure management isn’t just about preventing heart attacks and strokes; it may also be one of the most actionable strategies for preserving cognitive health.”
Researchers examined five years of data patterns for more than 8,500 people in the SPRINT trial, a large study of adults 50 years and older with hypertension. In the follow-up, 323 of the participants developed probable dementia.
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In one study, the team found the pulse pressure-heart rate index was a strong independent predictor of dementia risk in adults over 50. For participants under 65, every one-unit increase was associated with a 76% higher risk of developing dementia.
For participants under 65, an increase in the pulse pressure-heart rate index was associated with a 76% higher risk of developing dementia. (iStock)
The second study found that adults with consistently elevated or rapidly increasing pulse wave velocity were more likely to develop dementia than those with stable velocity, even after accounting for factors like smoking, gender and cardiovascular history.
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“Our findings suggest that vascular aging patterns may provide meaningful insight into future dementia risk,” said Nyirenda. “This reinforces the idea that managing vascular health earlier in life may influence long-term brain health.”
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The team emphasized that clinicians should tailor risk assessments and treatment strategies to the individual.
Further studies are needed to confirm these parameters and determine whether changing vascular aging trajectories reduces dementia risk. (iStock)
“You don’t want to wait until a patient starts manifesting cognitive decline before you act,” said senior study author Sula Mazimba, an associate professor at the University of Virginia.
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Researchers noted the study could not establish causation. Other limitations included the fact that participants already had hypertension and elevated cardiovascular risk, meaning the findings may not apply to people without those conditions.
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Further studies are needed to confirm these findings and to determine whether improving blood vessel health over time could reduce dementia risk.
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