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Blood test flags digestive disease risk years before symptoms appear

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Blood test flags digestive disease risk years before symptoms appear

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A simple blood test may detect Crohn’s disease years before symptoms appear, according to a new study reported by SWNS.

Canadian researchers say the discovery could enable earlier diagnosis and potential prevention of the chronic inflammatory bowel disease (IBD).

The test measures the immune system’s response to flagellin, a protein found in gut bacteria. Researchers found that this response is elevated in some people years before Crohn’s develops.

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The findings, published in Clinical Gastroenterology and Hepatology, highlight the “interplay” between gut bacteria and immune system responses as a key step in the disease’s development, per the SWNS report.

Crohn’s disease is a chronic inflammatory condition of the gastrointestinal tract that causes persistent digestive symptoms, pain and fatigue, significantly affecting quality of life. Its incidence among children has doubled since 1995, according to official figures.

Crohn’s disease is a type of inflammatory bowel disease (IBD) that causes swelling and irritation of the tissues, called inflammation, in the digestive tract.  (iStock)

The presence of flagellin antibodies long before symptoms appear suggests that the immune reaction may help trigger the disease, according to research leader Dr. Ken Croitoru, clinician-scientist and professor of medicine and immunology at the University of Toronto. 

A better understanding of this early process could lead to improved prediction, prevention and treatment, the expert said.

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“We haven’t cured anybody yet, and we need to do better.”

“With all the advanced biologic therapy we have today, patients’ responses are partial at best,” Croitoru told SWNS. “We haven’t cured anybody yet, and we need to do better.”

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“We wanted to know: Do people who are at risk, who are healthy now, have these antibodies against flagellin?” he said. “We looked, we measured, and yes indeed, at least some of them did.”

This new research is part of the Genetic, Environmental and Microbial (GEM) Project, which has followed more than 5,000 healthy first-degree relatives of people with Crohn’s disease worldwide since 2008. The project collects genetic, biological and environmental data to better understand how the disease develops.

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The presence of flagellin antibodies long before symptoms appear suggests that the immune reaction may help trigger the disease, according to the lead researcher. (iStock)

The study followed 381 first-degree relatives of Crohn’s patients, 77 of whom later developed the disease. Of those, more than 30% had elevated antibody responses.

The responses were strongest in siblings, underscoring the role of shared environmental exposure, researchers said.

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So far, 130 of the study participants have developed Crohn’s, giving researchers a rare opportunity to study its earliest stages. The average time from blood sample collection to diagnosis was nearly 2-½ years.

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Previous GEM research showed that an inflammatory immune response targeting gut bacteria can appear long before the disease develops. 

The study followed 381 first-degree relatives of Crohn’s patients, 77 of whom later developed the disease. (iStock)

In healthy people, gut bacteria coexist peacefully and play an essential role in digestive health — but in Crohn’s patients, the immune system appears to mount an abnormal response against the microbes, experts say.

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The Canadian team also confirmed that this pre-disease immune response was associated with intestinal inflammation and gut barrier dysfunction, both hallmarks of Crohn’s disease. 

The study did have some limitations, including that it did not include experiments to show exactly how the immune response might lead to Crohn’s disease.  (iStock)

Research team member Dr. Sun-Ho Lee, a gastroenterologist, commented that this new study supports the idea of designing a flagellin-directed vaccine for certain high-risk individuals to prevent the disease, according to SWNS.

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The study did have some limitations, including that it did not include experiments to show exactly how the immune response might lead to Crohn’s disease. 

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As a result, the researchers could not determine the biological steps linking the immune reaction to the onset of the illness. “Further validation and mechanistic studies are underway,” they noted.

Health

Most Americans are doing one nightly activity that’s wrecking their sleep, expert says

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Most Americans are doing one nightly activity that’s wrecking their sleep, expert says

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If you’re not sleeping well, there could be a variety of reasons, but one habit stands out as the biggest culprit.

Dr. Wendy Troxel, a licensed clinical psychologist and senior behavioral scientist at RAND based in Utah, revealed that phone use at night is the activity that is most likely to have a negative effect on slumber.

“Most people are aware of this, but probably the No. 1 habit that’s contributing to interrupted sleep and poor-quality sleep in Americans is the use of phones at night, particularly in bed,” she said in an interview with Fox News Digital.

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“About 90% of Americans are using their phones in bed, and as much as I would like to tell everybody to remove the phone entirely from the bedroom, I realize that ship has probably sailed by now.”

About 90% of Americans use their phones in bed, the sleep expert said. (iStock)

This disruption is driven by both blue light exposure and the stimulating content on phones, according to Troxel.

“There is blue light emitted from our devices, and blue light can suppress the hormone melatonin, which is the hormone of darkness.”

