Health
Do collagen supplements really improve skin? Major review reveals the truth
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Collagen supplements have exploded in popularity, touted as everything from an anti-aging miracle to a muscle recovery booster.
But a sweeping new review conducted by U.K. researchers suggests that while collagen may help improve skin elasticity and ease arthritis pain, it does little for athletic performance or wrinkle reduction.
Researchers from Anglia Ruskin University analyzed 16 systematic reviews and 113 randomized controlled trials involving nearly 8,000 participants worldwide, which they say is the most extensive evaluation of collagen’s health effects to date.
The review found consistent evidence that collagen supplementation improves skin elasticity and hydration over time and provides significant relief from osteoarthritis-related joint pain and stiffness, according to findings published in Aesthetic Surgery Journal Open Forum.
A large U.K. review found that collagen supplements may improve skin elasticity and hydration over time. (iStock)
The researchers, however, did not find meaningful improvements in post-exercise muscle recovery, soreness or tendon mechanical properties (strength, springiness and stretch resistance).
“Collagen is not a cure-all, but it does have credible benefits when used consistently over time, particularly for skin and osteoarthritis,” co-author Lee Smith, professor of public health at Anglia Ruskin University, said in a statement.
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“Our findings show clear benefits in key areas of healthy aging, while also dispelling some of the myths surrounding its use,” Smith added.
Collagen, the most abundant protein in the body, supports skin, bones, tendons, cartilage and connective tissue, according to experts. Natural collagen production begins to drop in early adulthood and declines more sharply with age.
The study found that collagen supplements may help reduce joint pain and stiffness in people with osteoarthritis. (iStock)
The review found that long-term collagen supplementation was linked to improved skin firmness and hydration, but did not help skin roughness — a proxy for visible wrinkles.
Benefits appear to accumulate gradually, suggesting that collagen should not be viewed as an “anti-wrinkle ‘quick fix,’ but as a foundational dermal support for individuals seeking holistic skin maintenance,” the researchers said.
“If we define anti-aging as a product or technique designed to prevent the appearance of getting older, then I believe our findings do support this claim for some parameters,” Smith told the BBC. “For example, an improvement in skin tone and moisture is associated with a more youthful-looking appearance.”
Collagen supplementation was linked to reduced pain and stiffness in people with osteoarthritis, with stronger benefits seen over longer periods of use, and showed modest improvements in muscle mass and tendon structure that may support healthy aging.
Collagen did not significantly improve skin roughness, a marker of visible wrinkles. (iStock)
However, it did not show meaningful results when used as a fast-acting sports performance supplement, and evidence for benefits related to cholesterol, blood sugar, blood pressure and oral health was mixed or inconclusive.
Dr. Daniel Ghiyam, a California-based physician and longevity specialist, said the findings align with what he sees in clinical practice.
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“Collagen is a targeted support tool, not a foundation of health or performance,” Ghiyam, who was not involved in the study, told Fox News Digital. “When marketed that way, it makes sense. When marketed as a cure-all, it doesn’t hold up to the data.”
The authors noted that while many previous collagen studies have received financial support from the supplement industry, the current review did not receive industry funding.
Experts say collagen supplements may offer modest benefits for skin hydration and joint comfort, but they are not a cure-all. (iStock)
The team called for more high-quality clinical trials examining long-term outcomes, optimal dosages and differences between collagen sources, such as marine, bovine and plant-based alternatives.
Among its limitations, the review could not determine whether certain forms of collagen work better than others or what the optimal regimen should be.
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While the review included randomized controlled trials, the quality of the studies varied, with newer research generally showing stronger results.
Experts say more data and studies are needed to build on the findings. They also noted that diet plays a crucial role in skin health.
Collagen supplements, often sold as powders or pills, may improve skin elasticity and ease joint pain, experts say. (iStock)
Dr. Erum Ilyas, a Pennsylvania-based dermatologist and chair of dermatology at Drexel University College of Medicine, noted that the review analyzed previously published meta-analyses rather than generating new primary data.
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“At this time, I have not seen sufficiently strong independent evidence to routinely recommend collagen supplements to my patients,” Ilyas, who was not involved in the review, told Fox News Digital.
“Although some studies show modest improvements in markers such as hydration and elasticity, there remains limited independent, biopsy-confirmed evidence demonstrating sustained increases in dermal collagen content,” she added.
Fox News Digital has reached out to the researchers for comment.
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The latest COVID-19 vaccine (2024-2025) has been linked to fewer serious heart-related events among U.S. veterans.
New research confirmed a small reduction in COVID-related cardiovascular events, or COVID-19-associated MACE, due to the vaccine.
MACE (major adverse cardiovascular events) is a composite measure of serious heart-related outcomes. It typically includes cardiovascular death, heart attack and stroke, and may also include hospitalization for heart failure.
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Using health records from the U.S. Department of Veterans Affairs, the researchers compared two groups of veterans — one that received the COVID and flu vaccine on the same day (nearly 350,000 people) and another group that received only the flu vaccine (nearly 700,000 people).
