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San Francisco 49ers at Tampa Bay Buccaneers: Predictions, picks and odds for NFL Week 10 game

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San Francisco 49ers at Tampa Bay Buccaneers: Predictions, picks and odds for NFL Week 10 game


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The San Francisco 49ers and Tampa Bay Buccaneers find themselves in very similar situations heading into Week 10. Both teams have four wins, are currently in second-place in their divisions, and have suffered tough losses to their divisional foes in first. They’ve also both suffered a myriad of injuries to their star skill position players and both teams have taken losses at the hands of the Kansas City Chiefs.

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There is one key difference between these teams though. The 49ers are coming off a bye, while the Buccaneers just played on Monday Night Football. The 49ers should be well-rested, while the Bucs might be more banged up than usual, getting one fewer day to recover.

With both teams missing key players, like Christian McCaffrey and Brandon Aiyuk on the 49ers’ side as well as Mike Evans and Chris Godwin on the Bucs’ side, you’d think both teams would be struggling on offense. However, both teams rank top-ten in points per play.

Here are our experts’ predictions for this Week 10 showdown.

PROP TALK: These are the best prop bets for NFL games this week 

Buccaneers vs. 49ers odds, moneyline, over/under

The 49ers are favorites to defeat the Buccaneers, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

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  • Spread: 49ers (-5.5)
  • Moneyline: 49ers (-250); Buccaneers (+200)
  • Over/under: 50.5

Not interested in this game? Our guide to NFL betting odds, picks and spreads has you covered with Thursday Night Football odds and Monday Night Football odds.

New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites.

FEELING LUCKY? Here are the best parlay bets and odds for NFL games this week 

NFL Week 10 odds, predictions and picks

Ravens vs. Bengals | Panthers vs. Giants | Bears vs. Patriots | Colts vs. Bills | Jaguars vs. Vikings | Chiefs vs. Broncos | Saints vs. Falcons | Buccaneers vs. 49ers | Commanders vs. Steelers | Chargers vs. Titans | Cardinals vs. Jets | Cowboys vs. Eagles | Texans vs. Lions | Rams vs. Dolphins

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Lorenzo Reyes: 49ers 28, Buccaneers 20

The Buccaneers play up to elite competition, with the top strength of victory (.647) — or the combined winning percentage of teams Tampa has defeated. The Bucs, in fact, are the only team above .600 in that stat. But the 49ers are coming off a bye week, and one they needed to heal up. Frankly, I can see this going both ways and would likely look elsewhere for a safer play, but given the extra rest — and the fact that Tampa has a slightly shorter week after playing Monday night — I’ll cautiously back the Niners.

Tyler Dragon: 49ers 25, Bucs 21

Will Christian McCaffrey make his season debut this week? San Francisco is coming off a Week 9 bye. While the Bucs are playing on a short week. The 49ers know they need to start performing better if they want to reclaim top status in the NFC West. San Francisco should win this game whether McCaffrey plays or not.

Richard Morin: 49ers 28, Buccaneers 27

San Francisco desperately needs to get going, but it won’t be an easy task on the road in Tampa Bay. I think the 49ers pull out the win, but the 5.5-point spread is a bit much for me.

Jordan Mendoza: 49ers 23, Buccaneers 16

Could Christian McCaffrey actually play? He’ll make an immediate difference and get San Francisco back to being solidified contenders.



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San Francisco, CA

Yes, an $8 Burger Exists in Downtown San Francisco

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Yes, an  Burger Exists in Downtown San Francisco


Sometimes life requires an easy hang, without the need for reservations and dressing up, and preferably with food that’s easy to rally folks behind. The newish Hamburguesa Bar is just such a place, opening in December 2025 and serving a tight food menu of smash and tavern burgers (made with beef ground in-house), along with hand-cut duck fat fries, poutine, and Caesar salad. The best part? Nothing here costs more than $20. Seriously, this spot has so much going for it, including solid cocktails and boozy shakes. It’s become a homing beacon for post-work hangs, judging by a recent weekday crowd.

Hamburguesa Bar’s drinks are the epitome of unfussy: Cocktail standards, four beers on tap, two choices of wine (red or white), boozy and non-boozy shakes, plus 21 beers by the can or bottle. Standards on the cocktail menu are just that, a list of drinks you’ve heard before — such as an Old Fashioned, daiquiri, gin or vodka martini, or Harvey Wallbanger — with no special tinctures or fat-washed liquors to speak of (that we know of, at least). I’m typically split on whether boozy shakes are ever worth it, but the Fruity Pebbles option ($14) makes a convincing case, mixed with a just-right amount of vodka and some cereal bits. (I’ll leave the more adventurous Cinnamon Toast shake made with Fireball to others with more positive experiences with that liquor.)

Downtown and SoMa has a reputation for restaurants closing early, but Hamburguesa Bar keeps later hours, closing at midnight from Monday through Saturday (closed Sundays). It’s also open for lunch at noon during those days, with the exception of Saturdays when it opens at 5 p.m.



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Iran conflict disrupts flights out of SFO

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Iran conflict disrupts flights out of SFO


SAN FRANCISCO (KRON) — Attacks on Iran by U.S. and Israeli forces have disrupted air travel across the Middle East, leading to thousands of flight cancellations and delays worldwide. The instability has reached the Bay Area, where international flights at San Francisco International Airport have been canceled or grounded. The travel disruptions followed retaliatory strikes […]



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Hundreds Rally in San Francisco Against U.S.-Israel Strikes on Iran | KQED

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Hundreds Rally in San Francisco Against U.S.-Israel Strikes on Iran | KQED


She acknowledged that Iranian Americans hold a range of political views, including some who support U.S. intervention, but said she believes the future of Iran should be determined by its people.

“The Iranian people in Iran can decide the future of their country,” she said. “War, I don’t think, is going to help.”

Speaking to the crowd, Mortazavi challenged what she described as a narrative that Iranians broadly support U.S. and Israeli military action.

“They want you to believe that every Iranian … is cheering on the United States and Israel,” she said. “That is unequivocally false.”

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She urged attendees to continue organizing beyond the rally and announced plans for additional demonstrations.

A demonstrator holds an Iranian flag as protesters gather outside the San Francisco Federal Building during a “Hands Off Iran” rally Feb. 28, 2026, in San Francisco. The demonstration called for an end to U.S. involvement in the strikes on Iran. (Gustavo Hernandez/KQED)

Dina Saadeh, an organizer with the Palestinian Youth Movement, said multiple groups mobilized quickly in response to the strikes.

“I’m angered today,” Saadeh told KQED. “People here don’t want to see our country engaged in more endless war.”

Saadeh described the protest as part of a broader effort to oppose sanctions, military escalation and what she called U.S. imperialism. She said participants were calling on elected officials to redirect public funds toward domestic needs.

“People want money for jobs and education, not for war and occupation,” she said.

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KQED’s María Fernanda Bernal contributed to this story.



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