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“But it’s not just the blue light that is causing sleep disruptions from our phones. It’s really the stimulating content that we’re consuming … (on) social media, which is designed to be addictive, so that you can’t put that phone down,” she added.

The combination of blue light and stimulating content keeps the mind alert and interrupts quality sleep. (iStock)

This content is also “very emotionally activating,” Troxel noted, which is “antithetical to the state we want to be in as we approach sleep.”

To counteract attachment to phones, the sleep expert recommends setting a boundary with one simple rule.

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“I recommend that you try to keep your phone more than arms’ distance away from you while in bed,” she advised. “And set a rule for yourself. If you’re going to use the phone, don’t do it in bed. In fact, make your feet be on the floor if you’re going to use that phone.”

“I recommend that you try to keep your phone more than arms’ distance away from you while in bed,” the sleep expert recommended. (iStock)

Setting this boundary creates “behavioral friction,” according to Troxel.

“As a clinical psychologist, I work with people to help them … break habits that aren’t serving them,” she said. “Having that little bit of behavioral friction makes the habit of immediately grabbing for the phone and scrolling while in bed a little more difficult.

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“And when that automatic behavior is a little more difficult, it’s less likely to occur.”

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Giant golden spiders could spread this summer; experts downplay health risk

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Giant golden spiders could spread this summer; experts downplay health risk

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Large, palm-sized spiders are spinning massive golden webs across porches and power lines, and, according to experts, they’re here to stay.

The Joro spider, which has a leg span up to 4 inches and markings of neon yellow, blue-black and red, was first recorded in Georgia in 2013.

Since its arrival — likely as a hitchhiker on a shipping container or an airplane from Asia, experts say — the arachnid has been steadily marching north. 

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The spiders have so far been spotted in Georgia, North Carolina, South Carolina and Tennessee. 

They are expected to spread throughout eastern North America, at least as far north as Pennsylvania and possibly further in warmer, coastal areas, according to Penn State.

Joro spiders can “fly” by shooting out silk parachutes that carry them on the wind. (Stuart Cahill/Boston Herald)

To travel, the spider uses a technique called “ballooning,” in which hatchlings release fine silk threads that catch air currents and carry them over long distances.

Ian Williams, an entomologist with Orkin, said he counted 200 adult spiders by September of last year on his one-acre property near Atlanta.

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“They’re quite intimidating looking spiders, and they make very large webs,” he told Fox News Digital. “The webbing itself, if it catches the sunlight, has a golden hue to it. And it’s very strong.”

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Despite the arachnid’s striking appearance, experts agree that people shouldn’t panic. Research shows the Joro is among the “shyest” spiders ever documented. When disturbed, they often sits motionless for over an hour rather than attacking.

Joro spiders like to spin their webs up high near houses, trees and even power lines, an expert said. (Stuart Cahill/Boston Herald)

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“While they’re large spiders, they don’t have large fangs. And, so, it’s difficult for them to bite humans,” Williams noted.

Even in the rare event of a nip, the expert said the venom is weak, comparable to a localized bee sting, and carries “no medical importance.”

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As an invasive species, the Joro’s impact is still being weighed by scientists.

“One of the big concerns is that they potentially out-compete native species of spiders,” Williams said. 

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Physical removal is more efficient than pesticides, according to an expert. (iStock)

A prolific hunter, the Joro spider catches everything from mosquitoes to large, meaty insects like cicadas. It is unclear whether it steals food from native garden spiders.

To prevent Joro spiders from nesting on your porch or property, experts recommend using a broom or long pole to knock the web down.

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“Spiders may get the message, ‘Hey, I’m not going to keep remaking my same web in the same area,’” Williams said.

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Physical removal is more effective than pesticides, which often miss the spiders in their high, open-air webs.

For those who spot a Joro spider in a new area, experts suggest logging the sighting on apps like iNaturalist to help researchers track their northern migration.

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Another state bans ‘gas station heroin’ as officials warn of deadly risks

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Another state bans ‘gas station heroin’ as officials warn of deadly risks

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Top stories

→ ‘Gas station heroin’ banned in another state amid nationwide crackdowns

→ New COVID variant spreads across US as CDC raises concerns

→ The real reasons you’re still exhausted after 8 hours of sleep

FDA Commissioner Martin Makary says tianeptine poses a “dangerous and growing health trend.” (Markus Scholz/picture alliance via Getty Images)

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→ March Madness sparks surprising surge in men’s sexual procedure

→ Cannabis benefits called into question in major study

→ ‘Call a Boomer’ payphones help cure loneliness across generations

Along a bustling sidewalk in Boston, a bright yellow payphone invites folks to “Call a Boomer.” (Matter Neuroscience)

Food for thought 

→ Eating meat tied to lower dementia risk, study suggests

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→ Stomach issues might have nothing to do with eating habits

→ Why your sugar cravings won’t go away, even after cutting sweets

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