For people older than 75, vaccine effectiveness against COVID-associated MACE was 50.7%. (iStock)
Out of more than one million veterans studied, the average age was about 70 and 92% were male, according to a press release.
Within about eight months, the results showed that those who received the 2024-2025 COVID vaccine had a lower risk of COVID-associated major cardiovascular events, with a relative vaccine effectiveness of 37.7%.
The COVID vaccine was linked to a 57.9% lower risk of cardiovascular death, 38.5% lower risk of heart attack and 41.9% lower risk of hospitalization for heart failure, the researchers stated. The result for stroke was not statistically significant.
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The benefit was greatest among adults ages 75 and older and those with underlying health conditions. In people over 75, the vaccine was 50.7% effective at preventing COVID-associated MACE.
As the study was observational, it could not prove cause and effect between the COVID-19 vaccine and lower risk of cardiovascular events, but only highlighted an association.
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Dr. Glenn Hirsch, cardiologist at National Jewish Health in Denver, Colorado, called these results “not overall surprising” in an interview with Fox News Digital.
After eight months, those who received the 2024-2025 COVID vaccine had a lower risk of COVID-associated major cardiovascular events. (iStock)
“This result is consistent with previous studies of the COVID-19 vaccine and other vaccines against infectious diseases [in] preventing cardiovascular events, including heart attack, cardiovascular cause of death or hospitalizations,” he said.
Acute inflammation in the body from infections like COVID-19 increases the risk of cardiovascular events and can cause further complications, according to the doctor.
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“This can lead to a higher risk of blood clotting, but can also make arterial plaques susceptible to rupture, which then leads to clot formation to heal a ruptured plaque,” he said. “This clotting can cause a near-total or complete occlusion of an artery, leading to these cardiovascular events.”
“Vaccines either prevent infection or reduce the severity of infection and subsequent inflammation, lowering the cardiovascular risk.”
Acute inflammation in the body from infections like COVID-19 can increase the risk of cardiovascular events, the study suggests. (iStock)
Despite the positive outcome, the overall benefit of the vaccine in this study was less than in previous studies, according to Hirsch, who was not involved in the research.
This could be due to the lower severity of illness seen in more recent COVID-19 variants, as well as immunity from prior infections among unvaccinated people, he noted. There has also been a decline in COVID testing, making it more difficult to link cardiovascular events to the virus.
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“The bottom line [is] that there is still evidence of benefit from COVID-19 vaccination like many other infectious disease vaccinations, and people should be encouraged to discuss these with their healthcare team annually,” Hirsch advised.
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“This is an observational trial and there can always be some confounding after necessary statistical adjustments and other potential benefits or harms, including adverse effects from vaccines that were not investigated in this study,” he added.
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A former “Real Housewives of Beverly Hills” star is speaking out about a fresh wave of health issues.
Brandi Glanville, 53, has been speaking publicly about ongoing swelling, lumps and paralysis of her face since 2023.
At the time, the reality star shared that she believed she had been infected with a parasite during a trip to Morocco, Fox News Digital previously reported.
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After the initial diagnosis, she suspected she contracted a parasite in Morocco and said she could feel it moving within her face.
Brandi Glanville attends the grand opening of Beverly Hills Rejuvenation Clinic West Hollywood in West Hollywood, Calif., on April 25, 2024. (Paul Archuleta/Getty Images)
Glanville was first diagnosed with stress-induced angioedema, a sudden swelling of the deeper layers of the skin and mucous membranes, according to Cleveland Clinic.
Angioedema “is a reaction similar to hives that affects deeper layers of the skin. It can appear with hives or alone,” Mayo Clinic states.
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Most recently, in a June 18 episode of her podcast “Brandi Glanville Unfiltered,” Glanville revealed that doctors discovered a “benign tumor” in one of her facial lymph nodes.
The reality star, who has previously speculated that a parasite may be contributing to her facial symptoms, said the finding could help explain the swelling and fluid buildup she has experienced and noted that she has had a lump in her face for “years.”
Brandi Glanville, 53, has been speaking publicly about ongoing swelling, lumps and paralysis of her face since 2023. (Mega/GC Images)
“I don’t know what’s wrong with me, guys. I thought I was fixed, and then it happened again and now it’s sinking in again,” Glanville said in another June podcast.
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“It could be why the fluid is going around my face and why I’m having a hard time,” she added.
While benign tumors of the face have been known to arise from fat tissue, blood vessels, skin structures, salivary glands or lymphatic tissue, Glanville has not publicly disclosed the specific type of diagnosis she received.
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Prior to learning of the tumor, Glanville said she saw dozens of doctors and spent over $100,000 trying to pinpoint the source of the issue.
Brandi Glanville shares images of painful facial burns caused by Nair hair removal cream in a viral TikTok video. (Brandi Glanville/TikTok)
The reality star emphasized that the tumor is “not cancerous.”
“I haven’t had a face lift yet!” she added.
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Glanville also said she suspected her ruptured breast implants could have played a role in her health issues, claiming the leaking silicone had clogged her lymph nodes.
Fox News Digital reached out to Glanville for comment.
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